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List of works by Kenneth Kolinsky

Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer ⬇️

scientific article published on December 16, 2011

Antitumor activity of HER1/EGFR tyrosine kinase inhibitor erlotinib, alone and in combination with CPT-11 (irinotecan) in human colorectal cancer xenograft models

scientific article published on 26 August 2006

Antitumor activity of capecitabine and bevacizumab combination in a human estrogen receptor-negative breast adenocarcinoma xenograft model

scientific article published on July 2007

Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models

scientific article published on June 2004

Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis

scientific article published on 03 February 2006

Characterization of a novel mitogen-activated protein kinase kinase 1/2 inhibitor with a unique mechanism of action for cancer therapy

scientific article

Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor r1530 for the treatment of solid tumors

scientific article

High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ‐secretase inhibitor, RO4929097 ⬇️

scientific article published on January 21, 2011

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

scientific article published on November 2006

In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models

scientific article

MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models ⬇️

scientific article published on February 11, 2013

MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer

scientific article published on 3 May 2011

Novel regimens of capecitabine alone and combined with irinotecan and bevacizumab in colorectal cancer xenografts.

scientific article

Preclinical evaluation of the novel multi-targeted agent R1530.

scientific article published on 8 May 2011

Preclinical evaluation of tumor microvascular response to a novel antiangiogenic/antitumor agent RO0281501 by dynamic contrast-enhanced MRI at 1.5 T

scientific article published in August 2006

Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models

scientific article published on 6 January 2010

Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach

scientific article published on 8 May 2014

Pyrazolobenzodiazepines: Part I. Synthesis and SAR of a potent class of kinase inhibitors ⬇️

scientific article published on August 21, 2010

RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models

scientific article published on 15 June 2010

RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation

scientific article published in August 2005

Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation ⬇️

scientific article published on December 28, 2011

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

scholarly article

Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy ⬇️

scientific article published on August 21, 2010

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