List of works by Massimo Santoro

A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

scientific article published in November 2007

A new mechanism of BRAF activation in human thyroid papillary carcinomas

scientific article published on January 2005

A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas

scientific article published on 11 September 2003

Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells

scientific article published on March 2004

BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas

scientific article

Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels

scientific article published on 10 April 2003

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

scientific article (publication date: October 2002)

Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors

scientific article published on August 2004

Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).

scientific article

Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement

scientific article published on February 2002

Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas

scientific article published in August 2004

HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias.

scientific article

Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice.

scientific article published on 4 March 2009

Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth

scientific article published on October 2002

Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma

scientific article published on 17 May 2005

Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations.

scientific article

Mutation of the PIK3CA gene in anaplastic thyroid cancer.

scientific article published on November 2005

NCOA4 transcriptional coactivator inhibits activation of DNA replication origins

scientific article published on 05 June 2014

RET activation and clinicopathologic features in poorly differentiated thyroid tumors

scientific article published in January 2002

RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture

scientific article published in November 2006

RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma.

scientific article

RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.

scientific article published on January 2007

Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes

scientific article published in January 2003

Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.

scientific article published on June 2004

TWIST1 plays a pleiotropic role in determining the anaplastic thyroid cancer phenotype

scientific article published on 9 March 2011

The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions

scientific article published on 01 January 2002

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

scientific article

The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.

scientific article published on 17 February 2009

The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues

scientific article

The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins

scientific article

Tumor suppressor role of the CL2/DRO1/CCDC80 gene in thyroid carcinogenesis

scientific article published on 10 May 2013

siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma

scientific article published on 13 December 2007

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