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List of works by Lei Guo

A comprehensive rat transcriptome built from large scale RNA-seq-based annotation

scientific article published on 04 August 2020

A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway

scientific article published on 09 December 2020

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

scientific article

A systematic evaluation of microRNAs in regulating human hepatic CYP2E1.

scientific article

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model

scientific article published on 11 June 2014

Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells

scientific article published in July 2016

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

scientific article

Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract

scientific journal article

Application of microarray-based analysis of gene expression in the field of toxicogenomics

scientific article published in January 2010

Assessment of usnic acid toxicity in rat primary hepatocytes using 13C isotopomer distribution analysis of lactate, glutamate and glucose ⬇️

scientific article published on July 23, 2011

Autophagy in drug-induced liver toxicity

scientific article published on 14 May 2014

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes

scientific article published on 21 October 2019

Calreticulin in cardiac development and pathology

scientific article

Calreticulin in the heart

scientific article

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade

scientific article

Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse

scientific article published on 10 October 2002

Carvedilol inhibits EGF-mediated JB6 P+ colony formation through a mechanism independent of adrenoceptors.

scientific article

Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

scientific article

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

scientific article published on 21 February 2020

Corrigendum to: "Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing"

scientific article published on 26 August 2020

Cross-platform comparability of microarray technology: intra-platform consistency and appropriate data analysis procedures are essential

scientific article

Cross-platform comparison of SYBR Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study

scientific article

DNA damage-induced apoptosis and mitogen-activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells.

scientific article

Development and application of TK6-derived cells expressing human cytochrome P450s for genotoxicity testing

scientific article published on 11 March 2020

Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

scientific article published on 15 October 2015

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.

scientific article

Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine

scientific article published on 30 November 2013

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

scientific article

Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone

scientific article published on 13 December 2018

Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells

scientific article published on 9 September 2016

Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells

scientific article published on 13 April 2015

Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells

scientific article published on 4 October 2017

Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity

scientific article published on January 2014

Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

scientific article published on 28 March 2020

Evaluation of external RNA controls for the assessment of microarray performance

scientific article published on September 2006

Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines

scientific article published on 13 August 2020

FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA

scientific article published on 01 January 2020

Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.

scientific article published on December 2008

Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

scientific article

Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats

scientific article

Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements

scientific article published on January 2010

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

scientific article

Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea

scientific article

Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.

scientific article published on 22 September 2007

Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network

scientific article

Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells

scientific article

Identification by mutational analysis of amino acid residues essential in the chaperone function of calreticulin

scientific article published on 16 November 2005

Identification of an N-domain Histidine Essential for Chaperone Function in Calreticulin ⬇️

scientific article published on December 12, 2003

Identification of translational microRNA biomarker candidates for ketoconazole-induced liver injury using next-generation sequencing

scientific article published on 20 October 2020

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

scientific article published on 19 March 2016

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

scientific article published on 28 March 2020

Mechanism study of goldenseal-associated DNA damage

scientific article published on 5 June 2013

Mechanisms of tolvaptan-induced toxicity in HepG2 cells.

scientific article

Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells

scientific article published on 4 March 2014

Metabolism, genotoxicity, and carcinogenicity of comfrey

scientific article

Methods for Establishing and Using a Stable Cell Line Expressing Both Gaussia Luciferase and Firefly Luciferase to Screen for Endoplasmic Reticulum Stress

scientific article published on 01 January 2020

Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.

scientific article

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

scientific article

MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation

scientific article published on 22 August 2019

Microarray scanner calibration curves: characteristics and implications

scientific article published on 15 July 2005

Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent ⬇️

scientific article published on March 2, 2012

Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline

scientific article published on 28 August 2020

Mitochondrial dysfunction induced by leflunomide and its active metabolite

scientific article published on 7 February 2018

Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells

scientific article published on 28 September 2015

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

scientific article

Next-generation sequencing in the clinic: promises and challenges

scientific article

Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells.

scientific article published on 18 March 2013

Polycystin-2 associates with tropomyosin-1, an actin microfilament component

scientific article published on January 2003

ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells

scientific article published on 9 October 2017

Rat toxicogenomic study reveals analytical consistency across microarray platforms

scientific article

Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells

scientific article

Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

scientific article published on 15 July 2019

Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors

scientific article published on 28 February 2008

Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports.

scientific article published on 5 January 2017

Review of usnic acid and Usnea barbata toxicity.

scientific article published on October 2008

Self-self hybridization as an alternative experiment design to dye swap for two-color microarrays

scientific article published on 01 January 2007

Sertraline induces endoplasmic reticulum stress in hepatic cells

scientific article

Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway

scientific article published on 5 November 2013

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes ⬇️

scientific article published on December 13, 2010

Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes

scientific article

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

scientific article

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies

scientific article

The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p.

scientific article published on 16 August 2017

The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.

scientific article

The role of autophagy in usnic acid-induced toxicity in hepatic cells.

scientific article published on 30 July 2014

The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone.

scientific article published on 3 April 2018

The role of hepatic cytochrome P450s in the cytotoxicity of sertraline

scientific article published on 05 May 2020

Toxicity of kava kava

scientific article

Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene

scientific article published on 01 January 2020

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment

scientific article

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