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List of works by Philip H. Elsinga

(11)C- and (18)F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography

scientific article published on 13 November 2015

(99m)technetium-HYNIC(tricine/TPPTS)-Aca-bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model

scientific article published on 30 June 2011

18F-FEAnGA for PET of β-glucuronidase activity in neuroinflammation

scientific article published on 8 February 2012

18F-FLT PET for visualization of laryngeal cancer: comparison with 18F-FDG PET.

scientific article published in February 2004

18F-fluorodeoxythymidine PET for evaluating the response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcomas.

scientific article published in March 2007

18th European Symposium on Radiopharmacy and Radiopharmaceuticals

article

3'-18F-fluoro-3'-deoxy-L-thymidine: a new tracer for staging metastatic melanoma?

scientific article

6-[F-18]Fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to conventional imaging with (123)I-metaiodobenzylguanidine scintigraphy, computer tomography, and magnetic resonance imaging in localizing tumors causing catecholamine

scientific article published on 21 July 2009

A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹⁸F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.

scientific article published on 15 November 2014

Agonist high- and low-affinity states of dopamine D2 receptors: methods of detection and clinical implications ⬇️

scientific article published on 09 December 2012

Agonist signalling properties of radiotracers used for imaging of dopamine D2/3 receptors

scientific article published on 7 October 2014

Altered sigma-1 receptor expression in two animal models of cognitive impairment

scientific article published in April 2015

An update of radiolabeled bombesin analogs for gastrin-releasing peptide receptor targeting

scientific article published on January 2013

Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients: a first-in-man study

scientific article published on 26 July 2013

Avenues to molecular imaging of dying cells: Focus on cancer.

scientific article published on 12 March 2018

Cerebral adenosine A₁ receptors are upregulated in rodent encephalitis

scientific article published on 7 February 2014

Comparison of (11)C-choline and (18)F-FDG PET in primary diagnosis and staging of patients with thoracic cancer.

scientific article published in February 2002

Comparison of 18F-FLT PET and 18F-FDG PET in esophageal cancer.

scientific article

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging

scientific article published on 20 September 2017

Comparison of sigma-ligands and metabolic PET tracers for differentiating tumor from inflammation.

scientific article published in January 2006

Copper-free 'click': 1,3-dipolar cycloaddition of azides and arynes

scientific article published on 13 August 2008

Correspondence re: H. Barthel et al., 3'-deoxy-3'-[(18)F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography. Cancer Res., 63: 3791-3798, 2003.

scientific article published in December 2003

Corrigendum to “A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging” [Bioorg. Med. Chem. 23 (2014) 192–202]

scholarly article by Nathalie Matusiak published in April 2015

Cross-coupling of [<sup>11</sup>C]methyllithium for <sup>11</sup>C-labelled PET tracer synthesis

scientific article published on 10 December 2020

Cutamesine Overcomes REM Sleep Deprivation-Induced Memory Loss: Relationship to Sigma-1 Receptor Occupancy

scientific article published in June 2015

Cytotoxicity of sigma-receptor ligands is associated with major changes of cellular metabolism and complete occupancy of the sigma-2 subpopulation

scientific article

Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists

scientific article published on 28 April 2021

Despite irreversible binding, PET tracer [11C]-SA5845 is suitable for imaging of drug competition at sigma receptors-the cases of ketamine and haloperidol

scientific article published on 13 May 2008

Detection and grading of soft tissue sarcomas of the extremities with (18)F-3'-fluoro-3'-deoxy-L-thymidine.

scientific article published in March 2004

Development and evaluation of interleukin-2 derived radiotracers for PET imaging of T-cells in mice

scientific article published on 28 February 2020

Development of [18F]-labeled pyrazolo[4,3-e]-1,2,4- triazolo[1,5-c]pyrimidine (SCH442416) analogs for the imaging of cerebral adenosine A2A receptors with positron emission tomography

scientific article published on 4 August 2014

Development of<sup>89</sup>Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration

scientific article published in 2022

Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with (11)C-SA4503 and microPET.

scientific article published on 18 March 2014

EANM guideline for the preparation of an Investigational Medicinal Product Dossier (IMPD)

scientific article published on 01 November 2014

EANM guideline on the validation of analytical methods for radiopharmaceuticals

scientific article published on 12 February 2020

Early response of sigma-receptor ligands and metabolic PET tracers to 3 forms of chemotherapy: an in vitro study in glioma cells.

scientific article published on September 2006

Editorial - EJNMMI radiopharmacy and chemistry

Effect of fenfluramine-induced increases in serotonin release on [18F]MPPF binding: a continuous infusion PET study in conscious monkeys.

scientific article published in January 2006

Effect of radiotherapy and chemotherapy on bone marrow activity: a 18F-FLT-PET study

scientific article published in January 2011

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines

scientific article published on 16 April 2019

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines

scientific article

Evaluation of 4′-[Methyl-11C]Thiothymidine in a Rodent Tumor and Inflammation Model ⬇️

scientific article published on February 7, 2012

Evaluation of [11C]SA5845 and [11C]SA4503 for imaging of sigma receptors in tumors by animal PET.

scientific article

Evaluation of [18F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood-brain barrier in rats: Kinetics, metabolism, and selectivity

scientific article published on 27 June 2016

Evaluation of a technetium-99m labeled bombesin homodimer for GRPR imaging in prostate cancer

scientific article

Evaluation of cardiac beta-adrenoreceptors in the isolated perfused rat heart using (S)-11C-CGP12388.

scientific article published in March 2004

Evaluation of fluorine-18-labeled alkylating agents as potential synthons for the labeling of oligonucleotides

scientific article published in April 2003

Ex Vivo Characterization of a Novel Iodine-123-Labelled Aminomethylchroman as a Potential Agonist Ligand for SPECT Imaging of Dopamine D2/3 Receptors

scientific article

Feasibility of [18F]-RGD for ex vivo imaging of atherosclerosis in detection of αvβ3 integrin expression

scientific article published on 20 February 2015

Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography

scientific article published on 16 May 2020

Fully automated synthesis module for the high yield one-pot preparation of 6-[]fluoro-l-DOPA

scientific article published in October 1999

Growth factor/peptide receptor imaging for the development of targeted therapy in oncology.

scientific article published on January 2008

Guidance on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals

scientific article

Guidance on current good radiopharmacy practice for the small-scale preparation of radiopharmaceuticals using automated modules: a European perspective

scientific article published on 01 August 2014

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

scientific article

Highlight selection of radiochemistry and radiopharmacy developments by editorial board (January-June 2020)

scientific article

Hunting for the high-affinity state of G-protein-coupled receptors with agonist tracers: Theoretical and practical considerations for positron emission tomography imaging

scientific article published on 18 November 2018

Imaging the folate receptor on cancer cells with 99mTc-etarfolatide: properties, clinical use, and future potential of folate receptor imaging.

scientific article published on 14 April 2014

Improved staging of patients with carcinoid and islet cell tumors with 18F-dihydroxy-phenyl-alanine and 11C-5-hydroxy-tryptophan positron emission tomography.

scientific article

Improving metabolic stability of fluorine-18 labeled verapamil analogs

scientific article published on 05 July 2018

In Vivo Evaluation of 1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-β-D-Glucopyronuronate: A Positron Emission Tomographic Tracer for Imaging β-Glucuronidase Activity in a Tumor/Inflammation Rodent Model ⬇️

scientific article published on February 1, 2012

In Vivo Evaluation of 11C-Preladenant for PET Imaging of Adenosine A2A Receptors in the Conscious Monkey

scientific article published on 6 January 2017

In vitro imaging of bacteria using 18F-fluorodeoxyglucose micro positron emission tomography

scientific article published on 10 July 2017

In vivo biodistribution of no-carrier-added 6-18F-fluoro-3,4-dihydroxy-L-phenylalanine (18F-DOPA), produced by a new nucleophilic substitution approach, compared with carrier-added 18F-DOPA, prepared by conventional electrophilic substitution.

scientific article published on 11 December 2014

In vivo evaluation of [11C]preladenant positron emission tomography for quantification of adenosine A2A receptors in the rat brain

scientific article

In vivo evaluation of [18F]FEAnGA-Me: a PET tracer for imaging β-glucuronidase (β-GUS) activity in a tumor/inflammation rodent model

scientific article

In vivo imaging of apoptosis in oncology: an update.

scientific article published on 26 April 2011

In vivo responses of human A375M melanoma to a σ ligand: 18F-FDG PET imaging

scientific article published on 12 August 2013

Induction of β-glucuronidase release by cytostatic agents in small tumors

scientific article published on 11 October 2012

Initial Evaluation of an Adenosine A2A Receptor Ligand, 11C-Preladenant, in Healthy Human Subjects

scientific article published on 9 March 2017

Is 18F-3'-fluoro-3'-deoxy-L-thymidine useful for the staging and restaging of non-small cell lung cancer?

scientific article published in October 2004

Manipulation of [11C]-5-hydroxytryptophan and 6-[18F]fluoro-3,4-dihydroxy-L-phenylalanine accumulation in neuroendocrine tumor cells.

scientific article

MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [(18)F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation

scientific article

Modular medical imaging agents based on azide-alkyne Huisgen cycloadditions: Synthesis and pre-clinical evaluation of 18F-labeled PSMA-tracers for prostate cancer imaging

scientific article published on 21 April 2020

Molecular imaging in neuroendocrine tumors: molecular uptake mechanisms and clinical results.

scientific article published on 09 April 2009

Multimerization Improves Targeting of Peptide Radio-Pharmaceuticals ⬇️

scientific article published on January 1, 2012

Myocardial beta-adrenoceptor downregulation in idiopathic dilated cardiomyopathy measured in vivo with PET using the new radioligand (S)-[11C]CGP12388.

scientific article

New imaging tracers for the infected diabetic foot (nuclear and optical imaging).

scientific article published on 26 February 2018

Nomenclature for radiopharmaceuticals, consultation of your opinion!

scientific article published on 18 January 2017

Novel Approach to Repeated Arterial Blood Sampling in Small Animal PET: Application in a Test-Retest Study with the Adenosine A1 Receptor Ligand [(11)C]MPDX.

scientific article

One pot 'click' reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition

scientific article published on 5 January 2010

Oxygen Activated, Palladium Nanoparticle Catalyzed, Ultrafast Cross-Coupling of Organolithium Reagents

scientific article published on 14 February 2017

Oxygen Activated, Palladium Nanoparticle Catalyzed, Ultrafast Cross-Coupling of Organolithium Reagents

P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study

scientific article

PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS.

scientific article published on January 2004

PET Tracers for Imaging of ABC Transporters at the Blood-Brain Barrier: Principles and Strategies

scientific article

PET imaging of adenosine A1 receptor occupancy

scientific article published on 09 October 2014

PET imaging of beta-adrenoceptors in human brain: a realistic goal or a mirage?

scientific article published on January 2004

PET tracers for imaging of the dopaminergic system.

scientific article published on January 2006

Pharmacokinetic Modeling of (<i>R</i>)-[<sup>11</sup>C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates

scientific article published on 14 December 2020

Pharmacokinetic modelling of [18F]MC225 for quantification of P-glycoprotein function at the blood-brain barrier in non-human primates with PET

scientific article published on 05 August 2020

Pharmacological screening identifies SHK242 and SHK277 as novel arginase inhibitors with efficacy against allergen-induced airway narrowing in vitro and in vivo

scientific article published on 08 April 2020

Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes

scientific article published on 19 March 2009

Positron emission tomography studies of human airways using an inhaled beta-adrenoceptor antagonist, S-11C-CGP 12388.

scientific article published in October 2005

Positron emission tomography studies on binding of central nervous system drugs and P-glycoprotein function in the rodent brain.

scientific article

Positron emission tomography: the conceptual idea using a multidisciplinary approach

scientific article

Potential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging

scientific article published on 27 January 2017

Potential applications for sigma receptor ligands in cancer diagnosis and therapy

scientific article

Preclinical Evaluation and Quantification of 18F-Fluoroethyl and 18F-Fluoropropyl Analogs of SCH442416 as Radioligands for PET Imaging of the Adenosine A2A Receptor in Rat Brain

scientific article published on 27 October 2016

Preoperative staging of pelvic lymph nodes in prostate cancer by 11C-choline PET.

scientific article published in March 2003

Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses

scientific article published on 11 July 2015

Probes for Non-invasive Matrix Metalloproteinase-targeted Imaging with PET and SPECT ⬇️

scientific article published on January 1, 2013

Proliferation markers for the differential diagnosis of tumor and inflammation

scientific article published on January 2008

Publisher Correction: In vitro imaging of bacteria using 18F-fluorodeoxyglucose micro positron emission tomography

scientific article published on 17 July 2019

Quantification of beta-adrenoceptor density in the human heart with (S)-[11C]CGP 12388 and a tracer kinetic model

scientific article published on 01 March 2002

Radiation Dosimetry of a Novel Adenosine A2A Receptor Radioligand [11C]Preladenant Based on PET/CT Imaging and Ex Vivo Biodistribution in Rats

scientific article published on 18 August 2016

Radiopharmaceutical chemistry for positron emission tomography

scientific article

Rapid reduction of sigma1-receptor binding and 18F-FDG uptake in rat gliomas after in vivo treatment with doxorubicin

scientific article published on 13 July 2007

Receptor imaging in the thorax with PET.

scientific article published in September 2004

Selectivity of 18F-FLT and 18F-FDG for differentiating tumor from inflammation in a rodent model.

scientific article published in April 2004

Sigma Receptors in Oncology: Therapeutic and Diagnostic Applications of Sigma Ligands ⬇️

scientific article published on January 1, 2010

Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [(11)C]SA4503.

scientific article published on 4 December 2015

Small molecule PET-radiopharmaceuticals

scientific article published on January 2014

Small-Animal PET with a σ-Ligand, 11C-SA4503, Detects Spontaneous Pituitary Tumors in Aged Rats ⬇️

scientific article published on June 19, 2013

Small-animal PET study of adenosine A(1) receptors in rat brain: blocking receptors and raising extracellular adenosine

scientific article published on 15 July 2011

Staging of carcinoid tumours with 18F-DOPA PET: a prospective, diagnostic accuracy study

scientific article published on September 2006

Steroid hormones affect binding of the sigma ligand 11C-SA4503 in tumour cells and tumour-bearing rats

scientific article published on 27 February 2009

Strain-promoted copper-free "click" chemistry for 18F radiolabeling of bombesin

scientific article published on 28 September 2011

Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-me

scientific article published on 29 October 2016

Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood-Brain Barrier

scientific article published on 26 June 2017

Synthesis and Evaluation of [18F]FEtLos and [18F]AMBF3Los as Novel 18F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors

scientific article published on 18 April 2020

Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier

scientific article published on 4 June 2015

Synthesis and characterization of a novel series of agonist compounds as potential radiopharmaceuticals for imaging dopamine D₂/₃ receptors in their high-affinity state

scientific article published on 2 January 2014

Synthesis and evaluation in rats of homologous series of [(18)F]-labeled dopamine D 2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers

scientific article published on 25 July 2015

Synthesis and evaluation in rats of the dopamine D2/3 receptor agonist 18F-AMC20 as a potential radioligand for PET.

scientific article published on 4 December 2014

Synthesis and evaluation of 11C- and 18F-labeled 1-[2-(4-alkoxy-3-methoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines as sigma receptor ligands for positron emission tomography studies ⬇️

scientific article published on April 1, 2003

Synthesis and evaluation of [18F]-FEAnGA as a PET Tracer for beta-glucuronidase activity

scientific article published on May 2010

Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expression

scientific article

Synthesis and evaluation of dopamine D3 receptor antagonist 11C-GR218231 as PET tracer for P-glycoprotein

scientific article published in August 2005

Synthesis and preclinical evaluation of 2-(2-furanyl)-7-[2-[4-[4-(2-[11C]methoxyethoxy)phenyl]-1-piperazinyl]ethyl]7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5-amine ([11C]Preladenant) as a PET tracer for the imaging of cerebral adenosine A2

scientific article published on 15 October 2014

Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression.

scientific article

Synthesis and preliminary evaluation of (S)-[11C]-exaprolol, a novel beta-adrenoceptor ligand for PET.

scientific article

Synthesis of Substituted Benzaldehydes via a Two-Step, One-Pot Reduction/Cross-Coupling Procedure.

scientific article published on 14 May 2019

Synthesis of [18F]RGD-K5 by catalyzed [3 + 2] cycloaddition for imaging integrin αvβ3 expression in vivo

scientific article published in July 2013

Tailored imaging of islet cell tumors of the pancreas amidst increasing options.

scientific article published on 25 June 2011

Test-Retest Repeatability of [18F]MC225-PET in Rodents: A Tracer for Imaging of P-gp Function

scientific article published on 03 February 2020

The cholinergic system, sigma-1 receptors and cognition

scientific article published on 07 January 2010

The new Regulation on clinical trials in relation to radiopharmaceuticals: when and how will it be implemented?

scientific article published on 11 January 2019

Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study.

scientific article

Ultrafast Photoclick Reaction for Selective F-Positron Emission Tomography Tracer Synthesis in Flow

scientific article

Untangling the web of European regulations for the preparation of unlicensed radiopharmaceuticals: a concise overview and practical guidance for a risk-based approach.

scientific article

Use of 11C-MPDX and PET to study adenosine A1 receptor occupancy by nonradioactive agonists and antagonists

scientific article published on 16 January 2014

VEGF-PET imaging is a noninvasive biomarker showing differential changes in the tumor during sunitinib treatment

scientific article published on 17 November 2010

Visualisation of bladder cancer using (11)C-choline PET: first clinical experience

scientific article published on 27 July 2002

Visualization of beta-Adrenoceptors Using PET.

scientific article published on March 1998

[(18)F]-(fluoromethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)propan-2-ol ([(18)F FPTC) a novel PET-ligand for cerebral beta-adrenoceptors

scientific article published on 7 November 2013

[18 F]Fluoroethoxybenzovesamicol in Parkinson's disease patients: Quantification of a novel cholinergic positron emission tomography tracer

scientific article published on 12 April 2019

[18F]FLT-PET and [18F]FDG-PET in the evaluation of radiotherapy for laryngeal cancer.

scientific article published on 18 August 2009

[18F]FLT-PET in oncology: current status and opportunities

scientific article

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