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Authors whose works are in public domain in at least one jurisdiction

List of works by Mark J. Mulvihill

1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

scientific article published on 10 November 2006

3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid as a highly potent and selective retinoic acid metabolic blocking agent

scientific article published on 28 February 2006

A Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

scientific article published on 25 June 2020

A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

scientific article published on 6 November 2006

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo

scientific article published on August 2007

Chemistry in Cancer Research: A Vital Partnership

scientific article published on 09 July 2007

Chemistry in cancer research: a vital partnership.

scientific article published in May 2007

Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1

scientific article

Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics

scientific article

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

scientific article

Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR.

scientific article

Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics

scientific article published on 23 May 2013

Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors ⬇️

scientific article published on December 21, 2012

Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

scientific article published on October 2008

Imidazo[1,5-a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2 ⬇️

scientific article published on February 3, 2011

Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal antibodies as alternative approaches.

scientific article published on January 2007

Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives

scientific article

Novel 1,4-Benzodiazepines from Acylnitroso-Derived Hetero-Diels−Alder Cycloadducts ⬇️

scientific article published on January 10, 2002

Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

scientific article published on 23 October 2007

Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases ⬇️

scientific article published on May 30, 2013

Nuphar Dimers: Crouching Sulfur, Hidden Reactivity

scientific article published on 14 June 2016

Palladium-catalyzed direct heck arylation of dual pi-deficient/pi-excessive heteroaromatics. Synthesis of C-5 arylated imidazo[1,5-a]pyrazines

scientific article published on 25 June 2008

Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).

scientific article published on March 2005

Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy ⬇️

scientific article published on December 23, 2010

Pursuit of Personalized Anticancer Therapy: Leveraging Collaboration Between Academia and the Biotech/Pharmaceutical Industry ⬇️

scientific article published on July 1, 2010

Regio- and stereoselective ring openings of 3-Aza-2-oxabicyclo[2.2.1]hept-5-ene systems with copper catalyst-modified grignard reagents: application to the synthesis of an inhibitor of 5-lipoxygenase

scientific article

Regio- and stereospecific syntheses of syn- and anti-1,2-imidazolylpropylamines from the reaction of 1,1'-carbonyldiimidazole with syn- and anti-1,2-amino alcohols

scientific article published in July 2004

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer

scientific article published on 30 March 2011

Small-Molecule ATP-Competitive Dual IGF-1R And Insulin Receptor Inhibitors: Structural Insights, Chemical Diversity And Molecular Evolution ⬇️

scientific article published on March 1, 2012

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

scientific article

Synthesis of substituted imidazo[1,5-a]pyrazines via mono-, di-, and directed remote metalation strategies

scientific article published on 01 November 2009

The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis ⬇️

scientific article published on September 21, 2010

The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming

scientific article published on 02 January 2014

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