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List of works by Tim Zacharewski

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice

scientific article published on 16 September 2015

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats

scientific article published on 05 May 2020

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action ⬇️

scientific article published on December 1, 1991

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice

scientific article published on 09 September 2020

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.

scientific article

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice

article published in 2019

2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice

scientific article published on 16 April 2018

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells

scientific article

6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor

scientific article published on April 1, 1992

6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities

scientific article published on 01 February 1988

A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling

scientific article published on 20 September 2005

A toxicogenomic approach for the risk assessment of the food contaminant acetamide

scientific article published on 24 December 2019

Ability of structurally diverse natural products and synthetic chemicals to induce gene expression mediated by estrogen receptors from various species.

scientific article published in October 2002

An approach for assessing estrogen receptor-mediated interactions in mixtures of three chemicals: a pilot study

scientific article published in August 2002

Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison

scientific article published on 5 December 2006

Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum

scientific article published on January 1997

Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced pS2 expression

scientific article published on May 1994

Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants

scientific article published on 01 October 1988

Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity

scientific article published on 01 October 1987

Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis

scientific article published on 2 September 2011

Assessing the estrogenic and dioxin-like activities of chemicals and complex mixtures using in vitro recombinant receptor-reporter gene assays

scientific article

Assessment of clone identity and sequence fidelity for 1189 IMAGE cDNA clones

scientific article

Assessment of interactions of diverse ternary mixtures in an estrogen receptor-alpha reporter assay

scientific article

Atrazine-Mediated Disruption of Steroidogenesis in BLTK1 Murine Leydig Cells.

scientific article published on 16 September 2015

Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.

scientific article

Automated dose-response analysis of the relative hepatic gene expression potency of TCDF in C57BL/6 mice

scientific article published on 12 August 2009

Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets

scientific article

BLTK1 Murine Leydig Cells: A Novel Steroidogenic Model for Evaluating the Effects of Reproductive and Developmental Toxicants ⬇️

scientific article published on March 29, 2012

Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs

scientific article published on 01 May 2022

Bioinformatics: databasing and gene annotation

scientific article published on January 2008

Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol

scientific article published on July 1998

Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology

scientific article

Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice

scientific article published on 01 November 2019

Comparative Toxicogenomics in Mechanistic and Predictive Toxicology

Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells

scientific article published on 14 August 2009

Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells

scientific article published on 29 November 2016

Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences.

scientific article published on 24 August 2004

Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytes

scientific article published on 15 February 2013

Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver

scientific article published on 29 September 2011

Comparative microarray analysis of basal gene expression in mouse Hepa-1c1c7 wild-type and mutant cell lines

scientific article

Comparative potencies of Aroclors 1232, 1242, 1248, 1254, and 1260 in male Wistar rats--assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs)

scientific article published on 01 May 1993

Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice

scientific article

Comparative temporal toxicogenomic analysis of TCDD- and TCDF-mediated hepatic effects in immature female C57BL/6 mice

scientific article

Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia

scientific article published on 28 April 2012

Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice

scientific article published on 07 September 2006

Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice

scientific article published on 27 November 2007

Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague–Dawley rats and C57BL/6 mice ⬇️

scientific article published on December 11, 2012

Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction.

scientific article

Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver

scientific article

Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.

scientific article published on 14 February 2017

Corrigendum to "Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity" [Toxicol. Appl. Pharmacol. 321 (2017) 1-17].

scientific article published on 2 March 2018

DNA binding properties of the Ah receptor in wild-type and variant mouse hepatoma cells

scientific article published on November 1991

Development and validation of bioassays for polychlorinated dibenzo-p-dioxins and dibenzofurans

scientific article published on January 1, 1991

Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review

scientific article published on October 1989

Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features

scientific article

Development of analytical methods for NMR spectra and application to a 13C toxicology study

article

Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells

scientific article

Differential estrogen receptor binding of estrogenic substances: a species comparison

scientific article

Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus

scientific article published on 8 February 2006

Distribution of androgen receptor mRNA expression and immunoreactivity in the brain of the green anole lizard.

scientific article published on January 2002

Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis

scientific article published on 25 August 2016

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells

scientific article

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships

scientific article published in April 1990

Effects of TCDD on the expression of nuclear encoded mitochondrial genes

scientific article

Effects of culture conditions on estrogen-mediated hepatic in vitro gene expression and correlation to in vivo responses.

scientific article published on 7 March 2006

Effects of tamoxifen and ethynylestradiol cotreatment on uterine gene expression in immature, ovariectomized mice

scientific article published on 13 July 2010

Empirical bayes gene screening tool for time-course or dose-response microarray data

scientific article

Estrogen receptor-mediated actions of polyphenolic catechins in vivo and in vitro

scientific article published in October 2002

Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells

scientific article published on 01 June 1991

Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155) ⬇️

scientific article published on November 1, 1997

Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters

scientific article published on 01 December 1998

Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro

scientific article published on March 1996

Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism

scientific article published on 26 February 2016

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis

scientific article

GP3: GenePix post-processing program for automated analysis of raw microarray data

scientific article

Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver

scientific article published on 14 November 2019

Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine

scientific journal article

Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes

scientific article

Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water

scientific article published on December 2011

Gestational and lactational exposure of male mice to diethylstilbestrol causes long-term effects on the testis, sperm fertilizing ability in vitro, and testicular gene expression

scientific article

Hydroxylated Polychlorinated Biphenyls (PCBs) as Estrogens and Antiestrogens: Structure–Activity Relationships ⬇️

scientific article published on 01 July 1997

Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo

scientific article

Identification and Characterization of Genes Susceptible to Transcriptional Cross-Talk between the Hypoxia and Dioxin Signaling Cascades Volume 19, Number 10, October, 2006, pp 1284−1293

article

Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades

scientific article

Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression

scientific article published on May 1997

Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article

Identification of temporal patterns of gene expression in the uteri of immature, ovariectomized mice following exposure to ethynylestradiol

scientific article published on 17 October 2003

In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists

scientific article

In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta.

scientific article published in February 2001

In vivo-in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue

scientific article published on 12 April 2006

Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners

scientific article published on 01 August 1989

Inhibition of estrogen-mediated uterine gene expression responses by dioxin

scientific article published on 17 October 2007

Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver

scientific article

Interaction of PAH-related compounds with the alpha and beta isoforms of the estrogen receptor

scientific article published in May 2001

Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.

scientific article

Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

scientific article

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice

scientific article (publication date: 2015)

Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice

scientific article published on 18 September 2017

Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: Characterization of 6-[125I]methyl-8-iodo-1, 3-dichlorodibenzofuran-Ah receptor complexes ⬇️

scientific article published on January 1, 1991

Naringenin: a weakly estrogenic bioflavonoid that exhibits antiestrogenic activity

scientific article published on 01 October 1995

Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice

scientific article

Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure

scientific article

Normalization of two-channel microarray experiments: a semiparametric approach.

scientific article published on 28 October 2004

Organochlorine exposure and risk for breast cancer

scientific article published on January 1997

Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice

scientific article published in March 2016

PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands

scientific article published on 18 December 2009

PPARα-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons ⬇️

scientific article published on June 27, 2013

Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies

scientific article published on 01 May 1989

Pharmacogenomics

Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin

scientific article (publication date: 5 November 1989)

Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships

scientific article published on June 1987

Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response

scientific article

Protocols for the assurance of microarray data quality and process control

scientific article

Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

scientific article published on 17 November 2015

Quantification of rainbow trout (Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with estradiol-17 beta or alpha-zearalenol

scientific article published in December 2000

RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice

scientific article published on 10 May 2015

Reciprocal mutagenesis between human alpha(L349, M528) and rainbow trout (M317, I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures.

scientific article

Single nuclei RNA sequencing assessment of the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article published on 10 August 2020

Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT

scientific article published on 16 October 2008

Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies

scientific article published on 01 September 1990

Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor

scientific article

Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum.

scientific article published in August 1995

Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program

scientific article

Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity

scientific article published on 30 March 2005

Temporal- and dose-dependent hepatic gene expression changes in immature ovariectomized mice following exposure to ethynyl estradiol.

scientific article published on 19 February 2004

Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife

scientific article

Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice

scientific article published on 17 July 2013

Toxicogenomics in risk assessment: applications and needs

scientific article

Transcription factor crosstalk controls the transcriptional response to AhR over activation by TCDD in thymic epithelial cells

Triazine Herbicides and Their Chlorometabolites Alter Steroidogenesis in BLTK1 Murine Leydig Cells ⬇️

scientific article published on April 16, 2013

Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians

scientific article

dbZach toxicogenomic information management system

scientific article published on March 2007

dbZach: A MIAME-compliant toxicogenomic supportive relational database

scientific article published on 10 January 2006

o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver

scientific journal article

o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats

scientific article published on 3 October 2013

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