List of works - Roelof Ottenhoff

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.

scientific article

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.

scientific article published on 20 December 2016

A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion

scientific journal article

Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard.

scientific article published on 21 May 2016

Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice

scientific article (publication date: 2 August 2002)

Anion exchanger 2 is essential for spermiogenesis in mice

scientific article

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

scientific article published on 03 July 2018

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism

scientific article

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation

scientific article published on January 2010

Dyscholesterolemia Protects Against Ischemia-Induced Ventricular Arrhythmias.

scientific article published in October 2015

Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice

scientific article published on 28 August 2015

Elevated globotriaosylsphingosine is a hallmark of Fabry disease.

scholarly article

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

scientific article

Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies

scientific article published on 22 May 2013

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

scientific article published on 2 January 2016

Glycosphingolipids and insulin resistance

scientific article published on January 2011

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

scientific article

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

scientific article published on 28 February 2020

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

scientific article published on 23 December 2020

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

scientific article

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects

scientific article published on 9 August 2013

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

scientific article published on 01 August 2018

Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

scientific article

Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice

scientific article published on 18 February 2010

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

scientific article

Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters

scientific article

Lyso-glycosphingolipid abnormalities in different murine models of lysosomal storage disorders.

scientific article published on 23 December 2015

Measuring liver triglyceride content in mice: non-invasive magnetic resonance methods as an alternative to histopathology

scientific article published on November 2013

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

scientific article

Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.

scientific article

Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity

scientific article

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

scientific article

Quantitative determination of liver triglyceride levels with 3T ¹H-MR spectroscopy in mice with moderately elevated liver fat content

scientific article published in November 2014

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

scientific article (publication date: 2015)

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

scientific article

Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice

scientific article

Regulation of intestinal LDLR by the LXR-IDOL axis

scientific article published on 09 November 2020

Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice

scientific article published in June 2003

Stabilization of Glucocerebrosidase by Active Site Occupancy.

scientific article published on 9 May 2017

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

scientific article published on 02 October 2019

Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein.

scientific article published on 16 July 2012

Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation

scientific article published on 3 August 2011

Ultrasensitive in situ visualization of active glucocerebrosidase molecules

scientific article published on 31 October 2010

Unexpected effects of fasting on murine lipid homeostasis--transcriptomic and lipid profiling

scientific article published on 4 March 2010

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

scientific article

List of works by Roelof Ottenhoff

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.

A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.

A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion

Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard.

Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice

Anion exchanger 2 is essential for spermiogenesis in mice

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism

Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation

Dyscholesterolemia Protects Against Ischemia-Induced Ventricular Arrhythmias.

Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice

Elevated globotriaosylsphingosine is a hallmark of Fabry disease.

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

Glycosphingolipids and insulin resistance

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects

Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

Induction of Sphk1 activity in obese adipose tissue macrophages promotes survival

Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters

Lyso-glycosphingolipid abnormalities in different murine models of lysosomal storage disorders.

Measuring liver triglyceride content in mice: non-invasive magnetic resonance methods as an alternative to histopathology

Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.

Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.

Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

Quantitative determination of liver triglyceride levels with 3T ¹H-MR spectroscopy in mice with moderately elevated liver fat content

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice

Regulation of intestinal LDLR by the LXR-IDOL axis

Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice

Stabilization of Glucocerebrosidase by Active Site Occupancy.

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein.

Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation

Ultrasensitive in situ visualization of active glucocerebrosidase molecules

Unexpected effects of fasting on murine lipid homeostasis--transcriptomic and lipid profiling

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes