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List of works by Chang-Koo Shim

A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata ⬇️

scientific article published in August 2007

A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: characterization and in vitro/in vivo evaluation

scientific article published on 17 December 2011

Addition of amino acid moieties to lapatinib increases the anti-cancer effect via amino acid transporters

scientific article published on 19 November 2013

Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. asiatica

scientific article published in April 2005

Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies

scientific article published on February 2007

Altered metabolism of orally administered loxoprofen in human subjects after an oral administration of loxoprofen for three consecutive days followed by a seven-day washout

scientific article

Altered pharmacokinetics and hepatic uptake of TBuMA in ethynylestradiol-induced cholestasis

scientific article published on 01 April 2006

Altered pharmacokinetics of daunorubicin in rats with CCl4-induced hepatic injury

scientific article published in September 2007

An aqueous extract of Poncirus fructus activates the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction.

scientific article published on 22 August 2010

An improved prediction of the human in vivo intestinal permeability and BCS class of drugs using the in vitro permeability ratio obtained for rat intestine using an Ussing chamber system

scientific article published on 31 August 2012

Anticancer efficacy of photodynamic therapy with hematoporphyrin-modified, doxorubicin-loaded nanoparticles in liver cancer

scientific article published on 24 July 2014

Antifibrotic effect of MMP13-encoding plasmid DNA delivered using polyethylenimine shielded with hyaluronic acid

scientific article

Antitumor effect of paclitaxel-loaded PEGylated immunoliposomes against human breast cancer cells

scientific article published on 9 September 2007

Application of a sample pooling method for the accelerated assessment of the rate of uptake of drugs by the brain in rats

scientific article

Assessment of siRNA pharmacokinetics using ELISA-based quantification

scientific article published on 16 December 2009

Biliary clearance of bromosulfophthalein in anesthetized and freely moving conscious rat.

scientific article published in March 2009

Characterization and in vitro evaluation of freeze-dried microparticles composed of granisetron-cyclodextrin complex and carboxymethylcellulose for intranasal delivery.

scientific article published on 27 August 2010

Characterization of the transport of uracil across Caco-2 and LLC-PK1 cell monolayers

scientific article published in October 2002

Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation

scientific article published on 08 November 2012

Chitosan oligosaccharide-arachidic acid-based nanoparticles for anti-cancer drug delivery

scientific article

Clinical pharmacokinetics of oxaliplatin and 5-fluorouracil administered in combination with leucovorin in Korean patients with advanced colorectal cancer.

scientific article published on 4 January 2006

Comparative in vitro release and clinical pharmacokinetics of leuprolide from Luphere 3M Depot, a 3-month release formulation of leuprolide acetate

scientific article published on 8 November 2016

Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: evidence for extrahepatic metabolism.

scientific article published in October 2005

Contribution of a significant first-pass effect of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in the liver to its poor bioavailability in rats

scientific article published in September 2009

Contribution of ion-pair complexation with bile salts to the transport of organic cations across LLC-PK1 cell monolayers

scientific article published on April 1, 2003

Decreased secretory transport of a quarternary ammonium, TBuMA, across LLC-PK1 cells by the anionic kidney extract

scientific article published on 15 May 2008

Determination of Belotecan in the Plasma, Bile, and Urine of Rats by High-Performance Liquid Chromatography with Fluorescence Detection and Its Application to a Pharmacokinetic Study

Determination of zabofloxacin in rat plasma by liquid chromatography with mass spectrometry and its application to pharmacokinetic study ⬇️

scientific article published on 09 November 2010

Differential changes in functional activity of organic cation transporters in rats with uranyl nitrate-induced acute renal failure

scientific article published on 01 August 2012

Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation

scientific article published on 23 August 2009

Dose dependency in the oral bioavailability of an organic cation model, tributylmethyl ammonium (TBuMA), in rats: association with the saturation of efflux by the P-gp system on the apical membrane of the intestinal epithelium

scientific article published in December 2005

Effect of a new hepatoprotective agent, YH-439, on the hepatobiliary transport of organic cations (OCs): selective inhibition of sinusoidal OCs uptake without influencing glucose uptake and canalicular OCs excretion

scientific article published in March 2005

Effect of an aqueous extract of dried immature fruit of Poncirus trifoliata (L.) Raf. on intestinal transit in rodents with experimental gastrointestinal motility dysfunctions

scientific article published on 15 September 2005

Effect of excipients on the stability and transport of recombinant human epidermal growth factor (rhEGF) across CACO-2 cell monolayers ⬇️

scientific article published on April 1, 2003

Effect of fatty acids on the transdermal delivery of donepezil: in vitro and in vivo evaluation

scientific article published on 20 October 2011

Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine

scientific article

Effect of nitric oxide on the sinusoidal uptake of organic cations and anions by isolated hepatocytes

scientific article

Effect of nonylphenol ethoxylates (NPEs) on barrier functions of epithelial cell membranes: opening of tight junctions and competitive inhibition of P-gp-mediated efflux

scientific article published on September 2005

Effect of permeation enhancers on transdermal delivery of fluoxetine: in vitro and in vivo evaluation

scientific article published on 5 September 2013

Effect of probenecid on the biliary excretion of belotecan

scientific article

Effects of tetraalkylammonium compounds with different affinities for organic cation transporters on the pharmacokinetics of metformin

scientific article

Efficacy of a new sustained-release microsphere formulation of exenatide, DA-3091, in Zucker diabetic fatty (ZDF) rats

scientific article published on 16 March 2010

Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticle and tumor

scientific article

Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts

scientific article published in September 2005

Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters

scientific article published on 10 January 2012

Enhanced in vitro cellular uptake of P-gp substrate by poloxamer-modified liposomes (PMLs) in MDR cancer cells

scientific article

Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031.

scientific article published in January 2003

Enhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluation

scientific article published on 13 February 2007

Enhancement of paracellular transport of heparin disaccharide across Caco-2 cell monolayers

scientific article published in February 2002

Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer

scientific article published on 01 September 2006

Evaluation of protein stability and in vitro permeation of lyophilized polysaccharides-based microparticles for intranasal protein delivery

scientific article published on 15 June 2011

Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain

scientific article

Expression and functional activity of P-glycoprotein in passaged primary human nasal epithelial cell monolayers cultured by the air-liquid interface method for nasal drug transport study.

scientific article

Fluorescence detection of Zabofloxacin, a novel fluoroquinolone antibiotic, in plasma, bile, and urine by HPLC: the first oral and intravenous applications in a pharmacokinetic study in rats.

scientific article published on July 2011

Functional consequences of genetic variations in the human organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population

scientific article

Functional impairment of rat taurine transporter by activation of nitrogen oxide through superoxide

scientific article published on 13 December 2011

Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation

scientific article published on 30 July 2007

Hepatobiliary excretion of tributylmethylamonium in rats with lipopolysaccharide-induced acute inflammation

scientific article

Hyaluronic acid complexed to biodegradable poly L-arginine for targeted delivery of siRNAs

scientific article

Hyaluronic acid derivative-based self-assembled nanoparticles for the treatment of melanoma

scientific article

Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene 1 and thyroid hormone responsive protein genes)

scientific journal article

Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats.

scientific article published on 3 January 2018

In vitro and in vivo evaluation of N,N,N-trimethylphytosphingosine-iodide (TMP) in liposomes for the treatment of angiogenesis and metastasis.

scientific article published on 27 May 2012

In vitro and in vivo evaluation of a novel nonscrotal matrix-type transdermal delivery system of testosterone

scientific article published in March 2005

Increased affinity to canalicular P-gp via formation of lipophilic ion-pair complexes with endogenous bile salts is associated with mw threshold in hepatobiliary excretion of quaternary ammonium compounds

scientific article published on 10 March 2010

Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells

scientific article published in November 2007

Investigation into the Efficacy of Val-SN-38, a Valine-Ester Prodrug of the Anti-Cancer Agent SN-38.

scientific article published on May 2012

Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells

scientific article published on 25 July 2008

Kinetic analysis about the bidirectional transport of 1-anilino-8-naphthalene sulfonate (ANS) by isolated rat hepatocytes ⬇️

scientific article published on April 1, 2003

Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway

scientific article published on 30 September 2010

Limited role of P-glycoprotein in the intestinal absorption of cyclosporin A.

scientific article published in April 2005

Liposome formulation of paclitaxel with enhanced solubility and stability

scientific article

Liver cancer targeting of Doxorubicin with reduced distribution to the heart using hematoporphyrin-modified albumin nanoparticles in rats

scientific article published on 05 October 2011

Long-term administration of an aqueous extract of dried, immature fruit of Poncirus trifoliata (L.) Raf. suppresses body weight gain in rats

scientific article published on 22 August 2009

Lung-specific delivery of paclitaxel by chitosan-modified PLGA nanoparticles via transient formation of microaggregates

scientific article

Mechanism of intestinal transport of an organic cation, tributylmethylammonium in Caco-2 cell monolayers

scientific article published on April 2006

Mechanism of the reduced elimination clearance of benzylpenicillin from cerebrospinal fluid in rats with intracisternal administration of lipopolysaccharide

scientific article published in November 2002

Mechanism of the stationary canalicular excretion of tributylmethyl ammonium in rats with a CCl4-induced acute hepatic injury

scientific article published in February 2005

Modulation of biodistribution and expression of plasmid DNA following mesenchymal progenitor cell-based delivery

scientific article published on 01 June 2008

Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer

scientific article published on 26 March 2010

Multiple alterations of canalicular membrane transport activities in rats with CCl(4)-induced hepatic injury

scientific article published in April 2003

Novel porous matrix of hyaluronic acid for the three-dimensional culture of chondrocytes

scientific article published on 20 November 2008

Opsonized erythrocyte ghosts for liver-targeted delivery of antisense oligodeoxynucleotides

scientific article

P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers

scientific article published in December 2002

Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery

scientific article

Pharmacokinetic characterization of dehydroevodiamine in the rat brain

scientific article published on February 2004

Pharmacokinetics and efficacy of a biweekly dosage formulation of exenatide in Zucker diabetic fatty (ZDF) rats

scientific article published on 11 September 2009

Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol

scientific article published on 3 December 2010

Pharmacokinetics and pharmacodynamics of ketoprofen plasters

scientific article published in January 2008

Physiologically based pharmacokinetic modeling of SNU-0039, an anti-Alzheimer's agent, in rats

scientific article published on 25 August 2011

Poloxamer/cyclodextrin/chitosan-based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride.

scientific article

Poly-L-arginine and dextran sulfate-based nanocomplex for epidermal growth factor receptor (EGFR) siRNA delivery: its application for head and neck cancer treatment

scientific article

Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery.

scientific article published on 29 June 2013

Preparation and evaluation of fexofenadine microemulsion for intranasal delivery

Preparation and evaluation of fexofenadine microemulsions for intranasal delivery

scientific article published on August 2010

Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome

scientific article

Preparation and evaluation of proliposomes containing salmon calcitonin

scientific article published in November 2002

Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride

scientific article

Preparation, characterization and in vitro intestinal absorption of a dry emulsion formulation containing atorvastatin calcium.

scientific article published in January 2009

Prokinetic activity of an aqueous extract from dried immature fruit of Poncirus trifoliata (L.) Raf.

scientific article published on 26 September 2005

Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in porous hyaluronic acid scaffold

scientific article published on 30 July 2011

Proliposomes as an intranasal dosage form for the sustained delivery of propranolol

scholarly article

Quantification of CKD-501, lobeglitazone, in rat plasma using a liquid-chromatography/tandem mass spectrometry method and its applications to pharmacokinetic studies

scientific article

Quantification of clotiazepam in human plasma by gas chromatography-mass spectrometry.

scientific article published on 6 March 2006

Rapid and sensitive determination of udenafil in plasma by LC-MS/MS for intranasal pharmacokinetic study in rats

scientific article published on 01 January 2011

Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis

scientific article

Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport

scientific article

Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats

scientific article published on 02 July 2012

Simple liquid chromatography-electrospray ionization mass spectrometry method for the routine determination of salmon calcitonin in serum

scientific article

Simultaneous Determination of Artesunate and Dihydroartemisinin Concentrations in Human Plasma by High Performance Liquid Chromatography-Mass Spectrometry with Electro-Spray Ionization

article by Kyeong-Ryoon Lee et al published 12 January 2010 in Analytical Letters

Skin permeation enhancement of diclofenac by fatty acids

scientific article published in August 2008

Small intestinal transit does not adequately represent postoperative paralytic ileus in rats

scientific article published on 01 December 2002

Smooth muscle relaxation activity of an aqueous extract of dried immature fruit of Poncirus trifoliata (PF-W) on an isolated strip of rat ileum.

scientific article published in August 2013

Synergic enhancing-effect of DEET and dodecylamine on the skin permeation of testosterone from a matrix-type transdermal delivery system.

scientific article

Testosterone-independent down-regulation of Oct2 in the kidney medulla from a uranyl nitrate-induced rat model of acute renal failure: effects on distribution of a model organic cation, tetraethylammonium

scientific article published in February 2009

The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel

scientific article

The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin

scientific article published on 19 December 2012

The suppressed expression and functional activity of hepatic P-glycoprotein in rats with protein-calorie malnutrition

scientific article

The transport of organic cations in the small intestine: current knowledge and emerging concepts

scientific article published on July 2006

Transfection of primary human nasal epithelial cells using a biodegradable poly (ester amine) based on polycaprolactone and polyethylenimine as a gene carrier

scientific article

Transient aggregation of chitosan-modified poly(d,l-lactic-co-glycolic) acid nanoparticles in the blood stream and improved lung targeting efficiency.

scientific article published on 6 July 2016

Transport of anti-allergic drugs across the passage cultured human nasal epithelial cell monolayer

scientific article published in October 2005

Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug

scientific article

Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression.

scientific article

[Study on the history of exchange in pharmaceutical science between Japan and Korea after the Modern period: focus on Korean students sent to Japan with expenses funded by the Japanese government]

scientific article published on 01 January 2009

[The history of pharmacy in Korea]

scientific article published on 01 January 2008

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