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List of works by Maartje van den Biggelaar

A novel chemical footprinting approach identifies critical lysine residues involved in the binding of receptor-associated protein to cluster II of LDL receptor-related protein

scientific article published on 01 May 2015

A single lysine of the two-lysine recognition motif of the D3 domain of receptor-associated protein is sufficient to mediate endocytosis by low-density lipoprotein receptor-related protein ⬇️

scientific article published on 07 December 2010

A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX

scientific article

Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model

scientific article published on 21 December 2021

Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis

scientific article published on 8 October 2013

Alternative trafficking of Weibel-Palade body proteins in CRISPR/Cas9-engineered von Willebrand factor-deficient blood outgrowth endothelial cells

scientific article published on 01 August 2019

C1 domain residues Lys 2092 and Phe 2093 are of major importance for the endocytic uptake of coagulation factor VIII ⬇️

scientific article published on April 8, 2011

CD29 identifies IFN-γ-producing human CD8+ T cells with an increased cytotoxic potential

scientific article published on 11 March 2020

Cell-Surface Proteomics to Unravel Cytokine-Induced Endothelial Activation ⬇️

scholarly article

Co-Trafficking of Coagulation Factor VIII with Von Willebrand Factor Alters the Macromolecular Structure Inside Secretory Weibel-Palade Bodies ⬇️

scholarly article

D'domain Region Arg782-Cys799 of Von Willebrand Factor contributes to Factor VIII binding

scientific article published on 26 September 2019

Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells

scientific article published on 10 January 2019

Differences between Platelets Derived from Neonatal Cord Blood and Adult Peripheral Blood Assessed by Mass Spectrometry

scientific article published on 21 August 2017

Distinct roles of Ser-764 and Lys-773 at the N terminus of von Willebrand factor in complex assembly with coagulation factor VIII

scientific article published on 20 November 2012

Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming

scientific article published on 01 November 2019

Endocytosis by macrophages: interplay of macrophage scavenger receptor-1 and LDL receptor-related protein-1

scientific article published on 27 June 2019

Establishment of outgrowth endothelial cells from peripheral blood

scientific article published on 23 August 2012

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote <i>ex vivo</i> Expansion of Hematopoietic Stem and Progenitor Cells

scientific article published on 25 February 2021

Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.

scientific article published on 5 September 2013

Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.

scientific article published on 21 April 2015

Factor VIII Region 1811–1818 Is Involved in Factor IXa Binding and Factor VIIIa Stability ⬇️

scholarly article

Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies

scientific article published on 22 September 2011

Factor VIII-driven changes in activated Factor IX explored by Hydrogen-Deuterium eXchange Mass Spectrometry

scientific article published on 17 July 2020

Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking

scientific article published on 5 January 2017

Flow-induced reorganization of laminin-integrin networks within the endothelial basement membrane uncovered by proteomics

scientific article published on 24 April 2020

GPA33: A Marker to Identify Stable Human Regulatory T Cells

scientific article published on 04 May 2020

Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages

scientific article published on 28 December 2017

Hepatitis B Virus Protein X Induces Degradation of Talin-1.

scientific article published on 19 October 2016

High-Throughput Assessment of Kinome-wide Activation States

scientific article published on 11 September 2019

Hydrogen-Deuterium Exchange Mass Spectrometry Identifies Activated Factor IX-Induced molecular Changes in Activated Factor VIII

scientific article published on 10 December 2020

Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components

scientific article published on 22 January 2016

In Vitro Erythropoiesis at Different pO<sub>2</sub> Induces Adaptations That Are Independent of Prior Systemic Exposure to Hypoxia

scientific article published on 23 March 2022

Integrated proteomic analysis of tumor necrosis factor α and interleukin 1β-induced endothelial inflammation

scientific article published on 25 August 2018

Interaction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells

scientific article published on 13 June 2019

Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles

scientific article published on 16 December 2008

Label-free Analysis of CD8+ T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells.

scientific article published on May 2017

Mass spectrometry-assisted study reveals that lysine residues 1967 and 1968 have opposite contribution to stability of activated factor VIII.

scientific article published on 3 January 2012

Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice

scientific article published on 12 April 2012

Paradigm of Biased PAR1 (Protease-Activated Receptor-1) Activation and Inhibition in Endothelial Cells Dissected by Phosphoproteomics

scientific article

Probing activation-driven changes in coagulation factor IX by mass spectrometry

scientific article published on 05 April 2021

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

scientific article published on 08 May 2018

Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells.

scientific article published on 05 February 2014

Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).

scientific article

SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function

scientific article published in 2024

SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

scientific article published in 2022

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

scientific article published on 15 February 2017

Specific N- and O-Linked Carbohydrate Structures Mediate Von Willebrand Factor Interaction with Galectins -1 and -3 ⬇️

scholarly article

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

scientific article published on 31 March 2009

Storage of factor VIII variants with impaired von Willebrand factor binding in Weibel-Palade bodies in endothelial cells

scientific article

The Adhesion G Protein-Coupled Receptor GPR97/ Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions

The D' domain of von Willebrand factor requires the presence of the D3 domain for optimal factor VIII binding

scientific article published on 11 September 2018

The Effect of von Willebrand Factor Normandy Mutations on Intracellular Co-Trafficking of Factor VIII to Storage Organelles. ⬇️

scholarly article

The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression

scientific article published on 31 January 2020

The Role of Factor VIII C Domains in Sorting to Weibel-Palade Bodies ⬇️

scholarly article

The effect of shiga toxin on weibel-palade bodies in primary human endothelial cells

scientific article published on January 2014

Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

scientific article published on 09 July 2018

Unique surface-exposed hydrophobic residues in the C1 domain of factor VIII contribute to cofactor function and von Willebrand factor binding

scientific article published on 28 November 2019

Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain

scientific article published in October 2011

Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells

scientific article published on 07 June 2018

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