List of works - Ying Liu

3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism

scientific article published in April 2004

A continuous fluorescence assay for phospholipase A2 with nontagged lipid

scientific article published on 3 February 2006

Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives

scientific article

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

scholarly article by Cong Li et al published 2018 in Frontiers in Pharmacology

Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.

scientific article published on 13 April 2014

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase ⬇️

scientific article published on October 15, 2003

Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives

scientific article

De novo design of multitarget ligands with an iterative fragment-growing strategy

scientific article published on 18 March 2014

Design, Synthesis, and Evaluation of Dihydrobenzo[cd]indole-6-sulfonamide as TNF-α Inhibitors

scientific article published on 4 April 2018

Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors

scientific article published on 17 March 2014

Direct observations of the cleavage reaction of an L-DPPC monolayer catalyzed by phospholipase A2 and inhibited by an indole inhibitor at the air/water interface.

scientific article published in April 2003

Discovery of Dual Target Inhibitors against Cyclooxygenases and Leukotriene A4 Hydrolyase ⬇️

scientific article published on May 4, 2011

Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase 1.

scientific article published on 8 March 2016

Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

scientific article published on 20 August 2015

Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells

scientific article published on 16 July 2016

Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog

scientific article published on 16 June 2020

Discovery of highly potent TNFα inhibitors using virtual screen

scientific article

Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen

scientific article

Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching

scientific article

Discovery of novel secretory phospholipase A2 inhibitors using virtual screen

scientific article published in July 2014

Diverse ways of perturbing the human arachidonic acid metabolic network to control inflammation.

scientific article

Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network

article

Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors

scientific article published on 01 March 2012

Identification of acylthiourea derivatives as potent Plk1 PBD inhibitors

scientific article published on 22 August 2016

Integrative structural modeling of a multidomain polo-like kinase

scientific article published on 25 November 2020

Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors

scientific article published in June 2006

Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase.

scientific article

Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis

scientific article published in May 2010

Molecular mechanism of 15-lipoxygenase allosteric activation and inhibition

scientific article published on 01 May 2018

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4.

scientific article published on 24 April 2018

Only one protomer is active in the dimer of SARS 3C-like proteinase

scientific article published on 24 March 2006

Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

scientific article published on 17 November 2012

Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds

scientific article published on 01 August 2020

Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase

scientific article

Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors ⬇️

scientific article published on April 22, 2011

Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.

scientific article published on 20 December 2016

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

scientific article published in Nature Communications

Targeting intrinsically disordered proteins at the edge of chaos

scientific article published on 29 September 2018

The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase.

scientific article published on 28 November 2005

The substrate specificity of SARS coronavirus 3C-like proteinase

scientific article

Virtual screening of novel noncovalent inhibitors for SARS-CoV 3C-like proteinase.

scientific article published in January 2005

List of works by Ying Liu

3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism

A continuous fluorescence assay for phospholipase A2 with nontagged lipid

Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase ⬇️

Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives

De novo design of multitarget ligands with an iterative fragment-growing strategy

Design, Synthesis, and Evaluation of Dihydrobenzo[cd]indole-6-sulfonamide as TNF-α Inhibitors

Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors

Direct observations of the cleavage reaction of an L-DPPC monolayer catalyzed by phospholipase A2 and inhibited by an indole inhibitor at the air/water interface.

Discovery of Dual Target Inhibitors against Cyclooxygenases and Leukotriene A4 Hydrolyase ⬇️

Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase 1.

Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells

Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog

Discovery of highly potent TNFα inhibitors using virtual screen

Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen

Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching

Discovery of novel secretory phospholipase A2 inhibitors using virtual screen

Diverse ways of perturbing the human arachidonic acid metabolic network to control inflammation.

Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network

Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors

Identification of acylthiourea derivatives as potent Plk1 PBD inhibitors

Integrative structural modeling of a multidomain polo-like kinase

Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors

Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase.

Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis

Molecular mechanism of 15-lipoxygenase allosteric activation and inhibition

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4.

Only one protomer is active in the dimer of SARS 3C-like proteinase

Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase

Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds

Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase

Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors ⬇️

Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.

Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Targeting intrinsically disordered proteins at the edge of chaos

The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase.

The substrate specificity of SARS coronavirus 3C-like proteinase

Virtual screening of novel noncovalent inhibitors for SARS-CoV 3C-like proteinase.