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List of works by Elisa Izaurralde

4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

scientific article published on 2 September 2014

4E-T-bound mRNAs are stored in a silenced and deadenylated form

scientific article published on 30 April 2020

4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay

scientific article published on 01 October 2020

A C-terminal silencing domain in GW182 is essential for miRNA function

scientific article published on 21 April 2009

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

scientific article published on 06 February 2017

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing

scientific article

A Molecular Link between miRISCs and Deadenylases Provides New Insight into the Mechanism of Gene Silencing by MicroRNAs ⬇️

scientific article published on December 1, 2012

A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex

scientific article published on 28 January 2019

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay

scientific article published on 22 February 2007

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

scientific article

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation

scientific article

A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting

scientific article

A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay

scientific article published on 01 September 2019

A novel class of RanGTP binding proteins

scientific article

A novel family of nuclear transport receptors mediates the export of messenger RNA to the cytoplasm

scientific article

A novel mode of RBD-protein recognition in the Y14–Mago complex ⬇️

scientific article published on June 1, 2003

A nuclear cap binding protein complex involved in pre-mRNA splicing

scientific article

A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export

scientific article

A role for eIF4AII in microRNA–mediated mRNA silencing ⬇️

scientific article published on May 1, 2013

A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export

scientific article

A tiny helper lightens the maternal load

scientific article

An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay

scientific article

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

scientific article

An efficient protein complex purification method for functional proteomics in higher eukaryotes

scientific article

An immersion in nucleocytoplasmic transport at the Garda lake

scientific article

An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay

scientific article

CRM1-mediated recycling of snurportin 1 to the cytoplasm

scientific article

CUP promotes deadenylation and inhibits decapping of mRNA targets.

scientific article

Complex genomic rearrangements lead to novel primate gene function

scientific article

Coordination of tRNA nuclear export with processing of tRNA.

scientific article published on April 1999

Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex

scientific article published on 01 June 2021

Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein

scientific article

Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein

scientific article

DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa

scientific article

Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p

scientific article

Deadenylation is a widespread effect of miRNA regulation

scientific article

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

scientific article

Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms

scientific article published on 29 June 2007

Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression

scientific article published on 01 July 2019

Directing mRNA export

scientific article published in March 2004

Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos

scientific article

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex ⬇️

scientific article

Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets

scientific article published on 18 December 2017

Elucidating the temporal order of silencing ⬇️

scientific article published on June 22, 2012

Erratum: An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay

scholarly article published in Nature Structural & Molecular Biology

Freedom versus constraint in protein function

scientific article published in June 2009

GENE REGULATION. Breakers and blockers—miRNAs at work

scientific article published on 23 July 2015

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

scientific article

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

scientific article

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

scientific article

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

scientific article

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

scientific article (publication date: February 2011)

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

scientific article

Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster

scientific article published on April 2006

Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster

scientific article published on 9 May 2004

Genome-wide analysis of nuclear mRNA export pathways in Drosophila

scientific article

Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila

scientific article

Getting to the root of miRNA-mediated gene silencing

scientific article published on January 2008

HPat provides a link between deadenylation and decapping in metazoa

scientific article published on April 2010

Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway.

scientific article

Highly preferential nucleation of histone H1 assembly on scaffold-associated regions

scientific article published on 01 December 1989

Importin provides a link between nuclear protein import and U snRNA export

scientific article published in October 1996

Interaction of DNA with nuclear scaffolds in vitro

scientific article published in March 1988

Making sense of nonsense

scientific article

Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation

scientific article published on 20 August 2015

MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay.

scientific article published on January 2006

Molecular architecture of 4E-BP translational inhibitors bound to eIF4E

scientific article

Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression

scientific article published on 22 August 2019

Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex

scientific article

NMR assignment of the Drosophila Argonaute2 PAZ domain

scientific article

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain

scientific article

NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation

scientific article

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival

scientific article published on 4 May 2009

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

scientific article

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

scientific article

Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species

scientific article

Nonsense-mediated mRNA decay: target genes and functional diversification of effectors

article

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

scientific article published on June 2004

Nuclear Export of Messenger RNA ⬇️

scientific article published on January 1, 2002

Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15.

scientific article published on August 2002

Nuclear transport of uracil-rich small nuclear ribonucleoprotein particles

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

scientific article

Nucleocytoplasmic transport enters the atomic age.

scientific article

Nucleus and gene expression

scientific article published on 14 May 2009

Nucleus and gene expression

Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export

scientific article published on 19 March 2001

P bodies: at the crossroads of post-transcriptional pathways

scientific article

P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

scientific article published on 2 April 2007

Participation of the nuclear cap binding complex in pre-mRNA 3' processing

scientific article

Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay

scientific article

REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus

scholarly article

REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export

scientific article published on 18 November 2002

RNA export

scientific article published on April 1995

RNAi: finding the elusive endonuclease

scientific article published in November 2004

RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.

scientific article published on February 2004

Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu.

scientific article

Rous sarcoma virus DR posttranscriptional elements use a novel RNA export pathway

scientific article

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

scientific article

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

scientific article

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

scientific article

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

scientific article

Similar Modes of Interaction Enable Trailer Hitch and EDC3 To Associate with DCP1 and Me31B in Distinct Protein Complexes

scientific article

Specific inhibition of DNA binding to nuclear scaffolds and histone H1 by distamycin. The role of oligo(dA).oligo(dT) tracts

scientific article

Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex

scientific article published on 24 October 2018

Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression

scientific article

Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B

scientific article

Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor

scientific article

Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast

scientific article published on 01 July 2018

Structure and assembly of the NOT module of the human CCR4-NOT complex

scientific article

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

scientific article

Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation

scientific article

Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins

scientific article

Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP

scientific article

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

scientific article

TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture

scientific article

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

scientific article

The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa

scientific article

The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates

scientific article

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

scientific article

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization

scientific article

The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes

scientific article

The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila

scientific article published in October 2001

The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing

scientific article published on 17 June 2009

The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold

scientific article

The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

scientific article

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.

scientific article published on October 2013

The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation

scientific article published on 19 October 2016

The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.

scientific article published on 8 February 2014

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus ⬇️

scientific article (publication date: 3 November 1997)

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

scientific article

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

scientific article

The interplay of nuclear mRNP assembly, mRNA surveillance and export

scientific article

The protein Mago provides a link between splicing and mRNA localization.

scientific article

The role of GW182 proteins in miRNA-mediated gene silencing

scientific article published on January 2013

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

scientific article published on December 2013

The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release

scientific article published on 21 September 2009

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

scientific article

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3

scientific article (publication date: April 2004)

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex

scientific article

The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex

scientific article

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition

scientific article published in December 2005

The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha

scientific article

Towards a molecular understanding of microRNA-mediated gene silencing

scientific article published on 16 June 2015

Transport of RNA between nucleus and cytoplasm

scientific article published on August 1, 1992

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

scientific article

Viruses, microorganisms and scientists meet the nuclear pore. Leysin, VD, Switzerland, February 26-March 1, 1998.

scientific article

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

scientific article

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.

scientific article published on 21 May 2007

miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning

scientific article published on 23 March 2016

miRISC recruits decapping factors to miRNA targets to enhance their degradation

scientific article

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