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List of works by Christine H. Chung

A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle

scientific article published on January 2009

A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma

scientific article

A phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic, platinum-refractory head and neck squamous cell carcinoma

scientific article published on 04 February 2013

A phase Ib study of utomilumab (PF-05082566) in combination with mogamulizumab in patients with advanced solid tumors

scientific article published on 04 December 2019

A randomized phase II efficacy and correlative studies of cetuximab with or without sorafenib in recurrent and/or metastatic head and neck squamous cell carcinoma.

scientific article published on 13 January 2015

Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer

scientific article published on 18 May 2009

Abstract 1493: The Twist box is required for Twist1-induced prostate cancer metastasis

Abstract 1812: LncRNAs as prognostic biomarkers in head and neck squamous cell carcinoma (HNSCC)

scholarly article

Abstract 1889: Smad4 inactivation correlates with EMT and cetuximab resistance in head and neck squamous cell carcinoma

Abstract 2474: Smad4 loss induces cetuximab resistance and increased metastatic potential in head and neck squamous cell carcinoma

Abstract 2901: An integrated matrix factorization algorithm for DNA methylation and gene expression identi es HNSCC clinical subtypes and GLI1 signaling speci c to HPV-negative HNSCC

article

Abstract 3100: MicroRNA profiling reveals miR-205 upregulation is associated with head and neck squamous cell carcinoma and modulates E2F1 signaling

Abstract 3409: Transcription factor signature of head and neck squamous cell carcinoma

Abstract 5314: Smad4 loss upregulates chemokine expression and promotes tumor inflammation and growth in head and neck cancer

scholarly article

Abstract 777: The CoGAPS matrix factorization algorithm infers feedback mechanisms from therapeutic inhibition of EGFR that increases expression of growth factor receptors

Abstract B45: The Twist box domain is required for Twist1-induced metastasis of prostate cancer cells

Activation of the NOTCH pathway in head and neck cancer ⬇️

scientific article published on 18 December 2013

Analysis of microsatellite mutations in buccal cells from a case-control study for lung cancer.

scientific article published on 6 November 2011

Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742)

scientific article published on 27 March 2018

Application of genomic and proteomic technologies in biomarker discovery

scientific article published on January 2012

Association of Tumor Size With Histologic and Clinical Outcomes Among Patients With Cytologically Indeterminate Thyroid Nodules

scientific article published on 01 September 2018

Autologous reconstitution of human cancer and immune system in vivo.

scientific article published on 19 December 2016

Biology of Human Papillomavirus–Related Oropharyngeal Cancer ⬇️

scientific article published on July 1, 2012

CHK it out! Blocking WEE kinase routs TP53 mutant cancer

scientific article published on August 2014

Cancer Risk Associated with Nuclear Atypia in Cytologically Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis

scientific article

Cancer Risk Stratification of Indeterminate Thyroid Nodules: A Cytological Approach.

scientific article

CancerInSilico: An R/Bioconductor package for combining mathematical and statistical modeling to simulate time course bulk and single cell gene expression data in cancer

scientific article published on 01 June 2018

Cetuximab activity in dysplastic lesions of the upper aerodigestive tract.

scientific article published on 10 December 2015

Chromosomal instability drives metastasis through a cytosolic DNA response

scientific article published on 17 January 2018

Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features

scientific article

Clinical applications of genomics in head and neck cancer

scientific article

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke

scientific article

CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network

scientific article

Comparative Shotgun Proteomics Using Spectral Count Data and Quasi-Likelihood Modeling.

scientific article

Comparative shotgun proteomics using spectral count data and quasi-likelihood modeling.

scientific article

Corrigendum to "Cetuximab activity in dysplastic lesions of the upper aerodigestive tract" [Oral Oncol. 53 (2016) 60-66].

scientific article

Current role of EGF receptor monoclonal antibodies and tyrosine kinase inhibitors in the management of head and neck squamous cell carcinoma

scientific article

Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma

scientific article

Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

scientific article

Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patients

scientific article

Diagnostic Accuracy of Follow-Up FDG PET or PET/CT in Patients With Head and Neck Cancer After Definitive Treatment: A Systematic Review and Meta-Analysis

scientific article published on September 2015

Dual blockade of the EGFR and COX-2 pathways: a phase II trial of cetuximab and celecoxib in patients with chemotherapy refractory metastatic colorectal cancer

scientific article

E1308: Phase II Trial of Induction Chemotherapy Followed by Reduced-Dose Radiation and Weekly Cetuximab in Patients With HPV-Associated Resectable Squamous Cell Carcinoma of the Oropharynx- ECOG-ACRIN Cancer Research Group

scientific article published on 28 December 2016

Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma

scientific article published on 17 December 2019

Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma

scientific article published on 30 December 2020

Emerging biomarkers in head and neck cancer in the era of genomics.

scientific article

Epidemiology of oral human papillomavirus infection

scientific article published on 27 September 2013

Estimation of immune cell content in tumor using single-cell RNA-seq reference data

scientific article published on 19 July 2019

Evaluation of ThyroSeq v2 performance in thyroid nodules with indeterminate cytology

scientific article published on 19 January 2017

Evaluation of a novel rash scale and a serum proteomic predictor in a randomized phase II trial of sequential or concurrent cetuximab and pemetrexed in previously treated non-small cell lung cancer

scientific article

Evolution of clinical trials in head and neck cancer

scientific article

Evolving role of human papillomavirus as a clinically significant biomarker in head and neck squamous cell carcinoma

scientific article published on 21 December 2018

FDG volumetric parameters and survival outcomes after definitive chemoradiotherapy in patients with recurrent head and neck squamous cell carcinoma

scientific article

Functional characterization of alternatively spliced GSN in head and neck squamous cell carcinoma

scientific article published on 26 July 2018

Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma.

scientific article

Gene expression profiles as markers of aggressive disease-EGFR as a factor

scientific article published on January 2007

Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma.

scientific article

Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma

scientific article published on May 2012

Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma

scientific article published on 21 September 2016

Genomics and proteomics: emerging technologies in clinical cancer research.

scientific article published on 2 October 2006

Glioma-Associated Oncogene Family Zinc Finger 1 Expression and Metastasis in Patients With Head and Neck Squamous Cell Carcinoma Treated With Radiation Therapy (RTOG 9003) ⬇️

scientific article published on February 28, 2011

HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma

scientific article published on 01 June 2018

Histoecology: Applying Ecological Principles and Approaches to Describe and Predict Tumor Ecosystem Dynamics Across Space and Time

scientific article published on 01 July 2020

Human papillomavirus and survival of patients with oropharyngeal cancer.

scientific article

Human papillomavirus in early laryngeal carcinoma

scientific article

Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications

scientific article published on 27 October 2009

Hypothyroidism as a consequence of intensity-modulated radiotherapy with concurrent taxane-based chemotherapy for locally advanced head-and-neck cancer

scientific article published on 04 July 2009

Impact of oncogene panel results on surgical management of cytologically indeterminate thyroid nodules

scientific article published on 06 April 2018

Implications of the New Face of Head and Neck Cancer

scientific article published on September 2015

Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas.

scientific article

Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy

scientific article published on 27 August 2012

Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma.

scientific article

Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance.

scientific article

Integrating Epidermal Growth Factor Receptor Assay With Clinical Parameters Improves Risk Classification for Relapse and Survival in Head-and-Neck Squamous Cell Carcinoma ⬇️

scientific article published on August 21, 2010

Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?

scientific article published on 03 October 2018

Long noncoding RNA, LINC00460, as a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC)

scientific article published on 15 February 2020

Loss of Trop2 Promotes Carcinogenesis and Features of Epithelial to Mesenchymal Transition in Squamous Cell Carcinoma ⬇️

scientific article published on October 4, 2011

Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC.

scientific article

MOLECULAR DETERMINANTS OF THYROID NODULES WITH INDETERMINATE CYTOLOGY AND RAS MUTATIONS

scientific article published on 21 July 2020

Modernizing Eligibility Criteria for Molecularly Driven Trials.

scientific article

Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression

article

Molecular portraits and the family tree of cancer

scientific article

NF-κB and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma

scientific article

Neoadjuvant Nivolumab for Patients With Resectable Merkel Cell Carcinoma in the CheckMate 358 Trial

scientific article published on 23 April 2020

New promising molecular targets in head and neck squamous cell carcinoma ⬇️

scientific article published on May 1, 2012

Nuclear epidermal growth factor receptor and p16 expression in head and neck squamous cell carcinoma

scientific article published on 19 October 2012

Opportunities and challenges in the era of molecularly targeted agents and radiation therapy

scientific article published on 15 March 2013

PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma

scientific article published on 04 June 2018

PTEN loss is associated with resistance to cetuximab in patients with head and neck squamous cell carcinoma

scientific article published on 04 March 2019

Patient choice for high-volume center radiation impacts head and neck cancer outcome

scientific article published on 02 September 2018

Phase 2 trial of oxaliplatin and pemetrexed as an induction regimen in locally advanced head and neck cancer

scientific article published on 15 July 2011

Phase I/II study of ADXS11-001 or MEDI4736 immunotherapies alone and in combination, in patients with recurrent/metastatic cervical or human papillomavirus (HPV)-positive head and neck cancer

scientific article published on 4 November 2015

Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements

scientific article published on 12 January 2012

Phase II trial of irinotecan plus cisplatin in patients with recurrent or metastatic squamous carcinoma of the head and neck

scientific article published in July 2008

Predicting survival in head and neck squamous cell carcinoma from TP53 mutation.

scientific article

Predictive Factors for Prophylactic Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement and Use in Head and Neck Patients Following Intensity-Modulated Radiation Therapy (IMRT) Treatment: Concordance, Discrepancies, and the Role of Gabapentin

scientific article

Preferential activation of the hedgehog pathway by epigenetic modulations in HPV negative HNSCC identified with meta-pathway analysis

scientific article

Preserving biological heterogeneity with a permuted surrogate variable analysis for genomics batch correction

scientific article published on 6 June 2014

Prognostic Implication of Persistent Human Papillomavirus Type 16 DNA Detection in Oral Rinses for Human Papillomavirus-Related Oropharyngeal Carcinoma

scientific article published on 30 July 2015

Proteomic analysis of oropharyngeal carcinomas reveals novel HPV-associated biological pathways

scientific article

Randomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the Radiation Therapy Oncology Group 0129 trial: long-term report of efficacy and toxicity

scientific article

Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma

scientific article (publication date: 13 September 2010)

Reliability and validity of the Vanderbilt Head and Neck Symptom Survey: a tool to assess symptom burden in patients treated with chemoradiation

scientific article published in January 2010

Retrospective review of positron emission tomography with contrast-enhanced computed tomography in the posttreatment setting in human papillomavirus-associated oropharyngeal carcinoma

scientific article

SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells.

scientific article

Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer

scientific article published on 23 December 2015

Strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program

scientific article

Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer

scientific article published on 17 March 2015

T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma

scientific article published on 01 June 2022

Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations.

scientific article

The KRAS-Variant and Cetuximab Response in Head and Neck Squamous Cell Cancer: A Secondary Analysis of a Randomized Clinical Trial

scientific article published on 22 December 2016

The twist box domain is required for Twist1-induced prostate cancer metastasis

scientific article published on 27 August 2013

Therapeutic targets in head and neck squamous cell carcinoma: Identification, evaluation, and clinical translation ⬇️

scientific article published on October 22, 2011

Thyroid Nodules with Indeterminate Cytology: Utility of the American Thyroid Association Sonographic Patterns for Cancer Risk Stratification

scientific article published on 17 July 2018

Tobacco Smoking and Increased Risk of Death and Progression for Patients With p16-Positive and p16-Negative Oropharyngeal Cancer ⬇️

scientific article published on May 7, 2012

Ultrasound characterization for thyroid nodules with indeterminate cytology: inter-observer agreement and impact of combining pattern-based and scoring-based classifications in risk stratification

scientific article published on 12 July 2019

Update on molecular diagnostic tests in head and neck cancer

scientific article published on June 2008

Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.

scientific article published on 10 August 2009

lncDIFF: a novel quasi-likelihood method for differential expression analysis of non-coding RNA

scientific article published on 02 July 2019

p16 Expression as a predictive biomarker of hypoxic cell-sensitizing agents in oropharyngeal cancer

scientific article published on 9 August 2010

p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma

scientific article

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