List of works - Tod Steinfeld

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

scientific article published on 22 December 2012

A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor

scientific article published on 3 May 2007

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

scientific article published on 24 December 2017

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents

scientific article published on 30 December 2015

Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual p

scientific article published on 9 February 2015

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

scientific article published on 18 January 2011

In Vitro Isolated Tissue Functional Muscarinic Receptor Assays ⬇️

scientific article published on March 1, 2010

In Vitro Muscarinic Receptor Radioligand‐Binding Assays ⬇️

scientific article published on March 1, 2010

In Vivo Pharmacodynamic Assays for M2 and M3 Muscarinic Receptors ⬇️

scientific article published on March 1, 2010

Multivalent Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) Molecules for the Treatment of COPD

scientific article published on January 1, 2012

Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation ⬇️

scientific article published on September 24, 2011

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

scientific article

Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist

scientific article published on 10 January 2009

Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues.

scientific article published on 30 April 2018

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

article

THRX-198321 Is a Bifunctional Muscarinic Receptor Antagonist and β2-Adrenoceptor Agonist (MABA) That Binds in a Bimodal and Multivalent Manner ⬇️

scientific article published on December 7, 2010

List of works by Tod Steinfeld

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents

Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual p

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

In Vitro Isolated Tissue Functional Muscarinic Receptor Assays ⬇️

In Vitro Muscarinic Receptor Radioligand‐Binding Assays ⬇️

In Vivo Pharmacodynamic Assays for M2 and M3 Muscarinic Receptors ⬇️

Multivalent Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) Molecules for the Treatment of COPD

Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation ⬇️

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist

Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues.

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

THRX-198321 Is a Bifunctional Muscarinic Receptor Antagonist and β2-Adrenoceptor Agonist (MABA) That Binds in a Bimodal and Multivalent Manner ⬇️