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List of works by Erich Wanker

A Y2H-seq approach defines the human protein methyltransferase interactome

scientific article

A directed protein interaction network for investigating intracellular signal transduction

scientific article

A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells

scientific article

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases

scientific article

A human protein-protein interaction network: a resource for annotating the proteome

scientific article

A molecular pathogenesis for transcription factor associated poly-alanine tract expansions

scientific article

A novel multiplex cell viability assay for high-throughput RNAi screening

scientific article

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

scientific article

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

scientific article

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

scientific article published on May 2001

Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice

scientific article published on 27 July 2016

Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate

scientific article published on 28 December 2016

Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners

scientific article published on 11 March 2013

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques.

scientific article

Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats

scientific article published on June 1999

Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains

scientific article published on 22 November 2007

Amyloid-β(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity

scientific article published on 25 July 2016

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

scientific article

An empirical framework for binary interactome mapping

scientific article

An integer programming framework for inferring disease complexes from network data

scientific article

Annexin A2 mediates apical trafficking of renal Na⁺-K⁺-2Cl⁻ cotransporter

scientific article published on 13 February 2014

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways

scientific article

Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils.

scientific article

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients

scientific article published in October 2001

Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2.

scientific article published in December 1998

Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen

scientific article

Correction: Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease

scientific article

Correction: Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology

scientific article published on 24 July 2020

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

scientific article published on 9 September 2015

Counting CAG repeats in the Huntington's disease gene by restriction endonuclease EcoP15I cleavage

scientific article published on August 2002

Current Approaches Toward Quantitative Mapping of the Interactome

scientific article published on 4 May 2016

DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy

scientific article published on 06 September 2019

DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells.

scientific article published on 8 August 2015

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

scientific article published on 26 March 2021

Detection of alpha-rod protein repeats using a neural network and application to huntingtin.

scientific article

Detection of mutations by flow cytometric melting point analysis of PCR products.

scientific article

Detection of polyglutamine aggregation in mouse models

scientific article published in January 1999

Development and application of a DNA microarray-based yeast two-hybrid system

scientific article

Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein

scientific article published in May 2004

Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

scientific journal article

Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions

scientific article

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

scientific article

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

scientific article

Efficient secretion of bacillus subtilis levanase by saccharomyces cerevisiae

scientific article published in January 1995

Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?

scientific article published on 18 February 2013

Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease

scientific article published on 18 August 2005

Evidence for the interaction of endophilin a3 with endogenous Kca2.3 channels in PC12 cells.

scientific article published on 30 July 2014

Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks.

scientific article

Expression of Bacillus subtilis levanase gene in Lactobacillus plantarum and Lactobacillus casei

scientific article published on 01 May 1995

Expression of the Bacillus subtilis levanase gene in Escherichia coli and Saccharomyces cerevisiae.

scientific article published in May 1991

Folding of oligoglutamines: a theoretical approach based upon thermodynamics and molecular mechanics

scientific article published in December 1999

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

scientific article (publication date: 8 August 1997)

Formation of polyglutamine inclusions in non-CNS tissue

scientific article published in May 1999

Functional association of the polyglutamine proteins ataxin-2 and huntingtin

Functional characterisation of human synaptic genes expressed in the Drosophila brain

scientific article published on 11 April 2016

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

scientific article published in June 2001

Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis

scientific article published in August 2005

Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models

scientific article

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

scientific article published on 7 August 2006

Green tea halts progression of cardiac transthyretin amyloidosis: an observational report

scientific article

HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice

scientific journal article

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration

scientific article (publication date: November 2013)

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

scientific article published in February 2014

HIPPIE: Integrating protein interaction networks with experiment based quality scores.

scientific article

Hip1 and Hippi participate in a novel cell death-signaling pathway

scientific article

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

scientific article published in October 2003

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders

scientific article published on 25 January 2017

Huntingtin aggregation monitored by dynamic light scattering

scientific article published on May 1998

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

scientific article

Huntingtin fragments form aggresome-like inclusion bodies in mammalian cells

scientific article published in January 2003

Huntingtin interacts with the receptor sorting family protein GASP2.

scientific article

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

scientific article published in August 1997

Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein

scientific article published on March 1999

Huntington's disease: from gene to potential therapy.

scientific article published on March 2001

IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse Chromosome 5

article

Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays

scientific article

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

scientific article published on March 2017

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

scientific article

Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1

scientific article

Identification of the mitochondrial MSRB2 as a binding partner of LG72.

scientific article published on 31 July 2014

In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells

scientific article

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles

scientific article published in December 2001

Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease

scientific article published on 9 January 2006

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

scientific article published on 11 February 2016

Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice

scientific article published on 30 January 2020

Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease

scientific article

Lithostathine quadruple-helical filaments form proteinase K-resistant deposits in Creutzfeldt-Jakob disease

scientific article published on 16 September 2003

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

scientific article published on 11 July 2018

Maximizing binary interactome mapping with a minimal number of assays

scientific article published on 29 August 2019

Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates

scientific article published in January 1999

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

scientific article published on 04 September 2018

Method for qualitative comparisons of protein mixtures based on enzyme-catalyzed stable-isotope incorporation

scientific article published in November 2005

Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones

article

Multiplex approaches in protein microarray technology.

scientific article

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease

scientific article published on 29 July 2003

Myc inhibition impairs autophagosome formation.

scientific article published on 09 August 2013

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation

scientific article

Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.

scientific article

Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease

scientific journal article

Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process

scientific article published on 15 July 2016

Pathogenic polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis

scientific article

Pathological consequences of VCP mutations on human striated muscle

scientific article published on 19 September 2006

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.

scientific article published on 26 March 2012

Plant nitric oxide synthase: a never-ending story?

article

Polyglutamine expansion and Huntington's disease

scientific article published in August 1998

Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers

scientific article published on 14 July 2009

Polyglutamine fibrillogenesis: the pathway unfolds

scholarly article

Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.

scientific article

Protein aggregation in Huntington's and Parkinson's disease: implications for therapy.

scientific article

Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.

scientific article

Purification and characterization of the Bacillus subtilis levanase produced in Escherichia coli ⬇️

scientific article published on May 1, 1995

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.

scientific article

Quantitative interaction proteomics of neurodegenerative disease proteins

scientific article published on 7 May 2015

Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.

scientific article published on 13 February 2015

SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation

scientific article published on 18 July 2013

Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology

scientific article published on 08 June 2020

Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy

scientific article published in January 2007

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils

scientific article

Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures

scientific article

Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers.

scientific article published on 28 January 2012

Systematic functional assessment of human protein-protein interaction maps.

scientific article published on January 2006

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

scientific article published on May 2015

The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.

scientific article

The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex

scientific article published on 3 January 2008

The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis

scientific article

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

scientific article published on 29 November 2014

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

scientific journal article

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

scientific article

The pathobiology of perturbed mutant huntingtin protein-protein interactions in Huntington's disease

scientific article published on 15 September 2019

The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes

scientific article published on 13 March 2017

The value of high quality protein-protein interaction networks for systems biology

scientific article

Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation.

scientific article published on January 2006

Therapy effects of green tea in a patient with systemic light-chain amyloidosis

scientific article published on 3 March 2008

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

scientific article

Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells

scientific article

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.

scientific article published in January 2013

Two Hybrid Technologies

article

UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome

scientific article published on 4 November 2008

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