Search filters

List of works by Stanley J. Korsmeyer

A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway

scientific article

A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a mu heavy chain disease protein

scientific article published on April 1986

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis ⬇️

scientific article published on January 1, 2002

A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth ⬇️

scientific article published on December 13, 2011

A Role for Bax in the Regulation of Apoptosis in Mouse Mast Cells

A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis ⬇️

scientific article published on December 1, 1997

A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro

scientific article published on 20 September 2006

A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter

scientific article published on June 1993

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

scientific article

A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

scientific article

A pre-translational defect in a case of human mu heavy chain disease

scientific article published on 01 July 1986

A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c.

scientific article

A role for proapoptotic BID in the DNA-damage response

scientific article published on August 2005

A spatially and temporally restricted mouse model of soft tissue sarcoma

scientific article published on 5 August 2007

A stapled BID BH3 helix directly binds and activates BAX

scientific article

A uniform deleting element mediates the loss of kappa genes in human B cells

scientific article published in July 1985

Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma

scientific article

Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor

scientific article

Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product ⬇️

scientific article published on August 15, 1993

Adenovirus E1B 19-kDa death suppressor protein interacts with Bax but not with Bad

scientific article published on 01 September 1996

Altered Hox expression and segmental identity in Mll-mutant mice

scientific article (publication date: 30 November 1995)

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma

scientific article published on January 1988

An Mll-dependent Hox program drives hematopoietic progenitor expansion

scientific journal article

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

scientific article (publication date: 2 June 2005)

Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes

scientific article published on 01 May 1996

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

scientific article published on 01 September 2004

Antigen receptor genes as molecular markers of lymphoid neoplasms

scientific article published on May 1987

Apoptosis in the development and maintenance of the immune system ⬇️

scientific article published on May 1, 2003

Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction ⬇️

scientific article published on November 1, 1997

Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome: involvement of Fas-Fas ligand interaction

scientific article published on 01 September 1995

Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals

scientific article published in August 2001

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

scientific journal article

B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation

scientific article published on August 1984

B cell, helper T cell, and suppressor T cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation ⬇️

scientific article published on 01 February 1982

B-lymphoid neoplasms: immunoglobulin genes as molecular determinants of clonality, lineage, differentiation, and translocation.

scientific article published on January 1988

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

scientific journal article

BAD is a pro-survival factor prior to activation of its pro-apoptotic function

scientific article

BAD partly reverses paclitaxel resistance in human ovarian cancer cells

scientific article

BAX Contributes to Apoptotic-Like Death Following Neonatal Hypoxia-Ischemia: Evidence for Distinct Apoptosis Pathways ⬇️

scientific article published on September 1, 2001

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

scientific article (publication date: 4 April 2003)

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

scientific article

BAX is required for neuronal death after trophic factor deprivation and during development

scientific journal article

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

scientific article

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

scientific article published on December 1996

BCL-2 FAMILY: Regulators of Cell Death ⬇️

scientific article published on January 1, 1998

BCL-2 family members and the mitochondria in apoptosis

scientific article (publication date: August 1999)

BCL-2 gene family and the regulation of programmed cell death

scientific article published on 01 April 1999

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

scientific article

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

scientific article (publication date: September 2001)

BCL-XL-regulated apoptosis in T cell development ⬇️

scientific article published on September 1, 1997

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death

scientific article published on August 1991

BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity

scientific journal article

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

scientific article published in May 1994

BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity ⬇️

scientific article published on September 26, 1997

BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma

scientific article published on 27 March 2006

BID regulation by p53 contributes to chemosensitivity

scientific article (publication date: November 2002)

BID, a Proapoptotic BCL-2 Family Member, Is Localized to Mouse Chromosome 6 and Human Chromosome 22q11 ⬇️

scientific article published on October 15, 1998

BID-dependent and BID-independent pathways for BAX insertion into mitochondria

scientific article published on 01 November 2000

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

scientific article

Bad-deficient mice develop diffuse large B cell lymphoma

scientific article

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

scientific journal article

Bax accelerates tumorigenesis in p53-deficient mice

scientific article

Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia

scientific article published in 2012

Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

scientific article

Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

scientific article

Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice

scientific article published on October 2004

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

scientific journal article

Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.

scientific article

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

scientific journal article

Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis

scientific journal article

Bcl-2 affects survival but not neuronal differentiation of PC12 cells ⬇️

scientific article published on 01 October 1993

Bcl-2 and Bax function independently to regulate cell death ⬇️

scientific article published on August 1, 1997

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

scientific article (publication date: 22 October 1993)

Bcl-2 gene family and the regulation of programmed cell death

scientific article

Bcl-2 gene family in the nervous system

scientific article published on January 1997

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

scientific article

Bcl-2 initiates a new category of oncogenes: regulators of cell death

scientific article published on August 1992

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

scientific article (publication date: 22 November 1990)

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

scientific article published on 01 June 1994

Bcl-2 maintains B cell memory

scientific article

Bcl-2 protein expression during murine development

scientific journal article

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death

scientific article

Bcl-2: B cell life, death and neoplasia

scientific article published on 01 January 1990

Bcl-2: a repressor of lymphocyte death

scientific article published on August 1, 1992

Bid regulation of neuronal apoptosis

scientific article published in June 2001

Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L)

scientific article

Breakpoints at 11q23 in infant leukemias with the t(11;19)(q23;p13) are clustered

scientific article published on 01 November 1992

Caspase regulation of genotoxin-induced neural precursor cell death

scientific article published in November 2003

Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function

scientific journal article

Cell Death in Development

scientific article published on 01 January 1999

Cell death induced by granzyme C.

scientific article

Cell death: critical control points

scientific article (publication date: 23 January 2004)

Checkpoints of dueling dimers foil death wishes

scientific article published on 01 October 1994

Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent

scientific article published on October 2001

Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes

scientific article

Clonal evolution of t(14;18) follicular lymphomas demonstrated by immunoglobulin genes and the 18q21 major breakpoint region

scientific article published on 01 May 1987

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

scientific article published in July 1985

Clustered arrangement of immunoglobulin λ constant region genes in man ⬇️

scientific article published on December 10, 1981

Collaboration of pim-1 and bcl-2 in lymphomagenesis

scientific article published on January 1, 1992

Coming to terms with death: apoptosis in cancer and immune development

scientific article published on 01 April 1994

Comparison of human genomics and genetic models of cancer to identify novel therapeutic targets

scientific article

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2 ⬇️

scientific article published on October 14, 1997

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

scientific article

Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study

scientific article published on 21 October 2004

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis

scientific article published on April 1993

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

scientific article published on September 1996

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

scientific journal article

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

scientific journal article

Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules

scientific article

Defects in yolk sac hematopoiesis in Mll-null embryos ⬇️

scientific article published on September 1, 1997

Definitive hematopoiesis requires the mixed-lineage leukemia gene

scientific article published in March 2004

Deletion of the human T-cell receptor δ-gene by a site-specific recombination

scientific article published in Nature

Deletional rearrangement in the human T-cell receptor alpha-chain locus

scientific article

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

scientific article published on May 1990

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population

scientific article published on May 1990

Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia ⬇️

scientific article (publication date: 5 July 1991)

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

scientific article published in August 1993

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

scientific article

Development expression of Hox11 and specification of splenic cell fate.

scientific article

Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells

scientific article

Developmental regulation of Eed complex composition governs a switch in global histone modification in brain

scientific article

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes

scientific journal article

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

scientific journal article

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia

scientific article

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

scientific article published on August 1999

Differential specificity of lymphocytotoxins from patients with systemic lupus erythematosus and inflammatory bowel disease ⬇️

scientific article published on 01 January 1976

Differentiation and cell death: lessons from the immune system

scientific article published on December 1994

Disorders of B cells and helper T cells in the pathogenesis of the immunoglobulin deficiency of patients with ataxia telangiectasia

scientific article

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

scientific article (publication date: September 2002)

Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC.

scientific article

Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells

scientific article

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis ⬇️

scientific article published on July 15, 1998

Enhanced Oxidative Stress and Altered Antioxidants in Brains of Bcl‐2‐Deficient Mice ⬇️

scientific article published on August 1, 1998

Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon

scientific article published in June 1997

Epstein-Barr virus immortalization of normal cells of B cell lineage with nonproductive, rearranged immunoglobulin genes.

scientific article

Erratum: Corrigendum: Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

scientific article published in November 2013

Errors of homeostasis and deregulated apoptosis ⬇️

scientific article published on October 1, 1997

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

scientific journal article

Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons

scientific article

Evolutionary comparison of murine and human delta T-cell receptor deleting elements

scientific article published on 01 December 1989

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

scientific article

Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells

scientific article published on November 1987

Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons.

scientific article

Expression of interleukin 2 receptors on activated human B cells ⬇️

scientific article published on November 1, 1984

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes

scientific article published on 01 September 1993

Expression of the bcl-2 protooncogene in the cycling adult mouse hair follicle

scientific article

FLT3 mutations in childhood acute lymphoblastic leukemia

scientific article published on 11 December 2003

Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors

scientific article published on July 1996

Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice

scientific journal article

Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo

scientific journal article

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

scientific article published on 13 March 2003

Gene mutations and alternate RNA splicing result in truncated Ig L chains in human gamma H chain disease

scientific article published in September 1988

Gene rearrangements as markers of clonal variation and minimal residual disease in acute lymphoblastic leukemia

scientific article published on 01 May 1987

Genetic transfer and expression of reconstructed yeast artificial chromosomes containing normal and translocated BCL2 proto-oncogenes

scientific article published in September 1993

Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias

scientific article

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK ⬇️

scientific article published on December 18, 2001

Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells

scientific article

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

scientific article

Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

scientific article

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX ⬇️

scientific article published on April 15, 1998

Heterodimerization with Bax is required for Bcl-2 to repress cell death

scientific article published on 01 January 1995

Hox11 controls the genesis of the spleen

scientific article published in Nature

Human B-Cell Precursor Leukemias ⬇️

scientific article published on 01 January 1984

Human J chain gene. Structure and expression in B lymphoid cells

scientific article

Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus

scientific article

Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics.

scientific article published in January 1985

Human delta T cell receptor: rearrangement, deletion, and translocation

scientific article published on 01 January 1988

Human immunoglobulin D segments encoded in tandem multigenic families ⬇️

scientific article published on December 17, 1981

Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells

scientific article

Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways

scientific article published on 01 December 1998

Immunoglobulin and T cell receptor gene configuration in acute lymphoblastic leukemia of infancy

scientific article published in August 1987

Immunoglobulin and T-cell receptor genes reveal the clonality, lineage, and translocations of lymphoid neoplasms.

scientific article published on January 1987

Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.

scientific article

Immunoglobulin gene rearrangements and expression in diffuse histiocytic lymphomas reveal cellular lineage, molecular defects, and sites of chromosomal translocation

scientific article published in February 1986

Immunoglobulin genes: rearrangement and translocation in human lymphoid malignancy

scientific article published on January 1984

Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms

scientific article published on 01 December 1983

Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms

scientific article published on 01 August 1991

In vitro enhancement of immunoglobulin gene expression in chronic lymphocytic leukemia

scientific article

Induction of differentiation in a case of common acute lymphoblastic leukemia

scientific article published on 01 November 1982

Induction of plasmacytoid differentiation by phorbol ester in B-cell lymphoma cell lines bearing 8;14 translocations ⬇️

scientific article published on June 1, 1984

Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification

scientific article published in February 2003

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

scientific article

Inhibition of virus-induced neuronal apoptosis by Bax.

scientific article published on July 1999

Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis

scientific article

Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase ⬇️

scientific article published on June 1, 1998

Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release

scientific article published in April 2003

Isolation of single-copy human genes from a library of yeast artificial chromosome clones

scientific article

Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2.

scientific article published on September 1993

Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells

scientific article published in February 2002

Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice

scientific article published on 01 April 2002

Lymphocytotoxic and RNA antibodies in inflammatory bowel disease: a comparative study in patients and their families.? ⬇️

scientific article published on 01 January 1976

Lymphocytotoxic antibody in inflammatory bowel disease. A family study

scientific article published on November 27, 1975

Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors

scientific article published on 01 October 1983

MLL, a mammalian trithorax- group gene, functions as a transcriptional maintenance factor in morphogenesis ⬇️

scientific article published on September 1, 1998

MLL-rearranged leukemias: insights from gene expression profiling ⬇️

scientific article published on October 1, 2003

Mcl-1 deficiency results in peri-implantation embryonic lethality

scientific article

Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners

scientific article

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members ⬇️

scientific article published on May 9, 2003

Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene

scientific article

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

scientific article

Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes

scientific article

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

scientific article published on 01 May 1993

Molecular thanatopsis: a discourse on the BCL2 family and cell death.

scientific article published on July 1996

Motor neuron degeneration is attenuated in bax-deficient neurons in vitro

scientific article published in March 1999

Mouse models of cell death

scientific article

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax ⬇️

scientific article published on August 15, 1995

Multiple genomic defects result in an alternative RNA splice creating a human gamma H chain disease protein.

scientific article published in September 1988

Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival

scientific article

Mutagenesis of the BH3 Domain of BAX Identifies Residues Critical for Dimerization and Killing ⬇️

scientific article published on October 1, 1998

NIH conference. Molecular genetic analysis of human lymphoid neoplasms. Immunoglobulin genes and the c-myc oncogene

scientific article

Neurodegeneration in Lurcher mice occurs via multiple cell death pathways

scientific article published on 01 May 2000

Neurotrophins support the development of diverse sensory axon morphologies.

scientific article

Normal human B cells display ordered light chain gene rearrangements and deletions

scientific article

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

scientific article published in February 2005

Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

scientific article

On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice.

scientific article

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis

scientific journal article

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

scientific article

Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice ⬇️

scientific article published on August 15, 1995

Peripheral blood T and B cells in chronic inflammatory bowel disease.

scientific article published in October 1974

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

scientific article published on 01 April 1999

Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

scientific article

Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation.

scientific article published in July 1998

Platelet-derived growth factor (PDGF) B and A homodimers transform murine fibroblasts depending on the genetic background of the cell.

scientific article published on December 1994

Prevention of lymphocyte cell death in sepsis improves survival in mice

scientific article published on December 1999

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

scientific article

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

scientific article

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

scientific journal article

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

scientific article

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

scientific article

Proapoptotic histone H1.2 induces CASP-3 and -7 activation by forming a protein complex with CYT c, APAF-1 and CASP-9

scientific article published on 28 June 2007

Programmed cell death and the regulation of homeostasis

scientific article published on 01 January 1999

Programmed cell death: Bcl-2.

scientific article

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

scientific article published in Nature

Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency

scientific journal article

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

scientific article

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

scientific article

Radiation-induced apoptosis is differentially regulated in primary B cells from normal mice and mice with the CBA/N X-linked immunodeficiency

scientific article published on 01 October 1995

Radiation-induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells

scientific article published on June 1997

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

scientific article published on 07 February 2007

Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family

scientific article

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia ⬇️

scientific article published on July 1, 1983

Rearrangements of genes for the antigen receptor on T cells as markers of lineage and clonality in human lymphoid neoplasms

scientific article published on 01 September 1985

Refinement of lymphoma cytogenetics by the chromosome 18q21 major breakpoint region

scientific article published on 01 December 1987

Regulated targeting of BAX to mitochondria.

scientific article

Regulation of B cell survival in xid mice by the proto-oncogene bcl-2

scientific article published on 01 March 1996

Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.

scientific article published on October 2003

Regulation of the humoral immune response: from immunoglobulin genes to regulatory T cell networks

scientific article published on May 1983

Regulators of cell death

scientific article (publication date: March 1995)

Rnx deficiency results in congenital central hypoventilation

scientific journal article

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

scientific article

Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus.

scientific article published on June 1994

Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response

scientific article published on 31 December 2002

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

scientific article

Serum Lymphocytotoxic and Lymphocytophilic Antibody Activity in Inflammatory Bowel Disease ⬇️

scientific article published on 01 October 1974

Skewed B cell VH family repertoire in Bcl-2-Ig transgenic mice

scientific article published on 01 December 1991

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

scientific article

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes ⬇️

scientific article published on December 1, 1981

Studies of human lymphocyte interactions with emphasis on soluble suppressor activity ⬇️

scientific article published on March 1, 1978

Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice ⬇️

scientific article published on August 1, 1998

Survival and death of prelymphomatous B-cells from N-myc/bcl-2 double transgenic mice correlates with the regulation of intracellular Ca2+ fluxes.

scientific article

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

scholarly article

Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

scientific journal article

Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets

scientific article published on 01 December 2003

T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia

scientific article published on August 1987

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

scientific article published on December 1993

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

scientific article

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

scientific journal article

The Ig heavy chain 3' end confers a posttranscriptional processing advantage to Bcl-2-IgH fusion RNA in t(14;18) lymphoma

scientific article published on 01 May 1998

The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus

scientific article

The VDAC2-BAK rheostat controls thymocyte survival

scientific article published on 25 August 2009

The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated.

scientific article

The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53

scientific article published on 01 September 1999

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

scientific article published on August 1992

The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2.

scientific article published in November 2000

The arrangement of immunoglobulin, T cell antigen receptor, and interleukin 2 receptor genes in human lymphoid neoplasms.

scientific article published in January 1986

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia

scientific article

The kappa-deleting element. Germline and rearranged, duplicated and dispersed forms

scientific article

The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis

scientific article published on 18 May 2007

The role of MLL in hematopoiesis and leukemia

scientific article

The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.

scientific article published on April 1990

The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein

scientific article

Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease

scientific article

Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma ⬇️

scientific article published on September 1, 1992

Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome

scientific article published on 01 May 2006

Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro

scientific article published on October 1998

Tuberin activates the proapoptotic molecule BAD.

scientific article

Uncleaved TFIIA is a substrate for taspase 1 and active in transcription

scientific article

Untangling the web: mitochondrial fission and apoptosis

scientific article published on 01 October 2004

Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3.

scientific article

VDAC2 inhibits BAK activation and mitochondrial apoptosis

scientific article

Variable amplification of immunoglobulin λ light-chain genes in human populations ⬇️

scientific article published on July 14, 1983

Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2.

scientific article

Zinc-induced neuronal death in cortical neurons

scientific article published on 01 June 2000

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes ⬇️

scientific article published on November 29, 1991

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.

scientific article

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

scientific article published on April 1989

c-Myc functionally cooperates with Bax to induce apoptosis

scientific article published on September 2002

cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes

scientific article published on September 2003

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

scientific article

p600, a unique protein required for membrane morphogenesis and cell survival

scientific article

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

scientific journal article

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

scientific article

Paulina is supported by:

About Paulina

Help