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List of works by Gillian Tozer

A comparative study of tumour blood flow modification in two rat tumour systems using endothelin-1 and angiotensin II: influence of tumour size on angiotensin II response

scientific article published in September 1996

A system for accurate and automated injection of hyperpolarized substrate with minimal dead time and scalable volumes over a large range

scientific article

Abstract 3279: Effects of the isoforms of the angiogenic growth factor VEGF on neo-vascularization and tumor response to the tyrosine kinase inhibitor cediranib

An automatic algorithm for the segmentation and morphological analysis of microvessels in immunostained histological tumour sections.

scientific article

An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate.

scientific article

Analysis of the horseradish peroxidase/indole-3-acetic acid combination in a three-dimensional tumor model

scientific article published in July 2004

Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression

scientific article published on 7 December 2006

Application of intravital microscopy in studies of tumor microcirculation.

scientific article published on January 2010

Application of multiphoton steady state and lifetime imaging to mapping of tumor vascular architecture in vivo

article

Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials.

scientific article published in January 2003

Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors.

scientific article

CAIMAN: an online algorithm repository for Cancer Image Analysis

scientific article published on 5 August 2010

Characterisation of the microcirculation of tumours where the blood supply originates from a single artery and vein

scientific article

Combretastatin A-4-phosphate effectively increases tumor retention of the therapeutic antibody, 131I-A5B7, even at doses that are sub-optimal for vascular shut-down

scientific article published in February 2007

Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging

scientific article

Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid

scientific article published in November 2000

Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma

scientific article published on 4 April 2017

Direct arterial injection of hyperpolarized 13 C-labeled substrates into rat tumors for rapid MR detection of metabolism with minimal substrate dilution.

scientific article

Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy - spatial and time dependent distribution

scientific article

Disrupting tumour blood vessels

scientific article

Do Anti-Angiogenic VEGF (VEGFxxxb) Isoforms Exist? A Cautionary Tale ⬇️

scientific article published on May 2, 2012

Effect of nitric-oxide synthesis on tumour blood volume and vascular activity: a phase I study

scientific article published on 01 February 2007

Effective gene transfer to solid tumors using different nonviral gene delivery techniques: Electroporation, liposomes, and integrin-targeted vector

article

Effects of Tin-Protoporphyrin IX on Blood Flow in a Rat Tumor Model ⬇️

scientific article published on May 1, 2003

Energy metabolism and blood perfusion in a mouse mammary adenocarcinoma during growth and following X irradiation

scientific article published on 01 February 1987

Enhancement of vascular targeting by inhibitors of nitric oxide synthase

scientific article published in December 2002

Estimation of apparent tumor vascular permeability from multiphoton fluorescence microscopic images of P22 rat sarcomas in vivo

scientific article published in January 2008

Evaluation of Sydnone-Based Analogs of Combretastatin A-4 Phosphate (CA4P) as Vascular Disrupting Agents for Use in Cancer Therapy

article

Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI.

scientific article published in April 2002

From bench to bedside for gene-directed enzyme prodrug therapy of cancer

scientific article

Gene delivery to hypoxic cells in vitro

scientific article published on September 2000

Generation of a novel mouse model for the inducible depletion of macrophages in vivo

scientific article published on 20 September 2012

Guidelines for the welfare and use of animals in cancer research

scientific article

Imaging biomarker roadmap for cancer studies ⬇️

scientific article

In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer

scientific article

Influence of soluble or matrix-bound isoforms of vascular endothelial growth factor-A on tumor response to vascular-targeted strategies

scientific article

Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy

scientific article

Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI ⬇️

scientific article published on March 23, 2011

Kinetic modeling of hyperpolarized (13)C pyruvate metabolism in tumors using a measured arterial input function.

scientific article published on 20 November 2012

Longitudinal imaging of the ageing mouse

scientific article

MALDI-MSI and label-free LC-ESI-MS/MS shotgun proteomics to investigate protein induction in a murine fibrosarcoma model following treatment with a vascular disrupting agent

scientific article

Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate.

scientific article

Measurement of tumor oxygenation: in vivo comparison of a luminescence fiber-optic sensor and a polarographic electrode in the p22 tumor

scientific article published on 01 June 2001

Measuring the velocity of fluorescently labelled red blood cells with a keyhole tracking algorithm.

scientific article published in January 2008

Mechanisms of cytotoxicity induced by horseradish peroxidase/indole-3-acetic acid gene therapy

scientific article published in January 2002

Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to vascular targeting agents ⬇️

scientific article published on October 8, 2010

Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies

scientific article published on June 2009

Modification of blood flow in the HSN tumour and normal tissues of the rat by the endothelin ET(B) receptor agonist, IRL 1620.

scientific article

NMR-based evaluation of the metabolic profile and response to dichloroacetate of human prostate cancer cells

scientific article published on 17 March 2014

Nitric oxide in biological fluids: analysis of nitrite and nitrate by high-performance ion chromatography ⬇️

scientific article published on 01 July 1995

Nitric oxide synthase inhibition enhances the tumor vascular-damaging effects of combretastatin a-4 3-o-phosphate at clinically relevant doses

scientific article

Online chromatic and scale-space microvessel-tracing analysis for transmitted light optical images ⬇️

scientific article published on September 14, 2012

Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide.

scientific article published on 5 May 2005

Pharmacological manipulation of blood flow

scientific article published on 01 January 1992

PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development

scientific article published on 8 December 2017

Quantitative Estimation of Tissue Blood Flow Rate

scientific article published on 01 January 2016

Quantitative estimation of tissue blood flow rate

scientific article published in January 2009

Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability

scientific article published on 24 October 2007

Radiation-induced Modification of Blood Flow Distribution in a Rat Fibrosarcoma ⬇️

scientific article published on July 1, 1991

Rational Design of Cholesterol Derivative for Improved Stability of Paclitaxel Cationic Liposomes

scientific article published on 8 March 2018

Recombinant " IMS TAG" proteins--a new method for validating bottom-up matrix-assisted laser desorption/ionisation ion mobility separation mass spectrometry imaging

scientific article

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study.

scientific article published on 8 July 2008

Relaxation and exchange dynamics of hyperpolarized 129Xe in human blood

scientific article published on 28 August 2014

Schedule dependence of combretastatin A4 phosphate in transplanted and spontaneous tumour models

scientific article published in November 2002

Semi-automated software for the three-dimensional delineation of complex vascular networks.

scientific article published in July 2003

Spatial heterogeneity of tumour blood flow modification induced by angiotensin II: relationship to receptor distribution.

scientific article published in March 1996

Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4.

scientific article published on 2 October 2016

Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth.

scientific article

TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

scientific article

Targeting cancer with gene therapy using hypoxia as a stimulus

scientific article published in January 2004

Targeting the vasculature of tumours: combining VEGF pathway inhibitors with radiotherapy

scientific article published on 05 September 2018

The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations.

scientific article published on May 2005

The biology of the combretastatins as tumour vascular targeting agents

scientific article

The comparative effects of the NOS inhibitor, Nomega-nitro-L-arginine, and the haemoxygenase inhibitor, zinc protoporphyrin IX, on tumour blood flow

scientific article published in November 1998

The contribution made by cell death and oxygenation to 31P MRS observations of tumour energy metabolism

scientific article published on September 1, 1992

The effects of hyperoxic and hypercarbic gases on tumour blood flow.

scientific article

The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification

scientific article published in July 2005

The energy metabolism of RIF-1 tumours following hydralazine

scientific article published on 01 November 1990

The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate

scientific article published on 18 June 2020

The influence of nitric oxide on tumour vascular tone

scientific article published on 01 January 1995

The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate.

scientific article

The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death

scientific article

The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells

scientific article published on 01 March 2002

The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses.

scientific article published on October 2002

The vascular targeting agent combretastatin A-4-phosphate induces neutrophil recruitment to endothelial cells in vitro

scientific article published in July 2003

Therapeutic targeting of the tumor vasculature

scientific article published in July 2004

Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics

scientific article

Tumour targeting by microtubule-depolymerizing vascular disrupting agents

scientific article

Tumour vascular disrupting agents: combating treatment resistance

scientific article published on October 2008

Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol

scientific article published on May 2004

Use of the hypertensive agent angiotensin II for modifying oxygen delivery to tumours.

scientific article

Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy

scientific article

Vascular effects dominate solid tumor response to treatment with combretastatin A‐4‐phosphate ⬇️

scientific article published on April 13, 2011

Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography.

scientific article published on 19 September 2017

Vascular response of tumour and normal tissues to endothelin-1 following antagonism of ETA and ETB receptors in anaesthetised rats ⬇️

scientific article published on 01 October 1997

ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature.

scientific article published in December 2002

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