List of works - Lynda Tyrrell

A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis.

scientific article published in February 2012

A new Nav1.7 mutation in an erythromelalgia patient ⬇️

scientific article published on January 30, 2013

A new Nav1.7 sodium channel mutation I234T in a child with severe pain

scientific article published on 10 April 2010

A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation.

scientific article

A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

scientific article

Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia

scientific article published on 16 May 2010

CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Na(v)1.8

scientific journal article

Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface

scientific article

Deletion mutation of sodium channel Na(V)1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability.

scientific article published in July 2011

Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily

scientific article

ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties

scientific article

Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation

scientific article published on 15 April 2009

Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials.

scientific article published on October 2009

Functional role of the C-terminus of voltage-gated sodium channel Na(v)1.8.

scientific article published on August 2004

Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy

scientific article published on 27 April 2014

Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.

scientific article

Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade

scientific article

Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders

scientific article

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.

scientific article

Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons

scientific article

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable

scientific article published on 19 September 2008

Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons

scientific article

Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating

scientific article

Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7.

scientific article

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

scientific article published on January 2012

Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution

scientific article

Transfection of rat or mouse neurons by biolistics or electroporation

scientific article published on 09 July 2009

Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.

scientific article

List of works by Lynda Tyrrell

A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis.

A new Nav1.7 mutation in an erythromelalgia patient ⬇️

A new Nav1.7 sodium channel mutation I234T in a child with severe pain

A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation.

A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia

CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Na(v)1.8

Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface

Deletion mutation of sodium channel Na(V)1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability.

Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily

ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties

Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation

Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials.

Functional role of the C-terminus of voltage-gated sodium channel Na(v)1.8.

Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy

Mexiletine-responsive erythromelalgia due to a new Na(v)1.7 mutation showing use-dependent current fall-off.

Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade

Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.

Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable

Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons

Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating

Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7.

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution

Transfection of rat or mouse neurons by biolistics or electroporation

Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.