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List of works by Jeffrey R Jasper

A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor

scientific article published on 3 May 2007

Adrenoceptors: a convergence of thinking

scientific article published in July 2002

Antimuscarinics for the treatment of overactive bladder: current options and emerging therapies.

scientific article published on January 2004

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

scientific article published on 28 May 2013

Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual p

scientific article published on 9 February 2015

Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency ⬇️

scientific article published on February 20, 2013

Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model ⬇️

scientific article

Human cloned alpha1A-adrenoceptor isoforms display alpha1L-adrenoceptor pharmacology in functional studies

scientific article

More roles for the (passive) giant. Focus on "The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms".

scientific article published on 4 November 2015

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

scientific article

Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist

scientific article published on 10 January 2009

Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues.

scientific article published on 30 April 2018

The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle.

scientific article

The small-molecule fast skeletal troponin activator, CK-2127107, improves exercise tolerance in a rat model of heart failure

scientific article published on 12 February 2015

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

scientific article

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