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List of works by Heng-Huan Lee

A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues

scientific article published on 29 May 2018

A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases

scientific article published on 19 November 2018

An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5

Analysis of Individual Signaling Complexes by mMAPS, a Flow-Proteometric System.

scientific article published on April 2016

Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.

scientific article published on 29 March 2018

COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport

scientific article

Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies ⬇️

scientific article published on 19 February 2020

Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase

scientific article

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

scientific article published on 12 January 2016

Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer

scientific article published on 10 March 2022

Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers

scientific article

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.

scientific article published in February 2018

Erratum: The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer

scientific article published on 01 October 2020

Essential role of PKCdelta in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells

scientific article

Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology

scientific article published on 25 March 2019

GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.

scientific article published on 02 August 2016

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.

scientific article published on 30 August 2016

High speed digital protein interaction analysis using microfluidic single molecule detection system

scientific article published on 24 May 2010

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

scientific article published on 13 May 2021

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

scientific article published on 15 July 2019

Induction of Epstein-Barr virus latent membrane protein 1 by a lytic transactivator Rta.

scientific article published on December 2004

Induction of the early growth response 1 gene by Epstein-Barr virus lytic transactivator Zta.

scientific article

Inhibition of the Epstein-Barr virus lytic cycle by Zta-targeted RNA interference

scientific article published in June 2004

Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis

scientific article

Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression.

scientific article

Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2.

scientific article

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

Non-canonical signaling mode of the epidermal growth factor receptor family

scientific article

PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.

scientific article published on 6 February 2017

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

scientific article published on 16 November 2015

Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device

scientific article

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

scientific article published on 18 July 2019

Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma

scientific article published on 05 October 2020

Role of the TSG101 gene in Epstein-Barr virus late gene transcription.

scientific article published on 20 December 2006

Targeting glycosylated PD-1 induces potent anti-tumor immunity

scientific article published on 10 March 2020

The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis

scientific article published on 03 July 2020

The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer

scientific article published on 01 August 2020

The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus

scientific article

Treatment of advanced basal cell carcinoma with sonidegib: perspective from the 30-month update of the BOLT trial

scientific article

mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes

scientific article

p53 acetylation is crucial for its transcription-independent proapoptotic functions

scientific article

p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.

scientific article

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