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List of works by Thomas Cech

3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing

scientific article

A bulged stem tethers Est1p to telomerase RNA in budding yeast

scientific article

A dimeric state for PRC2

scientific article

A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro

scientific article

A natural ribozyme with 3',5' RNA ligase activity

scientific article

A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression

scientific article

A practical validation study of a commercial accelerometer using good and poor sleepers

scientific article published on July 2016

A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity ⬇️

scientific article published on November 1, 2003

Academia and industry: Companies on campus

scientific article (publication date: 15 October 2014)

Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers

scientific article published on 11 September 2020

Atomic level architecture of group I introns revealed

scientific article

Beginning to understand the end of the chromosome

scientific article

Biochemical Properties and Biological Functions of FET Proteins

scientific article

Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer

scientific article

Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme

scientific article

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.

scientific article

Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase

scientific article

Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe

scientific article

Crawling out of the RNA world

scientific article

Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase

scientific article

DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA

scientific article

DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe

scientific article

Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance

scientific article

Dynamics of human telomerase recruitment depend on template- telomere base pairing

scientific article published on 31 January 2018

Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation

scientific article

Engineering cis-telomerase RNAs that add telomeric repeats to themselves

scientific article

Erratum: DNA cleavage catalysed by the ribozyme from Tetrahymena

scientific article published in Nature

Erratum: The Tetrahymena ribozyme acts like an RNA restriction endonuclease

scientific article published in Nature

Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction

scientific article

Evolution of Tetrahymena ribozyme mutants with increased structural stability

scientific article

Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase

scientific article

FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.

scientific article

FUS is sequestered in nuclear aggregates in ALS patient fibroblasts

scientific article

Finding the end: recruitment of telomerase to telomeres

scientific article

Fishing for fresh catalysts ⬇️

scientific article published on September 16, 1993

Fostering innovation and discovery in biomedical research

scientific article

From leaf to continent: The multi-scale distribution of an invasive cryptic pathogen complex on oak

scientific article published in 2018

Functional interaction between telomere protein TPP1 and telomerase

scientific article

G-strings at chromosome ends

scientific article published in Nature

Global expression changes resulting from loss of telomeric DNA in fission yeast

scientific article

Hammerhead nailed down

scientific article published in Nature

How a chemist looks at RNA.

scientific article

How do lncRNAs regulate transcription?

scientific article published on 27 September 2017

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA

scientific article

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro

scientific article

Human POT1 facilitates telomere elongation by telomerase

scientific article

Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing

scientific article

Human telomerase: biogenesis, trafficking, recruitment, and activation

scientific article

Identification of human TERT elements necessary for telomerase recruitment to telomeres

scientific article

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

scientific article (publication date: December 1981)

In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron

scientific article

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects ⬇️

scientific article

Inhibition of telomerase recruitment and cancer cell death

scientific article

Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p

scientific article

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.

scientific article

Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.

scientific article

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

scientific article

Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

article by Daniel T Youmans et al published 1 June 2018 in Genes & Development

Local RNA structural changes induced by crystallization are revealed by SHAPE

scientific article

Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency

scientific article

Many disease-associated variants of hTERT retain high telomerase enzymatic activity ⬇️

scientific article published on July 30, 2013

Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers

scientific article published on 10 April 2020

Metal ion catalysis in the Tetrahymena ribozyme reaction

scientific article (publication date: 7 January 1993)

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.

scientific article

Multiple POT1–TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA ⬇️

scientific article published on May 9, 2011

Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance

scientific article

Mutation in TERT separates processivity from anchor-site function

scientific article

Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers

scientific article

Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model

scientific article

N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex

scientific article

Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

scientific article published on 03 June 2021

Nucleic acid-binding specificity of human FUS protein

scientific article

Nurturing interdisciplinary research

scientific article

On the occasion of the 25th anniversary of the discovery of catalytic RNA.

scientific article

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

scientific article

POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

scientific article

Promiscuous RNA binding by Polycomb repressive complex 2.

scientific article

Protein-RNA interaction restricts telomerase from running through the stop sign

scientific article

RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure

scientific article

RNA World research-still evolving

scientific article

RNA finds a simpler way.

scientific article published in March 2004

RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells

scientific article published on 06 July 2020

RNA recognition by the DNA end-binding Ku heterodimer

scientific article

RNA seeds higher-order assembly of FUS protein

scientific article

RNase P branches out from RNP to protein: organelle-triggered diversification?

scientific article

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

scientific article

Regulation of histone methylation by automethylation of PRC2

scientific article published on 05 September 2019

Ribozyme self-replication?

scientific article published in Nature

Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena

scientific article

Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit

scientific article

Sharing publication-related data and materials: responsibilities of authorship in the life sciences

scientific article

Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines

scientific article published on 26 August 2019

SnapShot: Telomeres and Telomerase ⬇️

scientific article published on November 21, 2012

Soluble domains of telomerase reverse transcriptase identified by high-throughput screening ⬇️

scientific article

Structural basis for inactivation of PRC2 by G-quadruplex RNA

scientific article published on 21 September 2023

Structure and Function of Steroid Receptor RNA Activator Protein, the Proposed Partner of SRA Noncoding RNA

scientific article

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection

scientific article

Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site

scientific article

Switching human telomerase on and off with hPOT1 protein in vitro

scientific article (publication date: 27 May 2005)

Sydowia polyspora associated with current season needle necrosis (CSNN) on true fir (Abies spp.) ⬇️

scientific article published on April 24, 2010

TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer

scientific article published on 01 September 2021

Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing

scientific article

Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines

scientific article

Telomerase in bladder cancer: back to a better future?

scientific article published on 28 October 2013

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

scientific article

Tetrahymena telomerase is active as a monomer

scientific article

Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants

scientific article

The Euplotes La motif protein p43 has properties of a telomerase-specific subunit

scientific article

The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro

scientific article

The POT1-TPP1 telomere complex is a telomerase processivity factor

scientific article

The RNA Worlds in Context ⬇️

scientific article published on July 1, 2012

The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis

scientific article

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

scientific article

The chemical repertoire of natural ribozymes

scientific article

The future of research universities. Is the model of research-intensive universities still valid at the beginning of the twenty-first century?

scientific article published on September 2007

The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.

scientific article

The structure of human CST reveals a decameric assembly bound to telomeric DNA

scientific article

Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA.

scientific article

Toward predicting self-splicing and protein-facilitated splicing of group I introns

scientific article

Triple-helix structure in telomerase RNA contributes to catalysis

scientific article (publication date: June 2008)

Yeast telomerase RNA: a flexible scaffold for protein subunits

scientific article

Yeast telomerase is specialized for C/A-rich RNA templates

scientific article

erratum: Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle

scientific article published in Nature

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