List of works - Florian Holsboer

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

scientific article

A mega-analysis of genome-wide association studies for major depressive disorder

scientific article

Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions

scientific article

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

scientific article published on June 1, 1998

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

scientific article

Identification of common variants associated with human hippocampal and intracranial volumes

scientific article published on 15 April 2012

Common genetic variants influence human subcortical brain structures

scientific article

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

scientific article

17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro

scientific article

Neuroprotection against oxidative stress by estrogens: structure-activity relationship

scientific article

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

scientific article

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

scientific article

Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

scientific article published on 01 February 2000

Effects of Antidepressant Treatment on Neuroactive Steroids in Major Depression

scientific article published on July 1, 1998

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo

scientific article published on 09 December 2008

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

scientific article published on February 1, 2002

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

scientific article published on 14 September 2003

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

scientific article published on September 1994

Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists

scientific article

Development of the Brain's Default Mode Network from Wakefulness to Slow Wave Sleep

scientific article published on February 17, 2011

Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

scientific article published in September 2011

Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

scientific article published on January 1995

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects

scientific article

A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression

scientific article published on September 2009

Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts

scholarly article by P Muglia et al published 23 December 2008 in Molecular Psychiatry

RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

scientific article

Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections

scientific article

Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression

scientific article published in August 2005

Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

scientific article published on November 1993

Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders

scientific article published on 01 October 1995

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

scientific article published in July 2008

Progesterone receptor-mediated effects of neuroactive steroids

scientific article

Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks

scientific article (publication date: October 2009)

Genome-wide association study of major recurrent depression in the U.K. population

scientific article published in June 2010

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study

scientific article published on 24 August 2011

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice

scientific article

Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression

scientific article

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.

scientific article published in November 2001

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.

scientific article

Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure

scientific article

Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS.

scientific article published on December 1994

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.

scientific article

PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome

scientific article published on 27 July 2008

Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats

scientific article published in December 1995

Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

scientific journal article

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

scientific article published on 5 July 2006

The combined dexamethasone/CRH test as a potential surrogate marker in depression

scientific article

Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies

scientific article

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

scientific article

Stress responsive neurohormones in depression and anxiety

scientific article published on November 2003

List of works by Florian Holsboer

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

A mega-analysis of genome-wide association studies for major depressive disorder

Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

Identification of common variants associated with human hippocampal and intracranial volumes

Common genetic variants influence human subcortical brain structures

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro

Neuroprotection against oxidative stress by estrogens: structure-activity relationship

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

Effects of Antidepressant Treatment on Neuroactive Steroids in Major Depression

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists

Development of the Brain's Default Mode Network from Wakefulness to Slow Wave Sleep

Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects

A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression

Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts

RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections

Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression

Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

Progesterone receptor-mediated effects of neuroactive steroids

Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks

Genome-wide association study of major recurrent depression in the U.K. population

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice

Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.

Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure

Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS.

Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.

PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome

Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats

Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

The combined dexamethasone/CRH test as a potential surrogate marker in depression

Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

Stress responsive neurohormones in depression and anxiety