Search filters

List of works by Ann-Charlotte Granholm

6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factor

scientific article published on September 1996

A Cohort Study of the Temporal Stability of ImPACT Scores Among NCAA Division I Collegiate Athletes: Clinical Implications of Test-Retest Reliability for Enhancing Student Athlete Safety

scientific article published on 26 August 2020

A Non-invasive System for Delivering Neural Growth Factors across the Blood-Brain Barrier: A Review ⬇️

scientific article published on January 1, 1998

A dual-hit animal model for age-related parkinsonism

scientific article published on 21 October 2009

A high-fat/high-cholesterol diet inhibits growth of fetal hippocampal transplants via increased inflammation.

scientific article published on 7 March 2011

A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients

scientific article published on 02 February 2021

A non-invasive transport system for GDNF across the blood–brain barrier ⬇️

scientific article published on July 7, 1997

A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats

scientific article published on 19 December 2017

A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model ⬇️

scientific article published on January 1, 2011

A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra

scientific article published on 2 August 2006

Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.

scientific article published on January 2002

Age-Related Neurodegeneration and Memory Loss in Down Syndrome ⬇️

scientific article published on March 20, 2012

Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation

scientific article published on 19 December 2006

Age-induced changes in single locus coeruleus brain transplants grown in oculo: An in vivo electrochemical study ⬇️

scientific article published on September 1, 1991

Age-related alterations in noradrenergic input to the hippocampal formation: structural and functional studies in intraocular transplants

scientific article published on 01 January 1989

Age-related changes in cerebellar noradrenergic pre- and postsynaptic mechanisms: intrinsic vs extrinsic determinants evaluated with brain grafts in oculo

scientific article published in October 1987

Age-related deficits as working memory load increases: relationships with growth factors

scientific article published in January 2003

Altered NGF response but not release in the aged septo-hippocampal cholinergic system

scientific article published on 31 August 2005

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

scientific article

Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers

scientific article published on 30 July 2020

At the interface of sensory and motor dysfunctions and Alzheimer's disease

scientific article

BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function

scientific article published on 4 October 2016

BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease.

scientific article published on 19 November 2015

Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease

scientific article published on 18 May 2006

Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen

scientific article

Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory

scientific article published on January 2003

Blood-brain barrier penetration and in vivo activity of an NGF conjugate

scientific article published on January 1993

Blueberry extract enhances survival of intraocular hippocampal transplants.

scientific article

Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts

scientific article

Carrier mediated delivery of NGF: Alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors ⬇️

scientific article published on October 13, 1997

Catecholamine-containing grafts in parkinsonism: past and present.

scientific article published on April 1988

Centre of pressure velocity shows impairments in NCAA Division I athletes six months post-concussion during standing balance

scientific article published on 27 July 2020

Cerebellar noradrenergic systems in aging: studies in situ and in in oculo grafts

scientific article published on 01 September 1988

Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year

scientific article published in January 1999

Characterization of histaminergic H3 receptors in intraocular tuberomammillary transplants containing histaminergic neurons

scientific article published on 01 November 1995

Chemical signaling in the nervous system in health and disease: Nils-Ake Hillarp's legacy

scientific article published on 20 October 2009

Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors.

scientific article published in August 2004

Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats.

scientific article

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

scientific article

Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats

scientific article published on 20 February 2006

Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.

scientific article published on 20 September 2015

Collateral Sprouting of Central Noradrenergic Neurons during Aging: Histochemical and Neurochemical Studies in Intraocular Triple Transplants ⬇️

scientific article published on June 1, 1997

Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, Luigi Puglielli.

scientific article published in July 2005

Comparison of fetal rabbit brain xenografts to three different strains of athymic nude rats: electrophysiological and immunohistochemical studies of intraocular grafts

scientific article published on January 1, 1992

Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms

scientific article

Defects in enteric innervation and kidney development in mice lacking GDNF

scientific article published on 4 July 1996

Delayed development of GFA immunoreactivity in intraocular cortex cerebri grafts during thyroid hormone deficiency

scientific article

Delayed development of GFA immunoreactivity in the parietal cortex during thyroid hormone deficiency

scientific article

Delivery of trophic factors to the primate brain

scientific article

Designer receptors enhance memory in a mouse model of Down syndrome

scientific article

Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats

scientific article published on 22 June 2016

Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus ⬇️

scientific article published on January 1, 2011

Dietary blueberry supplementation affects growth but not vascularization of neural transplants.

scientific article published on 20 February 2008

Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study

scientific article published on 01 January 2019

Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene

scientific article published on 16 September 2008

Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer’s disease

scientific article published in 2021

Distribution of Thy-1-like immunoreactivity in normal, sympathetically denervated and grafted mouse irides

scientific article

Down Syndrome Biobank Consortium: A perspective

scholarly article

Down syndrome and Alzheimer's disease: Common pathways, common goals

scientific article published on 12 December 2014

ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age.

scientific article published on 17 August 2006

Effects of GDNF on fetal septal forebrain transplants in oculo

scientific article published on October 1996

Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat.

scientific article published on 12 January 2007

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

article by Ann-Charlotte Granholm et al published 4 June 2008 in Journal of Alzheimer's Disease

Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat

scientific article

Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts

scientific article

Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging

scientific article

Effects of glial cell line-derived neurotrophic factor deletion on ventral mesencephalic organotypic tissue cultures

scientific article published on 19 December 2006

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

scientific article

Effects of osteogenic protein-1 (OP-1) treatment on fetal spinal cord transplants to the anterior chamber of the eye.

scientific article

Electrophysiologic effects of ethanol in human brain xenografts in oculo: antagonism by Ro15-4513.

scientific article published in September 1990

Electrophysiological studies of human cerebral and cerebellar cortical tissue grafted to the anterior eye chamber of athymic rodents

scientific article

Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits

scientific article published on 13 March 2008

Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice ⬇️

scientific article published on December 8, 2010

Environmental influences on brain neurotrophins in rats

scientific article

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

scientific article published on January 2003

Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus.

scientific article

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

scientific article

Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study

scientific article published on 16 December 2014

Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat.

scientific article published in March 2003

Exosomal biomarkers in Down syndrome and Alzheimer's disease

scientific article published on 4 September 2017

Exosome release and cargo in Down syndrome

scientific article published on 01 July 2019

Fifth Annual Meeting of the American Society for Neural Transplantation and Repair

scientific article published in January 1999

Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome

scientific article published in February 2003

Further understanding the connection between Alzheimer's disease and Down syndrome

scientific article published on 16 June 2020

GDNF is required for kidney development and enteric innervation

scientific article published on January 1, 1996

Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo.

scientific article published on January 1995

Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum.

scientific article published on August 1997

Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway

scientific article published on January 2004

Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.

scientific article

Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons.

scientific article published on May 1995

Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF ⬇️

scientific article published on January 2, 2013

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue.

scientific article

Human fetal cerebellar and cortical tissue transplanted to the anterior eye chamber of athymic rats: electrophysiological and structural studies

scientific article

Human fetal mesencephalic tissue grafted to dopamine-denervated striatum of athymic rats: light- and electron-microscopical histochemistry and in vivo chronoamperometric studies

scientific article published on 01 February 1989

Human fetal tissues grafted to rodent hosts: structural and functional observations of brain, adrenal and heart tissues in oculo

scientific article published in January 1987

Human fetal xenografts of brainstem tissue containing locus coeruleus neurons: functional and structural studies of intraocular grafts in athymic nude rats

scientific article published in October 1992

Human ventral mesencephalic xenografts to the catecholamine-depleted striata of athymic rats: ultrastructure and immunocytochemistry

scientific article

Hypothalamic tissue stimulates hippocampal pyramidal neuron survival during development: evidence from intraocular double transplants

scientific article published on 01 January 1995

Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

scientific article published on 31 August 2017

Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome

scientific article published on 31 October 2019

Intracerebral xenografts of human mesencephalic tissue into athymic rats: immunochemical and in vivo electrochemical studies

scientific article

Intracranial atherosclerosis: correlation between in-vivo 3T high resolution MRI and pathology

scientific article

Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats

scientific article

Intraocular development and adrenergic innervation of cortical and subcortical brain areas: influence of thyroid hormone deficiency

scientific article published in January 1982

Intraocular fibre growth of grafted locus coeruleus neurons: sensory denervation counteracts alterations induced by thyroid hormone deficiency

scientific article published in June 1982

Intraocular hypothalamic transplants containing histaminergic neurons: innervation of host iris and hippocampal cografts

scientific article published in June 1990

Kidney Cografts Enhance Fiber Outgrowth from Ventral Mesencephalic Grafts to the 6-Ohda–Lesioned Striatum, and Improve Behavioral Recovery ⬇️

scientific article published on March 1, 1998

Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice.

scientific article

Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain

scientific article

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

scientific article published on February 2000

Memory and hippocampal architecture following short-term midazolam in western diet-treated rats

scientific article

Minocycline prevents cholinergic loss in a mouse model of Down's syndrome

scientific article

Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning

scientific article

Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice

scientific article published on 09 December 2008

Mood, memory and movement: an age-related neurodegenerative complex?

scientific article

Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies

scientific article published on February 1997

Morphological and electrophysiological studies of human hippocampal transplants in the anterior eye chamber of athymic nude rats

scientific article published on 01 May 1989

Motion capture and associated novel measurement devices for movement function in humans and animal models

scientific article published on 01 July 2014

Multiple changes in noradrenergic mechanisms in the coeruleo-hippocampal pathway during aging. Structural and functional correlates in intraocular double grafts

scientific article

Myocardium and cortex cerebri xenografts transplanted into the anterior chamber of the eye of athymic rats: a morphologic and electrophysiologic profile

scientific article published on 01 March 1987

NGF and anti-transferrin receptor antibody conjugate: short and long-term effects on survival of cholinergic neurons in intraocular septal transplants.

scientific article published in January 1994

Nerve growth factor in treatment and pathogenesis of Alzheimer's disease.

scientific article published on October 2006

Nerve growth factor metabolic dysfunction in Down's syndrome brains.

scientific article published on 11 February 2014

Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy

article published in 2019

Neuronal development in embryonic brain tissue derived from schizophrenic women and grafted to animal hosts

scientific article published on 01 October 1994

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

scientific article

Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail

scientific article

On the localization of Thy-1-like immunoreactivity in the rodent and human nervous system

scientific article published in January 1986

Ovarian hormones and cognition in the aged female rat: I. Long-term, but not short-term, ovariectomy enhances spatial performance

scientific article published in December 2003

Ovarian hormones and cognition in the aged female rat: II. progesterone supplementation reverses the cognitive enhancing effects of ovariectomy

scientific article

PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice

scientific article

Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations

scientific article published on 20 December 2005

Patterns of neurotrophin protein levels in male and female Fischer 344 rats from adulthood to senescence: how young is "young" and how old is "old"?

scientific article published on January 2008

Pilot Study and Review: Physiological Differences in BDNF, a Potential Biomarker in Males and Females with Autistic Disorder

scientific article published on 24 September 2014

Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice

scientific article

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

scientific article published on 9 December 2015

Progesterone counteracts estrogen-induced increases in neurotrophins in the aged female rat brain

scientific article published in December 2004

Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle-aged ovariectomized female rats

scientific article published in July 2006

Receptors for pro-resolving mediators are increased in Alzheimer's disease brain

scientific article published on 07 January 2020

Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome

scientific article published in April 2003

Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue

scientific article published on 23 November 2020

Resolution of inflammation is altered in Alzheimer's disease

scientific article

RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome

scientific article published on 16 January 2020

Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease

scientific article published on 22 November 2019

Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats

scientific article

Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin

scientific article

Structural and functional impairment of adrenergic input to intraocular cerebellar grafts during thyroid hormone deficiency

scientific article published on 01 January 1984

Systemic administration of a nerve growth factor conjugate reverses age-related cognitive dysfunction and prevents cholinergic neuron atrophy

scientific article published in September 1996

Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats

scientific article

The Noradrenergic System of Aged GDNF Heterozygous Mice

scientific article published in April 2003

The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease

scientific article published on 07 November 2019

The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior

scientific journal article

The noradrenergic system of aged GDNF heterozygous mice.

scientific article published on January 2003

Three-dimensional rodent motion analysis and neurodegenerative disorders

scientific article published on 12 October 2013

Thy-1-like immunoreactivity in human brain during development

scientific article published in July 1986

Thyroid hormone dependency in immature but not mature grafted locus coeruleus neurons. Evidence from intraocular innervation of iris transplants

scientific article published on 01 February 1981

Thyroid hormone dependency of the developing dorsal raphe nucleus but not the superior cervical ganglion. Evidence from intraocular grafting experiments

scientific article published on 01 January 1984

Thyroxin dependency of the developing locus coeruleus. Evidence from intraocular grafting experiments

scientific article published on 01 January 1981

Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion

scientific article published on 01 November 2000

Toluene exposure during maturation of intraocular brain tissue transplants: Alterations of host and graft cerebellar Purkinje neuron function and sensitivity to norepinephrine

scientific article published on 01 November 1988

Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins

scientific article published on 08 January 2020

Use of seniors as mentors to medical students: a collaboration between the University of South Carolina School of Medicine and the Medical University of South Carolina

scientific article published on February 1, 2011

Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet

scientific article published on 23 November 2011

Why do we need to use animal models to study cognition and aging?

scientific article

Paulina is supported by:

About Paulina

Help