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List of works by Philip Landfield

'Increased calcium-current' hypothesis of brain aging

scientific article published on July 1987

A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease

scientific article published on April 2007

Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons

scientific article published in October 1996

Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear

scholarly article by John C Gant et al published 3 November 2018 in Journal of Alzheimer's Disease

Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys

scientific article

Aging-related increase in hippocampal calcium channels

scientific article

Aging-related increases in voltage-sensitive, inactivating calcium currents in rat hippocampus. Implications for mechanisms of brain aging and Alzheimer's disease

scientific article published in January 1989

Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons

scientific article published in January 1990

An endocrine hypothesis of brain aging and studies on brain-endocrine correlations and monosynaptic neurophysiology during aging

scientific article published on January 1978

Apparent age-related resistance of type II hippocampal corticosteroid receptors to down-regulation during chronic escape training

scientific article published on 01 September 1989

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments ⬇️

scientific article published on October 30, 1981

Brain Creatine Kinase with Aging in F-344 Rats: Analysis by Saturation Transfer Magnetic Resonance Spectroscopy ⬇️

scientific article published on November 1, 1997

Ca2+ regulation and gene expression in normal brain aging

scientific article published in October 2004

Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture

scientific article

Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models

scientific article

Calcium channel density and hippocampal cell death with age in long-term culture.

scientific article published in July 1997

Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions

scientific article

Cannabinoid interactions with glucocorticoid receptors in rat hippocampus

scientific article published in November 1990

Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance ⬇️

scientific article published on May 1, 1991

Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging

scientific article published on 14 June 2006

Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging

scientific article published in May 1991

Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats ⬇️

scientific article published on November 19, 1984

Commentary on biomarkers of aging in the nervous system

scientific article published in January 1988

Computer-determined EEG patterns associated with memory-facilitating drugs and with ECS.

scientific article published in January 1976

Corticosteroid modulation of hippocampal potentials: increased effect with aging

scientific article published in September 1989

Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures.

scientific article

Delayed development of amnesia following electroconvulsive shock ⬇️

scientific article published on October 1, 1970

Delta-9-tetrahydrocannabinol-dependent alterations in brain structure

scientific article

Dietary restriction does not alter retinal aging in the Fischer 344 rat ⬇️

scientific article published on September 1, 1991

Disrupting Function of FK506-Binding Protein 1b/12.6 Induces the Ca2+-Dysregulation Aging Phenotype in Hippocampal Neurons ⬇️

scientific article published on February 2, 2011

Early Onset and Topographical Distribution of Hypertrophied Astrocytes in Hippocampus of Aging Rats: A Quantitative Study ⬇️

scientific article published on September 1, 1979

Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release.

scientific article published in March 2006

Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats ⬇️

scientific article published on March 29, 2013

Effects of electroconvulsive shock and brain stimulation on EEG cortical theta rhythms in rats ⬇️

scientific article published on April 1, 1972

Effects of posttrial electrical stimulation on the mesencephalic reticular formation on avoidance learning in rats

scientific article published in June 1970

Effects of posttrial hippocampal stimulation on memory storage and EEG activity ⬇️

scientific article published on April 1, 1973

Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release

scientific article published on 16 August 2006

Elevated Postsynaptic [Ca2+]iand L-Type Calcium Channel Activity in Aged Hippocampal Neurons: Relationship to Impaired Synaptic Plasticity ⬇️

scientific article published on December 15, 2001

Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices

scientific article published in March 2001

Estradiol reverses a calcium-related biomarker of brain aging in female rats

scientific article published on May 2009

Evolving aspects of the glucocorticoid hypothesis of brain aging: hormonal modulation of neuronal calcium homeostasis

scientific article

Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store

scientific article

Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices

scholarly article

FK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+], rescues memory and restores genomic regulation in the hippocampus of aging rats

scientific article published on 18 December 2017

FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?

scientific article

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment ⬇️

scientific article published on May 1, 2003

Glucocorticoid-Dependent Hippocampal Transcriptome in Male Rats: Pathway-Specific Alterations With Aging ⬇️

scientific article published on June 4, 2013

Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity

scientific article published in January 2002

Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation

scientific article

Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging

scientific article published on February 2010

Hippocampal aging and adrenocorticoids: quantitative correlations

scientific article published on December 8, 1978

Hippocampal aging in rats: A morphometric study of multiple variables in semithin sections ⬇️

scientific article published on 01 January 1981

Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment

scientific article published on February 2009

Hippocampal calcium dysregulation at the nexus of diabetes and brain aging

scientific article published on 17 July 2013

Hippocampal cell death

scientific article published on 01 May 1996

Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats

scientific article published in March 2007

Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging ⬇️

scientific article published on September 15, 1992

Hippocampal neurobiological mechanisms of age-related memory dysfunction

scientific article published on September 1988

Hippocampal neurodegeneration in aging

scientific article published in October 1996

Impaired Monosynaptic Potentiation in in Vitro Hippocampal Slices From Aged, Memory-deficient Rats ⬇️

scientific article published on September 1, 1977

Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats ⬇️

scientific article published on July 7, 1978

Impaired up-regulation of type II corticosteroid receptors in hippocampus of aged rats

scientific article published on 01 January 1989

Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

scholarly article

Increase in single L-type calcium channels in hippocampal neurons during aging

scientific article published in May 1996

Increased affinity of type II corticosteroid binding in aged rat hippocampus

scientific article published on October 1989

Increased hippocampal Ca2+ channel activity in brain aging and dementia. Hormonal and pharmacologic modulation

scientific article published on December 1994

Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels

scientific article published on 12 March 2007

Kinetic studies of the Na+-K+-ATPase enzyme system in brain and heart of aging rats ⬇️

scientific article published on November 1, 1984

Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease ⬇️

scientific article published on January 1, 2012

Long-term treatment with calcitriol (1,25(OH)2 vit D3) retards a biomarker of hippocampal aging in rats

scientific article

Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications

scientific article published on December 1993

Making the best of brain slices: comparing preparative methods

scientific article published on 01 June 1995

Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis

scientific article published on November 1, 1992

Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease

scientific article

Modification of memory systems: some neurobiological aspects ⬇️

scientific article published on May 1, 1972

Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides.

scientific article published on January 1987

Nathan Shock Memorial Lecture 1990. The role of glucocorticoids in brain aging and Alzheimer's disease: an integrative physiological hypothesis

scientific article published on January 1994

Neurotoxicity and drugs of abuse: cannabinoid interaction with brain glucocorticoid receptors.

scientific article published on January 1993

Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats

scientific article published on January 1, 1977

Phosphate/calcium alterations in the first stages of Alzheimer's disease: Implications for etiology and pathogenesis ⬇️

scientific article published on December 1, 1991

Postsynaptic membrane shifts during frequency potentiation of the hippocampal EPSP.

scientific article

Preface. Ca2+ and neuronal pathology

scientific article published on 01 July 2002

Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons

scientific article published in April 1987

Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats

scientific article published in November 1984

Quantification of synaptic vesicles in hippocampus of aging rats and initial studies of possible relations to neurophysiology ⬇️

scientific article published on 01 November 1979

Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems

scientific article

Redistribution of synaptic vesicles during long-term potentiation in the hippocampus

scientific article

Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease ⬇️

scientific article published on January 10, 2012

Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus

scientific article published in July 2015

Reversal of Glial and Neurovascular Markers of Unhealthy Brain Aging by Exercise in Middle-Aged Female Mice ⬇️

scientific article published on October 25, 2011

Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes

scientific article published on 8 May 2012

Sexually Dimorphic Effects of Dietary Vitamin D3 Supplementation on Cognition and the Gut Microbiome in Aging Rats (P14-006-19)

Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons

scientific article published on 01 June 1995

Statistical implications of pooling RNA samples for microarray experiments

scientific article

Stress hormones and brain aging: adding injury to insult?

scientific article published in May 1998

Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons

scientific article published in July 2002

Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats.

scientific article published in April 1988

The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats

scientific article

The glucocorticoid hypothesis of age-related hippocampal neurodegeneration: role of dysregulated intraneuronal calcium.

scientific article published on November 1994

The glucocorticoid hypothesis of brain aging and neurodegeneration: recent modifications

scientific article published on January 1, 1991

Theta rhythm: a temporal correlate of memory storage processes in the rat.

scientific article

Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats.

scientific article

Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.

scientific article

Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats

scientific article

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