Search filters

List of works by Toshio Miyata

A biologic role of HIF-1 in the renal medulla

scientific article

A disposable, ultra-fine endoscope for non-invasive, close examination of the intraluminal surface of the peritoneal dialysis catheter and peritoneal cavity

scientific article published on 16 October 2020

A novel Sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats.

scientific article published on 24 July 2008

A novel class of advanced glycation inhibitors ameliorates renal and cardiovascular damage in experimental rat models

scientific article

A novel clinical biomarker for myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis

scientific article published on 14 June 2010

A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia

scientific article published on 19 July 2007

A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates

scientific article

A novel prolyl hydroxylase inhibitor protects against cell death after hypoxia

scientific article published on 17 October 2013

A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies).

scientific article published on 12 June 2006

A sartan derivative with a very low angiotensin II receptor affinity ameliorates ischemic cerebral damage.

scientific article

A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice

scientific article published in February 2006

A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.

scientific article published on 7 March 2013

Accelerated glomerular injury in hemi-nephrectomized transgenic mice of mesangial cell-predominant serpin, megsin

scientific article published on 01 January 2004

Advanced glycation and advanced oxidation protein products: the effect of peritoneal dialysis

scientific article

Affinity adsorption of glucose degradation products improves the biocompatibility of conventional peritoneal dialysis fluid

scientific article published on January 2003

Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element pathway

scientific article published on 26 December 2007

Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms

scientific article published in October 2002

Angiotensin II type 1A receptor deficiency and longevity

scientific article published on 07 August 2009

Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation.

scientific article published on January 2007

Anti-Hypertensive Agents Inhibit In Vivo the Formation of Advanced Glycation End Products and Improve Renal Damage in a Type 2 Diabetic Nephropathy Rat Model ⬇️

scientific article published on May 1, 2003

Blockade of angiotensin II type-1 receptor increases salt sensitivity in Sprague-Dawley rats.

scientific article published in May 2009

Blockade of calcium influx through L-type calcium channels attenuates mitochondrial injury and apoptosis in hypoxic renal tubular cells

scientific article published on September 2004

Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning

scientific article published on 20 June 2019

Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model

scientific article published on 17 February 2010

Bone Marrow Adipocyte-Derived PAI-1 As a Negative Regulator of Hematopoietic Regeneration ⬇️

scholarly article

Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats

scientific article published on 31 January 2013

Carbonyl stress inhibitor towards new therapeutic interventions in diabetic nephropathy

scientific article

Carbonyl stress reduction in peritoneal dialysis fluid: development of a novel high-affinity adsorption bead

scientific article published on May 2007

Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model

scientific article published on 28 October 2007

Current issues and future perspectives of chronic renal failure.

scientific article published on January 2002

Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.

scientific article published on 11 September 2012

Diabetic nephropathy: a disorder of oxygen metabolism?

scientific article published on 15 December 2009

Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?

scientific article published on 13 March 2013

Drug discovery in renal disease--towards a more efficient framework

scientific article published on 18 March 2014

ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy

scientific article

Effect of edaravone on the estimated glomerular filtration rate in patients with acute ischemic stroke and chronic kidney disease

scientific article

Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid

scientific article

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

scientific article published on 8 June 2015

Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress.

scientific article

Establishment of a sandwich ELISA for human megsin, a kidney-specific serine protease inhibitor

scientific article published on 25 June 2007

Evidence of tubular hypoxia in the early phase in the remnant kidney model

scientific article

From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy: a detective story

scientific article

Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1.

scientific article published on 11 April 2018

Glucose dialysate induces mitochondrial DNA damage in peritoneal mesothelial cells.

scientific article

Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats

scientific article

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

scientific article

Glyoxalase I retards renal senescence

scientific article published on 12 October 2011

High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway

scientific article published on 5 April 2006

Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis

scientific article

Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.

scientific article published on 26 May 2015

Hypoxia and hypoxia-inducible factor in renal disease

scientific article published on 30 July 2008

Hypoxia in renal disease with proteinuria and/or glomerular hypertension

scientific article

Hypoxia-induced apoptosis in cultured glomerular endothelial cells: involvement of mitochondrial pathways.

scientific article

Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity

scientific article

Hypoxia-sensitive reporter system for high-throughput screening.

scientific article

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets ⬇️

scientific article published on October 27, 2010

Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives

scientific article published on 6 January 2018

Idiopathic carbonyl stress in a drug-naive case of at-risk mental state

scientific article published in October 2011

Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury

scientific article published on 27 May 2003

In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy

scientific article published on 27 September 2005

Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis

scientific article published on December 2005

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice

scientific article published on 09 May 2012

Inhibition of advanced glycation end products: an implicit goal in clinical medicine for the treatment of diabetic nephropathy?

scientific article published in April 2008

Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration.

scientific article published in April 2014

Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice

scientific article published on 17 February 2020

Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.

scientific article

Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis

scientific journal article

Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression

scientific article published on 17 September 2009

Involvement of endoplasmic reticulum (ER) stress in podocyte injury induced by excessive protein accumulation

scientific article published in December 2005

Keap1 inhibition attenuates glomerulosclerosis.

scientific article published on 11 February 2014

Mesangial cell-predominant functional gene, megsin ⬇️

scientific article published on June 1, 2003

Mesangial cell-predominant gene, megsin

scientific article

Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor

scientific article published on 9 August 2012

Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney

scientific article

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.

scientific article

Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure

scientific article published on 19 July 2010

New era for drug discovery and development in renal disease

scientific article published on 05 July 2011

Nitric oxide prevents alveolar senescence and emphysema in a mouse model

scientific article published on 10 March 2015

Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin

scientific article

Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion

scientific article

Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis

scientific article published on 27 April 2015

Plasminogen activator inhibitor-1 (PAI-1) molecule: new physiological roles and clinical applications

scientific article published on April 2014

Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence

scientific article published on 03 October 2013

Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.

scientific article published on 7 March 2017

Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis

scientific article

Points-to-consider documents: Scientific information on the evaluation of genetic polymorphisms during non-clinical studies and phase I clinical trials in the Japanese population

scientific article published on 15 March 2018

Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis

scientific article published on 6 February 2008

Protection of endothelial cells by dextran sulfate in rats with thrombotic microangiopathy

scientific article published on 10 August 2005

Proteomics and mesangial cell: serpin, megsin and plasmin

scientific article published on January 2004

Pyridoxamine improves functional, structural, and biochemical alterations of peritoneal membranes in uremic peritoneal dialysis rats

scientific article published in September 2005

Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker.

scientific article

Reduction of albuminuria by angiotensin receptor blocker beyond blood pressure lowering: evaluation in megsin/receptor for advanced glycation end products/inducible nitric oxide synthase triple transgenic diabetic nephropathy mouse model

scientific article

Relationship of Skin Autofluorescence to Severity of Retinopathy in Type 2 Diabetes

scientific article published on 28 May 2014

Relationship of skin autofluorescence to cardiovascular disease in Japanese hemodialysis patients

scientific article published on June 2010

Renal proximal tubular metabolism of protein-linked pentosidine, an advanced glycation end product

scientific article published on 01 August 2002

Renoprotection of angiotensin receptor blockers: beyond blood pressure lowering.

scientific article published on 13 February 2006

Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering

scientific article published on 19 October 2005

Role of chronic hypoxia and hypoxia inducible factor in kidney disease

scientific article published on February 2008

Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation.

scientific article

Serpinopathy and endoplasmic reticulum stress

scientific article

Skin autofluorescence is associated with renal function and cardiovascular diseases in pre-dialysis chronic kidney disease patients.

scientific article published on 29 June 2010

Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study

scientific article

Skin autofluorescence predicts cardiovascular mortality in patients on chronic hemodialysis

scientific article published on 24 January 2014

Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.

scientific article published on 24 July 2015

Structure-activity relationships of new 2-acylamino-3-thiophenecarboxylic acid dimers as plasminogen activator inhibitor-1 inhibitors

scientific article published on May 2010

Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors

scientific article published on 01 January 2011

Synergistic contributions of carbonyl stress and megsin in diabetic nephropathy

scientific article

TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche

scientific article published on 18 August 2017

Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

scientific article published on 30 January 2020

The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma

scientific article published on 9 December 2016

The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation.

scientific article published on 25 June 2008

Toward better dialysis compatibility: advances in the biochemistry and pathophysiology of the peritoneal membranes

scientific article

Transcriptional regulation of a mesangium-predominant gene, megsin

scientific article (publication date: November 2002)

Transdifferentiation of cultured tubular cells induced by hypoxia

scientific article published on March 2004

Translation of basic science into clinical medicine: novel targets for diabetic nephropathy

scientific article published on 11 February 2009

Ultrapure dialysate decreases plasma pentosidine, a marker of "carbonyl stress".

scientific article

Very high doses of valsartan provide renoprotection independently of blood pressure in a type 2 diabetic nephropathy rat model

scientific article published in September 2009

[Mechanisms in remodeling of the kidney].

scientific article

[Molecular pathophysiology of schizophrenia and preventive strategy in pubertal period]

scientific article published on 01 January 2011

[New perspective for drug discovery and clinical development in kidney disease]

scientific article published on 01 January 2012

[Post-genome research on megsin, a kidney-specific serpin gene]

scientific article published on 01 February 2006

[Post-genomic studies on kidney diseases and genomic drug design]

scientific article published on 01 February 2006

Paulina is supported by:

About Paulina

Help