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List of works by Helmut Sies

(-)-Epicatechin effects in rat liver epithelial cells: stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate

scientific article

(-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase

scientific article published on 06 June 2007

(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans

scientific article

2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade.

scientific article published on September 2002

6th COSTAM/SFRR (ASEAN/Malaysia) International Workshop on Micronutrients, Oxidative Stress, and the Environment

scientific article published in November 2006

A novel biologically active seleno-organic compound—1

article

Abstracts of the 1st International Conference of Collaborative Research Center 974: liver damage and regeneration, November 15-16, 2013, Düsseldorf, Germany

article

Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases

scientific article

Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts

scientific article published on July 2002

Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers

scientific article

Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT.

scientific article published on 17 October 2011

Amphiphilic properties of (-)-epicatechin and their significance for protection of cells against peroxynitrite

scientific article published in July 2003

An Encapsulated Fruit and Vegetable Juice Concentrate Increases Skin Microcirculation in Healthy Women

scientific article published on 05 August 2011

Anticoccidial and antiinflammatory activity of garlic in murine Eimeria papillata infections

scientific article published on 22 September 2010

Antioxidant activity of carotenoids ⬇️

scientific article published on December 1, 2003

Arginase-1 overexpression induces cationic amino acid transporter-1 in psoriasis

scientific article

Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts

scientific article published on 01 November 2005

Astaxanthin, canthaxanthin and beta-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes

scientific article

Attenuation of hepatic expression and secretion of selenoprotein P by metformin.

scientific article

Bioactivity and protective effects of natural carotenoids

scientific article

Biochemistry of Oxidative Stress

Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein

scientific article published on 01 May 1998

Carotenoids

scientific article

Carotenoids and UV protection

scientific article published in April 2004

Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight

scientific article

Carotenoids and protection against solar UV radiation

scientific article

Chemistry of biologically important synthetic organoselenium compounds.

scientific article

Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge

scientific article published in July 2003

Cocoa extract protects against early alcohol-induced liver injury in the rat.

scientific article published in October 2002

Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo

scientific journal article

Cocoa polyphenols and inflammatory mediators

scientific article

Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia

scientific article

Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics

scientific article published on 31 August 2005

Comparing nitrosative versus oxidative stress toward zinc finger-dependent transcription. Unique role for NO.

scientific article published on 16 January 2002

Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin

scientific article

Contribution of UVB and UVA to UV-dependent stimulation of cyclooxygenase-2 expression in artificial epidermis

scientific article published on 6 February 2004

Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species

scientific article published in January 2002

Cranberries and their bioactive constituents in human health ⬇️

scientific article

Critical role of L-arginine in endothelial cell survival during oxidative stress

scientific article published on 12 May 2003

Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio

scientific article published on 15 July 2006

Decomposition of S-nitrosocysteine via S- to N-transnitrosation

scientific article published on 18 April 2007

Defenses against peroxynitrite: selenocompounds and flavonoids.

scientific article

Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds.

scientific article published on 23 March 2011

Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects

scientific article published in November 2005

Dietary selenium affects intestinal development of Eimeria papillata in mice

scientific article published on 13 November 2013

Dietary selenium in adjuvant therapy of viral and bacterial infections

scientific article

Differential miRNA expression in the mouse jejunum during garlic treatment of Eimeria papillata infections

scientific article published on 08 February 2011

Direct evidence that (−)-epicatechin increases nitric oxide levels in human endothelial cells

article

Disturbed Redox Homeostasis in Oxidative Distress: A Molecular Link From Chronic Psychosocial Work Stress to Coronary Heart Disease?

scientific article published on 01 July 2017

Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst

scientific article

Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells

scientific article

Ebselen: prospective therapy for cerebral ischaemia

scientific article (publication date: March 2000)

Editor's Note

scientific article published in 2009

Editorial

Editorial

Editorial Year-end Note

Editors' Note

scientific article published on 01 January 2003

Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study

scientific article (publication date: 2005)

Eimeria papillata: upregulation of specific miRNA-species in the mouse jejunum.

scientific article

Elevated Lipid Peroxidation Biomarkers and Low Antioxidant Status in Atherosclerotic Patients with Increased Carotid or Iliofemoral Intima Media Thickness

Endothelial function, nitric oxide, and cocoa flavanols

scientific article published on January 2006

Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.

scientific article published on 6 June 2006

Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase

scientific article

Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases

scientific article published on 21 July 2003

Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells

scientific article

Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture

scientific article

Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential

scientific article published on 4 November 2003

Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy.

scientific article

Excited singlet molecular O₂(¹Δg) is generated enzymatically from excited carbonyls in the dark

scientific article

Extracellular generation of hydrogen peroxide is responsible for activation of EGF receptor by ultraviolet A radiation

scientific article published on 11 August 2006

Findings in redox biology: From H2O2 to oxidative stress

scientific article published on 01 September 2020

Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in humans

scientific article

Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase. ⬇️

scientific article published in July 2002

Fruit Juice Carotenol Fatty Acid Esters and Carotenoids As Identified by Matrix-Assisted Laser Desorption Ionization (MALDI) Mass Spectrometry†

scientific article published on 26 July 2002

Functional foods for health promotion: state-of-the-science on dietary flavonoids. Extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April 2009.

scientific article published in December 2009

Future directions in preclinical vitamin E research: panel discussion A.

scientific article

German-Japanese relationships in biochemistry: a personal perspective

scientific article published on December 2016

Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations

scientific article published in Journal of Biological Chemistry

Heat shock but not cold shock leads to disturbed intracellular zinc homeostasis

scientific article published on April 2010

Hepatic encephalopathy: clinical aspects and pathogenetic concept

scientific article published on 30 April 2013

Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity.

scientific article published on July 1983

High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects.

scientific article published in January 2009

High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism

scientific article

Highlight issue: enzymology of drug metabolism and toxicology

scientific article published on 01 August 2007

Highlight: GBM Meeting ‘Molecular Life Sciences 2011’

scientific article published in 2012

Highlight: molecular and cellular mechanisms of memory

scientific article published in November 2009

Highlight: ‘Regenerative Hepatology’

scientific article published on 01 October 2009

How I became a biochemist

scientific article published on 01 July 2007

How do dietary flavanols improve vascular function? A position paper

scientific article

HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity

scientific article

Human Fibroblasts Release Reactive Oxygen Species in Response to Treatment with Synovial Fluids from Patients Suffering from Arthritis

scientific article published in January 1990

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

scientific article

Hydroperoxide-Metabolizing Systems in Rat Liver

article

Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide

scientific article published on 01 September 1983

Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver

scientific article published in February 2003

In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite

scientific article published in August 2002

Incorporation of carotenoids from paprika oleoresin into human chylomicrons

scientific article

Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation

scientific article published on January 2004

Induction of glutathione peroxidase 4 expression during enterocytic cell differentiation

scientific article

Infrared-A radiation-induced matrix metalloproteinase 1 expression is mediated through extracellular signal-regulated kinase 1/2 activation in human dermal fibroblasts

scientific article published on 01 December 2002

Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action

scientific article published in March 2003

Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells.

scientific article published on 15 December 2015

Intervention with flaxseed and borage oil supplements modulates skin condition in women.

scientific article published on 2 September 2008

Intestinal selenoprotein P in epithelial cells and in plasma cells.

scientific article published on 21 October 2013

Involvement of selenoprotein P in protection of human astrocytes from oxidative damage.

scientific article published on 13 January 2006

Irradiation of cells with ultraviolet-A (320-400 nm) in the presence of cell culture medium elicits biological effects due to extracellular generation of hydrogen peroxide

scientific article published in April 2003

Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase

scientific article published on 6 May 2008

Limited availability of L-arginine increases DNA-binding activity of NF-kappaB and contributes to regulation of iNOS expression

scientific article published on 06 March 2007

Localization and regulation of pancreatic selenoprotein P.

scientific article

Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women

scientific article

Loss of the tyrosyl radical in mouse ribonucleotide reductase by (-)-epicatechin

scientific article published in January 2005

Lycopene-rich products and dietary photoprotection

scientific article

Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome

scientific article published in February 2003

Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions

scientific article published on 30 August 2006

Modulation of homologous gap junctional intercellular communication of human dermal fibroblasts via a paracrine factor(s) generated by squamous tumor cells

scientific article published on 29 August 2003

Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase

scientific article published on 8 November 2007

Mutagenic fingerprint of ozone in human cells.

scientific article published on May 2002

Myeloperoxidase-induced lipid peroxidation of LDL in the presence of nitrite. Protection by cocoa flavanols

scientific article published in January 2005

Myeloperoxidase-mediated LDL oxidation and endothelial cell toxicity of oxidized LDL: attenuation by (-)-epicatechin

scientific article (publication date: October 2006)

Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids

scientific article published in February 2003

Nitrite, a naturally occurring precursor of nitric oxide that acts like a 'prodrug'.

scientific article

Non-Nutritive Bioactive Food Constituents of Plants: Lycopene, Lutein and Zeaxanthin ⬇️

scientific article published on March 1, 2003

Nutritional protection against skin damage from sunlight

scientific article published on January 2004

Nutritional, dietary and postprandial oxidative stress

scientific article

O27. Dietary flavanols and vascular responses: Attenuation of NADPH oxidase and preservation of NO

article

On the opinion of the European Commission "Scientific Committee on Food" regarding the tolerable upper intake level of vitamin E (2003)

scientific article published on 01 February 2005

Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen

scientific article published on December 1983

Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance.

scientific article published in March 2010

Oxidative Stress

scientific article published on 24 April 2017

Oxidative Stress: Concept and Some Practical Aspects

scientific article published on 10 September 2020

Oxidative Stress: Damage to Intact Cells and Organs [and Discussion]

scientific article published on 01 December 1985

Oxidative modification of low-density lipoprotein: lipid peroxidation by myeloperoxidase in the presence of nitrite

scientific article published in September 2004

Oxidative stress: a concept in redox biology and medicine

scientific article

Ozone in arteriosclerotic plaques: searching for the "smoking gun"

scientific article published on 01 July 2004

Paracrine effect of TGF-beta1 on downregulation of gap junctional intercellular communication between human dermal fibroblasts.

scientific article published in June 2004

Peroxynitrite signaling: receptor tyrosine kinases and activation of stress-responsive pathways.

scientific article

Photoprotection by dietary carotenoids: concept, mechanisms, evidence and future development

scientific article published on 23 September 2011

Physiological evolution: Genomic redox footprints.

scientific article published on 15 May 2017

Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia

scientific article

Plasma antioxidants and longevity: a study on healthy centenarians.

scientific article published in April 2000

Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome

scientific article

Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity

scientific article published in January 2002

Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels

scientific article published on 10 February 2009

Polyphenols and health: update and perspectives

scientific article published on 14 April 2010

Post-translational processing of selenoprotein P: implications of glycosylation for its utilisation by target cells

scientific article

Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections

scientific article published on 26 June 2020

Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction

scientific article published on 9 June 2010

Protection against peroxynitrite.

scientific article

Protection against reactive oxygen species by selenoproteins

scientific article

Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference

scientific article

Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: protection by (-)-epicatechin

scientific article published on 22 December 2006

Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation

scientific article published in February 2005

Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling.

scientific article published on 19 September 2006

Radiation Hormesis: The Link to Nanomolar Hydrogen Peroxide

scientific article published on 12 July 2017

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

scientific article published on 30 March 2020

Reversible conversion of nitroxyl anion to nitric oxide

scientific article published on 01 January 2002

Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase

scientific article published on December 1991

Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress.

scientific article

Role of metabolic H2O2 generation: redox signaling and oxidative stress

scientific article published on 10 February 2014

Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity.

scientific article published in July 2003

Selectively Addressing Mitochondrial Glutathione and Thioredoxin Redox Systems

scientific article published on 01 March 2019

Selenenyl iodide: a new substrate for mammalian thioredoxin reductase

scientific article published in August 2003

Selenium homeostasis and antioxidant selenoproteins in brain: implications for disorders in the central nervous system

scientific article published on 13 March 2013

Selenium, oxidative stress, and health aspects

scientific article

Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes

scientific article published on 10 November 2018

Selenoprotein P

scientific article published on 01 January 2002

Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors

scientific article

Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity

scientific article published on September 2006

Selenoprotein P protects low-density lipoprotein against oxidation.

scientific article published in February 2004

Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation

scientific article published on January 2004

Singlet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine

scientific article published on 01 October 2006

Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion.

scientific article

Singlet oxygen-induced signaling effects in mammalian cells.

scientific article

Solar-simulated radiation induces secretion of IL-6 and production of isoprostanes in human skin in vivo

scientific article published on 21 February 2006

Special Issue: "Polyphenols and health"

scientific article published on 18 March 2016

Special issue "polyphenols and health"

scientific article published on 19 June 2014

Strategies of antioxidant defense ⬇️

scientific article published on July 15, 1993

Stromal resistance of fibroblasts against oxidative damage: involvement of tumor cell-secreted platelet-derived growth factor (PDGF) and phosphoinositide 3-kinase (PI3K) activation

scientific article published on 3 January 2008

Sulfur and selenium: the role of oxidation state in protein structure and function

scientific article published on October 2003

Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema

scientific article

Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema

scientific article (publication date: 2005)

Supranutritional selenium induces alterations in molecular targets related to energy metabolism in skeletal muscle and visceral adipose tissue of pigs

scientific article published on 30 April 2012

Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week

scientific article published on 01 February 2007

The Redox Code

scientific article

The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established

scientific article published on 30 March 2011

The early research and development of ebselen

scientific article

The presence of nitrite during UVA irradiation protects from apoptosis

scientific article published on 2 October 2003

The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E.

scientific article

The role of H 2 O 2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors.

scientific article published in January 1973

The use of total antioxidant capacity as surrogate marker for food quality and its effect on health is to be discouraged

scientific article published on 14 December 2013

Thioredoxin secreted upon ultraviolet A irradiation modulates activities of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human dermal fibroblasts.

scientific article published in March 2004

Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E.

scientific article

Total antioxidant capacity: appraisal of a concept

scientific article published on 01 June 2007

Toward understanding success and failures in the use of selenium for cancer prevention

scientific article published on 21 March 2013

Towards identifying novel anti-Eimeria agents: trace elements, vitamins, and plant-based natural products

scientific article published on 04 September 2014

Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation

scientific article published on December 1981

Tribute to Professor Minor J. Coon ⬇️

scientific article published on March 1, 2011

Tumor promoter TPA stimulates MMP-9 secretion from human keratinocytes by activation of superoxide-producing NADPH oxidase.

scientific article published in March 2005

Two centuries since discovery of dawn-of-life molecule

scientific article published in Nature

UVA-mediated downregulation of MMP-2 and MMP-9 in human epidermal keratinocytes

scientific article published on 01 August 2003

Ultraviolet A induced modulation of gap junctional intercellular communication by P38 MAPK activation in human keratinocytes

scientific article published on 28 November 2007

Ultraviolet-A irradiation but not ultraviolet-B or infrared-A irradiation leads to a disturbed zinc homeostasis in cells

scientific article

Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events

scientific article

Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes.

scientific article published on June 2014

Use of isolated liver perfusion in metabolic studies: ground-laying work in experimental hepatology ⬇️

scientific article published on June 1, 2011

Vascular effects of cocoa rich in flavan-3-ols

scientific article published in August 2003

Vitamins E and C are safe across a broad range of intakes

scientific article

cis-trans isomers of lycopene and beta-carotene in human serum and tissues

scientific article (publication date: April 1992)

β-Carotene and other carotenoids in protection from sunlight ⬇️

scientific article

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