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List of works by Ralf Heilker

Activation and translocation of glucokinase in rat primary hepatocytes monitored by high content image analysis

scientific article published on 23 September 2008

Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule

scientific article published on 12 September 2018

An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction

scientific article published on 25 June 2010

Assay Related Target Similarity (ARTS) - chemogenomics approach for quantitative comparison of biological targets

scientific article published on 29 July 2011

Automated high content screening for phosphoinositide 3 kinase inhibition using an AKT 1 redistribution assay.

scientific article published in June 2006

Automated high throughput screening for serine kinase inhibitors using a LEADseeker scintillation proximity assay in the 1536-well format

scientific article

CXCR2 inverse agonism detected by arrestin redistribution.

scientific article published on 22 September 2009

Cell-based assays in practice: cell markers from autofluorescent proteins of the GFP-family.

scientific article published on September 2008

Comparison of G-protein coupled receptor desensitization-related beta-arrestin redistribution using confocal and non-confocal imaging

scientific article published in January 2006

Confocal fluorescence microscopy for high-throughput screening of G-protein coupled receptors.

scientific article published in January 2005

Confocal optics microscopy for biochemical and cellular high-throughput screening

scientific article

Development of a miniaturized 96-Transwell air-liquid interface human small airway epithelial model

scientific article published on 03 August 2020

Differentiation of hiPS Cells into Definitive Endoderm for High-Throughput Screening

scientific article published on 01 January 2019

Endothelin receptor in virus-like particles: ligand binding observed by fluorescence fluctuation spectroscopy.

scientific article published on July 2004

Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air-liquid interface model

scientific article published on 23 August 2021

G protein-coupled receptor internalization assays in the high-content screening format

scientific article published in January 2006

G-protein-coupled receptor-focused drug discovery using a target class platform approach

scientific article

High content screening of CXCR2-dependent signalling pathways.

scientific article published on January 2010

High-Content Analysis of CCR2 Antagonists on Human Primary Monocytes ⬇️

scientific article published on May 3, 2011

High-throughput screening of interactions between G protein-coupled receptors and ligands using confocal optics microscopy

scientific article published in January 2005

In vivo inhibition of epidermal growth factor receptor autophosphorylation prevents receptor internalization.

scientific article published on 18 September 2010

Novel fluorescent proteins for high-content screening.

scientific article published on 25 September 2006

Optimized and far-red-emitting variants of fluorescent protein eqFP611.

scientific article published in March 2008

Peptide protein binding assay using ImageFlashPlates or Imaging Beads

scientific article published in December 2004

Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived Neurons

scientific article published on 28 March 2017

Pharmacological profiling of chemokine receptor-directed compounds using high-content screening

scientific article published in January 2008

Phenotypic analysis of chemokine-driven actin reorganization in primary human neutrophils

scientific article published on 28 February 2014

Photoconvertible fluorescent protein EosFP: biophysical properties and cell biology applications

scientific article

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC-derived air-liquid interface model

scientific article published on 16 April 2020

Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease

scientific article

The power of combining phenotypic and target-focused drug discovery

article

Time-resolved fluorescence measurements using microlens array and area imaging devices

scientific article published in February 2004

Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611

scientific article

Upscaling of hiPS Cell-Derived Neurons for High-Throughput Screening

scientific article published on 16 November 2016

hiPS Cell-Derived Neurons for High-Throughput Screening

scientific article published on 01 January 2019

iPS cell derived neuronal cells for drug discovery

scientific article published on 03 August 2014

mRuby, a bright monomeric red fluorescent protein for labeling of subcellular structures

scientific article (publication date: 2009)

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