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List of works by Jessica Spinelli

Accumulation of succinate controls activation of adipose tissue thermogenesis

scientific article published in Nature

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

scientific article published on 2 March 2017

An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues

scientific article published on 4 September 2017

Fumarate is a terminal electron acceptor in the mammalian electron transport chain

scientific article published on 3 December 2021

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

scientific article published on 26 January 2021

Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition

scientific article published on 26 November 2024

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance

scientific article published on 30 July 2020

MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

scholarly article published on 19 January 2024

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.

scientific article published on 12 October 2017

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

scientific article published on July 2016

Mitochondrial efficiency directs cell fate

scientific article published in February 2022

Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function

scientific article published on 30 September 2022

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

scientific article published on 09 July 2020

Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis

scientific article published in July 2023

SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

scientific article published on 13 July 2021

Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.

scientific article published in February 2018

Strength in numbers: Phosphofructokinase polymerization prevails in the liver.

scientific article

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance ⬇️

scholarly article

The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

scientific article published on 6 December 2022

The multifaceted contributions of mitochondria to cellular metabolism.

scientific article published on 27 June 2018

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

scientific article published on 13 September 2018

Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine

scientific article published in 2022

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