List of works - Weiya Xia

A delayed chemically induced tumorigenesis in Brca2 mutant mice

scientific article published in March 2004

A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing.

scientific article published on 26 January 2018

A novel hTERT promoter-driven E1A therapeutic for ovarian cancer.

scientific article published on 11 August 2009

AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

scientific article published on 12 January 2016

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

scientific article

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway

scientific article

Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer

scientific article

Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells

scientific article

Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.

scientific article

Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis

scientific article

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

scientific article

Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.

scientific article published on 29 March 2018

Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1.

scientific article published on September 2006

Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

scientific article published on 29 January 2020

Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

scientific article published on 08 October 2020

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

scientific article

CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

scientific article published on 08 November 2019

CXCR4 expression in early breast cancer and risk of distant recurrence

scientific article published on 25 November 2009

Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway

scientific article published on March 2004

Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers

scientific article published on 01 November 2006

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

scientific article published on 26 March 2007

Deubiquitination and Stabilization of PD-L1 by CSN5.

scientific article published on 14 November 2016

Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer

scientific article published on August 2008

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

scientific article

Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase

scientific article

E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation

scientific article

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

scientific article published on 12 January 2016

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. ⬇️

scientific article published on May 2013

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

scientific article published on 20 January 2008

EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling

scientific article

Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer

scientific article published on 10 March 2022

Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

scientific article published on October 2007

Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1

scientific article

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.

scientific article published in February 2018

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

scientific article published in July 2005

Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing.

scientific article published on 27 April 2018

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

scientific article published on 29 June 2018

Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

scientific article published on 02 September 2013

GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.

scientific article published on 02 August 2016

Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation

scientific article published on 02 October 2018

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.

scientific article published on 30 August 2016

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

scientific article published on 13 May 2021

IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression

scientific article published on 22 December 2011

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

scientific article published on 15 July 2019

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

scientific article

Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis

scientific article

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

scientific article published on 13 November 2017

Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression.

scientific article

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta

scientific article published on October 2009

Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion

scientific article (publication date: August 2007)

Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.

scientific article published on December 2003

Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers

scientific article published on September 2008

MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation

scientific article

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

scientific article

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

scientific article published on 31 January 2019

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

Modeling familial cancer with induced pluripotent stem cells

scientific article

Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.

scientific article published on 10 May 2007

Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.

scientific article published on January 2005

Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer

scientific article published on July 2009

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

scientific article published on June 2005

Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis

scientific journal article

Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation

scientific article published on 6 October 2016

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

scientific article published on 03 June 2019

PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.

scientific article published on 6 February 2017

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

scientific article published on 14 September 2020

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

scientific article published on 16 November 2015

Palmitoylation stabilizes PD-L1 to promote breast tumor growth

scientific article published on 04 December 2018

Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation

scientific article

Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers.

scientific article

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

scientific article published in January 2018

Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.

scientific article published on June 2004

Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer

scientific article published in October 2002

Prostate-specific antitumor activity by probasin promoter-directed p202 expression.

scientific article

RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus

scientific article

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

scientific article published on 18 July 2019

Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma

scientific article published on 05 October 2020

Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.

scientific article published in September 2002

STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis

scientific article published on January 2004

STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.

scientific article

Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy

scientific article published on March 2004

Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene.

scientific article published in November 2002

TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.

scientific article

TNFalpha induces HIF-1alpha expression through activation of IKKbeta

scientific article published on 17 September 2009

TRIM24 links a non-canonical histone signature to breast cancer

scientific article

Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models

scientific article published on 01 July 2007

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer

scientific article published on 01 December 2018

The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression

The crosstalk of mTOR/S6K1 and Hedgehog pathways

scientific article

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

scientific article published on 08 April 2020

The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells

scientific article published on 22 June 2017

The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells

scientific article

Tyrosine phosphorylation controls PCNA function through protein stability

scientific article

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

scientific article published on November 2004

beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer

scientific article

beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma

scientific article published on 01 March 2003

p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs.

scientific article

List of works by Weiya Xia

A delayed chemically induced tumorigenesis in Brca2 mutant mice

A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing.

A novel hTERT promoter-driven E1A therapeutic for ovarian cancer.

AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway

Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer

Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells

Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.

Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.

Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1.

Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

CXCR4 expression in early breast cancer and risk of distant recurrence

Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway

Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

Deubiquitination and Stabilization of PD-L1 by CSN5.

Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase

E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. ⬇️

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling

Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer

Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing.

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.

GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.

Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression.

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta

Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion

Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast.

Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers

MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

Modeling familial cancer with induced pluripotent stem cells

Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer.

Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.

Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis

Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

Palmitoylation stabilizes PD-L1 to promote breast tumor growth

Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation

Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers.

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.

Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer

Prostate-specific antitumor activity by probasin promoter-directed p202 expression.

RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma

Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.