List of works - Andrea Caricasole

A Phenotypic Screening Assay for Modulators of Huntingtin-Induced Transcriptional Dysregulation ⬇️

scientific article published on April 5, 2013

A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity

scientific article published on 21 June 2002

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

scientific article

Aryl azoles with neuroprotective activity--parallel synthesis and attempts at target identification

scientific article published on 4 November 2007

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

scientific article published on March 2017

BLUEPRINT to decode the epigenetic signature written in blood.

scientific article

Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons

scientific article published on 01 May 2002

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

scientific article

Conformational modulation mediated by polyglutamine expansion in CAG repeat expansion disease-associated proteins

scientific article published on 9 August 2016

Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ.

scientific article published on 21 June 2015

Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology

scientific article published in February 2006

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells

scientific article

Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells

scientific article published on 5 November 2007

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

scientific article

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

scientific article published on 18 October 2002

Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction

scientific article published on 23 January 2012

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

scientific article

Group II metabotropic glutamate receptors regulate the vulnerability to hypoxic brain damage.

scientific article

How to achieve confidence in drug discovery and development: managing risk (from a reductionist to a holistic approach)

scientific article published on 01 June 2009

Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.

scientific article published on 25 April 2013

Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene

scientific article

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

scientific article

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity

scientific article published on 29 April 2008

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

scientific article

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

scientific article published in March 2005

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

scientific article published in October 2008

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy

scientific article published in April 2007

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

scientific article

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

scientific journal article

Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors

scientific article published in December 2008

Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties

scientific journal article

Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine

scientific article

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay

scientific article published on 22 August 2019

Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation

scientific article

Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models

scientific article published on 11 July 2017

Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy

scientific article

Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery.

scientific article

Reference genes selection for transcriptional profiling in blood of HD patients and R6/2 mice

scientific article published in January 2013

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

scientific article published on 22 April 2008

The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?

scientific article

The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.

scientific article published in January 2006

Therapeutic targets for Alzheimer's disease

scientific article published on 01 May 2009

Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13

scientific article published on 31 October 2019

VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin

scientific article

siRNA screen identifies QPCT as a druggable target for Huntington's disease

scientific article

List of works by Andrea Caricasole

A Phenotypic Screening Assay for Modulators of Huntingtin-Induced Transcriptional Dysregulation ⬇️

A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

Aryl azoles with neuroprotective activity--parallel synthesis and attempts at target identification

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

BLUEPRINT to decode the epigenetic signature written in blood.

Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

Conformational modulation mediated by polyglutamine expansion in CAG repeat expansion disease-associated proteins

Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ.

Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells

Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

Group II metabotropic glutamate receptors regulate the vulnerability to hypoxic brain damage.

How to achieve confidence in drug discovery and development: managing risk (from a reductionist to a holistic approach)

Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.

Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors

Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties

Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay

Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation

Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models

Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy

Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery.

Reference genes selection for transcriptional profiling in blood of HD patients and R6/2 mice

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?

The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.

Therapeutic targets for Alzheimer's disease

Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13

VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin

siRNA screen identifies QPCT as a druggable target for Huntington's disease