"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strains.
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(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties
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(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity
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(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent
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(E)-5-(2-Bromovinyl)-2?-deoxyuridine (BVDU)
(E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis
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(E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
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(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity
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(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection.
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(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine in the therapy of thymidine kinase-positive and -deficient herpes simplex virus experimental keratitis
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scientific article published on May 1, 1991
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication
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(S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity
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scientific article (publication date: 5 May 1978)
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity
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1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation
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1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors
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1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2-{[4-(3,4-dichlorophenyl)-1,2,3-thiadiazol-5-yl]sulfanyl}acetanilides as HIV-1 inhibitors
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1,2,4-Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV-1) in vitro
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1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells
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1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants
1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries
scientific article published on 8 September 2017
18 Synthesis and metabolic study of 1H,3H-oxazolo[3,4-a]benzimidazoles, a new class of non-nucleoside HIV-1 RT inhibitors
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2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri
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2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.
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2-(2,6-Dihalo-phenyl)-3-heteroaryl-2-ylmethyl-1, 3-thiazolidin-4-ones: anti-HIV agents.
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2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance
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2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action
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2-5A synthetase activity induced by interferon α, β, and γ in human cell lines differing in their sensitivity to the anticellular and antiviral activities of these interferons
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scientific article published on March 1, 1982
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections
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2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside Derivatives
2′-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation
3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine
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3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues
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3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties
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3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2''
3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins
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3,5-Bis(Phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A Novel Group of Cytotoxic Agents
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3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins
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3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties
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3-Benzamido, Ureido and Thioureidoimidazo[1,2-a]pyridine Derivatives as Potential Antiviral Agents
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32 Interferon induction by polynucleotides, modified polynucleotides, and polycarboxylates
scientific article published on 01 January 1981
4 Viral entry as the primary target of anti-HIV activity of chicoric acid and its tetra-acetyl esters
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4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family.
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4-(β-Arylvinyl)-3-(β-arylvinylketo)-1-ethyl-4-piperidinols and Related Compounds: A Novel Class of Cytotoxic and Anticancer Agents
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4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation
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40 Interferon inducers: General survey and classification
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5'-Nor carbocyclic 5'-deoxy-5'-(isobutylthio)adenosine and a 2',3'-dideoxy-2',3'-didehydro derivative
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5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity
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5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication
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5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series
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5-Hydroxypyrido[2,3- b ]pyrazin-6(5 H )-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
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5-Nitro-2′-deoxyuridine 5′-monophosphate is a potent irreversible inhibitor of Lactobacillus caesi thymidylate synthetase
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scientific article published on October 30, 1978
5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives
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5-Propyl-2'-deoxyuridine: a specific anti-herpes agent
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scientific article published on March 1, 1978
5-Substituted 2'-deoxyuridines which selectively inhibit herpes simplex virus replication
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5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase
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5-Substituted uracil arabinonucleosides as potential antiviral agents
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scientific article published on March 1, 1979
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity
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5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells
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6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins
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6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity
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6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity
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6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains
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7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase
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9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system
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9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo
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9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys
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9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections
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9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.
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9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo
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A 40-Year Journey in Search of Selective Antiviral Chemotherapy*
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A Cutting‐Edge View on the Current State of Antiviral Drug Development
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A New Topical Treatment for Resistant Herpes Simplex Infections
A case of human orf in an immunocompromised patient treated successfully with cidofovir cream
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A combination of poor adherence and a low baseline susceptibility score is highly predictive for HAART failure.
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A continuous high molecular weight base-paired structure is not an absolute requirement for a potential polynucleotide inducer of interferon
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scientific article published on April 15, 1977
A guided tour through the antiviral drug field
A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells
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A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.
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A mercapto analogue of 5'-noraristeromycin
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A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate
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A novel and efficient approach to discriminate between pre- and post-transcription HIV inhibitors
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A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470.
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A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities
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A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine
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A novel selective broad-spectrum anti-DNA virus agent
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A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase
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A potent interferon inducer derived from poly (7-deazainosinic acid)
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A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
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A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses
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A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export
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A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity
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A time-of-drug addition approach to target identification of antiviral compounds
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AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.
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AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.
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AMD3100/CXCR4 Inhibitor
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AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
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ANN-QSAR model for selection of anticancer leads from structurally heterogeneous series of compounds.
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Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.
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Abatement of Cutaneous Kaposi's Sarcoma Associated with Cidofovir Treatment
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Absence of infectious retinitis after injection of human cytomegalovirus into rabbit eyes
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Ac2IDU, BVDU, and Thymine Arabinoside Therapy in Experimental Herpes Keratitis
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Activation of herpes simplex virus (HSV) type 1 genome by temperature-sensitive mutants of HSV type 2
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scientific article published on January 30, 1982
Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft cultures
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Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures
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Activities of masked 2',3'-dideoxynucleoside monophosphate derivatives against human immunodeficiency virus in resting macrophages
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Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models
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Activities of various compounds against murine and primate polyomaviruses
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Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses
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Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes
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Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro.
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Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor
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Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV
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Activity of recombinant HIV-1 integrase on mini-HIV DNA.
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Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems
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Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo
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Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures
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Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains.
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Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections
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Acyclic Nucleoside Phosphonates in the Chemotherapy of DNA Virus and Retrovirus Infections
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Acyclic Nucleoside Phosphonates: A New Dimension To The Chemotherapy Of Dna Virus And Retrovirus Infections
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Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection
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Acyclic nucleoside phosphonates: An unfinished story
Acyclic nucleoside phosphonates: a key class of antiviral drugs
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Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity.
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Acyclic nucleotide analogues based on phosphonic acids
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Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.
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Additions and Corrections - Resolution of Aristeromycin Enantiomers
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Adverse Events and Autopsy Findings after Intravitreous Cidofovir (HPMPC) Therapy in Patients with Acquired Immune Deficiency Syndrome (AIDS)
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Ajoene [(e,z)-4,5,9-trithiadodeca-1, 6, 11-triene 9 oxide] does not exhibit antiviral activity at subtoxic concentrations
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Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility
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Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds
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Alopecia in laboratory animals induced by a polyampholyte, polyethylene alanine.
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Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
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Amides of antibiotic streptonigrin and amino dicarboxylic acids or aminosugars. Synthesis and biological evaluation
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Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.
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An Animal Model for Cidofovir (HPMPC) Toxicity: Intraocular Pressure and Histopathologic Effects
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An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice
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An Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014
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An active interferon inducer obtained from Hemophilus influenzae type B
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An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives
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An epimer of 5'-noraristeromycin and its antiviral properties.
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An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs
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Analogues of acyclic nucleosides derived from tris-(hydroxymethyl)phosphine oxide or bis-(hydroxymethyl)phosphinic acid coupled to DNA nucleobases.
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Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives
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Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes
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Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends
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Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua.
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Anti-HIV activity of dextran sulphate as determined under different experimental conditions
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Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone
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Anti-HIV agents to be used in drug combination regimens
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Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109.
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Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action
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Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.
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Anti-HIV-1 activity of benzothiadiazine dioxide
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Anti-angiogenic activity of a novel multi-substrate analogue inhibitor of thymidine phosphorylase
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Anti-complement activity of polynucleotides
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Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles
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Anti-herpes activity of deoxythymidine analogues: specific dependence on virus-induced deoxythymidine kinase
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Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo.
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Anti-herpesvirus chemotherapy: experimental and clinical aspects. Concluding remarks
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Anti-human immunodeficiency virus type 1 activities and pharmacokinetics of novel 6-substituted acyclouridine derivatives
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Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered
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Antiadenovirus activities of several classes of nucleoside and nucleotide analogues
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Anticonvulsant phenytoinergic pharmacophores and anti-HIV activity — Preliminary evidence for the dual requirement of the 4-aminophthalimide platform and the N-(1-adamantyl) substitution for antiviral properties
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Antimalarial chloroquine metamorphosed into antiviral agent against HIV with four modes of actions
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Antimetabolic activities of 2-fluoro-L-histidine
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Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of new s-triazine-based heterocycles
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Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds
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Antiproliferative and antiviral activity of three libraries of adamantane derivatives
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Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines.
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Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected [...]
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Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine
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Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics
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Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice
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Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates
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Antitumor Potential of Acyclic Nucleoside Phosphonates
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Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures
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Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity
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Antiviral Activity Spectrum of Nucleoside and Nucleotide Analogues
Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): DNA viruses
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Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): retroviruses and hepadnaviruses
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Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile 2006 (1st edition).
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Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile 2008 (2nd edition): RNA viruses
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Antiviral Drug Development – Success and Failure: A Personal Perspective with a Japanese Connection
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Antiviral Research, at its 30th anniversary, remembrances from its Editor-in-Chief
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Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds
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Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.
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Antiviral activity of 5-ethyl pyrimidine deoxynucleosides
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Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines
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Antiviral activity of Hawaiian medicinal plants against human immunodeficiency Virus Type-1 (HIV-1).
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Antiviral activity of O'-alkylated derivatives of cytosine arabinoside
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scientific article (publication date: 15 February 1975)
Antiviral activity of O′-methylated derivatives of adenine arabinoside
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scientific article (publication date: 15 April 1977)
Antiviral activity of a novel compound P-4018 against different strains of herpes simplex virus in vitro and in vivo
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Antiviral activity of aliphatic nucleoside analogues: structure-function relationship
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Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique
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Antiviral activity of carbopol, a cross-linked polycarboxylate
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Antiviral activity of cyclosaligenyl prodrugs of acyclovir, carbovir and abacavir
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Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts
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Antiviral activity of ganciclovir elaidic acid ester against herpesviruses
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Approved Antiviral Drugs over the Past 50 Years
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Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine
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CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor
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Carbocyclic Adenosine Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Antiviral Agents: Recent Advances
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Charge modification of plasma and milk proteins results in antiviral active compounds
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ChemInform Abstract: Antiinfluenza Virus Agents: Synthesis and Mode of Action
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ChemInform Abstract: Design, Synthesis and Enzymatic Activity of Highly Selective Human Mitochondrial Thymidine Kinase Inhibitors
ChemInform Abstract: Difluorinated Carbaacyclonucleosides: Synthesis and Evaluation of Antiviral Activity
ChemInform Abstract: Selective Inhibitors of Picornavirus Replication
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Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity
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Chemoenzymatic synthesis and antiviral evaluation of conformationally constrained and 3'-methyl-branched carbanucleosides using both enantiomers of the same building block
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Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors
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Cidofovir in the treatment of poxvirus infections
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Cidofovir, a new approach for the treatment of cervix intraepithelial neoplasia grade III (CIN III)
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Cidofovir: Induction of apoptosis in human papilloma virus (HPV)-containing cell lines
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Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa
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Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections
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Combination of Azidothymidine (AZT) and (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) Inhibits the Replication of Herpes Simplex Virus Type 1 (HSV-1) and Type 2 (HSV-2) and Varicella Zoster Virus (VZV) Strains That Are Deficient in the Expression of th
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Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues
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Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector
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Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus
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Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential
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Current treatment of hepatitis B virus infections
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Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds
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Cytotoxic 4'-aminochalcones and related compounds
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Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds
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DNA-Dependent protein kinase is not required for efficient lentivirus integration
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Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy
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Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods
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Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycle
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Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore
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Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity
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Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors
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Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR
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Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity
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Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy
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Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication
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Design of nucleoside, oligonucleotide and polynucleotide analogues as antiviral agents
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Design, Synthesis, and Biological Evaluation of Novel 4-Aminopiperidinyl-linked 3,5-Disubstituted-1,2,6-thiadiazine-1,1-dione Derivatives as HIV-1 NNRTIs
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Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti-HIV-1 Agents
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Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles
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Design, Synthesis, and Molecular Docking Studies of a Conjugated Thiadiazole-Thiourea Scaffold as Antituberculosis Agents
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Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization
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Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs
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Syntheses et Activites Biologiques de Nouvelles (E)-Alcenyl-5 Desoxy-2′ Uridines
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Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides
Synthesis and Antiviral Activity of 1.4-Dioxane, 1.4-Oxathiane and 1,4-Morpholine Nucleoside Analogues
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Synthesis and Antiviral Activity of 6-Benzyl Analogs of 1-[(2-Hydroxyethoxy)methyl]-5-(phenylthio)thymine (HEPT) as Potent and Selective Anti-HIV-1 Agents
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Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′‐Dideoxynucleosides
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Synthesis and Antiviral Evaluation of 3'-Substituted Thymidine Analogues Derived from 3'-Amino-3'-deoxythymidine
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Synthesis and Antiviral Properties of Aza-Analogues ofAcyclovir
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Synthesis and Antiviral/Antiproliferative Activity of Some N-Sulfonylbenzimidazoles
Synthesis and Biological Activity of 3′-Modified 2′-5′ Adenylate Trimers
Synthesis and Biological Activity of Some 2-Aminopurine Carbonucleosides
Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine
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Synthesis and Biological Evaluation of Alkenyldiarylmethane HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors That Possess Increased Hydrolytic Stability
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Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors
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Synthesis and Biological Evaluation of a Series of New Cyclohexenyl Nucleosides
Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines
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Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections
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Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication
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Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent
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Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates.
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Synthesis and anti-BVDV activity of acridones as new potential antiviral agents
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Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine.
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Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds
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Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
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Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
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Synthesis and anti-HIV activity evaluation of novel 2,4-disubstituted 7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo-[4,5-e][1,2]thiadiazines
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Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors
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Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues
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Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives
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Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.
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Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)
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Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors
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Synthesis and anti-HIV activity of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivatives
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Synthesis and anti-HIV activity of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene) amino]-N(4,6-dimethyl-2-pyrimidinyl)-benzene sulfonamide and its derivatives
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Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors
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Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments.
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Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings
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Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems
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Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives
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Synthesis and anti-HIV activity of novel cyclopentenyl nucleoside analogues of 8-azapurine
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Synthesis and anti-HIV activity of some isatin derivatives
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Synthesis and anti-HIV activity of some new aminoadamantane heterocycles
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Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency
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Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides
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Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs).
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Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines
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Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors
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Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2
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Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives
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Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds
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Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues
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Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles
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Synthesis and anti-herpes activity of 5-trifluorovinyl-2′-deoxyuridine
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Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility
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Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
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Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives
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Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine
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Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells
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Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine
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Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation
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Synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives
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Synthesis and antiviral activities of arabinofuranosyl-5-ethylpyrimidine nucleosides. Selective antiherpes activity of 1-(beta-D-arabinofuranosyl)-5-ethyluracil
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Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues
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Synthesis and antiviral activity assay of novel (E)-3',5'-diamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine.
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Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine.
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Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.
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Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles
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Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.
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Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1.
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Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds
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Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety
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Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines
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Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogs of acyclovir and ganciclovir
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Synthesis and antiviral activity of 3-substituted imidazo[1,2-a]pyridines
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Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines
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Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.
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Synthesis and antiviral activity of 6-benzoyl-benzoxazolin-2-one and 6-benzoyl-benzothiazolin-2-one derivatives
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Synthesis and antiviral activity of 6-chloropurine arabinoside and its 2'-deoxy-2'-fluoro derivative
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Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines
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Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides
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Synthesis and antiviral activity of acyclic analogues of 1,5-anhydrohexitol nucleosides using Mitsunobu reaction
Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain
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Synthesis and antiviral activity of benzyl-substituted imidazo[1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives
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Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents
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Synthesis and antiviral activity of monofluorinated cyclopropanoid nucleosides
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Synthesis and antiviral activity of novel derivatives of 2'-beta-C-methylcytidine.
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Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides
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Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues
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Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives
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Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
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Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine
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Synthesis and antiviral activity of three pyrazole analogues of distamycin A.
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Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine)
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Synthesis and antiviral and antineoplastic activities of some novel carbocyclic guanosine analogues with a cyclobutane ring
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Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives
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Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases
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Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides.
scientific article
Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives
scientific article
Synthesis and antiviral evaluation of 3′-substituted thymidine analogues derived from 3′-amino-3′-deoxythymidine
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core
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Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
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Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid.
scientific article published on January 2004
Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides.
scientific article published on January 2005
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives
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Synthesis and antiviral evaluation of phosphoramidate derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine
scientific article published on September 2001
Synthesis and antiviral evaluation of pyridine fused heterocyclic and nucleosidic derivatives
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Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues
scientific article published in January 2004
Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides
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Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design
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Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine
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Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs
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scientific article published on January 1, 1984
Synthesis and antiviral properties of arabino and ribonucleosides of 1,3-dideazaadenine, 4-nitro-1,3-dideazapurine and diketopiperazine.
scientific article
Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles
scientific article published in October 2002
Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide
scientific article published on 18 January 2006
Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators
scientific article published on January 2006
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors
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Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines
scientific article published in January 2002
Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir
scientific article published in November 2002
Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine
scientific article published on 2 February 2006
Synthesis and biological evaluation of 2,3-diaryl substituted-1,3-thiazolidin-4-ones as anti-HIV agents
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Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives
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Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.
scientific article published on 9 March 2010
Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives
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Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine
scientific article published on November 2003
Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives
scientific article published on January 2006
Synthesis and biological evaluation of 6-substituted 5-alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs
scientific article published on 14 February 2011
Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors
scientific article published on 27 March 2014
Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase
scientific article published on 27 November 2014
Synthesis and biological evaluation of N- and O-alkylated bicyclic furanopyrimidines as non-nucleosidic inhibitors of human cytomegalovirus.
scientific article published on January 2005
Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate
scientific article published on 01 February 1999
Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides
scientific article published on May 2003
Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides
scientific article published on July 2005
Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base
Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains
scientific article published on 10 May 2019
Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine
scientific article (publication date: July 1990)
Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
scientific article published on 18 July 2009
Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues
scientific article published on December 2003
Synthesis and biological evaluation of isomeric dinucleoside monophosphates and monomethylphosphonates of 9-beta-D-arabinofuranosyladenine and related analogues
scientific article published on 01 October 1988
Synthesis and biological evaluation of isonucleosides derived from methyl 3,5-anhydro-2-O-(2-fluorobenzyl)-D-xylofuranosides
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Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase
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Synthesis and biological evaluation of novel 1'-branched and spironucleoside analogues.
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Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs
scientific article published on 24 September 2009
Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
scientific article published on 23 May 2011
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
scientific article published on 30 January 2008
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors
scientific article
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs
scientific article published on 9 January 2013
Synthesis and biological evaluation of some alpha-[6-(1'-carbamoylalkylthio)-1 H-pyrazolo[3,4-D]pyrimidin-4-yl]thioalkylcarboxamide acyclonucleosides
scientific article published in January 2007
Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives
scientific article published on 01 September 1990
Synthesis and chemotherapeutic activity of a carbocyclic analogue of tegafur
scientific article published on 01 September 1998
Synthesis and cytostatic and antiviral activities of 1-beta-D-ribofuranosyl-5-alkylcytosine (5-alkylcytidine) cyclic 3',5'-monophosphates
scientific article (publication date: 1989)
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine
scientific article published on 01 January 1995
Synthesis and cytotoxic evaluation of some styryl ketones and related compounds
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents
scientific article
Synthesis and evaluation of in vitro antiviral activity of 2-[3-(substituted phenyl)-4,5-dihydro-1H-5-pyrazolyl]benzofuran-3-yl chloride derivatives
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Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives
scientific article published on June 2009
Synthesis and evaluation of novel 4-substituted styryl quinazolines as potential antimicrobial agents.
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Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
scientific article published in April 2001
Synthesis and fluorescent properties of 6-(4-biphenylyl)-3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine analogues of acyclovir and ganciclovir
scientific article published on May 2003
Synthesis and fluorescent properties of the tricyclic analogues of acyclovir linked with nitrogen hetbrocyclic units
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Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors
scientific article
Synthesis and in vitro cytotoxic and antiviral activities of 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and derivatives
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Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
scientific article published on 13 February 2009
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs
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Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles
scientific article published on September 2005
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs
scientific article
Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication
scientific article
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4
scientific article
Synthesis and studies of new 2-(coumarin-4-yloxy)-4,6-(substituted)-S-triazine derivatives as potential anti-HIV agents
scientific article published on May 2009
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogs: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyridine against herpes simplex virus type 1
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scientific article published on March 1, 1984
Synthesis of (Z) and (E) α-alkenyl phosphonic acid derivatives of purines and pyrimidines
Synthesis of 1,5-Anhydrohexitol Nucleosides as Mimics of AZT, D4T and DDC
Synthesis of 2?-Deoxy-5-(isothiazol-5-yl)uridine and Its Interaction with the HSV-1 Thymidine Kinase
article
Synthesis of 2′-Deoxy-2′ -Fluoro-D-Arabinopyranopyranosyl Nucleosides and Their 3′,4′-Seco analogues
Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach
scientific article published on August 2002
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents
scientific article published on March 2003
Synthesis of 3'-Fluoro-3'-Deoxyribonucleosides; Anti-HIV-1 and Cytostatic Properties
article
Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents
article published in 1998
Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry
scientific article published on 12 October 2007
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition
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scientific article published on March 1, 1980
Synthesis of 5′-N-(α-Amino-β-mercaptoacyl)amino-5′-deoxynucleosides as potential antiviral compounds
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scientific article published on August 1, 1991
Synthesis of 6-arylthio analogs of 2',3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication
scientific article published on January 2006
Synthesis of Pyranose Nucleosides
Synthesis of Thymidine Analogues with a Cyanoimido Substituent
Synthesis of a difluoromethylenephosphonate analogue of AZT 5'-triphosphate and its inhibition of HIV-1 reverse transcriptase
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scholarly article
Synthesis of acyclic nucleotide analogues derived from 2-(aminomethyl)purine bases
scholarly article
Synthesis of adamantane spiro sultones as potential antiviral agents
scientific article published in 1992
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors
scientific article published on 19 September 2008
Synthesis of aza-analogues of Ganciclovir
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Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents
scientific article published on October 2010
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents
scientific article published in January 2004
Synthesis of new benzimidazole-coumarin conjugates as anti-hepatitis C virus agents
scientific article published on 8 October 2007
Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities
scientific article published in March 2002
Synthesis of novel aza-analogues of tiazofurin with 2-[5,5-bis(hydroxymethyl)pyrrolidin-2-yl] framework as sugar mimic.
scientific article published in January 2012
Synthesis of novel carbocyclic nucleosides with a modified cyclopentane ring and evaluation of their antiviral activity
scientific article
Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs
scientific article published on 22 August 2007
Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents.
scientific article published on 25 February 2007
Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents
scientific article
Synthesis of unusual bicyclic nucleosides bearing an unsaturated side-chain, as potential inhibitors of varicella-zoster virus (VZV).
scientific article published on May 2003
Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues
scientific article published in January 2004
Synthesis, Anti-HIV and Cytotoxic Activity of Some Novel Isatine-Sulfisomidine Derivatives
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Synthesis, Antiviral and Cytotoxicity Studies of Novel N-substituted Indophenazine Derivatives
scientific article published on May 2012
Synthesis, Antiviral, Antibacterial and Antitumor Cell Activities of 2'-Deoxy-2'-fluoropuromycin
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scientific article published on 01 June 1995
Synthesis, Biological Evaluation, and Structure Analysis of a Series of New 1,5-Anhydrohexitol Nucleosides
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Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir
scientific article published on January 2001
Synthesis, Cytostatic Activity and Inhibition of Ribonucleotide Reductase by 5′-Phosphoramidates and 5′-Diphosphates, of 2′-O-Allyl-arabinofuranosyl Nucleosides
scientific article published on 01 April 1999
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin
scientific article (publication date: May 1989)
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues
scientific article published on 2 August 2006
Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids.
scientific article published on February 2005
Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors
scientific article published on September 2005
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound
scientific article published on 7 March 2008
Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).
scientific article published on November 1998
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid
scientific article published on 19 January 2010
Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin mannich bases
scientific article
Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one
scientific article
Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives
scientific article published on 7 August 2007
Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines
scientific article
Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds
scientific article published on 19 August 2007
Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles
scientific article published in October 2009
Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives
scientific article published on 11 September 2008
Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives
scientific article published in February 2013
Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes
scientific article
Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine
scientific article
Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones
scientific article published on 6 August 2010
Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide
scientific article published on 9 March 2009
Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues.
scientific article published on July 1998
Synthesis, antiviral and cytostatic activities, of carbocyclic nucleosides incorporating a modified cyclopentane ring. IV. Adenosine and uridine analogues
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Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors
scientific article published on May 2001
Synthesis, conformational analysis and antiviral and antitumoral activity of new 1,2-disubstituted carbocyclic nucleosides.
scientific article published in September 2002
Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles
scientific article published on August 2006
Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates
scientific article
Synthesis, in vitro and in vivo release kinetics, and anti-HIV activity of a sustained-release prodrug (mPEG-AZT) of 3'-azido-3'-deoxythymidine (AZT, Zidovudine).
scientific article
Synthesis, protonation behavior, conformational analysis, and regioselective enzymatic acylation of the novel diamino analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).
scientific article published in October 2003
Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues
scientific article published on May 2003
Synthesis, structural studies, and biological evaluation of some purine substituted 1-aminocyclopropane-1-carboxylic acids and 1-amino-1-hydroxymethylcyclopropanes.
scientific article published in April 2003
Synthesis, structure and in vitro anti-human immunodeficiency virus activity of novel 3-methyl-1H,3H-thiazolo[3,4-a]benzimidazoles
scientific article published on September 1998
Synthesis, structure-activity relationship and antiviral activity of 3'-N,N-dimethylamino-2',3'-dideoxythymidine and its prodrugs
scientific article published on 20 May 2010
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues
scientific article published on 01 February 1986
Systemic cidofovir in papillomatosis
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T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use
scientific article
TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication
scientific article published on May 1, 1992
TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication
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TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosides.
scientific article published on October 1993
TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides
scientific article (publication date: 7 August 1992)
TSAO-T analogues bearing amino acids at position N-3 of thymine: synthesis and anti-human immunodeficiency virus activity
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TSG101: a novel anti-HIV-1 drug target
scientific article published on January 2010
Tanovea® for the treatment of lymphoma in dogs
scholarly article by Erik De Clercq published August 2018 in Biochemical Pharmacology
Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.
scientific article published on 23 March 2018
Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus
scientific article published on 01 March 2019
Ten Paths to the Discovery of Antivirally Active Nucleoside and Nucleotide Analogues
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scientific article published on April 1, 2012
Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF).
scientific article published on 28 April 2016
Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)?
scientific article published on 11 May 2012
Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later
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Tetrazolium-based plaque assay for HIV-1 and HIV-2, and its use in the evaluation of antiviral compounds
scientific article published in December 1989
The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication
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The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro
scientific article published on May 1987
The 5'-monophosphates of 5-propyl- and 5-ethyl-2'-deoxyuridine do not inhibit the replication of deoxythymidine kinase deficient (TK-) mutants of herpes simplex virus
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scientific article published on October 15, 1980
The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase
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The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil).
scientific article published on 31 December 2008
The Acyclic Nucleoside Phosphonates (ANPs): Antonín Holý's Legacy
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scientific article published on 08 April 2013
The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor
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The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis
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The HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (Part V ☆ ): Capravirine and Its Analogues
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scientific article published on January 1, 2012
The HIV-1 reverse transcription (RT) process as target for RT inhibitors
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The Holý Trinity: the acyclic nucleoside phosphonates
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The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication
scientific article (publication date: October 2007)
The Importance of the 4′-Hydroxyl Hydrogen for the Anti-trypanosomal and Antiviral Properties of (+)-5′-Noraristeromycin and Two 7-Deaza Analogues
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scientific article published on June 1, 1998
The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages
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The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine
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The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication
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scientific article published on December 1, 1994
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs
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The Nucleoside Reverse Transcriptase Inhibitors, Nonnucleoside Reverse Transcriptase Inhibitors, and Protease Inhibitors in the Treatment of HIV Infections (AIDS)
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The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
scientific article published in July 2003
The acyclic nucleoside phosphonates from inception to clinical use: historical perspective
scientific article published on 7 November 2006
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors
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The anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil.
scientific article published on February 2001
The anti-yellow fever virus activity of ribavirin is independent of error-prone replication
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The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil.
scientific article
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.
scientific article published in January 1989
The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level
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The antiviral agent cidofovir [(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine] has pronounced activity against nasopharyngeal carcinoma grown in nude mice
scientific article published on 01 February 1998
The antiviral spectrum of (E)-5-(2-bromovinyl)-2 '-deoxyuridine
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scientific article published on August 1, 1984
The bicyclam AMD3100 story
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The changing face of Hepatitis C: Recent Advances on HCV Inhibitors Targeting NS5A.
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The clinical potential of the acyclic (and cyclic) nucleoside phosphonates. The magic of the phosphonate bond
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scientific article published on 08 April 2011
The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine
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The cytostatic activity of 5‐(1‐azidovinyl)‐2′‐deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene‐transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (λ = 254 nm) exposure
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scientific article published on October 2, 1995
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones
scientific article published on 29 March 2008
The design of drugs for HIV and HCV
scientific article
The discovery of antiviral agents: ten different compounds, ten different stories
scientific article
The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2
scholarly article by Xueyi Lu published in May 2018
The effects of cidofovir 1% with and without cyclosporin a 1% as a topical treatment of acute adenoviral keratoconjunctivitis: a controlled clinical pilot study
scientific article published in May 2002
The emerging role of fusion inhibitors in HIV infection.
scientific article
The history of antiretrovirals: key discoveries over the past 25 years
scientific article published in September 2009
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines
scientific article
The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling
article
The interaction of polyxanthylic acid with polyadenylic acid
scientific article published on 01 March 1977
The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis
scientific article published on January 2004
The journey towards elucidating the anti-HCMV activity of alkylated bicyclic furano pyrimidines.
scientific article published on January 2005
The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures
scientific article published on January 2011
The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
scientific article
The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations
scientific article published on 25 October 2006
The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.
scientific article published on January 2005
The novel immunosuppressive agent mycophenolate mofetil markedly potentiates the antiherpesvirus activities of acyclovir, ganciclovir, and penciclovir in vitro and in vivo
scientific article
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations
scientific article
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations.
scientific article published on 15 September 2007
The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation
scientific article
The nucleoside derivative 5'-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
scientific article
The nucleotide analog cidofovir suppresses basic fibroblast growth factor (FGF2) expression and signaling and induces apoptosis in FGF2-overexpressing endothelial cells
scientific article
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.
scientific article
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.
scientific article published on January 1995
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase
scientific article published on February 2005
The race for interferon-free HCV therapies: a snapshot by the spring of 2012.
scientific article published on 30 August 2012
The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention
scientific article
The relationship between incorporation of E-5-(2-Bromovinyl)-2'-deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity
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scientific article published on January 25, 1983
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A.
scientific article
The role of tenofovir in the prevention of HIV infections
article
The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cells
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scientific article published on September 1, 1998
The sulfonic acid polymers PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)] and related analogues are highly potent inhibitors of angiogenesis
scientific article published on 01 January 1997
The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.
scientific article published on 12 March 2008
The unabated synthesis of new nucleoside analogues with antiviral potential: a tribute to Morris J. Robins
scientific article published on May 2009
Therapeutic Approaches to HHV-6 Infection
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections
scientific article published in September 2004
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives
scientific article
Therapy for herpesvirus infections
Therapy for herpesvirus infections
Therapy of poxvirus infections
article
Therapy of varicella-zoster virus infection--mechanism of action of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
scientific article
Thiazolo[4,5-d]pyrimidines. Part II. Synthesis and anti-human cytomegalovirus activity in vitro of certain acyclonucleosides and acyclonucleotides derived from the guanine analogue 5-aminothiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione
scientific article published on January 1998
Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity
scientific article published in May 2000
Thiosugars. X. Novel nucleoside analogues derived from 4-thio-L-lyxofuranose
scientific article published in October 2003
Thiosugars. XII. Synthesis of new 3'-O-substituted 2',5'-anhydro-2'-thio-alpha-D-pentofuranosyl nucleoside analogues.
scientific article
Thymidine analogs as potential antiviral agents
scientific article published on January 2008
Thymidylate synthetase as target enzyme for the inhibitory activity of 5-substituted 2'-deoxyuridines on mouse leukemia L1210 cell growth
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scientific article published on 01 March 1981
Topical cidofovir (HPMPC) is an effective adjuvant to surgical treatment of anogenital condylomata acuminata
scientific article published in August 2003
Towards Efficient and Accurate SARS-CoV-2 Genome Sequence Typing Based on Supervised Learning Approaches
scientific article published in 2022
Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies
scientific article published on 30 August 2013
Translation of mouse interferon mRNA in Xenopus laevis oocytes and in rabbit reticulocyte lysates
scientific article published on May 30, 1978
Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice
scientific article published on 01 January 1991
Treatment of a bowenoid papulosis of the penis with local applications of cidofovir in a patient with acquired immunodeficiency syndrome
scientific article
Treatment of anogenital papillomavirus infections with an acyclic nucleoside phosphonate analogue
scientific article published in October 1995
Treatment of classical Kaposi's sarcoma with intralesional injections of cidofovir: report of a case
scientific article published on 01 July 1998
Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].
scientific article
Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).
scientific article published in May 1998
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
scientific article published on September 1994
Tricyclic etheno analogs of PMEG and PMEDAP: Synthesis and biological activity
scientific article published in 2006
Triple-helical polynucleotides. Mixed triplexes of the poly(uridylic acid)-poly(adenylic acid)-poly(uridylic acid) class
scientific article published on February 24, 1976
Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells
scientific article
Tumor necrosis factor antagonizes inhibitory effect of azidothymidine on human immunodeficiency virus (HIV) replication in vitro
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scientific article published on February 14, 1990
Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones
scientific article published on 30 March 2016
Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?
scientific article published on January 2010
Unexpected Results in the Reaction of 5′-Tosyl TSAO-m3T With Amines
Unusual lability of 5'-O-tert-butyldimethylsilyl group on 4''-acyl TSAO derivatives
scientific article published in May 2003
Update on human herpesvirus 6 biology, clinical features, and therapy
scientific article
Use of Cyclohexene Epoxides in the Preparation of Carbocyclic Nucleosides
Use of cotton rats to evaluate the efficacy of antivirals in treatment of measles virus infections
scientific article
Use of digoxigenin-labelled probes for the quantitation of HBV-DNA in antiviral drug evaluation
scientific article published on 01 August 1999
Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.
scientific article published on May 1996
Utilisation des antiviraux pour les orthopoxviroses
scientific article published on 01 June 2004
Varicella-zoster virus in the human corneal endothelium: a case report
scientific article published on January 1, 1980
Viral DNA Polymerase Inhibitors
Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease
scientific article
Visna in sheep as a model for chemotherapy of lentiviral central nervous system infections
scientific article published on 01 January 1998
Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era
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scientific article published on 05 April 2012
Xylotubercidin against herpes simplex virus type 2 in mice
scientific article
Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes, and paraductions
scientific article published on July 2010
Zidovudine‐Resistant Human Immunodeficiency Virus Type 1 Strains Subcultured in the Presence of Both Lamivudine and Quinoxaline HBY 097 Retain Marked Sensitivity to HBY 097 but Not to Lamivudine
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scientific article published on November 1, 1997
Zinc(II) complexes of constrained antiviral macrocycles.
scientific article
[18] Procedures for the measurement of interferon mRNA distribution in induced mouse cells
scientific article published on 01 January 1981
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1
scientific article (publication date: May 1992)
cycloSal-2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine Monophosphate (cycloSal-d4TMP): Synthesis and Antiviral Evaluation of a New d4TMP Delivery System
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scientific article published on April 23, 1998
cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system
scientific article
cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade
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d4TMP Delivery from 7-SubstitutedcycloSal-d4TMPs
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scientific article published on May 1, 2003
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors
scientific article
synthesis and preliminary biologic evaluation of 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles as a novel class of influenza virus A inhibitors
scientific article published on 20 February 2012