Search filters

List of works by Harma Ellens

A Mechanism-Based Mathematical Model of Aryl Hydrocarbon Receptor-Mediated CYP1A Induction in Rats Using β-Naphthoflavone as a Tool Compound ⬇️

scientific article published on September 15, 2010

A novel application of t-statistics to objectively assess the quality of IC50 fits for P-glycoprotein and other transporters

scientific article published on 2 December 2014

A structural model for the mass action kinetic analysis of P-gp mediated transport through confluent cell monolayers

scientific article published on January 2014

Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions.

scientific article published on 25 April 2013

Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay

scientific article

Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.

scientific article

Derivation of a system-independent Ki for Pgp-mediated digoxin transport from systemdependent IC50 data

scientific article published on 9 January 2018

Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells

scientific article published on 17 August 2011

Disposition and metabolism of darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in humans

scientific article published on 30 December 2013

Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier.

scientific article published on August 2004

Extrapolation of Elementary Rate Constants of P-glycoprotein-Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells

scientific article published on 16 November 2016

Fitting the Elementary Rate Constants of the P-gp Transporter Network in the hMDR1-MDCK Confluent Cell Monolayer Using a Particle Swarm Algorithm ⬇️

scientific article published on October 18, 2011

Hepatobiliary Disposition of Atovaquone: A Case of Mechanistically Unusual Biliary Clearance

scientific article published on 13 April 2018

If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

scientific article

Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin

scientific article published on 13 October 2016

Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

scientific article published on 29 October 2007

Mechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein med

scientific article published on 07 June 2018

Microvilli Morphology Can Affect Efflux Active P-Glycoprotein in Confluent MDCKII -hMDR1-NKI and Caco-2 Cell Monolayers.

scientific article published on 16 November 2016

Optimizing the in vitro and clinical assessment of drug interaction risk by understanding co-medications in patient populations.

scientific article published on 16 April 2013

P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites.

scientific article published on 30 November 2006

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds ⬇️

scientific article published on September 19, 2012

Prediction of the Transporter-Mediated Drug-Drug Interaction Potential of Dabrafenib and Its Major Circulating Metabolites

scientific article published on 20 March 2017

The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.

scientific article published on 22 October 2004

The importance of villous physiology and morphology in mechanistic physiologically-based pharmacokinetic models

scientific article published on 30 August 2013

The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km.

scientific article published on 22 September 2005

Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp

scientific article

Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.

scientific article published on 25 April 2013

Paulina is supported by:

About Paulina

Help