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List of works by Klaus Rajewsky

A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells

scientific article

A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

scientific article published on 01 September 1996

A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.

scientific article published on May 2015

A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency

scientific article published on 21 June 2016

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

scientific article (publication date: 25 December 1995)

A critical role of λ5 protein in B cell development

article

A dual role for B cells in Plasmodium chabaudi chabaudi (AS) infection?

scientific article published on July 1994

A functional antibody mutant with an insertion in the framework region 3 loop of the VH domain: implications for antibody engineering

scientific article published on April 1, 1992

A new V gene expressed in lambda-2 light chains of the mouse

article

A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines ⬇️

scientific article published on October 1, 1979

A novel allele for inducible Cre expression in germinal center B cells

scientific article published on 20 November 2018

A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire.

scientific article published on 30 November 2017

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

scientific article published in Science

A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function

scientific article published in November 2005

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

scientific article published in Science

Aberrant T cell differentiation in the absence of Dicer.

scientific article

Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes

scientific article

Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen

scholarly article

Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice

scientific journal article

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen

scientific article published on February 1, 1992

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination

scientific article published on February 2014

Activation of Stat3 signaling in AgRP neurons promotes locomotor activity

scientific article published in March 2008

Activation of mouse complement by monoclonal mouse antibodies ⬇️

scientific article published on 01 December 1981

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin κ-chain locus

Altered directionality in the cre- loxP site-specific recombination pathway 1 1Edited by M. Yaniv

article published in 2001

Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal

scientific article published in August 1998

An explanation for the defect in secretion of IgM Mott cells and their predominant occurrence in the Ly-1 B cell compartment

scientific article published on 01 February 1992

An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression

scientific article published on 23 April 2015

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

scientific article (publication date: 2001)

Analysis of V Gene Expression in the Immune Response by Cell Fusion ⬇️

scientific article published on January 1, 1978

Analysis of the B-cell progenitor compartment at the level of single cells

scientific article published in July 1994

Analysis of the repertoire of anti-(4-hydroxy-3-nitro-phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies ⬇️

scientific article published on December 1, 1979

Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response ⬇️

scientific article published on June 1, 1978

Antibodies generated from human immunoglobulin miniloci in transgenic mice

scientific article published on April 1994

Antibody repertoire in a mouse with a simplified D(H) locus: the D-limited mouse

scientific article

Antibody repertoires generated by VH replacement and direct VH to JH joining.

scientific article published in July 2006

Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19.

scientific article published on July 1998

B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.

scientific article

B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain

B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta

scientific article

B cell development under the condition of allelic inclusion.

scientific article published in March 1997

B cell receptor signal strength determines B cell fate

scientific article published in February 2004

B cell recruitment and selection in mouse GALT germinal centers

scientific article published on January 2006

B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity

scientific article

B cells are addicted to immunoglobulin production in the ER

B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens

scientific article

B cells of chronic lymphatic leukemia express V genes in unmutated form

article

B lymphocyte-specific, Cre-mediated mutagenesis in mice

scientific article published on March 1997

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

scientific article published on 18 October 2019

B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS

scientific article published on 01 December 2020

B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease

scientific article (publication date: February 2001)

B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19.

scientific article

BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells

scholarly article

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

scientific article

BCR-dependent lineage plasticity in mature B cells

scientific article published on 01 February 2019

BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma

scientific article published on December 2010

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells

scientific article

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers

scientific article published in December 1994

Biology of Hodgkin's lymphoma

scientific article

Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells

scientific article published in October 2012

Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes

scientific article published on July 1995

Burnet's unhappy hybrid ⬇️

scientific article published on August 13, 1998

Bypass of lethality with mosaic mice generated by Cre– loxP -mediated recombination

scientific article published on 01 October 1996

CD5-positive B cells in healthy elderly humans are a polyclonal B cell population

scientific article published on 01 October 2000

CD8(+) T cells in Hodgkin's disease tumor tissue are a polyclonal population with limited clonal expansion but little evidence of selection by antigen

scientific article published on July 2000

CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway

scientific article published on 27 June 2011

CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia

scientific article published on 08 August 2020

CRISPR/Cas9-Mediated In Vitro Mutagenesis in GC-Like B Cells

scientific article published in January 2017

Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation

article

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells

scientific article published on 20 April 2016

Cellular origin of human B-cell lymphomas.

scientific article

Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts

scientific article published on June 1986

Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

scientific article

Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction

scientific article

Clonal selection and learning in the antibody system

scientific article published on June 1996

Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease

scientific article published on 01 January 1998

Common cytokine receptor γ chain (γc)-deficient B cells persist in T cell-deficient γc mice and respond to a T-independent antigen

scientific article published on 01 June 2000

Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL.

scientific article

Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance

scientific article (publication date: February 2004)

Conditional gene targeting

article

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis

scientific article published on 19 May 2008

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

scientific article

Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma

scientific article

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

scientific article published on 07 November 2019

Contribution of Receptor Editing to the Antibody Repertoire

scientific article published in Science

Control idiotope expression by monoclonal anti-idiotope antibodies

scientific article published on January 1980

Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody

scientific article published in May 1981

Corrigendum: Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors

scientific article published on 17 April 2020

Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

article

Critical functions for c-Myb at three checkpoints during thymocyte development

scientific article

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

scientific article published in Nature

Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation

scientific article

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

article

DNA polymerase kappa deficiency does not affect somatic hypermutation in mice

scientific journal article

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

scientific article

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

scientific article published on 17 March 2005

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

scientific article (publication date: July 1994)

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans

scientific article

Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction.

scientific article published on July 1993

Detection of clonal immunoglobulin rearrangements in paraffin embedded tissues by PCR

scientific article

Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction.

scientific article published on September 1995

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

article

Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals

scientific article published on 03 May 2009

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

scientific article

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage

scientific article published on March 2008

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

scientific journal article

Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes

scholarly article

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

scholarly article

Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression

scientific article published in June 1997

Direct in vivo VH to JH rearrangement violating the 12/23 rule

scientific article

Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.

scientific article published in October 2000

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.

scientific article

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.

scientific article published in January 2017

EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency

scientific article published in October 2000

Early B-cell development in the mouse: insights from mutations introduced by gene targeting

scientific article published on February 1994

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

scientific article

Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes

scientific article published on October 2003

Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages

scientific article

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

scientific article published on 11 October 2016

Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells

scientific article published on 01 September 2019

Efficient and Precise CRISPR/Cas9-Mediated MECP2 Modifications in Human-Induced Pluripotent Stem Cells

scientific article published on 02 July 2019

Efficient generation of B lymphocytes by recognition of self-antigens

scientific article published on 4 July 2011

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes

scientific article published on 16 January 2016

Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors

article

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells

Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction

scientific article

Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

scientific article published in February 2018

Erratum: Memory B-cell persistence is independent of persisting immunizing antigen

scientific article published in Nature

Erratum: Requirement of mammalian DNA polymerase-β in base-excision repair

scientific article published in Nature

Evidence for a large compartment of IgM-expressing memory B cells in humans.

scientific article published in February 1997

Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions

article

Excision of the Frt-flanked neo R cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination

article published in 2007

Expansion and functional activity of Ly-1+ B cells upon transfer of peritoneal cells into allotype-congenic, newborn mice

scholarly article by Irmgard Förster & Klaus Rajewsky published 1987 in European Journal of Immunology

Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements

scientific article

FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses

scientific article published in January 2006

FOXO1 couples metabolic activity and growth state in the vascular endothelium

scientific article published on 06 January 2016

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

article

Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis

scientific article

Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen

scientific article published on December 2011

Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production

scientific article published on 5 June 2006

Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein

scientific article

From a dream to reality

scientific article

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins

scientific article

Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis

scientific article published on 10 June 2020

Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

scientific article

Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa

scientific article

Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains

scientific article published in September 1997

Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions

scientific article published on 01 November 1993

Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

scientific article

Generation of long-lived B cells in germ-free mice

scholarly article by Irmgard Förster et al published July 1991 in European Journal of Immunology

Generation of memory B cells inside and outside germinal centers

scientific article published on 10 April 2014

Generation of mice with a conditional Foxp2 null allele

scientific journal article

George Klein: 1925-2016.

scientific article published on 13 March 2017

Hair loss and defective T- and B-cell function in mice lacking ORAI1

scientific article

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region

scientific article published on June 1981

Heterogeneous and monoclonal helper T cells induce similar anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response I. Isotype distribution ⬇️

scientific article published on February 1, 1984

Heterogeneous and monoclonal helper T cells induce similar anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response II. Lambda light chain dominance and idiotope expression ⬇️

scientific article published on 01 February 1984

High-resolution description of antibody heavy-chain repertoires in humans

scientific article

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

scientific article

Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

scientific article published on August 1997

Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease.

scientific article published on February 2000

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development

scientific article published in November 1994

Hodgkin's disease: clonal Ig gene rearrangements in Hodgkin and Reed-Sternberg cells picked from histological sections

article

How alpha beta T cells deal with induced TCR alpha ablation

scientific article published on 10 July 2001

Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life

scientific article published in December 1993

Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells

scientific article published on November 1998

Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis

scientific article

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

scientific journal article

I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion

scientific article published in August 2004

I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis

scientific article published in July 2007

IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells

scientific article published on 3 August 2006

Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma

scientific article published on April 1999

Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody ⬇️

scientific article published on April 1, 1976

Idiotypic analysis of the response of C57BL/6 mice to the (4-hydroxy-3-nitrophenyl)acetyl group ⬇️

scientific article published on August 1, 1977

Idiotypic regulation by isologous monoclonal anti-idiotope antibodies

scientific article published on 01 March 1981

Ig heavy chain class switching in Rag-deficient mice

scientific article published on 01 March 1998

Ig-α Cytoplasmic Truncation Renders Immature B Cells More Sensitive to Antigen Contact

scientific article published on 01 November 1999

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta

scientific article

IgH class switching and translocations use a robust non-classical end-joining pathway

scientific article (publication date: 27 September 2007)

IkappaB kinase signaling is essential for maintenance of mature B cells

scientific journal article

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination.

scientific article published on 5 December 2011

Immune dysregulation and malignant lymphoma

scientific article published in April 1995

Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model

scientific article published on February 2012

Immunity to viruses in B cell-deficient mice: influence of antibodies on virus persistence and on T cell memory

scientific article published in September 1996

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells

scientific article

Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity

scientific article

Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.

scientific article

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes

scientific article published on 27 April 2020

Immunoglobulin heavy and light chain gene sequences of a human CD5 positive immunocytoma and sequences of four novel VHIII germline genes

scientific article published in September 1992

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

scientific article published on 01 March 1993

Immunological memory: lessons from the past and a look to the future

scientific article published in February 2016

Impaired Immunosuppressive Response to Ultraviolet Radiation in Interleukin-10–Deficient Mice

article

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice

scientific article published in July 1995

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

scientific article published in September 1997

Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background

scientific article published in December 2002

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

scientific article

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

scientific article published in July 2013

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

article

Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes

scientific article published on January 2001

Inducible gene targeting in mice

scientific article (publication date: 8 September 1995)

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells

scientific article published on April 1994

Inexpensive upgrading of a FACS I and isolation of rare somatic variants by double-fluorescence sorting

scientific article

Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins

scientific article published on 4 January 2013

Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.

scientific article

Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail

scientific article

Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse

scientific article

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses

scientific article published on July 1995

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

scientific article published on November 1995

Interleukin-10-deficient mice develop chronic enterocolitis

scientific article (publication date: 22 October 1993)

Interleukin-4-deficient mice

scientific article published on October 1993

Intraclonal generation of antibody mutants in germinal centres

scientific article published on December 1991

Ir-LDHB: map position and functional analysis

scientific article published in December 1973

Isolated hapten-binding receptors of sensitized lymphocytes I. Receptors from nylon wool-enriched mouse T lymphocyte lack serological markers of immunoglobulin constant domain but express heavy chain variable portions ⬇️

scientific article published on August 1, 1977

Isolated hapten-binding receptors of sensitized lymphocytes. IV. Expression of immimoglobulin variable regions in (4-hydroxy-3-nitrophenyl) acetyl (NP)-specific receptors isolated from murine B and T lymphocytes ⬇️

scientific article published on April 1, 1979

Isolated hapten-binding receptors of sensitized lymphocytes: V. Cellular origin of receptor molecules ⬇️

scientific article published on 01 October 1979

Isolation and characterization of anti-monosialoganglioside monoclonal antibody 19-9 class-switch variants

scientific article published on December 1985

Isolation of immunoglobulin class-switch and variable-region variants from mouse myeloma and hybridoma cell lines

scientific article published on 01 January 1982

Isolation of myeloma variants with predefined variant surface immunoglobulin by cell sorting ⬇️

scientific article published on August 1, 1978

Isolation of variants of mouse myeloma X63 that express changed immunoglobulin class

scientific article

Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues

scientific article

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

scientific article

Ku80 is required for immunoglobulin isotype switching

scientific article published on April 1998

L&H Cells in Lymphocyte-Predominant Hodgkin's Disease

scientific article published on 01 March 1998

L-selectin and β7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes

scientific article published on 01 November 1998

L-selectin and β7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes

scholarly article by Norbert Wagner et al published November 1998 in European Journal of Immunology

LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1

Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines

scientific article published on December 2002

Lambda chain expression at different stages of ontogeny in C57BL/6, BALB/c and SJL mice

scientific article published on 01 August 1981

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

scientific article (publication date: 16 April 1999)

Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

scientific article

Lymphocyte development Essential features

article

Lymphocyte development: overview

scientific article published on April 2008

Lymphocyte populations and immune responses in CD5-deficient mice

article

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

scientific article

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

scientific article

M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice

scientific journal article

M17: a novel gene expressed in germinal centers.

scientific article published on August 1994

MHC class I expression in mice lacking the proteasome subunit LMP-7

scientific article published in Science

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma

scientific article

Mature T cells depend on signaling through the IKK complex

scientific article published in September 2003

Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells

scientific article published on January 1999

Mechanism of neonatally induced idiotype suppression and its relevance for the acquisition of self-tolerance

scientific article published on June 1984

Mechanisms promoting translocations in editing and switching peripheral B cells

scientific article

Memory B-cell persistence is independent of persisting immunizing antigen.

scientific article published in October 2000

MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb

MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb

scientific article (publication date: 5 October 2007)

Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

scientific journal article

Michael S. Neuberger 1953-2013

scientific article

MicroRNA control in the immune system: basic principles

scientific article (publication date: 9 January 2009)

MicroRNA profiling of the murine hematopoietic system

scientific article

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation

scientific article

MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways

scientific article published on 06 August 2013

Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enh

scientific article published in August 1996

Molecular Single-Cell Analysis of Hodgkin- and Reed-Sternberg Cells Harboring Unmutated Immunoglobulin Variable Region Genes

article

Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells

scientific article published in April 1999

Molecular basis of an isogeneic anti-idiotypic response.

scientific article published on December 1984

Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient.

scientific article published on April 1996

Molecular single-cell analysis of Hodgkin and Reed-Sternberg cells

scientific article published on April 1995

Molecular single-cell analysis of the clonal relationship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease

scientific article published in November 2000

Monoclonal antibodies against murine cell surface antigens: anti-H-2, anti-Ia and anti-T cell antibodies

scientific article published on 01 January 1978

Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice

scientific article published on 01 June 1995

Mouse model for acute Epstein-Barr virus infection

scientific article

Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood

scholarly article

Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease

article

NEMO/IKK gamma-deficient mice model incontinentia pigmenti

scientific article published in June 2000

NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells

scholarly article

Natural occurrence and origin of somatically mutated memory B cells in mice ⬇️

scientific article published on August 1, 1992

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.

scientific article published on 26 August 2013

New variants of inducible Cre recombinase: a novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility

scientific article published on May 2001

Normal and malignant B-cell development with special reference to Hodgkin's disease

scientific article published on January 1997

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo

scientific article

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells

scientific article published on 17 October 2018

Obituary: César Milstein (1927-2002)

scientific article (publication date: 25 April 2002)

On the Structure of the T-cell Receptor for Antigen ⬇️

scientific article published on January 1, 1977

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

scientific article

PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones.

scientific article published on 20 November 2015

PI3 kinase signals BCR-dependent mature B cell survival

scientific article published on October 2009

PLC-gamma2 is essential for formation and maintenance of memory B cells

scientific article published on 09 March 2009

Phenotypic and molecular characterization of human peripheral blood B-cell subsets with special reference to N-region addition and J kappa-usage in V kappa J kappa-joints and kappa/lambda-ratios in naive versus memory B-cell subsets to identify trac

scientific article published in January 1999

Pillars article: a critical role of lambda 5 protein in B cell development. Cell. 1992. 69: 823-831.

scientific article published in February 2010

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

scientific journal article

Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

scientific article published on 09 February 2009

Postnatal DNA demethylation and its role in tissue maturation.

scientific article published on 23 May 2018

Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects

scientific article

Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells

Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production

scientific article published on December 2008

Production of high affinity autoantibodies in autoimmune New Zealand Black/New Zealand white F1 mice targeted with an anti-DNA heavy chain

article

Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genes

scientific article

Protocol for Efficient CRISPR/Cas9/AAV-Mediated Homologous Recombination in Mouse Hematopoietic Stem and Progenitor Cells

scientific article published on 19 June 2020

RETRACTED: Silencing of B cell receptor signals in human naive B cells

retracted scientific article

Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo ⬇️

scientific article published on October 27, 1998

Rapid generation of inducible mouse mutants

scientific article

Rare occurrence of classical Hodgkin's disease as a T cell lymphoma

scientific article published on January 2000

Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice

scientific article published on January 1999

Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus

article

Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster

scientific article published in March 1996

Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification

scientific article

Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation

scientific article

Recombination between antibody heavy chain variable-region genes: evidence for gene conversion

scientific article published on August 1983

Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice

scientific article

Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human

scientific article published on 01 December 2001

Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human

scholarly article by Andreas Bräuninger et al published December 2001 in European Journal of Immunology

Regulation of microRNA expression and abundance during lymphopoiesis

scientific article

Regulation of repertoire development through genetic control of DH reading frame preference

scientific article published on December 2008

Regulation of the germinal center response by microRNA-155

scientific article (publication date: 27 April 2007)

Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development ⬇️

scholarly article

Requirement of mammalian DNA polymerase-beta in base-excision repair.

scientific article

Requirement of mammalian DNA polymerase-β in base-excision repair

scientific article published in Nature

Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.

scientific article published in February 1998

Resistance to murine acquired immunodeficiency syndrome (MAIDS)

scientific article published in Science

Retraction

Role of NFkappaB signaling in normal and malignant B cell development.

scientific article published on January 2007

STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis

scientific article published on 3 September 2014

Secondary V(D)J recombination in B-1 cells

scientific article published in Nature

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine

scientific article published on 18 February 2014

Shutdown of class switch recombination by deletion of a switch region control element.

scientific article

Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses

scientific article published on 8 January 2018

Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program

scientific article

Single cell analysis of Hodgkin/Reed-Sternberg cells

scientific article published on January 1996

Single-cell PCR analysis of T helper cells in human lymph node germinal centers

scientific article published on March 2000

Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity

scientific article published on April 2014

Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling

scientific article published on 6 January 2006

Somatic H-2Kk variants reveal nonidentity of serological and cytotoxic T cell-defined Kk determinants

scientific article published in October 1983

Somatic hypermutation in normal and transformed human B cells

scientific article published in April 1998

Somatic hypermutation in the heavy chain locus correlates with transcription

scientific article

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

scientific article published in August 1996

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

scientific article published on February 1985

Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

scientific article published on December 2000

Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells

article

Somatic variants of murine immunoglobulin λ light chains ⬇️

scientific article published on July 22, 1982

Somatic variation of H-2Kk expression and structure in a T-cell lymphoma: instability, stabilization, high production and structural mutation ⬇️

scientific article published on January 1, 1983

Specific control of responsiveness by two complementing Ir loci in the H-2 complex

scientific article published on November 1, 1975

Specific enrichment of antigen-binding receptors from sensitized murine lymphocytes

scientific article published on August 1, 1976

Specificity, duration and mechanism of idiotype suppression induced by neonatal injection of monoclonal anti-idiotope antibodies into mice

scientific article published on 01 July 1984

Spontaneous class switch recombination in B cell lymphopoiesis generates aberrant switch junctions and is increased after VDJ rearrangement.

scientific article published in November 2007

Spontaneous immunoglobulin class switching in myeloma and hybridoma cell lines differs from physiological class switching

scientific article published on January 1982

Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways

scientific article published on January 1989

Stepwise intraclonal maturation of antibody affinity through somatic hypermutation

scientific article

Stringent doxycycline dependent control of CRE recombinase in vivo

scientific article published on December 2002

Study of murine B-cell development through analysis of immunoglobulin variable region genes

scientific article published on May 4, 1992

Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice

scientific article published on 15 November 2013

Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

article

Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) epstein-barr virus-infected b cells in angioimmunoblastic t cell lymphoma.

scientific article

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function

scientific article published on 3 February 2016

Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer

scientific article published in June 2004

Switch from NP-specific IgG3 to IgG1 in the mouse hybridoma cell line S24/63/63

scientific article published on 01 March 1982

Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line

scientific article

Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis

scientific article

T cell-dependent antibody production by Ly-1 B cells

scientific article published in May 1992

T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.

scientific article published on 21 August 2013

T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis

scientific article

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation

scientific article published on 8 November 2004

T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells ⬇️

scientific article published on 01 July 1992

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells

scientific article published on 03 June 2019

TET proteins and 5-methylcytosine oxidation in hematological cancers

scientific article

THE ORIGIN OF HODGKIN AND REED/STERNBERG CELLS IN HODGKIN'S DISEASE

TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.

scientific article

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

scientific article published in Nature

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

scientific article published on March 12, 1992

Targeted disruption of the V(H) 81X gene: influence on the B cell repertoire.

scientific article published in January 1997

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus

scientific article

Temporally and spatially regulated somatic mutagenesis in mice

scientific article

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

scientific journal article

The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain

scientific journal article

The B-cell antigen receptor integrates adaptive and innate immune signals

scientific article

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition

scientific article published on 31 May 2017

The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation.

scientific article

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

scientific journal article

The DNA deamination model of somatic antibody diversification

scientific article published in March 2015

The Herzenberg lecture: how to make a B-1 cell?

scientific article

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

scientific article

The advent and rise of monoclonal antibodies

scientific article published on 01 November 2019

The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

scientific article

The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3-nitrophenyl)acetyl(NP) antibodies ⬇️

scientific article published on April 1, 1979

The expression of a set of antibody variable regions in lipopolysaccharide-reactive B cells at various stages of ontogeny and its control by anti-idiotypic antibody

scientific article published on 01 April 1983

The immune response against anti-idiotope antibodies II. The induction of antibodies bearing the target idiotope (Ab3 beta) depends on the frequency of the corresponding B cells

scientific article published on 01 September 1983

The immune response against anti-idiotope antibodies. I. Induction of idiotope-bearing antibodies and analysis of the idiotope repertoire

scientific article published on 01 December 1982

The lingering enigma of the allelic exclusion mechanism

scientific article

The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches

scientific article published in 2021

The molecular mechanism of B cell activation by toll-like receptor protein RP-105

scientific article published on July 1998

The origin of CD95-gene mutations in B-cell lymphoma

scientific article published in February 2002

The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses

scientific article

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

scientific article

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

scientific article published on 18 April 2016

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections

scientific article

Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting

scholarly article

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

scientific article published on 11 June 2006

Tuning somatic hypermutation by transcription

scientific article published in January 1999

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

scientific article

Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma.

scientific article

Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.

scientific article

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

scientific article

VH replacement in primary immunoglobulin repertoire diversification.

scientific article

Vagaries of conditional gene targeting

scientific article published on July 2007

Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.

scientific article published on October 1994

Variable-region gene analysis of B-cell subsets derived from a 4-year-old child. Somatically mutated memory B cells accumulate in the peripheral blood already at young age.

scientific article

Years in Cologne ⬇️

scientific article published on November 7, 2012

Yin Yang 1 is a critical regulator of B-cell development

scientific article published on May 2007

c-Myb is critical for B cell development and maintenance of follicular B cells

scientific article

miR-155 regulates HGAL expression and increases lymphoma cell motility

scientific article published on 16 November 2011

miR-23∼27∼24 clusters control effector T cell differentiation and function

scientific article published on February 2016

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation

scientific article

sgRNA Sequence Motifs Blocking Efficient CRISPR/Cas9-Mediated Gene Editing

article

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