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List of works by Saskia S Scheij

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.

scientific article

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.

scientific article published on 20 December 2016

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis

scientific article published on 8 November 2013

Curdlan-mediated regulation of human phagocyte-specific chitotriosidase.

scientific article published on 10 June 2010

Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates

scientific article published on 18 July 2014

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

scientific article published on 30 December 2015

Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis

scientific article published on 23 December 2018

EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux.

scientific article published on 12 January 2017

Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

scientific article published on 25 August 2011

Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement.

scientific article published on 7 July 2016

Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies

scientific article published on 22 May 2013

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

scientific article published on 2 January 2016

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.

scientific article published on 17 February 2018

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis

scientific article published on 7 September 2017

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

scientific article published on 28 February 2020

Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors

scientific article published on 17 October 2014

Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism

scientific article published on 18 November 2015

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

scientific article

In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases.

scientific article published on 9 February 2015

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

scientific article published on 01 August 2018

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

scientific article

LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis

scientific article

Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases

scientific article published on 03 March 2016

N-azidoacetylmannosamine-mediated chemical tagging of gangliosides

scientific article published on 27 March 2007

Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.

scientific article

Potent and Selective Activity-Based Probes for GH27 Human Retaining α-Galactosidases

scientific article published on 11 August 2014

Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice

scientific article

Regulation of intestinal LDLR by the LXR-IDOL axis

scientific article published on 09 November 2020

Stabilization of Glucocerebrosidase by Active Site Occupancy.

scientific article published on 9 May 2017

TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase

scientific article published on 30 October 2007

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

scientific article published on 02 October 2019

The glucosylceramide synthase inhibitor N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin induces sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.

scientific article

Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma

scientific article published on 8 December 2022

Unexpected effects of fasting on murine lipid homeostasis--transcriptomic and lipid profiling

scientific article published on 4 March 2010

Very low serum adiponectin levels in patients with type 1 Gaucher disease without overt hyperglycemia

scientific article published on 01 March 2007

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