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List of works by Falk Nimmerjahn

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

scientific journal article

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

scientific article published on 23 November 2011

A Humanized Mouse Identifies the Bone Marrow as a Niche with Low Therapeutic IgG Activity

A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors

scientific article published on 6 December 2015

A constant threat for HIV: Fc-engineering to enhance broadly neutralizing antibody activity for immunotherapy of the acquired immunodeficiency syndrome

scientific article published on 03 July 2015

A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques

scientific article

Activating and inhibitory FcgammaRs in autoimmune disorders.

scientific article published on October 2006

Active NF-kappaB signalling is a prerequisite for influenza virus infection.

scientific article published on August 2004

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation

scientific article

Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity.

scholarly article

Alternative splicing generates putative soluble CD83 proteins that inhibit T cell proliferation

scientific article

Analysis of dendritic cells in human lymphoid organs

Analyzing antibody-Fc-receptor interactions

scientific article

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

scientific article published in Science

Anti-inflammatory actions of intravenous immunoglobulin

scientific article

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1.

scientific article

Antibodies, Fc receptors and cancer

scientific article published on 8 February 2007

Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy.

scientific article

Antibody-mediated modulation of immune responses.

scientific article published on July 2010

Antigen delivery to CD11c+CD8- dendritic cells induces protective immune responses against experimental melanoma in mice in vivo.

scientific article published on 14 May 2014

B cell expression of the inhibitory Fc gamma receptor is unchanged in early MS.

scientific article published in June 2010

B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo

scientific article

B cells are critical for autoimmune pathology in Scurfy mice

scientific article

B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis

scientific article published on 28 December 2014

Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion

scientific article

Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis.

scientific article

Bone- and cartilage-protective effects of a monoclonal antibody against colony-stimulating factor 1 receptor in experimental arthritis.

scientific article published in November 2014

Both FcγRIV and FcγRIII are essential receptors mediating type II and type III autoimmune responsesviaFcRγ-LAT-dependent generation of C5a

scientific article published on 01 December 2009

Broad requirement for terminal sialic acid residues and FcγRIIB for the preventive and therapeutic activity of intravenous immunoglobulins in vivo

scientific article published on 07 March 2014

CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.

scientific article

Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes

scientific article published on 16 March 2015

Clarifying the Confusion between Cytokine and Fc Receptor "Common Gamma Chain".

scientific article published in August 2016

Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A.

scientific article

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

scientific article

Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

scientific article published in September 2017

Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions

scientific article

Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate

scientific article

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

scientific article

Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis

scientific article published on 15 June 2009

Deregulated Fcγ receptor expression in patients with CIDP.

scientific article

Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB.

scientific article published on 19 January 2018

Determining immunoglobulin-specific B cell receptor repertoire of murine splenocytes by next-generation sequencing

scientific article published on 09 April 2022

Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis

scientific article

Differential Contribution of Three Activating IgG Fc Receptors (Fc RI, Fc RIII, and Fc RIV) to IgG2a- and IgG2b-Induced Autoimmune Hemolytic Anemia in Mice

scientific article published on 01 February 2008

Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

scientific article

Dissecting FcγR Regulation Through a Multivalent Binding Model

Dissecting FcγR Regulation through a Multivalent Binding Model

scientific article published on 27 June 2018

Dissecting the mechanism of action of intravenous immunoglobulin in human autoimmune disease: lessons from therapeutic modalities targeting Fcγ receptors

scientific article published on 25 July 2020

Divergent immunoglobulin g subclass activity through selective Fc receptor binding

scientific article published on December 2005

Editorial: Autoantibodies

Effects of intravenous immunoglobulins on mice with experimental epidermolysis bullosa acquisita

scientific article published on 20 October 2014

Efficient generation and expansion of antigen-specific CD4+ T cells by recombinant influenza viruses

scientific article published on December 2003

Efficient generation of a monoclonal antibody against the human C-type lectin receptor DCIR by targeting murine dendritic cells

scientific article

Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors

scientific article published in November 2016

Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export

scientific article

Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis

scientific article published on 01 October 2007

Eosinophils Mediate Basophil-Dependent Allergic Skin Inflammation in Mice

scientific article published on 22 March 2019

Epstein-Barr virus nuclear antigen 1 evades direct immune recognition by CD4+ T helper cells

scientific article published on September 2004

Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination

scientific article published on January 2006

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women.

scientific article published on 2 May 2018

Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis

scientific article published on 24 April 2020

Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between Fc RI and Fc RIV

scientific article published on 01 November 2008

Expression Profiling and Glycan Engineering of IgG Subclass 1-4 in Nicotiana benthamiana

scientific article published on 24 July 2020

Expression and function of the inhibitory Fcγ-receptor in CIDP.

scientific article published in June 2011

Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies

scientific article published on December 2008

Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice

scientific article published on 03 March 2020

Fc-engineering significantly improves the recruitment of immune effector cells by anti-ICAM-1 antibody MSH-TP15 for myeloma therapy

scientific article published on 04 June 2020

Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis

scientific article published on 4 March 2015

Fc-receptors as regulators of immunity.

scientific article published on January 2007

Fcgamma receptors: old friends and new family members

scientific article

FcgammaRIV: a novel FcR with distinct IgG subclass specificity

scientific journal article

Fcγ Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita

scientific article published on 01 January 2019

Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo

scientific article published on 7 November 2011

Fcγ receptor deficiency attenuates diabetic nephropathy

scientific article published on 2 August 2012

Fcγ receptor-dependent expansion of a hyperactive monocyte subset in lupus-prone mice

scientific article published on 01 August 2009

Fcγ receptors III and IV mediate tissue destruction in a novel adult mouse model of bullous pemphigoid.

scientific article published in August 2014

FcγR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities

scientific article published on 13 May 2015

FcγRIIB: a modulator of cell activation and humoral tolerance.

scientific article published on March 2012

FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo

scientific article

FcγRs in health and disease.

scientific article published on January 2011

Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss

scientific article published on 19 March 2019

Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury

article

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

scientific article

Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies

scientific article published on 11 January 2017

High amounts of specific antibodies are produced upon antigen stimulation during adaptive immune responses. Preface

article

High-resolution definition of humoral immune response correlates of effective immunity against HIV.

scientific article

How immunoglobulin G antibodies kill target cells: revisiting an old paradigm

scientific article published on January 2014

Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in Lyme arthritis

scientific article published on 02 July 2020

Human IgG/Fc gamma R interactions are modulated by streptococcal IgG glycan hydrolysis

scientific article

Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment

scientific article published on 16 December 2016

IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM).

scientific article

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1.

scientific article

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

scientific article published on 12 June 2017

IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice.

scientific article

IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells

article published in 2018

Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages

scientific article published on 27 July 2016

Immune regulation: FcgammaRIIB--regulating the balance between protective and autoreactive immune responses.

scientific article published on 27 May 2008

Immunomodulation in Primary Immune Thrombocytopenia: A Possible Role of the Fc Fragment of Romiplostim?

scientific article published on 4 June 2019

Immunomodulation of immunothrombocytopenia

scientific article published on 6 April 2016

Impact of FcγR variants on the response to alemtuzumab in multiple sclerosis

scientific article published on 04 November 2019

Impact of Plasma Membrane Domains on IgG Fc Receptor Function

scientific article published on 30 June 2020

Impact of a Three Amino Acid Deletion in the CH2 Domain of Murine IgG1 on Fc-Associated Effector Functions

scientific article published on 01 September 2008

Impact of differential glycosylation on IgG activity

scientific article published on January 2011

Impact of immune complex size and glycosylation on IgG binding to human FcγRs

scientific article published on 18 March 2013

Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block.

scientific article

Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy

scholarly article

In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury.

scientific article published on 11 August 2016

In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner

scholarly article

Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation

scholarly article by Mario M. Zaiss et al published 29 April 2010 in Arthritis and Rheumatism

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

scientific article published on 16 April 2012

Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

scientific article published on 10 June 2013

Influence of activating Fcgamma receptors on osteoclast differentiation and bone metabolism

Intravenous immunoglobulin in neurology--mode of action and clinical efficacy

scientific article published on 06 January 2015

Intravenous immunoglobulin therapy: how does IgG modulate the immune system?

scientific article

Keeping T-he Killers at Bay via FcγRIIb

scientific article published on 01 January 2020

LILR-B1 blocks activating FcγR signaling to allow antibody dependent enhancement of dengue virus infection

scientific article published on 05 February 2014

Latent membrane protein 1 of Epstein-Barr virus induces CD83 by the NF-kappaB signaling pathway

scientific article

Low level of FcγRIII expression on murine natural killer cells

scientific article published on 21 January 2012

Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients

scientific article published on 03 January 2022

Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy

scientific article published on May 2003

Mechanisms of Autoantibody-Induced Pathology.

scientific article

Mechanisms of IVIG efficacy in chronic inflammatory demyelinating polyneuropathy.

scientific article published on May 2010

Mechanisms of action of intravenous immunoglobulins

scientific article

Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo

scientific article published on 01 January 2019

Molecular and Cellular Pathways of Immunoglobulin G Activity In Vivo

article published in 2014

Molecular factors modulating the anti-inflammatory activity of IVIg in ITP

Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo

scientific article

More Rules, Still Exceptions: Understanding Immunomodulatory Antibody Activity In Vivo

scientific article published on 01 April 2018

NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases

scientific article published on 23 September 2013

No Need for Constant Help: Human IgG2 Antibodies Have an Autonomous Agonistic Activity for Immunotherapy of Cancer

scientific article published on 01 January 2015

Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcγR.

scientific article published on 15 July 2013

Of mice and men: the need for humanized mouse models to study human IgG activity in vivo

scientific article published on 05 September 2012

Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases

scientific article published on 08 November 2018

Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors

scientific article

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice

scientific article published on 08 October 2015

Radon Improves Clinical Response in an Animal Model of Rheumatoid Arthritis Accompanied by Increased Numbers of Peripheral Blood B Cells and Interleukin-5 Concentration

scientific article published on 16 February 2022

Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets

scientific article

Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc.

scientific article

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease

scientific article

Regulatory T cells protect from local and systemic bone destruction in arthritis.

scientific article published on 17 May 2010

Releasing the Brakes: Targeting FcγRIIB on B Cells to Enhance Antibody-Dependent Lymphoma Immunotherapy

Relevance of Receptor for Advanced Glycation end Products (RAGE) in Murine Antibody-Mediated Autoimmune Diseases

scientific article published on 01 July 2019

Reply to — IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist

scientific article published on 01 May 2014

Role of sialylation in the anti-inflammatory activity of intravenous immunoglobulin - F(ab')₂ versus Fc sialylation

STAT1-dependent IgG cell-surface expression in a human B cell line derived from a STAT1-deficient patient

scientific article

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

scientific article

Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

scientific article

Sialylation of anti-histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells

scientific article published on 27 January 2016

Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis

scientific article published on 05 October 2020

Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.

scientific article published on 18 May 2015

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

scientific article published on 16 March 2018

Stringent doxycycline-dependent control of gene activities using an episomal one-vector system

scientific article

Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection

scientific article

Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammation

scientific article published in December 2017

Sweet and sour: the role of glycosylation for the anti-inflammatory activity of immunoglobulin G.

scientific article published on January 2014

TLR7/9-mediated monocytosis and maturation of Gr-1hi inflammatory monocytes towards Gr-1lo resting monocytes implicated in murine lupus

Targeting B cells and autoantibodies in the therapy of autoimmune diseases

scientific article published on 29 April 2014

Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology

scientific article published on 01 September 2021

The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity

scientific article published on 01 December 2019

The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation

scientific article published on 22 June 2015

The Tumor Milieu Promotes Functional Human Tumor-Resident Plasmacytoid Dendritic Cells in Humanized Mouse Models

scientific article published on 08 September 2020

The antiinflammatory activity of IgG: the intravenous IgG paradox

scientific article

The inhibitory Fcγ receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells

article

The novel tribody [(CD20)(2)xCD16] efficiently triggers effector cell-mediated lysis of malignant B cells

scientific article published on 4 June 2012

The role of Fc receptors and complement in autoimmunity

scientific article published on 29 November 2012

The role of Fcgamma receptors in murine autoimmune thrombocytopenia.

scientific article

The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo

scientific article published on February 2011

The role of sialic acid as a modulator of the anti-inflammatory activity of IgG.

scientific article published on 22 March 2012

There Is (Scientific) Strength in Numbers: A Comprehensive Quantitation of Fc Gamma Receptor Numbers on Human and Murine Peripheral Blood Leukocytes

scientific article published on 05 February 2020

Three blocks are not enough--Blocking of the murine IgG receptor FcγRIV is crucial for proper characterization of cells by FACS analysis.

scientific article published on 3 July 2015

Translating Inhibitory Fc Receptor Biology into Novel Therapeutic Approaches

scientific article

Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling

scientific article

Tumor location determines tissue-specific recruitment of tumor-associated macrophages and antibody-dependent immunotherapy response.

scientific article

Two sequential layers of antibody-mediated control of Legionella pneumophila infection

scientific article published on 18 June 2019

Unlocking the bone: Fcγ-receptors and antibody glycosylation are keys to connecting bone homeostasis to humoral immunity

scientific article published on July 2015

bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression.

scientific article

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