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List of works by Joseph A. Beavo

A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition

scientific article (publication date: 2013)

Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells

scientific article published on 20 June 2017

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

scientific article

Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi

scientific article

Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei

scientific article

Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization

scientific article

Cyclic GMP phosphodiesterases and regulation of smooth muscle function

scientific article

Cyclic Nucleotides and Phosphodiesterases in Monocytic Differentiation ⬇️

scientific article published on January 1, 2011

Cyclic nucleotide analogs as probes of signaling pathways.

scientific article

Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation

scientific article

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

scientific article

Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents.

scientific article published on August 2007

Differential effects of PDE5 inhibitors on cardiac dysfunction in the MDX ouse model of Duchenne muscular dystrophy.

scientific article published on 29 August 2013

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

scientific article

Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression

scientific article

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

scientific article

Enzyme Assays for cGMP Hydrolyzing Phosphodiesterases ⬇️

scientific article published on January 1, 2013

Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy ⬇️

scientific article published on January 1, 2011

GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides

scientific article published on September 2002

Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.

scholarly article

Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm

scientific article published on 18 May 2005

Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation.

scientific article published in July 2003

Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors ⬇️

scientific article published on August 30, 2011

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks

scientific article published on 27 February 2020

Kinobead/LC-MS Phosphokinome Profiling Enables Rapid Analyses of Kinase-Dependent Cell Signaling Networks

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis

scientific article published on 23 March 2016

Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A.

scholarly article

Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A

scientific article

Molecular targets for PDE inhibitor-mediated improvement of cardiac dysfunction in the mdx mouse?

scientific article published in August 2011

PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte

scientific article

PDE3 and PDE4 Isozyme-Selective Inhibitors Are Both Required for Synergistic Activation of Brown Adipose Tissue ⬇️

scientific article published on March 14, 2013

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

scientific journal article

Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes

scientific article

Phosphodiesterase type 5: expanding roles in cardiovascular regulation

scientific article

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

scientific journal article

Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals

scientific article

Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases ⬇️

scientific article published on January 1, 2011

Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells

scientific article published on 26 November 2001

Reply to Kass and Takimoto: Cardiac hypertrophy without cGKI and PDE5 in cardiac myocytes

scientific article published on 24 May 2010

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy

scientific article

Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.

scientific article

Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages.

scientific article

SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.

scientific article published on 06 September 2016

Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation

scientific article

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.

scientific article

Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE

scientific article

Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages

scientific article published in November 2004

Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics

scientific article

The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland ⬇️

scientific article published on December 27, 2010

The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

scientific article

The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites

scientific article

The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis ⬇️

scientific article published on September 29, 2011

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

scientific article

Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain

scientific article

Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond.

scientific article

cAMP-Specific Phosphodiesterases 8A and 8B, Essential Regulators of Leydig Cell Steroidogenesis ⬇️

scientific article published on January 9, 2012

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