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List of works by Cindy P.A.A. van Roomen

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.

scientific article

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.

scientific article published on 20 December 2016

Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard.

scientific article published on 21 May 2016

Aortic microcalcification associates with elastin fragmentation in Marfan syndrome.

scientific article

Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity.

scientific article

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism

scientific article

Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-alpha- and interleukin-1beta-treated human preadipocytes are potent leptin producers

scientific article published on 06 October 2005

Dyscholesterolemia Protects Against Ischemia-Induced Ventricular Arrhythmias.

scientific article published in October 2015

Elevated globotriaosylsphingosine is a hallmark of Fabry disease.

scholarly article

Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice

scientific article published on 24 July 2010

Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies

scientific article published on 22 May 2013

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

scientific article published on 2 January 2016

Glycosphingolipids and insulin resistance

scientific article published on January 2011

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

scientific article

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

scientific article

Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

scientific article

Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice

scientific article published on 18 February 2010

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

scientific article

Lyso-glycosphingolipid abnormalities in different murine models of lysosomal storage disorders.

scientific article published on 23 December 2015

Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction

scientific article published on May 2014

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

scientific article published on 08 December 2020

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

scientific article

Myeloid Kdm6b deficiency results in advanced atherosclerosis

scientific article published on 01 June 2018

Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy

scientific article published on 10 July 2019

Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.

scientific article

Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis

scientific article published on 01 October 2018

Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss

scientific article published on 02 November 2019

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

scientific article (publication date: 2015)

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

scientific article

Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice

scientific article

Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes

scientific article published on December 2008

Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G/+ Marfan Mouse Model

scientific article published on 9 June 2016

Stabilization of Glucocerebrosidase by Active Site Occupancy.

scientific article published on 9 May 2017

TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase

scientific article published on 30 October 2007

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

scientific article published on 29 October 2019

Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques

scholarly article published in April 2024

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

scientific article published on 02 October 2019

Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation

scientific article published on 3 August 2011

Unexpected effects of fasting on murine lipid homeostasis--transcriptomic and lipid profiling

scientific article published on 4 March 2010

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

scientific article