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List of works by Helenius J. Kloosterboer

3beta-OH-tibolone acutely dilates rat muscle arterioles similar to 3alpha-OH-tibolone

scientific article published in March 2008

7alpha-Methyl-ethinyl estradiol is not a metabolite of tibolone but a chemical stress artifact.

scientific article

Antioxidant effect of the active metabolites of tibolone

scientific article published on 23 July 2014

Conversion of tibolone to 7alpha-methyl-ethinyl estradiol using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry: interpretation and clinical implications.

scientific article

Difference in signalling between various hormone therapies in endometrium, myometrium and upper part of the vagina

scientific article published on 11 December 2007

Different effects of tibolone and continuous combined estrogen plus progestogen hormone therapy on sex hormone binding globulin and free testosterone levels--an association with mammographic density

scientific article published in February 2005

Effect of tibolone administration on central and peripheral levels of allopregnanolone and beta-endorphin in female rats

scientific article

Effects of tibolone metabolites on human endometrial cell lines in co-culture

scientific article

Effects of tibolone on nuclear receptors in human endometrial cells

scientific article published on 21 April 2006

Effects of tibolone on sulfatase pathway of estrogens metabolism and on growth of MCF-7 human breast tumors implanted in ovariectomized nude mice

scientific article published on 7 August 2006

Endothelium-dependent dilatory effects of 3alpha-OH-tibolone in gracilis muscle arterioles of the female Wistar rat.

scientific article published in May 2005

Estetrol prevents and suppresses mammary tumors induced by DMBA in a rat model

scientific article published in April 2012

Estrogen and tibolone metabolite levels in blood and breast tissue of postmenopausal women recently diagnosed with early-stage breast cancer and treated with tibolone or placebo for 14 days

scientific article published on 01 February 2007

Histological and immunohistochemical evaluation of postmenopausal endometrium after 3 weeks of treatment with tibolone, estrogen only, or estrogen plus progestagen

scientific article published on 07 July 2006

Hormone replacement therapy dependent changes in breast cancer‐related gene expression in breast tissue of healthy postmenopausal women ⬇️

scientific article published on September 16, 2011

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

scientific article published on 12 February 2009

In vitro studies of tibolone in breast cells.

scientific article

Levels of tibolone and estradiol and their nonsulfated and sulfated metabolites in serum, myometrium, and vagina of postmenopausal women following treatment for 21 days with tibolone, estradiol, or estradiol plus medroxyprogestrone acetate

scientific article published on 01 February 2007

Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily

scientific article

Oestradiol and mirtazapine restore the disturbed tail-temperature of oestrogen-deficient rats

scientific article

Progestagenic effects of tibolone are target gene-specific in human endometrial cells

scientific article published on 31 July 2006

Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer

scientific article published on 8 September 2009

Progestins induce catalase activities in breast cancer cells through PRB isoform: correlation with cell growth inhibition

scientific article published on 19 April 2009

Receptor profiling and endocrine interactions of tibolone

scientific article

Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites

scientific article (publication date: August 2009)

The estrogenic component of tibolone reduces adiposity in female aromatase knockout mice

scientific article published in May 2009

Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects

scientific article published in November 2005

Tibolone and its metabolites induce antimitogenesis in human coronary artery smooth muscle cells: role of estrogen, progesterone, and androgen receptors

scientific article published in February 2004

Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid

scientific article published on 21 September 2004

Tibolone is not converted by human aromatase to 7alpha-methyl-17alpha-ethynylestradiol (7alpha-MEE): analyses with sensitive bioassays for estrogens and androgens and with LC-MSMS.

scientific article published on March 2003

Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily

scientific article

Tibolone: a selective tissue estrogenic activity regulator (STEAR).

scientific article published in August 2004

Tissue-selectivity: the mechanism of action of tibolone

scientific article published in August 2004

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