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List of works by Emil R. Unanue

A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity ⬇️

scientific article published on November 27, 2012

APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells.

scientific article published on April 2003

Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes

scientific article published on 01 December 2004

Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells

scientific article

Activation of type B T cells after protein immunization reveals novel pathways of in vivo presentation of peptides

scientific article published on 01 January 2007

Altered peptide ligands make their entry

scientific article published on 01 January 2011

Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex

scientific article published on 01 March 2006

Antigen presentation events during the initiation of autoimmune diabetes in the NOD mouse

scientific article published on 24 March 2016

Antigen presentation events in autoimmune diabetes.

scientific article published on 15 December 2011

Antigen presentation in the autoimmune diabetes of the NOD mouse

scientific article published on 05 February 2014

Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?

scientific article

Antigen processing

scientific article

Autoantibodies and CD4 T cells target a beta cell retroviral envelope protein in non-obese diabetic mice

scientific article

Autoimmune diabetes mellitus--much progress, but many challenges

scientific article published on January 2008

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells ⬇️

scientific article published on December 12, 2011

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

scientific article (publication date: 14 November 2008)

Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization

scientific article

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

scientific article

Binding of immunogenic peptides to Ia histocompatibility molecules. 1985.

scientific article published in October 2005

Brigitte Askonas 1923–2013

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility

scientific article (publication date: 23 May 2003)

CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes ⬇️

scientific article published on August 26, 2011

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

scientific article published on 27 December 2009

Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans ⬇️

scientific article published on January 10, 2011

Chemical identification of a low abundance lysozyme peptide family bound to I-Ak histocompatibility molecules

scientific article

Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms

scientific article published on 08 September 2021

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

scientific article published on 02 May 2016

Conformational isomers of a peptide-class II major histocompatibility complex

scientific article

Correction: Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse.

scientific article published on 13 January 2014

Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing

scientific article published on 01 September 2003

Cutting edge: chemical dominance does not relate to immunodominance: studies of the CD4+ T cell response to a model antigen

scientific article published on 01 July 2002

Cutting edge: the relative distribution of T cells responding to chemically dominant or minor epitopes of lysozyme is not affected by CD40-CD40 ligand and B7-CD28-CTLA-4 costimulatory pathways

scientific article published on 01 September 2002

Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization

scientific article published on August 2006

Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse

scientific article

Dendritic Cells Process and Present Antigens Across A Range of Maturation States

scientific article published on 01 June 2003

Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules

scientific article

Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node

scientific article

Diabetes is predicted by the beta cell level of autoantigen

scientific article published on October 2005

Distinct recognition by two subsets of T cells of an MHC class II-peptide complex

scientific article

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

scientific article published on 21 December 2007

Dressing for the occasion: APCs make antigens presentable

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

scientific article

Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation

scientific article published on January 2014

Endoplasmic reticulum: an interface between the immune system and metabolism

scientific article published on January 2014

Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response

scientific article

First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules

scientific article

Following immunization antigen becomes concentrated in a limited number of APCs including B cells

scientific article published in December 2004

From antigen processing to peptide-MHC binding

scientific article

Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins

scientific article

Granzymes drive a rapid listeriolysin O-induced T cell apoptosis

scientific article published on July 2008

Herman Eisen (1918-2014).

scientific article published in December 2014

Herman N. Eisen, M.D. (1918-2014): Scholar, Gentleman, and AAI President (1968-1969).

scientific article published in March 2015

IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes

scientific article

Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J. Immunol. 1981. 127: 1869-1875.

scientific article published in July 2007

Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells

scientific article published on March 2006

Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1).

scientific article published on 18 September 2013

Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.

scientific article

Impact of lymphocyte apoptosis on the innate immune stages of infection

scientific article published on 01 January 2007

In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket

scientific article published in February 2002

In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.

scientific article published on December 2006

Influence of saccharide size on the cellular immune response to glycopeptides

scientific article published in June 2003

Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells

scientific article

Intracellular pathogens and antigen presentation-new challenges with Legionella pneumophila

scientific article published on 01 June 2003

Ita Askonas and her influence in the field of antigen presentation

scientific article published on 7 December 2013

Ito cells, stellate cells, and myofibroblasts: new actors in antigen presentation

scientific article published on January 2007

Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice

scientific article

Listeriolysin O Is Strongly Immunogenic Independently of Its Cytotoxic Activity ⬇️

scientific article published on March 5, 2012

Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule

scientific article published in April 2004

Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens

scientific article published on 25 September 2006

Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.

scientific article

Macrophages and dendritic cells in islets of Langerhans in diabetic autoimmunity: a lesson on cell interactions in a mini-organ

scientific article

Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets

scientific article published on December 2016

Mechanisms and Immunological Effects of Apoptosis Caused by Listeria Monocytogenes

scientific article published on January 1, 2012

MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity

scientific article

Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

scientific article published in August 2005

Neutrophils Influence the Level of Antigen Presentation during the Immune Response to Protein Antigens in Adjuvants ⬇️

scientific article published on August 2, 2010

Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process ⬇️

scientific article published on January 21, 2013

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

scientific article published in Nature

Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.

scientific article published on 14 October 2013

Perspective on antigen processing and presentation.

scientific article

Perspectives on anti-CD47 antibody treatment for experimental cancer

scientific article

Podocytes use FcRn to clear IgG from the glomerular basement membrane

scholarly article

Predicting peptides bound to I-Ag7 class II histocompatibility molecules using a novel expectation-maximization alignment algorithm

scientific article published on February 2007

Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells

scientific article

Presentation of Type B Peptide–MHC Complexes from Hen Egg White Lysozyme by TLR Ligands and Type I IFNs Independent of H2-DM Regulation ⬇️

scientific article published on July 25, 2011

Processing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system ⬇️

scientific article published on February 24, 2012

Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

scientific article published on 01 April 2020

RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice

scientific article

Recombinant Listeria monocytogenes expressing a cell wall-associated listeriolysin O is weakly virulent but immunogenic

scientific article published on 10 August 2009

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion ⬇️

scientific article published on November 7, 2011

Regulation of autoimmune diabetes by non-islet-specific T cells - a role for the glucocorticoid-induced TNF receptor

scientific article published on 01 February 2004

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice.

scientific article published on 13 November 2017

Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition

scholarly article

Starting in Immunology by Way of Immunopathology ⬇️

scientific article published on January 1, 2011

Studies with Listeria Monocytogenes Lead the Way

scientific article published on 01 January 2012

T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.

scientific article

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

scientific article published on August 2017

Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation

scientific article published on 25 September 2009

The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity

scientific article published on 01 August 2019

The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

scientific article published on 09 March 2020

The Secrets of the Class II MHC Peptidome Start To Be Revealed

scientific article published on 01 February 2016

The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen

scientific article published on February 2009

The central role of antigen presentation in islets of Langerhans in autoimmune diabetes

scientific article

The ever surprising field of antigen presentation ⬇️

scientific article published on 06 January 2013

The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form

scientific article published on 01 May 2007

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.

scientific article

The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection

scientific article

The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles

scientific article published on 27 March 2018

The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse

scientific article published on July 2016

The wide diversity and complexity of peptides bound to class II MHC molecules

scientific article

Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction

scientific article

Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice

scientific article published on 03 July 2018

Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.

scientific article

Unconventional recognition of peptides by T cells and the implications for autoimmunity ⬇️

scientific article published on 07 September 2012

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

scientific article

Unique features in the presentation of insulin epitopes in autoimmune diabetes: an update

scientific article

Variations in MHC Class II Antigen Processing and Presentation in Health and Disease

scientific article published on 22 February 2016

Viral infections and nonspecific protection--good or bad?

scientific article published on 01 September 2007

Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice

scientific article published on 8 April 2008

ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditions

scientific article

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