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List of works by Howard D. Thames

A 100-year Nordic perspective on the dose-time problem in radiobiology

scientific article published in January 1995

A New Method for Computer Generation of Dose Distributions from External X- and Gamma-Ray Sources ⬇️

scientific article published on 01 January 1973

A Parametric Method for Estimation of Dose-Modifying Factors: Low-Dose Extrapolation Limit

scientific article published on January 1, 1977

A Test for Dose-Modifying Factors

scientific article published on 01 November 1978

A biochemical definition of cure after brachytherapy for prostate cancer

scientific article published on 27 April 2020

A dose-surviving fraction curve for mouse colonic mucosa

scientific article published on 01 March 1983

A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer

scientific article

A morphometric analysis of glomerular and tubular alterations following fast-neutron irradiation of the pig and monkey kidney ⬇️

scientific article published on July 15, 1998

A new isoeffect curve for change in dose per fraction

scientific article published on 01 November 1983

Ablative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in Patients With Inoperable Intrahepatic Cholangiocarcinoma: A Retrospective Dose Response Analysis

scientific article published on 26 October 2015

Accelerated fractionation in the radiation treatment of head and neck cancer. A critical comparison of different strategies

scientific article published on January 1988

Accelerated fractionation vs hyperfractionation: rationales for several treatments per day.

scientific article published on February 1983

Accelerated repopulation during fractionated irradiation of a murine ovarian carcinoma: downregulation of apoptosis as a possible mechanism

scientific article published on 01 July 1996

An improved computer model for 60cobalt dose distributions

scientific article published on 01 September 1977

Biochemical and clinical significance of the posttreatment prostate-specific antigen bounce for prostate cancer patients treated with external beam radiation therapy alone: a multiinstitutional pooled analysis

scientific article published on 01 October 2006

Biological bases for high RBE values for late effects of neutron irradiation

scientific article published on 01 December 1982

Breast conservation after neoadjuvant chemotherapy

scientific article published on 01 February 2005

Breast conservation after neoadjuvant chemotherapy: the MD Anderson cancer center experience

scientific article published on 01 June 2004

Cancer stem cells and radiotherapy.

scientific article published on May 2009

Changes in TCD50 as a measure of clonogen doubling time in irradiated and unirradiated tumors

scientific article published on 01 October 1991

Changes in clonogen number and radiation sensitivity in mouse jejunal crypts after treatment with dimethylsulfoxide and retinoic acid

scientific article published on 01 June 1996

Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships

scientific article published on 01 February 1982

Changes in the radiation sensitivity of mouse skin during fractionated and prolonged treatments

scientific article published on 01 September 1994

Chemoresistance is not a cause of the apparent failure of adjuvant chemotherapy in postmenopausal women.

scientific article

Clinical evidence for tumor clonogen regeneration: interpretations of the data.

scientific article

Clinical radiobiology of malignant melanoma

article

Clinical radiobiology of squamous cell carcinoma of the oropharynx

scientific article published in June 1991

Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients

scientific article

Cluster model analysis of late rectal bleeding after IMRT of prostate cancer: a case-control study

scientific article published in March 2006

Cluster models of dose–volume effects

scientific article published on 01 August 2004

Combined modality in advanced Hodgkin's disease

scientific article published on 01 August 1998

Comparing cell survival estimated from in vivo and in vitro data: beware in vivo heterogeneity

scientific article published on 01 July 1994

Comparison of alternative biochemical failure definitions based on clinical outcome in 4839 prostate cancer patients treated by external beam radiotherapy between 1986 and 1995.

scientific article published in November 2003

Comparison of continuous and pulsed low dose rate brachytherapy: biological equivalence in vivo

scientific article published in February 1994

Comparison of mathematical models for radiation fractionation.

scientific article published in September 1976

Comparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapy

scientific article published in December 2004

Computational Modeling of Micrometastatic Breast Cancer Radiation Dose Response

scientific article

Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies.

scientific article published on 12 August 2009

Corrigendum to “HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Rad

article

Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation

scientific article published on August 2005

Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference

scientific article

Defining recurrence after radiation for prostate cancer

scientific article

Definitions of biochemical failure that best predict clinical failure in patients with prostate cancer treated with external beam radiation alone: a multi-institutional pooled analysis

scientific article published on 01 March 2005

Definitive radiotherapy for squamous cell carcinoma of the tonsillar fossa

scientific article published on 01 March 1989

Dependence of stability on inter-enzyme distance in cooperative systems ⬇️

scientific article published on September 21, 1973

Direct Estimation of Latent Time for Radiation Injury in Late-responding Normal Tissues: Gut, Lung, and Spinal Cord

scientific article published on 01 January 1989

Direct analysis of quantal radiation response data

scientific article

Direct evidence that prostate tumors show high sensitivity to fractionation (low α/β ratio), similar to late-responding normal tissue ⬇️

scientific article published on 01 January 2002

Diurnal Variations in the Expression of Radiation-Induced Apoptosis

scientific article published on 01 April 1998

Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression

scientific article published on 12 June 2011

Does Unintentional Splenic Radiation Predict Outcomes After Pancreatic Cancer Radiation Therapy?

scientific article

Does Variation in thein VitroCellular Radiosensitivity Explain the Shallow Clinical Dose—control Curve for Malignant Melanoma?

scientific article published on 01 January 1990

Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?

scientific article published on August 2005

Does incomplete repair explain the apparent failure of the basic LQ model to predict spinal cord and kidney responses to low doses per fraction?

scientific article published in July 1988

Dose response of squamous cell carcinomas of the upper respiratory and digestive tracts

scientific article

Dose-response relationship for supraglottic laryngeal carcinoma

scientific article published on 01 March 1983

Dose-response relationships for late radiation effects in the head and neck: Regarding the analysis of the RTOG 8313 trial, fu et al IJROBP 32:577–588; 1995

article

Dose-survival characteristics of mouse jejunal crypt cells ⬇️

scientific article published on 01 November 1981

Dose-volume conundrum for response of prostate cancer to brachytherapy: summary dosimetric measures and their relationship to tumor control probability

scientific article published on April 2004

Dose-volume response analyses of late rectal bleeding after radiotherapy for prostate cancer

scientific article published in June 2004

Dr. H. Rodney Withers (1932 - 2015).

scientific article published in May 2015

Early and Late Normal-tissue Injury after Postmastectomy Radiotherapy Alone or Combined with Chemotherapy

scientific article published on 01 November 1989

Early and late injuries in mouse rectum after fractionated X-ray and neutron irradiation

scientific article published on 01 March 1993

Early fractionation methods and the origins of the NSD concept

scientific article published on January 1988

Effect of [(18)F]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice

scientific article published on 14 March 2014

Effect of continuous infusion of bleomycin on the time for completion of repair of sublethal radiation damage in mouse lip mucosa during fractionated irradiation

scientific article published in August 1988

Effect of dose per fraction on the division potential of lethally irradiated plateau-phase CHO cells exposed to isoeffective fractionation regimens

scientific article published in January 1986

Effect of dose-rate on total body irradiation: lethality and pathologic findings

scientific article published on 01 December 1985

Effect of latency on calculated complication rates

scientific article published on 01 October 1986

Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition.

scientific article published on June 2005

Estimation of α/β for Late Rectal Toxicity Based on RTOG 94-06 ⬇️

scientific article published on March 4, 2011

Ex vivo γH2AX radiation sensitivity assay in prostate cancer: Inter-patient and intra-patient heterogeneity.

scientific article published on 14 September 2017

Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts.

scientific article

Factors predictive of having four or more positive axillary lymph nodes in patients with positive sentinel lymph nodes: implications for selection of radiation fields

scientific article published on 01 July 2004

Failure definition-dependent differences in outcome following radiation for localized prostate cancer: can one size fit all?

scientific article published in February 2005

Final Report of Radiation Therapy Oncology Group Protocol 9003: Provocative, but Limited Conclusions From Exploratory Analyses.

scientific article

First scatter to off-axis points and the Clarkson method

scientific article published in May 1973

Flexure dose: the low-dose limit of effective fractionation

scientific article published in September 1983

Fractionation effect on radiation-induced growth retardation of tibia in rabbits and rats

scientific article published on 01 January 1998

Fractionation parameters for human tissues and tumors

scientific article

Fractionation sensitivity and latency of telangiectasia after postmastectomy radiotherapy: a graded-response analysis

scientific article

Fractionation sensitivity of a functional endpoint: impaired shoulder movement after post-mastectomy radiotherapy

article

GTV differentially impacts locoregional control of non-small cell lung cancer (NSCLC) after different fractionation schedules: subgroup analysis of the prospective randomized CHARTWEL trial

scientific article

HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Rad

scientific article published on 29 November 2016

HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology G

scientific article published on 2 December 2014

Heterogeneity in hyperthermic sensitivities of rat 13762NF mammary adenocarcinoma cell clones of differing metastatic potentials

scientific article published on 01 September 1982

How well is the probability of tumor cure after fractionated irradiation described by Poisson statistics?

scientific article published on 01 December 1990

Hyperfractionation

scientific article published on 01 October 1982

Immunohistochemically detected p53 mutations in epithelial tumors and results of treatment with chemotherapy and radiotherapy. A treatment-specific overview of the clinical data.

scientific article

Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice

scientific article published in March 2005

Impact of increased cell loss on the repopulation rate during fractionated irradiation in human FaDu squamous cell carcinoma growing in nude mice

scientific article published on 01 July 2003

Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours.

scientific article published on 17 August 2016

Improved biochemical relapse-free survival with increased external radiation doses in patients with localized prostate cancer: the combined experience of nine institutions in patients treated in 1994 and 1995

scientific article published on 01 February 2005

In memoriam: H. Rodney Withers (21 September 1932-25 February 2015).

scientific article published in May 2015

In regard to Solomon et al.: EGFR blockade with ZD1839 ("Iressa") potentiates the antitumor effects of single and multiple fractions of ionizing radiation in human A431 squamous cell carcinoma. IJROBP 2003;55:713-723

scientific article published on 01 September 2003

Incidence and latency of radiation reactions

scientific article published on 01 March 1989

Increasing external beam dose for T1-T2 prostate cancer: effect on risk groups

scientific article published on 5 June 2006

Induction of transforming growth factor alpha in irradiated mouse jejunum

scientific article published on 01 December 1998

Influence of technologic advances on outcomes in patients with unresectable, locally advanced non-small-cell lung cancer receiving concomitant chemoradiotherapy

scientific article

Investigation of bladder dose and volume factors influencing late urinary toxicity after external beam radiotherapy for prostate cancer

scientific article

Is the rate of repair of radiation-induced sublethal damage in rat spinal cord dependent on the size of dose per fraction?

scientific article published in April 1987

Late radiation response of kidney assayed by tubule-cell survival

scientific article published on June 1986

Late rectal toxicity on RTOG 94-06: analysis using a mixture Lyman model

scientific article

Latent-time estimation for late cutaneous and subcutaneous radiation reactions in a single-follow-up clinical study

scientific article published on 01 July 1989

Long-term multi-institutional analysis of stage T1-T2 prostate cancer treated with radiotherapy in the PSA era.

scientific article published in November 2003

Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG.

scientific article published on 11 January 2016

Machine segmentation of pelvic anatomy in MRI-assisted radiosurgery (MARS) for prostate cancer brachytherapy

scientific article published on 04 July 2020

Metaanalyse klinischer Studien zur alleinigen Chemotherapie im Vergleich zur Kombination aus Chemotherapie plus Strahlentherapie bei der Behandlung des Morbus Hodgkin

Mitigation and Treatment of Radiation-Induced Thoracic Injury With a Cyclooxygenase-2 Inhibitor, Celecoxib ⬇️

scientific article published on 05 June 2012

Multifraction radiation response of mouse lung

scientific article published in April 1985

New anticancer agents: in vitro and in vivo evaluation.

scientific article

New options in direct analysis of dose-response data

scientific article

Optimal design of multifraction assays of colony survival in vivo.

scientific article published on May 1983

Overall treatment time and tumor control dose for head and neck tumors: The dog leg revisited

scientific article published on 01 October 1992

PSA after radiation for prostate cancer

scientific article published on May 2004

PSA nadir predicts biochemical and distant failures after external beam radiotherapy for prostate cancer: a multi-institutional analysis

scientific article published on 29 September 2005

Pathologic tumor size and lymph node status predict for different rates of locoregional recurrence after mastectomy for breast cancer patients treated with neoadjuvant versus adjuvant chemotherapy

scientific article published in July 2002

Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies.

scientific article published on 7 September 2006

Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation

scientific article published on 22 May 2007

Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy.

scientific article published on 17 August 2006

Predicting radiosensitivity using DNA end-binding complex analysis

scientific article published on February 2004

Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining

scientific article

Prognostic value of HIF-1α expression during fractionated irradiation.

scientific article

Prognostic value of radiobiological hypoxia during fractionated irradiation for local tumor control

scientific article

Proliferation kinetics of a murine fibrosarcoma during fractionated irradiation

scientific article published on 01 November 1988

Protection of acute and late radiation damage of the gastrointestinal tract by WR-2721

scientific article published on 01 February 1986

Protection of mouse jejunal crypt cells by WR-2721 after small doses of radiation

scientific article published on May 1986

Protective effects of S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice ⬇️

scientific article published on May 1, 1982

Radiation dose-fractionation and dose-rate relationships for long-term repopulating hemopoietic stem cells in a murine bone marrow transplant model

scientific article published on 01 October 1993

Radiation for prostate cancer: use of biochemical failure as an endpoint following radiotherapy

scientific article

Radiation nephropathy in the rhesus monkey: morphometric analysis of glomerular and tubular alterations

scientific article published on 01 February 1995

Radiation response of the monkey kidney following contralateral nephrectomy

scientific article published on 01 September 1994

Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation.

scientific article published on July 2010

Randomized phase III study of chemoradiation with or without amifostine for patients with favorable performance status inoperable stage II-III non-small cell lung cancer: preliminary results

scientific article published in January 2002

Recovery from radiation damage in mouse lung: interpretation in terms of two rates of repair

scientific article published on 01 February 1993

Recovery from sublethal damage during fractionated irradiation of human FaDu SCC

scientific article published on 01 March 2005

Repair capacity and kinetics for human mucosa and epithelial tumors in the head and neck: clinical data on the effect of changing the time interval between multiple fractions per day in radiotherapy.

scientific article published on February 1996

Repair capacity and kinetics of human skin during fractionated radiotherapy: erythema, desquamation, and telangiectasia after 3 and 5 year's follow-up

scientific article published on 01 June 1989

Repair factors for multifraction irradiations

scientific article published in January 1984

Repair in mouse lung between multiple small doses of X rays

scientific article published on 01 May 1983

Repair rate in mouse lung after clinically relevant radiation doses per fraction

scientific article published on 01 January 1995

Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation.

scientific article

Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours

scientific article

Residual γH2AX foci predict local tumour control after radiotherapy.

scientific article published on 25 July 2013

Response of fibrosarcoma cell subpopulations to small doses of radiation delivered in situ

scientific article published on 01 February 1983

Response of plateau-phase C3H 10T1/2 cells to radiation and concurrent administration of bleomycin

scientific article published in November 1989

Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma

scientific article

Retrospective investigation of the prognostic value of the β1 integrin expression in patients with head and neck squamous cell carcinoma receiving primary radio(chemo)therapy

scientific article published in PLoS ONE

Rod Withers' Data are Available Online

scientific article published on 01 February 2017

Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment

scientific article published on 01 January 1997

State vector models of the cell cycle II: The first three moments of the transit time distribution ⬇️

scientific article published on March 7, 1979

State vector models of the cell cycle III: Continuous time cell cycle models ⬇️

scientific article published on November 21, 1979

State-vector models of the cell cycle. 1. Parametrization and fits to labeled mitoses data

scientific article published on August 22, 1977

Survival of mouse testicular stem cells after gamma of neutron irradiation

scientific article published on 01 March 1980

Syngeneic and allogeneic bone marrow engraftment after total body irradiation: dependence on dose, dose rate, and fractionation

scientific article published on 01 February 1991

Test of equal effect per fraction and estimation of initial clonogen number in microcolony assays of survival after fractionated irradiation

scientific article published on November 1980

The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems. ⬇️

scientific article

The Withers Archive: Online Availability of H. Rodney Withers' Data

scientific article

The Withers archive: Online availability of rod Wither's data

scientific article

The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer

scientific article published in September 2003

The effect of patient-to-patient variability on the accuracy of predictive assays of tumor response to radiotherapy: a theoretical evaluation

scientific article published in July 1989

The effect of proliferative status and clonogen content on the response of mouse jejunal crypts to split-dose irradiation

scientific article published on 01 February 1997

The high steepness of dose-response curves for late-responding normal tissues

scientific article published in May 1989

The impact of young age on locoregional recurrence after doxorubicin-based breast conservation therapy in patients 40 years old or younger: How young is "young"?

scientific article published on 5 June 2006

The kinetics of repair in mouse lung after fractionated irradiation

scientific article published on 01 December 1987

The origins of translational radiation oncology - In memoriam H. Rodney Withers (21 September 1932-25 February 2015).

scientific article published in April 2015

The proliferative response of mouse jejunal crypt cells to radiation-induced cell depletion is not mediated exclusively by transforming growth factor alpha

scientific article published on 01 June 2001

The ratio of positive to excised nodes identifies high-risk subsets and reduces inter-institutional differences in locoregional recurrence risk estimates in breast cancer patients with 1-3 positive nodes: an analysis of prospective data from British

scientific article

The response of Chinese hamster ovary cells to fast neutron radiotherapy beams. III. Variation in biological effectiveness with position in the cell cycle

scientific article published on November 1, 1978

The role of overall treatment time in the outcome of radiotherapy of prostate cancer: an analysis of biochemical failure in 4839 men treated between 1987 and 1995.

scientific article published on 17 April 2010

The translational research chain: is it delivering the goods?

scientific article

Time factor for tonsillar carcinoma

scientific article published on 01 October 1995

Time-dose considerations for normal-tissue tolerance

scientific article published on January 1989

Time-dose factors in radiotherapy: a review of the human data.

scientific article

Tissue repair capacity and repair kinetics deduced from multifractionated or continuous irradiation regimens with incomplete repair.

scientific article published on January 1984

Tumor radioresistance in clinical radiotherapy

scientific article published in January 1982

Tumor sensitizing effect by misonidazole in a clinically relevant radiation dose range

scientific article published on 01 March 1984

Tumor volume and local control probability: clinical data and radiobiological interpretations

scientific article published on August 1996

Twice-daily fractionation schemes for advanced head and neck cancer

scientific article published on 01 June 1984

Use of the LQ model with large fraction sizes results in underestimation of isoeffect doses

scientific article published on 20 September 2013

Variations in radiation sensitivity and repair among different hematopoietic stem cell subsets following fractionated irradiation

scientific article published on 01 July 1995

Will identifying or targeting altered marker expression in response to cytotoxic therapy be of prognostic or therapeutic value?

scientific article published on 28 July 2003

Year of treatment as independent predictor of relapse-free survival in patients with localized prostate cancer treated with definitive radiotherapy in the PSA era

scientific article published on 31 May 2005

γH2AX assay in ex vivo irradiated tumour specimens: A novel method to determine tumour radiation sensitivity in patient-derived material.

scientific article

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