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List of works by Diane P Copeland

A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2.

scientific article

A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease

scientific article published on 16 May 2007

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation

scientific article published on January 2010

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease

scientific article

Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann-Pick C mice.

scientific article published in February 2012

Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy

scientific article published on 25 March 2010

Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.

scientific article published in July 2009

Measurement of lysosomal glucocerebrosidase activity in mouse liver using a fluorescence-activated cell sorter assay

scientific article published in November 2004

Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease

scientific article (publication date: 24 November 2010)

Systemic Delivery of a Glucosylceramide Synthase Inhibitor Reduces CNS Substrates and Increases Lifespan in a Mouse Model of Type 2 Gaucher Disease ⬇️

scientific article published on August 17, 2012

The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function

scientific article published on 24 December 2010

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