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List of works by Gavin Thurston

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

scientific article published on 15 September 2013

A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

scientific article

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.

scientific article

Activated STAT3 is a mediator and biomarker of VEGF endothelial activation

scientific article

Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer.

scientific article

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.

scientific article

Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.

scientific article

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

scientific article

Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.

scientific article

Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade

scientific article

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

scholarly article

Angiopoietin-2-driven vascular remodeling in airway inflammation

scientific article

Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation

scientific article

Bispecific Antibodies and Antibody-Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs

scientific article published on 20 January 2017

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.

scientific article published on 16 March 2016

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors

scientific article

Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage

scientific article

Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

scientific article published on March 2009

Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts

scientific article

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis

scientific article published on 18 September 2011

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice

scientific article

Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors ⬇️

scientific article published on December 15, 2010

Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis

scientific article published on 15 December 2009

Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer

scientific article

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

scholarly article

In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy

scientific article

Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts

scientific article

Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents

scientific article published on June 2006

Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis

scientific article

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

scientific article published on 22 August 2016

Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade

scientific article published on 26 February 2016

Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis

scientific article

The Complex Role of Angiopoietin-2 in the Angiopoietin-Tie Signaling Pathway ⬇️

scientific article published on September 1, 2012

The anti-inflammatory actions of angiopoietin-1.

scientific article

VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

scientific article

VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade

scholarly article

VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis

scientific article published on 30 September 2008

VEGF-mediated cross-talk within the neonatal murine thymus

scientific article published on 16 December 2008

Vascular endothelial growth factor and other signaling pathways in developmental and pathologic angiogenesis

scientific article published in July 2004

Vascular endothelial growth factor blockade reduces plasma cytokines in a murine model of polymicrobial sepsis

scientific article

Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization

scientific journal article

Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis

scientific journal article

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