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List of works by John Duley

A new mechanism of toxicity of 2-chlorodeoxyadenosine (2CdA).

scientific article published in January 1994

A novel route of ATP synthesis ⬇️

scientific article published on May 28, 1992

A spectrophotometric procedure for determining the activity of various rat tissue oxidases

scientific article published on 01 November 1975

ADA activity and DATP levels in erythrocytes after bone marrow transplantation

scientific article published on 01 January 2000

ATP formation from deoxyadenosine in human erythrocytes: evidence for a hitherto unidentified route involving adenine and S-adenosylhomocysteine hydrolase

scientific article published on 01 February 1989

Accelerated purine base salvage--a possible cause of elevated nucleotide pool in the erythrocytes of patients with uraemia

scientific article published on 01 January 1994

Adenylosuccinate lyase deficiency--first British case

scientific article published in October 2004

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

scientific article

Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population

scientific article

An alternative pathway of adenylate and ATP synthesis

scientific article published on 01 January 1991

An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure

scientific article published in October 2004

Analysis of human alcohol- and aldehyde-metabolizing isozymes by electrophoresis and isoelectric focusing

scientific article published on 01 May 1985

Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3

scientific article published on 01 December 1982

Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism.

scientific article published on 13 July 2016

Colonic thioguanine pro-drug: Investigation of microbiome and novel host metabolism

scientific article published on 4 October 2017

Demonstration of induction of erythrocyte inosine monophosphate dehydrogenase activity in Ribavirin-treated patients using a high performance liquid chromatography linked method ⬇️

scientific article published on July 14, 1995

Deoxy GTP accumulates in thymocytes, but not in T or B lymphocytes in simulated PNP deficiency

scientific article published on 01 January 1989

Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE).

scientific article published in November 2002

Determination of nicotinamide phosphoribosyltransferase activity in human erythrocytes: high-performance liquid chromatography-linked method

scientific article published on September 1, 1992

Dihydropyrimidinase deficiency presenting in infancy with severe developmental delay

scientific article published in January 1993

Distinct inhibitory effects of 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine on DNA methyltransferase in human T-lymphocytes

scientific article published on 01 April 1999

Distinct neurological syndrome in two brothers with hyperuricaemia

scientific article published on 01 November 1992

Do ITPA and TPMT genotypes predict the development of side effects to AZA?

scientific article published on July 2006

Does Low-Dose Allopurinol, with Azathioprine, Cyclosporin and Prednisolone, Improve Renal Transplant Immunosuppression? ⬇️

scientific article published on 01 January 1994

Ecto-Nucleotidases in Isolated Intact Rat Vagi, Nodose Ganglia, and Superior Cervical Ganglia ⬇️

scientific article published on 01 January 1998

Effect of Cladribine, Fludarabine, and 5-AZA-Deoxycytidine on S-Adenosylmethionine (SAM) and Nucleotides Pools in Stimulated Human Lymphocytes ⬇️

scientific article published on 01 January 1998

Effects of Cladribine, Fludarabine and 5-aza-deoxycytidine on s-adenosylmethionine (SAM) and nucleotides pools in stimulated human lymphocytes

scholarly article

Effects of adenosine analogues on ATP concentrations in human erythrocytes. Further evidence for a route independent of adenosine kinase

scientific article published on 01 October 1991

Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver

scientific article

Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia

scientific article published in October 2004

Erythrocyte CDP-choline accumulation in haemolytic anaemia and renal failure (RF)

scientific article published on 01 January 1998

Erythrocyte thiopurine methyl transferase assessment prior to azathioprine use in the UK.

scientific article published in July 2002

Familial juvenile gouty nephropathy with renal urate hypoexcretion preceding renal disease

scientific article published on 01 June 1991

Fast and slow methylators: do racial differences influence risk of allograft rejection?

scientific article published on 01 June 1993

Further evidence for a 'new' purine defect, inosine triphosphate (ITP) pyrophosphohydrolase deficiency

scientific article published in January 1989

Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency

scientific article (publication date: June 2001)

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

scientific article

Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype

scientific article published in October 2004

Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians

article

Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity

scientific article published in December 2005

HPLC assay of uridine monophosphate synthase (UMPS) in chorionic villus samples (CVS) and erythrocytes (RBC)

scientific article published on 01 January 1991

Heterogeneity of symptomatology in two male siblings with thymine uraciluria

scientific article published on 01 January 1995

Identification of a 7-basepair deletion in the adenine phosphoribosyltransferase gene as a cause of 2,8-dihydroxyadenine urolithiasis

scientific article published on 01 July 1994

Immunochemical homologies among L-alpha-hydroxyacid oxidase isozymes

scientific article published on 01 January 1977

Importance of the human erythrocyte in the diagnosis of inherited purine and pyrimidine disorders

scientific article published in January 1990

Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease

scientific article

Inosine triphosphate pyrophosphohydrolase deficiency in a kindred with adenosine deaminase deficiency

scientific article published on 01 May 1990

Investigation of receptors responsive to pyrimidines ⬇️

scientific article published on 01 November 1997

L-alpha-Hydroxyacid oxidase isozymes. Purification and molecular properties

scientific article published on 01 March 1976

Long-term Safety and Efficacy of Low-dose Azathioprine and Allopurinol Cotherapy in Inflammatory Bowel Disease: A Large Observational Study

scientific article published on 6 June 2016

Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease

scientific article published in September 2008

Low-dose allopurinol plus azathioprine/cyclosporin/prednisolone, a novel immunosuppressive regimen

scientific article

Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease

scientific article

Mechanisms of deoxyguanosine lymphotoxicity. Human thymocytes, but not peripheral blood lymphocytes accumulate deoxy-GTP in conditions simulating purine nucleoside phosphorylase deficiency

scientific article published on 01 January 1990

Monitoring of inosine monophosphate dehydrogenase activity in mononuclear cells of children with acute lymphoblastic leukemia: enzymological and clinical aspects

scientific article

Mutation in the ITPA gene predicts intolerance to azathioprine

scientific article

Nomenclature for alleles of the thiopurine methyltransferase gene

scientific article published on April 2013

Normal uric acid concentrations in a purine nucleoside phosphorylase (PNP) deficient child presenting with severe chicken pox, possible immunodeficiency and developmental delay.

scientific article published on January 1994

Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease

scientific article

Nucleotide degradation products in cerebrospinal fluid (CSF) in inherited and acquired pathologies

scientific article published in October 2004

Obituary to Lynette Fairbanks, PhD

scholarly article

Observations on the use of allopurinol in combination with azathioprine or mercaptopurine

scientific article published in December 2005

Origin and characteristics of an unusual pyridine nucleotide accumulating in erythrocytes: positive correlation with degree of renal failure

scientific article published in September 2003

Pitfalls in the determination of mutant alleles of the thiopurine methyltransferase gene ⬇️

scientific article published on November 1, 2001

Preface

Preface to a supplement to Pharmacy World on the 5TH Symposium of the European Society for the Study of Purine & Pyrimidtne Metabolism in Man (ESSPPMM 1995)

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

scientific article published on 01 October 2008

Pyrimidines and CNS regulation

scientific article published on 01 March 1996

Raised IMP-dehydrogenase activity in the erythrocytes of a case of purine nucleoside phosphorylase (PNP) deficiency

scientific article published in January 1991

Reduced renal excretion of uric acid in the hirsutism-skeletal dysplasia--mental retardation syndrome

scientific article published in June 1994

Renal Urate Hypoexcretion Preceding Renal Disease in a New Kindred with Familial Juvenile Gouty Nephropathy (FJGN) ⬇️

scientific article published on 01 January 1991

S-adenosylmethionine increases erythrocyte ATP in vitro by a route independent of adenosine kinase

scientific article published in December 1990

SAH-hydrolase activity in haemolysate and intact erythrocytes; the effect of adenosine analogues

scientific article published on 01 January 1994

Screening for purine and pyrimidine disorders using dried urine spots

scientific article published on 01 January 2000

Severe Debilitating Polyarticular Gout and Terminal Renal Failure in an Allopurinol ‘Non-Responder’ ⬇️

scientific article published on 01 January 1998

Splitting a therapeutic dose of thioguanine may avoid liver toxicity and be an efficacious treatment for severe inflammatory bowel disease: a 2-center observational cohort study

scientific article published in December 2014

Successful Pregnancies with Thiopurine-Allopurinol Co-Therapy for Inflammatory Bowel Disease

scientific article published on 4 May 2015

Succinylpurines do not modify glutamate or adenosine effects in the CNS.

scientific article published in January 1998

Succinylpurines induce neuronal damage in the rat brain

scientific article published in January 1998

Superactive UMP Hydrolase: Cause or Consequence of Haemolytic Anaemia? ⬇️

scientific article published on January 1, 1991

The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene

scientific article

The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease

scientific article published on 01 April 1999

The genetic basis of the interaction between pyrimidine 5' nucleotidase I deficiency and hemoglobin E.

scientific article published in October 2004

The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients

scientific article published on 01 May 1992

The self-association of L-alpha hydroxyacid oxidase

scientific article (publication date: 14 April 1976)

Thiopurine methyltransferase activity and efficacy of azathioprine immunosuppression in transplant recipients

scientific article published on 01 January 1991

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

scientific article published in July 2004

Urinary uracil concentrations are a useful guide to genetic disorders associated with neurological deficits and abnormal pyrimidine metabolism ⬇️

scientific article published on 01 July 1997

When to investigate for purine and pyrimidine disorders. Introduction and review of clinical and laboratory indications ⬇️

scientific article published on June 1, 1997

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