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List of works by Stephen J Gardell

A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity

scientific article published on 25 June 2021

A novel clinical approach to evaluating changes in fat oxidation in healthy, overnight-fasted subjects

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage

scientific article

A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia

scientific article published on 8 January 2009

Abetapp secretases are co-expressed with Abetapp in the pancreatic islets.

scientific article published in August 2001

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice

scientific article published on 27 January 2009

Boosting NAD+ with a small molecule that activates NAMPT

scientific article published on 19 July 2019

Cardiovascular drug discovery in the academic setting: building infrastructure, harnessing strengths, and seeking synergies

scientific article published on 13 July 2010

Electrochemiluminescence assay for basic carboxypeptidases: inhibition of basic carboxypeptidases and activation of thrombin-activatable fibrinolysis inhibitor

scientific article published on August 2003

Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training.

scientific article

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade

scholarly article

Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: comparative studies of the pH dependencies of the native and Phe-248-mutant forms

scientific article published in 1986

GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs

scientific article published in September 2009

Impaired Mitochondrial Energetics Characterize Poor Early Recovery Of Muscle Mass Following Hind Limb Unloading In Old Mice

scientific article published on 19 March 2018

Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis

scientific article

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse

scientific article

Measurement of Pyridine Nucleotides in Biological Samples Using LC-MS/MS

scientific article published on 01 January 2019

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

scientific article (publication date: 13 February 2003)

Metabolomics Analyses of Muscle Atrophy Induced by Hind Limb Unloading

scientific article published on 01 January 2019

Miniaturizable homogenous time-resolved fluorescence assay for carboxypeptidase B activity ⬇️

scientific article published on June 1, 2003

Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action

scientific article published on 10 July 2007

P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold

scientific article published in June 2005

Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides

scientific article (publication date: 7 April 2003)

Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol

scientific article published on 15 September 2016

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

scientific journal article

Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity

scientific article published on 21 September 2007

Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells

scientific article published on 05 October 2013

Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia

scientific article

Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.

scientific article published on 6 November 2017

Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss

scientific article published on 26 July 2007

Targeted Metabolomic Profiling of Plasma and Survival in Heart Failure Patients

scientific article published in November 2017

The Failing Heart Relies on Ketone Bodies as a Fuel

scientific article published on 27 January 2016

The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model.

scientific article published on 27 February 2009

Use of Ion Chromatography/Mass Spectrometry for Targeted Metabolite Profiling of Polar Organic Acids

scientific article published on 26 October 2016

gamma-Secretase: characterization and implication for Alzheimer disease therapy

scientific article published in November 2002

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