List of works - David Mendelowitz

5-Hydroxytryptamine 1A/7 and 4alpha receptors differentially prevent opioid-induced inhibition of brain stem cardiorespiratory function

scientific article

5HT1A receptors inhibit glutamate inputs to cardiac vagal neurons post-hypoxia/hypercapnia ⬇️

scientific article published on September 14, 2011

5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

scientific article published on 6 March 2008

ATP facilitates glutamatergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus

scientific article published on 6 February 2008

Advances in Parasympathetic Control of Heart Rate and Cardiac Function.

scientific article published in August 1999

Altered neurobiological function of brainstem hypoglossal neurons in DiGeorge/22q11.2 Deletion Syndrome

scientific article published on 4 July 2017

Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency

scientific article

Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem.

scientific article

Clonidine, an alpha2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus

scientific article published on 8 June 2010

Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem ⬇️

scientific article published on 08 May 2013

Dexmedetomidine decreases inhibitory but not excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus

scientific article

Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart

scientific article published on 25 November 2020

Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability

scientific article

Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea

scientific article published on January 2014

GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons.

scientific article

Hard to swallow: Developmental biological insights into pediatric dysphagia

scientific article

Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats

scientific article published on 24 August 2016

Ketamine differentially blocks sensory afferent synaptic transmission in medial nucleus tractus solitarius (mNTS).

scientific article

Ketamine inhibits presynaptic and postsynaptic nicotinic excitation of identified cardiac parasympathetic neurons in nucleus ambiguus

scientific article published in March 2002

Ketamine inhibits sodium currents in identified cardiac parasympathetic neurons in nucleus ambiguus

scientific article published in March 2002

Modulation of Bulbospinal Rostral Ventral Lateral Medulla Neurons by Hypoxia/Hypercapnia but Not Medullary Respiratory Activity ⬇️

scientific article published on October 29, 2012

Musings on the wanderer: what's new in our understanding of vago-vagal reflexes?: II. Integration of afferent signaling from the viscera by the nodose ganglia.

scientific article

Neurotransmission to parasympathetic cardiac vagal neurons in the brain stem is altered with left ventricular hypertrophy-induced heart failure

scientific article

Nociceptin Inhibits γ-Aminobutyric Acidergic Inputs to Cardiac Parasympathetic Neurons in the Nucleus Ambiguus ⬇️

scientific article published on January 1, 2002

Optogenetic approaches to characterize the long-range synaptic pathways from the hypothalamus to brain stem autonomic nuclei

scientific article

Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function.

scientific article

Optogenetic stimulation of locus ceruleus neurons augments inhibitory transmission to parasympathetic cardiac vagal neurons via activation of brainstem α1 and β1 receptors.

scientific article published on April 2014

Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia/hypercapnia in rats

scientific article published on 25 March 2016

Parasympathetic Vagal Control of Cardiac Function

scientific article published on March 2016

Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit.

scientific article published in September 2002

Perinatal sulfur dioxide exposure alters brainstem parasympathetic control of heart rate ⬇️

scientific article published on March 14, 2013

Postnatal Sulfur Dioxide Exposure Reversibly Alters Parasympathetic Regulation of Heart Rate ⬇️

scientific article published on June 17, 2013

Prenatal nicotine exposure alters the nicotinic receptor subtypes that modulate excitation of parasympathetic cardiac neurons in the nucleus ambiguus from primarily alpha3beta2 and/or alpha6betaX to alpha3beta4.

scientific article

Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons.

scientific article published on 25 June 2009

Propofol enhances both tonic and phasic inhibitory currents in second-order neurons of the solitary tract nucleus (NTS).

scientific article published on 7 November 2007

Purinergic P2X receptors facilitate inhibitory GABAergic and glycinergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

scientific article published on 14 June 2008

Respiratory modulation of premotor cardiac vagal neurons in the brainstem

scientific article

Respiratory sinus arrhythmia: endogenous activation of nicotinic receptors mediates respiratory modulation of brainstem cardioinhibitory parasympathetic neurons

scientific article (publication date: 19 September 2003)

Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts

scientific article published on 28 January 2019

Synaptic activation of hypoglossal respiratory motorneurons during inspiration in rats

scientific article published in November 2002

Synaptic and Intrinsic Activation of GABAergic Neurons in the Cardiorespiratory Brainstem Network ⬇️

scientific article published on May 3, 2012

The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: a mechanism for rapid eye movement sleep-dependent changes in heart rate

scientific article

The role of 5-HT3 and other excitatory receptors in central cardiorespiratory responses to hypoxia: implications for sudden infant death syndrome

scientific article published on June 2009

Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons

scientific article

List of works by David Mendelowitz

5-Hydroxytryptamine 1A/7 and 4alpha receptors differentially prevent opioid-induced inhibition of brain stem cardiorespiratory function

5HT1A receptors inhibit glutamate inputs to cardiac vagal neurons post-hypoxia/hypercapnia ⬇️

5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

ATP facilitates glutamatergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus

Advances in Parasympathetic Control of Heart Rate and Cardiac Function.

Altered neurobiological function of brainstem hypoglossal neurons in DiGeorge/22q11.2 Deletion Syndrome

Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency

Chronic intermittent hypoxia and hypercapnia inhibit the hypothalamic paraventricular nucleus neurotransmission to parasympathetic cardiac neurons in the brain stem.

Clonidine, an alpha2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus

Developmental changes in GABAergic neurotransmission to presympathetic and cardiac parasympathetic neurons in the brainstem ⬇️

Dexmedetomidine decreases inhibitory but not excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus

Evidence of Superior and Inferior Sinoatrial Nodes in the Mammalian Heart

Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability

Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea

GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons.

Hard to swallow: Developmental biological insights into pediatric dysphagia

Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats

Ketamine differentially blocks sensory afferent synaptic transmission in medial nucleus tractus solitarius (mNTS).

Ketamine inhibits presynaptic and postsynaptic nicotinic excitation of identified cardiac parasympathetic neurons in nucleus ambiguus

Ketamine inhibits sodium currents in identified cardiac parasympathetic neurons in nucleus ambiguus

Modulation of Bulbospinal Rostral Ventral Lateral Medulla Neurons by Hypoxia/Hypercapnia but Not Medullary Respiratory Activity ⬇️

Musings on the wanderer: what's new in our understanding of vago-vagal reflexes?: II. Integration of afferent signaling from the viscera by the nodose ganglia.

Neurotransmission to parasympathetic cardiac vagal neurons in the brain stem is altered with left ventricular hypertrophy-induced heart failure

Nociceptin Inhibits γ-Aminobutyric Acidergic Inputs to Cardiac Parasympathetic Neurons in the Nucleus Ambiguus ⬇️

Optogenetic approaches to characterize the long-range synaptic pathways from the hypothalamus to brain stem autonomic nuclei

Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function.

Optogenetic stimulation of locus ceruleus neurons augments inhibitory transmission to parasympathetic cardiac vagal neurons via activation of brainstem α1 and β1 receptors.

Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia/hypercapnia in rats

Parasympathetic Vagal Control of Cardiac Function

Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit.

Perinatal sulfur dioxide exposure alters brainstem parasympathetic control of heart rate ⬇️

Postnatal Sulfur Dioxide Exposure Reversibly Alters Parasympathetic Regulation of Heart Rate ⬇️

Prenatal nicotine exposure alters the nicotinic receptor subtypes that modulate excitation of parasympathetic cardiac neurons in the nucleus ambiguus from primarily alpha3beta2 and/or alpha6betaX to alpha3beta4.

Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons.

Propofol enhances both tonic and phasic inhibitory currents in second-order neurons of the solitary tract nucleus (NTS).

Purinergic P2X receptors facilitate inhibitory GABAergic and glycinergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

Respiratory modulation of premotor cardiac vagal neurons in the brainstem

Respiratory sinus arrhythmia: endogenous activation of nicotinic receptors mediates respiratory modulation of brainstem cardioinhibitory parasympathetic neurons

Sudden Heart Rate Reduction Upon Optogenetic Release of Acetylcholine From Cardiac Parasympathetic Neurons in Perfused Hearts

Synaptic activation of hypoglossal respiratory motorneurons during inspiration in rats

Synaptic and Intrinsic Activation of GABAergic Neurons in the Cardiorespiratory Brainstem Network ⬇️

The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: a mechanism for rapid eye movement sleep-dependent changes in heart rate

The role of 5-HT3 and other excitatory receptors in central cardiorespiratory responses to hypoxia: implications for sudden infant death syndrome

Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons