List of works - Cyrille Krul

Carcinogenicity.

scientific article

Considering new methodologies in strategies for safety assessment of foods and food ingredients

scientific article

Development of a panel of high-throughput reporter-gene assays to detect genotoxicity and oxidative stress

scientific article published on 18 December 2013

Genotoxicty and mutagenicity

scientific article published on 01 July 2005

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions.

scientific article published on 15 November 2017

Implementation challenges for designing integrated in vitro testing strategies (ITS) aiming at reducing and replacing animal experimentation

scientific article published on 17 January 2012

Integrated analysis of toxicity data of two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties to improve the understanding of side effects-A toxicopathologist׳s view.

scientific article

International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity.

scientific article published on 17 February 2014

Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model.

scientific article

Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies

scientific article published in 2022

Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity

scientific article published on January 2006

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop

scientific article published on 16 September 2009

Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: expert opinions on the state of affairs and the way forward.

scientific article published on 15 February 2014

Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe

scientific article published on 28 October 2014

State of the art on alternative methods to animal testing from an industrial point of view: ready for regulation?

scientific article published on 4 May 2014

The 3T3 neutral red uptake phototoxicity test: practical experience and implications for phototoxicity testing--the report of an ECVAM-EFPIA workshop

scientific article published on 9 June 2012

The transferability from rat subacute 4-week oral toxicity study to translational research exemplified by two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties.

scientific article published on 28 March 2015

Toxicology in the 21st century--working our way towards a visionary reality

scientific article

Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency.

scientific article

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.

scientific article published on 10 January 2018

List of works by Cyrille Krul

Carcinogenicity.

Considering new methodologies in strategies for safety assessment of foods and food ingredients

Development of a panel of high-throughput reporter-gene assays to detect genotoxicity and oxidative stress

Genotoxicty and mutagenicity

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions.

Implementation challenges for designing integrated in vitro testing strategies (ITS) aiming at reducing and replacing animal experimentation

Integrated analysis of toxicity data of two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties to improve the understanding of side effects-A toxicopathologist׳s view.

International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity.

Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model.

Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies

Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop

Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: expert opinions on the state of affairs and the way forward.

Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe

State of the art on alternative methods to animal testing from an industrial point of view: ready for regulation?

The 3T3 neutral red uptake phototoxicity test: practical experience and implications for phototoxicity testing--the report of an ECVAM-EFPIA workshop

The transferability from rat subacute 4-week oral toxicity study to translational research exemplified by two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties.

Toxicology in the 21st century--working our way towards a visionary reality

Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency.

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.