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List of works by Stephen R Morairty

Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy

scientific article published on March 2013

Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia.

scientific article

Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone

scientific article

GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus.

scientific article published on 20 April 2006

Homeostatic sleep pressure is the primary factor for activation of cortical nNOS/NK1 neurons

scientific article

Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep

scientific article

Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease.

scientific article published in July 2013

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression

scientific article

Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease

scientific article

The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.

scientific article

The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats

scientific article published on 31 January 2014

The wake-promoting effects of hypocretin-1 are attenuated in old rats.

scientific article

Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.

scientific article

Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques

scientific article published on 06 April 2019

Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.

scientific article

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