List of works by Florian Holsboer

"Anxietas tibiarum". Depression and anxiety disorders in patients with restless legs syndrome.

scientific article published in January 2005

17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro

scientific article

A follow-up case-control association study of tractable (druggable) genes in recurrent major depression

scientific article published on 31 May 2011

A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder

scientific article published on 17 April 2015

A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression

scientific article published on September 2009

A hypomorphic vasopressin allele prevents anxiety-related behavior

scientific article

A mega-analysis of genome-wide association studies for major depressive disorder

scientific article

A new strategy to analyze possible association structures between dynamic nocturnal hormone activities and sleep alterations in humans

scientific article published on 14 January 2009

A novel chronic social stress paradigm in female mice

scientific article published on 25 January 2010

A polymorphism in the Crhr1 gene determines stress vulnerability in male mice

scientific article published on 28 April 2014

ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder

scientific article published on November 2003

ABCB1 gene variants and antidepressant treatment outcome: A meta-analysis

scientific article published on 2 April 2015

ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: Relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression☆ ⬇️

scientific article published on January 1, 1984

AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms

scientific article published on 2 June 2010

ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples

scientific article published on 29 May 2012

Acoustic oddball during NREM sleep: a combined EEG/fMRI study

scientific article

Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways

scientific article published in July 2002

Activation of c-Fos contributes to amyloid beta-peptide-induced neurotoxicity

scientific article

Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway.

scientific article published in June 1996

Activity of the GR in G2 and mitosis

scientific article published in June 2002

Activity of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: correlations with gadolinium-enhancing lesions and ventricular volume

scientific article

Acute and chronic neuroendocrine effects of interferon-beta 1a in multiple sclerosis

scientific article

Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression

scientific article published on 28 January 2008

Acute cortisol administration promotes sleep intensity in man.

scientific article

Acute effects of interferon beta-1a on plasma cytokine levels in patients with MS

scientific article published on 01 October 2000

Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area — Possible novel signalling pathways

article

Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain

scientific article published on 01 October 2000

Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personality

scientific article published on 23 March 2010

Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation

scientific article

Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats

scientific article published on 01 April 2000

Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions

scientific article

Allopregnanolone acts as an inhibitory modulator on alpha1- and alpha6-containing GABA-A receptors.

scientific article published on February 1996

Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin

scientific journal article

Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders

scientific article published on 01 October 1995

Altered processing of acoustic stimuli during sleep: reduced auditory activation and visual deactivation detected by a combined fMRI/EEG study

scientific article published in May 2002

Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775.

scientific article published on December 2003

Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions

scientific article

Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons--dissociation from cholesterol homeostasis

scientific article published on 20 April 2011

Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice

scientific article

Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro

scientific article published in July 2003

Antidepressants do not modulate estrogen receptor alpha-mediated gene expression

scientific article

Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels

scientific journal article

Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern

scientific article published on January 1, 1992

Antipsychotic drugs antagonise human serotonin type 3 (5-HT3) receptor currents in a noncompetitive manner

scholarly article by G Rammes et al published 5 August 2004 in Molecular Psychiatry

Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats

scientific article published in December 1995

Are there meaningful biomarkers of treatment response for depression?

scientific article published on 21 February 2014

Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice

scientific article

Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample

scientific article

Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study

scientific article published on 24 November 2015

Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans

scientific article (publication date: November 2014)

Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder

scientific article

Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients

scientific article published on February 2010

Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders

scientific article

Atrial natriuretic hormone decreases endocrine response to a combined dexamethasone-corticotropin-releasing hormone test

scientific article published on 01 March 1998

Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores

scientific article published on 10 February 2016

B-HT 920--a novel dopamine autoreceptor agonist in the treatment of patients with schizophrenia

scientific article

B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells

scientific article

BAG-1 diversely affects steroid receptor activity

scientific article published on January 2012

Behavioral and endocrine response to cholecystokinin tetrapeptide in patients with posttraumatic stress disorder

scientific article published on 01 January 2000

Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder

scientific article published on 01 February 1999

Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior.

scientific article published in November 1998

Behavioural performance in three substrains of mouse strain 129 ⬇️

scientific article published on July 11, 1997

Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway

scientific article published on April 2001

Bidirectional effects of the neuroactive steroid tetrahydrodeoxycorticosterone on GABA-activated Cl- currents in cultured rat hypothalamic neurons

scientific article published on June 1999

Blood mononuclear cell proteome suggests integrin and Ras signaling as critical pathways for antidepressant treatment response

scientific article published on 4 February 2014

Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder

scientific article

Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment

scientific article published on November 1988

Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men

scientific article

CHL1, ITGB3 and SLC6A4 gene expression and antidepressant drug response: results from the Munich Antidepressant Response Signature (MARS) study

scientific article published on 06 May 2015

CRE-mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death.

scientific article published on January 2002

CRF signaling: molecular specificity for drug targeting in the CNS.

scientific article

CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues

scientific article

CRH signaling. Molecular specificity for drug targeting in the CNS.

scientific article

CRH-sub-1 receptor antagonists for the treatment of depression and anxiety

scientific article

CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells

scientific article

Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating

scientific article

Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

scientific article published on November 1993

Central Administration of IL-1 Reduces Anxiety and Induces Sickness Behaviour in Rats ⬇️

scientific article published on October 1, 1997

Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists

scientific article

Central and peripheral administration of atriopeptin is anxiolytic in rats.

scientific article published in March 1997

Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice

scientific article

Centrally administered oligodeoxynucleotides in rats: occurrence of non-specific effects ⬇️

scientific article published on July 23, 1997

Cerebrospinal fluid biomarkers for major depression confirm relevance of associated pathophysiology

scientific article

Changes in late auditory evoked potentials induced by corticotropin-releasing hormone and corticotropin fragment 4-9 in male controls

scientific article published on 01 January 1996

Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment

scientific article

Characterization of the B-Raf interactome in mouse hippocampal neuronal cells ⬇️

scientific article published on November 3, 2010

Childhood abuse and depression in adulthood: The mediating role of allostatic load

Circadian changes in the sensitivity of the corticotropin-releasing hormones-stimulated HPA system after arginine vasopressin and atrial natriuretic hormone in human male controls ⬇️

scientific article published on 01 January 1995

Clinical and neurobiological effects of tianeptine and paroxetine in major depression

scientific article published in April 2003

Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project

scientific article published on 30 June 2008

Clinical risk factors for weight gain during psychopharmacologic treatment of depression: results from 2 large German observational studies

scientific article published on June 2015

Clozapine-induced increase in plasma levels of soluble interleukin-2 receptors

scientific article published on 01 October 1995

Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function

scientific article

Cognitive performance in rats differing in their inborn anxiety

scientific article published in June 2002

Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging

scientific article published on November 1996

Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder

scientific article published in October 2008

Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity

scientific article published on 28 December 2017

Common genetic variants influence human subcortical brain structures

scientific article

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells

scientific article

Computerized brain tomography measures compared with spontaneous and suppressed plasma cortisol levels in major depression

scientific article published on 01 January 1989

Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge

scientific article

Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep

scientific article

Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775.

scientific article published on 30 May 2008

Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response

scientific article

Cordance derived from REM sleep EEG as a biomarker for treatment response in depression--a naturalistic study after antidepressant medication

scientific article published on 19 February 2015

Correction: Compound A, a Dissociated Glucocorticoid Receptor Modulator, Inhibits T-bet (Th1) and Induces GATA-3 (Th2) Activity in Immune Cells

scientific article (publication date: 23 May 2012)

Corrigendum to “Regulation of the developing hypothalamic–pituitary–adrenal axis in corticotropin releasing hormone receptor 1-deficient mice”

scholarly article published in Neuroscience

Corticosteroid receptor function is decreased in depressed patients

scientific article published on 01 March 1997

Corticotropin releasing factor receptor antagonists for major depressive disorder

scientific article

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

scientific article

Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat

scientific article published on 01 October 1994

Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats

scientific article published on October 1994

Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression?

scientific article published on 01 April 1997

Corticotropin-releasing hormone modulators and depression

scientific article

Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice

scientific article

Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells

scientific article

Corticotropin-releasing-factor induced pituitary-adrenal response in depression

scientific article published on 01 January 1984

Cortisol enhances non-REM sleep and growth hormone secretion in elderly subjects

scientific article published on 01 July 1997

Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression

scientific article published on 01 April 1995

Cytokine expression and molecular mechanisms of their auto/paracrine regulation of anterior pituitary function and growth

scientific article published on May 1998

DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range

scientific article published in January 1995

Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models

scientific article

Dehydroepiandrosterone response to the adrenocorticotropin test and the combined dexamethasone and corticotropin-releasing hormone test in patients with multiple sclerosis

scientific article published on 01 December 1999

Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity

scientific article

Depletion of the neural precursor cell pool by glucocorticoids

scientific article published in January 2010

Depression, comorbidities and the TNF-α system

Development of the brain's default mode network from wakefulness to slow wave sleep

scientific article published on 17 February 2011

Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders

scientific article

Dexamethasone nonsuppression in transgenic mice expressing antisense RNA to the glucocorticoid receptor

scientific article published on 01 January 1994

Dexamethasone stimulated gene expression in peripheral blood indicates glucocorticoid-receptor hypersensitivity in job-related exhaustion

scientific article published on 3 March 2014

Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients

scientific article

Dexamethasone suppression test in severe schizophrenic illness: effects of plasma dexamethasone and caffeine levels

scientific article published on 01 June 1987

Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment

scientific article published in March 2005

Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro

scientific article published on 01 December 1993

Differential effects of the enantiomers R(-) and S(+) oxaprotiline on major endogenous depression, the sleep EEG and neuroendocrine secretion: studies on depressed patients and normal controls

scientific article published on June 1993

Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-Glycoprotein gene disruption ⬇️

scientific article published on October 15, 2003

Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro

scientific article

Differential regulation of interleukin-1 receptor antagonist by proopiomelanocortin peptides adrenocorticotropic hormone and beta-endorphin

scientific article published on September 1999

Dissociation of REM sleep and nocturnal penile tumescence in volunteers treated with brofaremine

scientific article published on 01 February 1987

Distinct panicogenic activity of sodium lactate and cholecystokinin tetrapeptide in patients with panic disorder.

scientific article published in January 2012

Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

scientific article published on January 1995

Do efficacy and effectiveness samples differ in antidepressant treatment outcome? An analysis of eligibility criteria in randomized controlled trials

scientific article published on 10 August 2010

Downregulation of brain mineralocorticoid and glucocorticoid receptor by antisense oligodeoxynucleotide treatment fails to alter spatial navigation in rats

scientific article

Dreamed movement elicits activation in the sensorimotor cortex

scientific article published on 27 October 2011

Dysregulation of the hypothalamic-pituitary-adrenocortical system in panic disorder

scientific article published on 01 July 1996

EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units

scientific article

Early life stress determines the effects of glucocorticoids and stress on hippocampal function: Electrophysiological and behavioral evidence respectively

scientific article published on 2 February 2018

Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1.

scientific article published on 4 June 2012

Effect of Chronic Administration of Selective Glucocorticoid Receptor Antagonists on the Rat Hypothalamic–Pituitary–Adrenocortical Axis ⬇️

scientific article published on April 2, 2003

Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers

scientific article published in June 2004

Effect of mirtazapine on metabolism and energy substrate partitioning in healthy men

scholarly article by Johannes M Hennings et al published 10 January 2019 in JCI insight

Effect of psychosocial stress on FKBP5 and NR3C1 gene expression in healthy young men

article

Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats.

scientific article published on May 2003

Effects of 5HT3 receptor antagonism by tropisetron on the sleep EEG and on nocturnal hormone secretion

scientific article published in October 1994

Effects of Genetic Background, Gender, and Early Environmental Factors on Isolation-Induced Ultrasonic Calling in Mouse Pups: An Embryo-Transfer Study

scientific article published on 20 August 2008

Effects of antidepressant treatment on neuroactive steroids in major depression

scientific article

Effects of brofaremine (CGP 11 305A), a short-acting, reversible, and selective inhibitor of MAO-A on sleep, nocturnal penile tumescence and nocturnal hormonal secretion in three healthy volunteers

scientific article published on 01 January 1987

Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients

scientific article published on 01 January 2001

Effects of ethanol administration and induction of anxiety-related affective states on the acoustic startle reflex in sons of alcohol-dependent fathers

scientific article published in March 2004

Effects of flumazenil on recovery sleep and hormonal secretion after sleep deprivation in male controls

scientific article published in August 1995

Effects of light or dark phase testing on behavioural and cognitive performance in DBA mice

scientific article published in October 2006

Effects of rapid eye movement sleep deprivation on fear extinction recall and prediction error signaling

scientific article

Effects of transgenic overproduction of CRH on anxiety-like behaviour

scientific article published on June 2002

Effects of trimipramine on sleep EEG, penile tumescence and nocturnal hormonal secretion. A long-term study in 3 normal controls

scientific article published in January 1989

Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats

scientific article published on November 1999

Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats

scientific article published on 01 February 2000

Endotoxin enhances EEG alpha and beta power in human sleep.

scientific article published in March 1994

Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

scientific journal article

Epigenetic aspects of posttraumatic stress disorder

scientific article published on January 2011

Erratum: Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients

article

Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor

scientific article published on 12 December 2002

Estimating the heritability of reporting stressful life events captured by common genetic variants

scientific article published on 14 December 2012

Ethanol administration dampens the prolactin response to psychosocial stress exposure in sons of alcohol-dependent fathers

scientific article published on 25 February 2009

Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

scientific journal article

Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression

scientific article published in August 2005

Evidence supporting the match/mismatch hypothesis of psychiatric disorders

scientific article published on 15 February 2014

Exaggerated corticotrophic cell response to human corticotropin-releasing hormone in two patients during long-term carbamazepine treatment

scientific article published on 01 July 1988

Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity

scientific article published on 7 February 2007

FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression

article

FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls

scientific article

FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications

scientific article

Family history of depression is associated with younger age of onset in patients with recurrent depression

scientific article

Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis

scientific article published in February 2005

Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls

scientific article published in January 1994

Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism

scientific article

Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling

scientific article

Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates

scientific article published in July 2004

Functional antagonism of gonadal steroids at the 5-hydroxytryptamine type 3 receptor

scientific article

Functional antagonistic properties of clozapine at the 5-HT3 receptor

scientific article published on August 1996

Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action

scientific article

Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods

scientific article

Functional properties of deoxycorticosterone and spironolactone: molecular characterization and effects on sleep-endocrine activity

scientific article published on July 1993

GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment

scientific article published in January 2002

Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response

scientific article

Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks

scientific article (publication date: October 2009)

Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein

scientific article

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

scholarly article published 28 August 2017

Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks

scientific article published on January 2011

Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation

scientific article published in July 2008

Genetic modification of corticosteroid receptor signalling: novel insights into pathophysiology and treatment strategies of human affective disorders

scientific article

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

scientific article

Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression

scientific article

Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease

scientific article published on 8 June 2010

Genetics of rapid eye movement sleep in humans

scientific article published on 07 July 2015

Genetics of stress response and stress-related disorders

scientific article

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo

scientific article published on 09 December 2008

Genome-wide association study of antidepressant treatment-emergent suicidal ideation

scientific article published on 26 October 2011

Genome-wide association study of major recurrent depression in the U.K. population.

scientific article published in June 2010

Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts

scholarly article by P Muglia et al published 23 December 2008 in Molecular Psychiatry

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

scientific article

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

scientific article

Glucocorticoid Repression of 3',5'-Cyclic-Adenosine Monophosphate-Dependent Human Corticotropin-Releasing-Hormone Gene Promoter Activity in a Transfected Mouse Anterior Pituitary Cell Line ⬇️

scientific article published on September 1, 1990

Glucocorticoid and mineralocorticoid receptors in rat neocortical and hippocampal brain cells in culture: characterization and regulatory studies.

scientific article published in March 1993

Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice

article

Glucocorticoid regulation of astrocytic fate and function

scientific article

Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro

scientific article published on January 1997

Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells

scientific article published on 5 January 2009

Glucocorticoids inhibit the autoregulatory induction of interleukin-1 in monocytes after endotoxin stimulation

scientific article published on 01 July 1996

Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

scientific article published in September 2011

Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man.

scientific article published in May 1995

HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients.

scientific article published on 30 September 2008

HTR2A gene variation is involved in antidepressant treatment response

scientific article published in January 2010

Heritability of sleep electroencephalogram

scientific article published on 11 April 2008

Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS.

scientific article published on December 1994

Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity

scientific article

High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.

scientific article published on May 1998

High susceptibility to chronic social stress is associated with a depression-like phenotype

scientific article published on 25 October 2009

High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats

scientific article

High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit

scientific article published on 6 November 2015

High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response

scientific article

High-quality antidepressant discovery by understanding stress hormone physiology

scientific article published on December 2003

Hippocampal N-acetylaspartate levels before trauma predict the development of long-lasting posttraumatic stress disorder-like symptoms in mice

scientific article published on 8 October 2008

Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure

scientific article

Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders

scientific article published on 01 April 1998

Human corticotropin-releasing hormone in depression--correlation with thyrotropin secretion following thyrotropin-releasing hormone

scientific article published on 01 June 1986

Hypothalamic-Pituitary-Adrenocortical Dysfunction in Elderly, Male Marathon Runners: Feedback Sensitivity, Stress Response, and Effects on Verbal Memory

scientific article published on 28 September 2016

Hypothalamic-pituitary-adrenal system adaptation to detoxification in alcohol-dependent patients is affected by family history of alcoholism

scientific article

Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide

scientific article published on 01 November 1994

Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice

scientific article published on January 2004

Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone ⬇️

scientific article published on November 1, 2003

Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression

scientific article published in February 2005

IGF-I in major depression and antidepressant treatment response

scientific article published on 5 January 2015

Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients

scientific article

Identification and characterization of a 3',5'-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing hormone gene promoter

scientific article published on November 1, 1992

Identification of common variants associated with human hippocampal and intracranial volumes

scientific article published on 15 April 2012

Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919).

scientific article

Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models

scientific article published on February 2009

Impact of high and low anxiety on cognitive performance in a modified hole board test in C57BL/6 and DBA/2 mice

scientific article published on January 2003

Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice.

scientific article published on 7 August 2007

Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression

scientific article

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.

scientific article

In silico structural and functional characterization of the RSUME splice variants

scientific article

Increased ACTH concentrations associated with cholecystokinin tetrapeptide-induced panic attacks in patients with panic disorder

scientific article published in March 2000

Increased HPA axis response to psychosocial stress in remitted depression: the influence of coping style

scientific article published on 27 September 2014

Increased anxiety-related behaviour in Hint1 knockout mice

scientific article

Increased growth hormone response to apomorphine in Parkinson disease compared with multiple system atrophy

scientific article

Increased sleep pressure reduces resting state functional connectivity

scientific article

Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice

scientific article published in October 2002

Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders

scientific article published on 24 December 2009

Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism

scientific article

Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides.

scientific article published in March 1997

Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results

scientific article

Induction of NF-kappaB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-kappaB and neuroprotection by antioxidants.

scientific article published in October 1998

Infusions of tyrosine hydroxylase antisense oligodeoxynucleotide into substantia nigra of the rat: effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour

scientific article published on 01 February 1997

Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90.

scientific article published on February 2004

Integrating systemic information at the molecular level: cross-talk between steroid receptors and cytokine signaling on different target cells

scientific article

Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals

scientific article

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study

scientific article published on 24 August 2011

Interleukin-1β Stimulates both Central and Peripheral Release of Vasopressin and Oxytocin in the Rat

scientific article published on 01 April 1995

Intermediate glucocorticoid feedback of corticotropin secretion in patients with major depression

scientific article published on 01 November 1995

Intracellular molecular signaling. Basis for specificity to glucocorticoid anti-inflammatory actions

scientific article published on February 2009

Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study

scientific article published on November 2010

Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons

scientific article published on 25 January 2012

Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one.

scientific article published on April 2015

Intraperitoneal administration of bacterial endotoxin enhances noradrenergic neurotransmission in the rat preoptic area: relationship with body temperature and hypothalamic--pituitary--adrenocortical axis activity.

scientific article published on December 1995

Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG.

scientific article

Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking.

scientific article published in June 2009

Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk

scientific article

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

scientific article published on 14 September 2003

Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds

scientific article published on 10 December 2012

Lipopolysaccharide increases EEG delta activity within non-REM sleep and disrupts sleep continuity in rats

scientific article published in May 1995

Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders

scientific article

Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder

scientific article

Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice

scientific article

Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders

scientific article

Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge.

scientific article published on June 1997

Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2.

scientific article published on 7 November 2014

Low cortisol and risk and resilience to stress-related psychiatric disorders

scientific article published on February 2012

Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice

scientific article

Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity

scientific article published on March 2002

Met and unmet needs in the management of depressive disorder in the community and primary care: the size and breadth of the problem.

scientific article

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.

scientific article

Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation

scientific article published on 13 December 2011

Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress

scientific article published in January 2015

Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: A translational approach

Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: a translational approach

scientific article published on 23 July 2014

Mice selected for high versus low stress reactivity: a new animal model for affective disorders

scientific article published on 23 May 2008

Mice with mutations in the HPA-system as models for symptoms of depression

scientific article

Mining the human cerebrospinal fluid proteome by immunodepletion and shotgun mass spectrometry

scientific article

Mirtazapine provokes periodic leg movements during sleep in young healthy men.

scientific article published on May 2013

Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice

scientific article published on 6 May 2010

Modeling the pharmacokinetics and pharmacodynamics of dexamethasone in depressed patients

scientific article published on January 1, 1992

Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis.

scientific article published on September 1996

Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production

scientific article

Molecular understanding of cytokine-steroid hormone dialogue: implications for human diseases

scientific article published on November 2006

Monitoring ketamine treatment response in a depressed patient via peripheral mammalian target of rapamycin activation

scientific article published in July 2011

Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations

scientific article

Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders

scientific article published in June 2004

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.

scientific article published in November 2001

Neural correlates of dream lucidity obtained from contrasting lucid versus non-lucid REM sleep: a combined EEG/fMRI case study

scientific article

Neural correlates of insight in dreaming and psychosis

scientific article

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

scientific article

Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology

scientific article published on 01 November 2001

Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects

scientific article

Neuronal actions of glucocorticoids: focus on depression

scientific article published on 08 September 2007

Neuropeptide S receptor gene -- converging evidence for a role in panic disorder

scientific article

Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?

scientific article

Neuroprotection against oxidative stress by estrogens: structure-activity relationship

scientific article

Neuroscience-driven discovery and development of sleep therapeutics

scientific article

Neurosteroids: molecular mechanisms of action and psychopharmacological significance.

scientific article published on January 1996

Nocturnal sleep EEG in patients with HIV infection

scientific article published in January 1991

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

Nuclear orphan receptor as a repressor of glucocorticoid receptor transcriptional activity

scientific article

Nur77 induction and activation are necessary for interleukin-1 stimulation of proopiomelanocortin in AtT-20 corticotrophs

scientific article published on April 2004

On the Need of Objective Vigilance Monitoring: Effects of Sleep Loss on Target Detection and Task-Negative Activity Using Combined EEG/fMRI

scientific article

On the gender differences in sleep-endocrine regulation in young normal humans

scientific article

Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial

scientific article published on 26 November 2008

Outcomes of 1014 naturalistically treated inpatients with major depressive episode

scientific article published on 22 January 2010

Overweight and obesity affect treatment response in major depression

scientific article

Oxidative stress-resistant cells are protected against haloperidol toxicity

scientific article published on 01 April 1996

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

scientific article published on 5 July 2006

PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome

scientific article published on 27 July 2008

Paroxetine treatment improves motor symptoms in patients with multiple system atrophy

scientific article published in October 2006

Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression

scientific article published on 26 February 2010

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

scientific article

Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation

scientific article published on 22 December 2006

Pharmacogenomics and antidepressant drugs

scientific article

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.

scientific article

Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test

scientific article published in December 2003

Phenome-transcriptome correlation unravels anxiety and depression related pathways

scientific article published on 20 January 2011

Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder

scientific article

Phosphopeptide enrichment by IEF.

scientific article published on November 2006

Plasma dexamethasone kinetics during the DST after oral and intravenous administration of the test drug

scientific article published on 01 November 1987

Plasma fibrinogen: now also an antidepressant response marker?

scientific article published on 28 January 2014

Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections

scientific article

Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex

scientific article published on 10 January 2018

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

scientific article

Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment

scientific article

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

scientific article published in July 2008

Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders

scientific article published in December 2009

Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients

scientific article published on January 2009

Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression

scientific article

Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder

scientific article

Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder

scientific article

Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes

scientific article

Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences

scientific article published on 12 February 2009

Prediction of antidepressant treatment response from gray matter volume across diagnostic categories

scientific article published on 03 August 2013

Prediction of the development of a first major depressive episode with a rapid eye movement sleep induction test using the cholinergic agonist RS 86.

scientific article published in June 2004

Pregnenolone enhances EEG delta activity during non-rapid eye movement sleep in the rat, in contrast to midazolam

scientific article published in May 1994

Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats

scientific article

Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine

scientific article published on 16 July 2008

Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators

scientific article published in October 1996

Progesterone receptor-mediated effects of neuroactive steroids

scientific article

Progesterone-induced changes in sleep in male subjects

scientific article (publication date: May 1997)

Proliferation rates and gene expression profiles in human lymphoblastoid cell lines from patients with depression characterized in response to antidepressant drug therapy

scientific article

Protection against oxidative stress-induced neuronal cell death--a novel role for RU486.

scientific article

Protein biomarkers in a mouse model of extremes in trait anxiety

scientific article published on 14 June 2006

Proteomic Differences in Blood Plasma Associated with Antidepressant Treatment Response

scientific article published on 31 August 2017

Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways

scientific article published on 23 August 2011

Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates

scientific article published in December 2012

Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways

scientific article published on 13 January 2009

Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways

scientific article

Psychiatric disorders biomarker identification: from proteomics to systems biology

scientific article published on September 2008

Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters

scientific article published on 17 August 2013

Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone.

scientific article

Psychopathological correlates of plasma cortisol after dexamethasone suppression: a polydiagnostic approach

scientific article published on 01 January 1986

Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD.

scientific article

REM sleep, hippocampus, and memory processing: insights from functional neuroimaging studies

scientific article

RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response

scientific article published on 31 March 2015

RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity

scientific article

RSUME inhibits VHL and regulates its tumor suppressor function.

scientific article published on 15 December 2014

RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

scientific article

Rapid eye movement-related brain activation in human sleep: a functional magnetic resonance imaging study

scientific article published in May 2005

Real-time imaging of amygdalar network dynamics in vitro reveals a neurophysiological link to behavior in a mouse model of extremes in trait anxiety

scientific article published in October 2013

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice

scientific article

Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly

scientific article published on 01 September 1997

Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

scientific article published on 01 February 2000

Reduced hippocampus volume in the mouse model of Posttraumatic Stress Disorder ⬇️

scientific article published on November 23, 2010

Reduced leptin levels in human narcolepsy

scientific article published on October 2000

Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model.

scientific article published on 25 July 2002

Regulation of proteins mediating neurodegeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

scientific article published on 13 October 2009

Regulation of rat mineralocorticoid receptor expression in neurons by progesterone ⬇️

scientific article published on September 1, 1995

Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder

scientific article published on 12 July 2006

Reply to “Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression”

Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels

scientific article

Response of ACTH and cortisol to human corticotropin-releasing hormone after short-term abstention from alcohol abuse

scientific article published on 01 July 1988

Resting state functional MRI connectivity predicts hypothalamus-pituitary-axis status in healthy males

scientific article published on 29 December 2012

Retinoic acid as a novel medical therapy for Cushing's disease in dogs

scientific article

Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression

scientific article

Role of the hsp70 cochaperone BAG1 in glucocorticoid receptor function and stress-related diseases

scholarly article

Savoxepine: invalidation of an "atypical" neuroleptic response pattern predicted by animal models in an open clinical trial with schizophrenic patients

scientific article published in January 1991

Searching for non-genetic molecular and imaging PTSD risk and resilience markers: Systematic review of literature and design of the German Armed Forces PTSD biomarker study

scientific article

Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression. Implications for pathophysiology of DST nonsuppression

scientific article published on 01 February 1987

Serial partial sleep deprivation in depression--clinical effects and dexamethasone suppression test results

scientific article published in January 1988

Shortened dexamethasone half-life in depressed dexamethasone nonsuppressors

scientific article published on 01 August 1986

Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs

scientific article

Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery

scientific article published on March 1989

Sleep and active renin levels--interaction with age, gender, growth hormone and cortisol

scientific article published on 29 January 2010

Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression

scientific article

Sleep endocrine effects of antigluco- and antimineralocorticoids in healthy males

scientific article published in July 1994

Sleep endocrine effects of megestrol acetate in healthy men.

scientific article published on September 1998

Sleep in schizophrenia: a polysomnographic study on drug-naive patients

scientific article published in January 1997

Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men

scientific article published on 01 January 1998

Smoking affects plasma-soluble interleukin-2 receptor levels in patients with schizophrenia

scientific article published on 01 January 1997

Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.

scientific article published on May 1995

Somatostatin impairs sleep in elderly human subjects

scientific article published in May 1997

Sonic hedgehog regulates CRH signal transduction in the adult pituitary

scientific article

State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine

scientific article published in February 2003

Steroid effects on central neurons and implications for psychiatric and neurological disorders.

scientific article published on November 1994

Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship

scientific article published on May 1996

Stress responsive neurohormones in depression and anxiety

scientific article published on November 2003

Structural brain changes in patients with recurrent major depressive disorder presenting with anxiety symptoms

scientific article

Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis

scientific article published on 20 September 2006

Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action

scientific article

Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins

scientific article

TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies

scientific article published on 6 April 2010

Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress

scientific article

Ten years of Nature Reviews Neuroscience: insights from the highly cited

scientific article

The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety

scientific article published in July 2002

The CpG island shore of the GLT-1 gene acts as a methylation-sensitive enhancer

scientific article

The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders

scientific article published on 08 July 2008

The Munich Vulnerability Study on Affective Disorders: risk factors for unipolarity versus bipolarity

scientific article published in April 2003

The Munich Vulnerability Study on Affective Disorders: stability of polysomnographic findings over time

scientific article published in September 2002

The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects

scientific article published on 26 May 2008

The Munich vulnerability study on affective disorders: premorbid polysomnographic profile of affected high-risk probands

scientific article

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction

scientific article published on 10 January 2007

The binary corticosteroid response: transcriptional regulation by mineralo- and glucocorticoid receptors.

scientific article published on November 1994

The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.

scientific article

The clinical application of ABCB1 genotyping in antidepressant treatment: a pilot study

scientific article published on 23 July 2013

The combined dexamethasone/CRH test as a potential surrogate marker in depression

scientific article

The controversial link between antidepressants and suicidality risks in adults: data from a naturalistic study on a large sample of in-patients with a major depressive episode

scientific article

The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved

scientific article published on 13 May 2011

The effect of dexamethasone dosage upon plasma cortisol and dexamethasone during the DST

scientific article published on 01 June 1990

The effect of neuroendocrine secretion on brain morphology and EEG sleep in patients with eating disorders

scientific article published in January 1989

The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety

scientific article

The genetic architecture of the human cerebral cortex

The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation

scientific article (publication date: October 2003)

The hypothalamic-pituitary-adrenocortical (HPA) system and anti-depressive drug (AD) action.

scientific article

The modified hole board as a differential screen for behavior in rodents

scientific article published on 01 August 2001

The neural correlates and temporal sequence of the relationship between shock exposure, disturbed sleep and impaired consolidation of fear extinction

scientific article

The neuronal transporter gene SLC6A15 confers risk to major depression

scientific article

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

scientific article published on September 1994

The pre-morbid psychometric profile is stable over time in subjects at high familial risk for affective disorders

scientific article published on 01 October 1998

The prospect of FKBP51 as a drug target

scientific article published on 13 May 2012

The role of the hypothalamic-pituitary-adrenocortical system during inflammatory conditions

scientific article published on January 1994

The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice

scientific article published on 20 June 2007

Therapeutic Action of Fluoxetine is Associated with a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress Disorder

scientific article

Three-Year long-term outcome of 458 naturalistically treated inpatients with major depressive episode: severe relapse rates and risk factors

scientific article published on 4 March 2014

Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls

scientific article published on 3 January 2011

Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder

scientific article

Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression

scientific article published in December 2005

Transcription factor-mediated molecular mechanisms involved in the functional cross-talk between cytokines and glucocorticoids

scientific article

Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding

scientific article

Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress

scientific article published on 25 July 2008

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects

scientific article

Transrepression of NF-kappaB is not required for glucocorticoid-mediated protection of TNF-alpha-induced apoptosis on fibroblasts.

scientific article

Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects ⬇️

scientific article published on November 1, 2003

Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression

scientific article published in March 2005

Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition

scientific article

Underlying mechanisms of cAMP- and glucocorticoid-mediated inhibition of FasL expression in activation-induced cell death.

scientific article published on 17 February 2012

Unravelling the GSK3β-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder.

scientific article published in October 2018

Unstable prefrontal response to emotional conflict and activation of lower limbic structures and brainstem in remitted panic disorder

scientific article

Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies

scientific article

VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men.

scientific article published in October 1996

Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes

scientific article published on 18 November 2009

Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome

scientific article

Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression

scientific article published on 6 January 2009

Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders.

scientific article

Ventral tegmental area (VTA) injections of tyrosine hydroxylase phosphorothioate antisense oligonucleotide suppress operant behavior in rats

scientific article

Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation

scientific article published in February 2011

XAP2 inhibits glucocorticoid receptor activity in mammalian cells

scientific article

Ziprasidone-related tardive dyskinesia

scientific article

[The Munich Vulnerability Study of Affective Disorders. Overview of the results at index study]

scientific article published on 01 July 1998

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