List of works - Lei Guo

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

scientific article

Rat toxicogenomic study reveals analytical consistency across microarray platforms

scientific article

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

scientific article

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies

scientific article

Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential

scientific article

Next-generation sequencing in the clinic: Promises and challenges

scientific article published on November 19, 2012

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

scientific article published on December 13, 2010

Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study

scientific article

Evaluation of external RNA controls for the assessment of microarray performance

scientific article published on September 2006

Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse

scientific article published on 10 October 2002

Polycystin-2 associates with tropomyosin-1, an actin microfilament component

scientific article published on January 2003

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade

scientific article

Microarray scanner calibration curves: characteristics and implications

scientific article published on 15 July 2005

Identification of an N-domain Histidine Essential for Chaperone Function in Calreticulin

scientific article published on December 12, 2003

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells

scientific article

Toxicity of kava kava

scientific article

Review of usnic acid and Usnea barbata toxicity.

scientific article published on October 2008

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway

scientific article published on 5 November 2013

Identification by mutational analysis of amino acid residues essential in the chaperone function of calreticulin

scientific article published on 16 November 2005

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent

scientific article published on March 2, 2012

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment

scientific article

Sertraline induces endoplasmic reticulum stress in hepatic cells

scientific article published on May 24, 2014

Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats

scientific article published on 6 September 2006

Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes

scientific article

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model

scientific article published on 11 June 2014

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

scientific article

Calreticulin in cardiac development and pathology

scientific article

Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract

scientific journal article

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

scientific article published on 6 September 2006

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

scientific article

Endoplasmic Reticulum Stress in Drug- and Environmental Toxicant-Induced Liver Toxicity

scientific article published on January 1, 2014

The role of autophagy in usnic acid-induced toxicity in hepatic cells.

scientific article published on 30 July 2014

Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea

scientific article

Metabolism, genotoxicity, and carcinogenicity of comfrey

scientific article

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

scientific article published on 15 October 2015

Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

scientific article

Calreticulin in the heart

scientific article

Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.

scientific article

Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.

scientific article published on 22 September 2007

A systematic evaluation of microRNAs in regulating human hepatic CYP2E1.

scientific article

Mechanisms of tolvaptan-induced toxicity in HepG2 cells

scientific article

Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.

scientific article published on December 2008

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

scientific article

Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

scientific article

Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network

scientific article

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

scientific article

Mechanism study of goldenseal-associated DNA damage

scientific article published on June 5, 2013

Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors

scientific article published on 28 February 2008

Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells

scientific article published on 28 September 2015

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

scientific article published on September 30, 2015

List of works by Lei Guo

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

Rat toxicogenomic study reveals analytical consistency across microarray platforms

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies

Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential

Next-generation sequencing in the clinic: Promises and challenges

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study

Evaluation of external RNA controls for the assessment of microarray performance

Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse

Polycystin-2 associates with tropomyosin-1, an actin microfilament component

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade

Microarray scanner calibration curves: characteristics and implications

Identification of an N-domain Histidine Essential for Chaperone Function in Calreticulin

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells

Toxicity of kava kava

Review of usnic acid and Usnea barbata toxicity.

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway

Identification by mutational analysis of amino acid residues essential in the chaperone function of calreticulin

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment

Sertraline induces endoplasmic reticulum stress in hepatic cells

Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats

Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

Calreticulin in cardiac development and pathology

Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

Endoplasmic Reticulum Stress in Drug- and Environmental Toxicant-Induced Liver Toxicity

The role of autophagy in usnic acid-induced toxicity in hepatic cells.

Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea

Metabolism, genotoxicity, and carcinogenicity of comfrey

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

Calreticulin in the heart

Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.

Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.

A systematic evaluation of microRNAs in regulating human hepatic CYP2E1.

Mechanisms of tolvaptan-induced toxicity in HepG2 cells

Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

Mechanism study of goldenseal-associated DNA damage

Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors

Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells