List of works by Erich Nigg

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

scientific article

A bacterial type III secretion-based protein delivery tool for broad applications in cell biology

scientific article

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

scientific article published in January 1998

A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring

scientific article

A licence for duplication

scientific article published in Nature

A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation

scientific journal article

A monoclonal antibody specific for snRNPs U1 and U2

scientific article published on 01 May 1986

Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.

scientific article published on 3 September 2012

Active cyclin B1-Cdk1 first appears on centrosomes in prophase

scientific article

Assembly and cell cycle dynamics of the nuclear lamina

scientific article published on August 1, 1992

Assembly-disassembly of the nuclear lamina

scientific article published on February 1, 1992

Assessment of current mass spectrometric workflows for the quantification of low abundant proteins and phosphorylation sites

scientific article

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity

scientific article

Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction

scientific article published on 27 February 2012

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A

scientific article published on 12 August 2013

Aurora kinases link chromosome segregation and cell division to cancer susceptibility

scientific article published on February 2004

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

scientific article

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

scientific article (publication date: 2002)

Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process

scientific article (publication date: 7 March 2003)

Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells

scientific article

Band 3-glycophorin A association in erythrocyte membranes demonstrated by combining protein diffusion measurements with antibody-induced cross-linking

scientific article published on 01 April 1980

Biogenesis of the nuclear lamina: in vivo synthesis and processing of nuclear protein precursors.

scientific article published on April 1986

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle

scientific article

Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation

scientific article

C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle.

scientific article

Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation

scientific article published in Nature

Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.

scientific article

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.

scientific article published on June 1994

Cell cycle regulation of central spindle assembly.

scientific article published on 28 July 2004

Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans

scientific article

Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1.

scientific article published on 6 May 2002

Cell cycle. The NIMA kinase joins forces with Cdc2.

scientific article published on October 1995

Cell-cycle-regulated expression of STIL controls centriole number in human cells

scientific article

Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases

scientific article published on 01 September 1993

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

scientific article

Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP

scientific article

Centrosome aberrations: cause or consequence of cancer progression?

scientific article

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

scientific article

Centrosome duplication: of rules and licenses

scientific article published on 26 March 2007

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

scientific article

Centrosome-associated NDR kinase regulates centrosome duplication

scientific article published on February 2007

Centrosomes as signalling centres

scientific article

Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole

scientific article

Cep164, a novel centriole appendage protein required for primary cilium formation

scientific article

Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion

scientific article

Characterization of A 54-kD protein of the inner nuclear membrane: evidence for cell cycle-dependent interaction with the nuclear lamina ⬇️

scientific article published on August 1, 1991

Characterization of mammalian NIMA-related kinases

scientific article published on January 1, 1997

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

scientific article

Comparative conservation analysis of the human mitotic phosphoproteome

scientific article published on 20 April 2008

Complex formation of Plk1 and INCENP required for metaphase-anaphase transition

scientific article

Control of centriole length by CPAP and CP110.

scientific article

Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases

scientific article

Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes

scientific article published on 01 July 1985

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells.

scientific article

Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control?

scientific article

Cytoskeletal targets for viral transforming proteins with tyrosine protein kinase activity

scientific article published on 01 January 1982

Cytostatic factor: an activity that puts the cell cycle on hold

scientific article

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects

scientific article published on 23 September 2005

Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting

scientific article published on 2 November 2005

Differential expression of nuclear lamin proteins during chicken development

scientific article

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites ⬇️

scientific article published on February 1, 1991

Dimeric association of band 3 in the erythrocyte membrane demonstrated by protein diffusion measurements

scientific article published in Nature

Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase 1.

scientific article published on 25 January 2012

Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.

scientific article published on April 1996

Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation.

scientific article

Ectopic expression of an A-type lamin does not interfere with differentiation of lamin A-negative embryonal carcinoma cells ⬇️

scientific article published on November 1, 1991

Evaluation and Improvement of Quantification Accuracy in Isobaric Mass Tag-Based Protein Quantification Experiments

scientific article published on 27 June 2016

Evaluation of data-dependent and -independent mass spectrometric workflows for sensitive quantification of proteins and phosphorylation sites

scientific article

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

scientific article

From proteome lists to biological impact--tools and strategies for the analysis of large MS data sets

scientific article

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

scientific article published on 01 December 1998

Geminin Regulates Multiple Steps of the Chromosome Inheritance Cycle

scientific article published on 16 January 2006

HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes

scientific article published on 01 April 2006

Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway

scientific article

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

scientific article published on 2 May 2013

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

scientific article

Human TPX2 is required for targeting Aurora-A kinase to the spindle

scientific article

Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint

scientific article

Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins.

scientific article

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C

scientific article

Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase

scientific article published on 01 March 1990

Identification of phosphorylation sites in the polo-like kinases Plx1 and Plk1 by a novel strategy based on element and electrospray high resolution mass spectrometry

scientific article published in November 2002

Immunofluorescent localization of a 39,000-dalton substrate of tyrosine protein kinases to the cytoplasmic surface of the plasma membrane.

scientific article

Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide ⬇️

scientific article published on September 1, 1982

Immunological characterization of avian MAP kinases: evidence for nuclear localization ⬇️

scientific article published on July 1, 1992

Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission

scientific article published on 27 June 2006

Influence of influenza and Sendai virus on the rotational mobility of Band 3 proteins in human erythrocyte membranes.

scientific article published in December 1980

Influence of temperature and cholesterol on the rotational diffusion of band 3 in the human erythrocyte membrane ⬇️

scientific article published on August 7, 1979

Inhibition of Centrosome Separation after DNA Damage: A Role for Nek2

article

Isoprenylation of rab proteins on structurally distinct cysteine motifs.

scientific article published in August 1992

KIF14 and citron kinase act together to promote efficient cytokinesis

scientific article

Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1

scientific article

Labeling of human erythrocyte membranes with eosin probes used for protein diffusion measurements. Inhibition of anion transport and photo-oxidative inactivation of acetylcholinesterase ⬇️

scientific article published on January 19, 1979

M-phase MELK activity is regulated by MPF and MAPK.

scientific article published on 17 April 2006

MAT1 ('menage à trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.

scientific article published on October 1995

MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH

scientific article

Mitogen-activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34cdc2

scientific article published on 01 April 1992

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly

scientific article

Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

scientific article

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates ⬇️

scientific article published on November 1, 1991

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods

scientific article

Nuclear export of proteins: the role of nuclear retention.

scientific article published in August 1993

Nuclear import-export: in search of signals and mechanisms.

scientific article published on July 1991

Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits.

scientific article

Nuclear substructure antigens

scientific article published on 01 January 1986

Oligosaccharide motion in erythrocyte membranes investigated by picosecond fluorescence polarization and microsecond dichroism of an optical probe

scientific article

On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

scientific article published on 01 October 1997

On the nature of crossreactions observed with antibodies directed to defined epitopes.

scientific article published in October 1982

On the regulation, function, and localization of the DNA-dependent ATPase PICH.

scientific article

Origins and consequences of centrosome aberrations in human cancers

scientific article published on December 2006

PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition

scientific article

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

scientific article

PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint

scientific article

PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.

scientific article

Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation

scientific article published on 8 November 2007

Phosphoproteome analysis of the human mitotic spindle

scientific article

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis

scientific article published on 31 October 2005

Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150

scientific article (publication date: August 1997)

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

scientific article

Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome

scientific article

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

scientific article

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells

scientific article

Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora

scientific article

Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation

scientific article

Plk4-induced centriole biogenesis in human cells

scientific article

Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation

scientific journal article

Polo-like kinase-1 is a target of the DNA damage checkpoint

scientific article published on 01 September 2000

Polo-like kinases and the orchestration of cell division

scientific article (publication date: June 2004)

Polo-like kinases.

scientific article published in March 2013

Polo-like kinases: positive regulators of cell division from start to finish.

scientific article

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.

scientific article published on 17 February 2016

Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint

scientific article

Protein kinases in the control of mitosis: focus on nucleocytoplasmic trafficking.

scientific article published on January 1995

Protein localization to the nucleolus: a search for targeting domains in nucleolin

scientific article published on 01 July 1993

Proteome analysis of the human mitotic spindle

scientific article

Proteomic characterization of the human centrosome by protein correlation profiling

scientific article

Purification of mitotic spindles from cultured human cells

scientific article

Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging.

scientific article published on 18 August 2016

Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages

scientific article published in October 2009

Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1

scientific article

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

scientific article

Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression

scientific article

RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin

scientific article published on 22 October 2008

Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs

scientific article

Regulating centrosomes by protein phosphorylation.

scientific article

Regulation of Aurora-A kinase on the mitotic spindle

scientific article published on 21 November 2003

Regulation of cell division: stop the SIN!

scientific article

Regulation of p34cdc2 protein kinase activity by phosphorylation and cyclin binding.

scientific article published on January 1992

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2

scientific article

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

scientific article (publication date: 27 September 2002)

Rootletin forms centriole-associated filaments and functions in centrosome cohesion

scientific article

Rotational diffusion of band 3 in the red cell membrane: measurements using triplet probes

scientific article published on January 1, 1979

Rotational diffusion of band 3 proteins in membranes from En(a—) and neuraminidase-treated normal human erythrocytes

scientific article published on 01 August 1980

Rotational diffusion of erythrocyte membrane proteins.

scientific article published on January 1981

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

scientific article

STIL microcephaly mutations interfere with APC/C-mediated degradation and cause centriole amplification

scientific article published on 30 January 2014

SUMO-dependent regulation of centrin-2.

scientific article published on 25 August 2009

Sgt1 is required for human kinetochore assembly

scientific article

Signal transduction. Capturing polo kinase

scientific article

Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain.

scientific article

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling

scientific article

Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3.

scientific article

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome

scientific article

Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface

scientific article

Structural basis for microtubule recognition by the human kinetochore Ska complex

scientific article

Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres

scientific article published on 14 September 2015

Structural centrosome aberrations promote non-cell-autonomous invasiveness.

scientific article published on 22 March 2018

Structural centrosome aberrations sensitize polarized epithelia to basal cell extrusion

scientific article published on 01 June 2018

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together

scientific article

Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization

scientific article

Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans.

scientific article published on May 1995

Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1

scientific article (publication date: 4 September 2003)

Targeting lamin proteins to the nuclear envelope: the role of CaaX box modifications.

scientific article

Targets of cyclin-dependent protein kinases.

scientific article

Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions

scientific article

The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo

scientific article

The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis.

scientific article

The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis.

scientific article published on June 2000

The Plk1-dependent phosphoproteome of the early mitotic spindle

scientific article

The Polo kinase Plk4 functions in centriole duplication

scientific article

The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.

scientific article published in February 2018

The Ska complex promotes Aurora B activity to ensure chromosome biorientation.

scientific article published on 3 October 2016

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

scientific journal article

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

scientific article

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4

scientific article

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

scientific article

The centrosome duplication cycle in health and disease.

scientific article

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

scientific article

The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase

scientific article (publication date: March 2002)

The fates of chicken nuclear lamin proteins during mitosis: evidence for a reversible redistribution of lamin B2 between inner nuclear membrane and elements of the endoplasmic reticulum.

scientific article

The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles

scientific article

The histone chaperone Asf1 is dispensable for direct de novo histone deposition in Xenopus egg extracts

scientific article published on 19 June 2007

The role of the head and tail domain in lamin structure and assembly: analysis of bacterially expressed chicken lamin A and truncated B2 lamins

scientific article published on January 1, 1992

The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle

scientific article

The substrates of the cdc2 kinase

scientific article published on August 1, 1991

The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells

scientific article

The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein.

scientific article published in May 1983

Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2

scientific article

Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions

scientific article

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.

scientific article published in January 2010

Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology

scientific article

Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis

scientific article

Viral transactivators E1A and VP16 interact with a large complex that is associated with CTD kinase activity and contains CDK8

scientific article

Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity

scientific article

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