Search filters

List of works by Sriram Krishnaswamy

A rapid pro-hemostatic approach to overcome direct oral anticoagulants

scientific article published on 25 July 2016

Active site-independent recognition of substrates and product by bovine prothrombinase: a fluorescence resonance energy transfer study

scientific article published on 26 February 2004

Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.

scientific article

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis

scientific article published on 12 April 2018

An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase

scientific article

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT ⬇️

scientific article published on July 19, 2011

Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin

scientific article

Clotting in whole blood: analysis of a biochemical reaction network

scientific article published on 01 July 2002

Cofactor proteins in the assembly and expression of blood clotting enzyme complexes

scientific article

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

scientific article published on 04 June 2018

Computational Investigations on the Effects of Gurney Flap on Airfoil Aerodynamics

scientific article published on 14 January 2015

Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis

scientific article

Effect of Reynolds Number on Aerodynamics of Airfoil with Gurney Flap

scholarly article by Shubham Jain et al published 2015 in International Journal of Rotating Machinery

Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex

scientific article published on 28 August 2020

Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate

scientific article published on 4 October 2002

FVIII-VWF dos-à-dos

scientific article published on August 2015

Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.

scholarly article

Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase

scientific article published on 2 September 2008

FcRn augments induction of tissue factor activity by IgG-containing immune complexes

scientific article published on 18 March 2020

Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III.

scientific article published on 12 February 2004

Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples

scientific article published on 02 February 2022

Imaging coagulation reactions in vivo ⬇️

scientific article published on March 8, 2012

Killing 2 proteinases with 1 (dual-acting) stone ⬇️

scientific article published on 01 March 2012

Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states

scientific article

Meizothrombin Is an Unexpectedly Zymogen-like Variant of Thrombin ⬇️

scientific article published on July 19, 2012

Membrane Binding by Prothrombin Mediates Its Constrained Presentation to Prothrombinase for Cleavage ⬇️

scientific article published on August 12, 2013

Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation

scientific article published on 31 October 2013

Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding

scientific article

Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase

scientific article

New insights into the spatiotemporal localization of prothrombinase in vivo

scientific article

Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V

scientific article published on 21 December 2018

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

scientific article published on 31 October 2017

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase

scientific article

Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate

scientific article

Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides

scientific article published on 06 September 2013

Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase

scientific article published on 11 September 2007

Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex

scientific article published on 20 July 2017

Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium ⬇️

scientific article published on February 20, 2013

Supercharged blood coagulation

scientific article published on 01 February 2009

The Contribution of Factor Xa to Exosite-dependent Substrate Recognition by Prothrombinase ⬇️

scientific article published on 08 January 2002

The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase

scientific article published on 24 March 2016

The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions

scientific article published on 10 February 2005

Three-dimensional solution structure of Tropidechis carinatus venom extract trocarin: a structural homologue of Xa and prothrombin activator

scientific article published on 3 October 2002

Paulina is supported by:

About Paulina

Help