List of works - John Duley

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

scientific article

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

scientific article

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

scientific article published on 01 October 2008

Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease

scientific article

The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene

scientific article

Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease

scientific article published in September 2008

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

scientific article published in July 2004

Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease

scientific article

The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients

scientific article published on 01 May 1992

Nomenclature for alleles of the thiopurine methyltransferase gene

scientific article published on April 2013

Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen

scientific article

Mutation in the ITPA gene predicts intolerance to azathioprine

scientific article

Analysis of human alcohol- and aldehyde-metabolizing isozymes by electrophoresis and isoelectric focusing

scientific article published on 01 May 1985

Dihydropyrimidinase deficiency presenting in infancy with severe developmental delay

scientific article published in January 1993

Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver

scientific article

Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians

article

Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency

scientific article (publication date: June 2001)

Erythrocyte thiopurine methyl transferase assessment prior to azathioprine use in the UK.

scientific article published in July 2002

When to investigate for purine and pyrimidine disorders. Introduction and review of clinical and laboratory indications

scientific article published on June 1, 1997

L-alpha-Hydroxyacid oxidase isozymes. Purification and molecular properties

scientific article published on 01 March 1976

Observations on the use of allopurinol in combination with azathioprine or mercaptopurine

scientific article published in December 2005

Demonstration of induction of erythrocyte inosine monophosphate dehydrogenase activity in Ribavirin-treated patients using a high performance liquid chromatography linked method

scientific article published on July 14, 1995

Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity

scientific article published in December 2005

Distinct neurological syndrome in two brothers with hyperuricaemia

scientific article published on 01 November 1992

The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease

scientific article published on 01 April 1999

A spectrophotometric procedure for determining the activity of various rat tissue oxidases

scientific article published on 01 November 1975

Effects of adenosine analogues on ATP concentrations in human erythrocytes. Further evidence for a route independent of adenosine kinase

scientific article published on 01 October 1991

Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure

scientific article published in September 2003

Splitting a therapeutic dose of thioguanine may avoid liver toxicity and be an efficacious treatment for severe inflammatory bowel disease: a 2-center observational cohort study

scientific article published in December 2014

S-adenosylmethionine increases erythrocyte ATP in vitro by a route independent of adenosine kinase

scientific article published in December 1990

Monitoring of inosine monophosphate dehydrogenase activity in mononuclear cells of children with acute lymphoblastic leukemia: enzymological and clinical aspects

scientific article

Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism.

scientific article published on 13 July 2016

Pyrimidines and CNS regulation

scientific article published on 01 March 1996

Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease

scientific article

A novel route of ATP synthesis

scientific article published on May 28, 1992

Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype

scientific article published in October 2004

Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population

scientific article

Long-term Safety and Efficacy of Low-dose Azathioprine and Allopurinol Cotherapy in Inflammatory Bowel Disease: A Large Observational Study

scientific article published on 6 June 2016

Familial juvenile gouty nephropathy with renal urate hypoexcretion preceding renal disease

scientific article published on 01 June 1991

Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE).

scientific article published in November 2002

Adenylosuccinate lyase deficiency--first British case

scientific article published in October 2004

Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene

scientific article published on November 1, 2001

ATP formation from deoxyadenosine in human erythrocytes: evidence for a hitherto unidentified route involving adenine and S-adenosylhomocysteine hydrolase

scientific article published on 01 February 1989

The self-association of L-alpha hydroxyacid oxidase

scientific article (publication date: 14 April 1976)

Normal uric acid concentrations in a purine nucleoside phosphorylase (PNP) deficient child presenting with severe chicken pox, possible immunodeficiency and developmental delay.

scientific article published on January 1994

Succinylpurines induce neuronal damage in the rat brain

scientific article published in January 1998

Mechanisms of deoxyguanosine lymphotoxicity. Human thymocytes, but not peripheral blood lymphocytes accumulate deoxy-GTP in conditions simulating purine nucleoside phosphorylase deficiency

scientific article published on 01 January 1990

Ecto-Nucleotidases in Isolated Intact Rat Vagi, Nodose Ganglia, and Superior Cervical Ganglia

scientific article published on 01 January 1998

Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3

scientific article published on 01 December 1982

Urinary uracil concentrations are a useful guide to genetic disorders associated with neurological deficits and abnormal pyrimidine metabolism

scientific article published on 01 July 1997

List of works by John Duley

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease

The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene

Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease

The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients

Nomenclature for alleles of the thiopurine methyltransferase gene

Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen

Mutation in the ITPA gene predicts intolerance to azathioprine

Analysis of human alcohol- and aldehyde-metabolizing isozymes by electrophoresis and isoelectric focusing

Dihydropyrimidinase deficiency presenting in infancy with severe developmental delay

Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver

Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians

Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency

Erythrocyte thiopurine methyl transferase assessment prior to azathioprine use in the UK.

When to investigate for purine and pyrimidine disorders. Introduction and review of clinical and laboratory indications

L-alpha-Hydroxyacid oxidase isozymes. Purification and molecular properties

Observations on the use of allopurinol in combination with azathioprine or mercaptopurine

Demonstration of induction of erythrocyte inosine monophosphate dehydrogenase activity in Ribavirin-treated patients using a high performance liquid chromatography linked method

Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity

Distinct neurological syndrome in two brothers with hyperuricaemia

The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease

A spectrophotometric procedure for determining the activity of various rat tissue oxidases

Effects of adenosine analogues on ATP concentrations in human erythrocytes. Further evidence for a route independent of adenosine kinase

Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure

Splitting a therapeutic dose of thioguanine may avoid liver toxicity and be an efficacious treatment for severe inflammatory bowel disease: a 2-center observational cohort study

S-adenosylmethionine increases erythrocyte ATP in vitro by a route independent of adenosine kinase

Monitoring of inosine monophosphate dehydrogenase activity in mononuclear cells of children with acute lymphoblastic leukemia: enzymological and clinical aspects

Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism.

Pyrimidines and CNS regulation

Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease

A novel route of ATP synthesis

Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype

Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population

Long-term Safety and Efficacy of Low-dose Azathioprine and Allopurinol Cotherapy in Inflammatory Bowel Disease: A Large Observational Study

Familial juvenile gouty nephropathy with renal urate hypoexcretion preceding renal disease

Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE).

Adenylosuccinate lyase deficiency--first British case

Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene

ATP formation from deoxyadenosine in human erythrocytes: evidence for a hitherto unidentified route involving adenine and S-adenosylhomocysteine hydrolase

The self-association of L-alpha hydroxyacid oxidase

Normal uric acid concentrations in a purine nucleoside phosphorylase (PNP) deficient child presenting with severe chicken pox, possible immunodeficiency and developmental delay.

Succinylpurines induce neuronal damage in the rat brain

Mechanisms of deoxyguanosine lymphotoxicity. Human thymocytes, but not peripheral blood lymphocytes accumulate deoxy-GTP in conditions simulating purine nucleoside phosphorylase deficiency

Ecto-Nucleotidases in Isolated Intact Rat Vagi, Nodose Ganglia, and Superior Cervical Ganglia

Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3

Urinary uracil concentrations are a useful guide to genetic disorders associated with neurological deficits and abnormal pyrimidine metabolism