List of works - Saburo Sone

5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor ⬇️

scientific article published on February 26, 2011

A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone2 in natural killer cell-depleted severe combined immunodeficient mice

scientific article published on January 2009

A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer ⬇️

scientific article published on March 10, 2011

A novel Src kinase inhibitor, M475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration

scientific article published on 4 June 2005

A peptide mimetic of human interferon (IFN)-beta

scientific article

A report of two bronchioloalveolar carcinoma cases which were rapidly improved by treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 ("Iressa")

scientific article (publication date: May 2003)

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice

scientific article published on 29 April 2015

Activity of a new vascular targeting agent, ZD6126, in pulmonary metastases by human lung adenocarcinoma in nude mice.

scientific article

Antiangiogenic therapies for malignant pleural mesothelioma.

scientific article published on January 2011

Cancer screening

scientific article published on January 2005

Clinical trials for drug approval: a pilot study of the view of doctors at Tokushima University Hospital

scientific article published on August 2006

Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors

scientific article published on 20 October 2009

Current status and perspective of angiogenesis and antivascular therapeutic strategy: non-small cell lung cancer

scientific article

Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer.

scientific article

E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor.

scientific article published on 6 May 2011

E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangiogenic cytokine production profiles.

scientific article

Early growth response 4 is involved in cell proliferation of small cell lung cancer through transcriptional activation of its downstream genes

scientific article

Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells

scientific article (publication date: February 2003)

Effects of local administration of interferon-beta on proliferation of retinal pigment epithelium in rabbit after laser photocoagulation

scientific article

Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats ⬇️

scientific article published on 01 January 2012

Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression.

scientific article

Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property

scientific article

Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice

scientific article

Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice

scientific article

Genetic modification of dendritic cells and its application for cancer immunotherapy

scientific article

Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells.

scientific article

Globalization of clinical trials

scientific article published on April 2003

Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile analysis of non-small cell lung cancer in mice ⬇️

scientific article published on January 27, 2012

Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice.

scientific article

Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.

scientific article

MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer

scientific article

Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironment ⬇️

scientific article published on September 26, 2012

Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancer.

scientific article published on 8 February 2012

Molecular mechanisms of angiogenesis in non-small cell lung cancer, and therapeutics targeting related molecules

scientific article

Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone

scientific article published on December 2007

Molecular targeting in the treatment of lung cancer--toward the development of individualized treatment

scientific article published on September 2004

Multifunctional interleukin-1beta promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules

scientific article

Phase II study of tailored S-1 monotherapy with a 1-week interval after a 2-week dosing period in elderly patients with advanced non-small cell lung cancer

scientific article

Pleural Mesothelioma Instigates Tumor-Associated Fibroblasts To Promote Progression via a Malignant Cytokine Network ⬇️

scientific article published on July 18, 2011

Post launch studies

scientific article

Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity

scientific article published on December 2005

Role of Tyrosine Kinase Inhibitors in Tumor Immunology ⬇️

scientific article published on January 1, 2011

SU6668, a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model

scientific article published on August 2012

Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor

scientific article (publication date: 2004)

Surfactant Protein-D Regulates Effector Cell Function and Fibrotic Lung Remodeling in Response to Bleomycin Injury ⬇️

scientific article published on December 28, 2011

Surfactant protein A suppresses lung cancer progression by regulating the polarization of tumor-associated macrophages.

scientific article published on 14 March 2013

The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association

scientific article

The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice ⬇️

scientific article published on November 16, 2010

Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells ⬇️

scientific article published on June 26, 2012

Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.

scientific article published on 10 January 2011

[Bridging between molecular biology and clinical aspect of respiratory tract diseases: discussion]

scientific article published on 01 July 2003

[Cancer prevention].

scientific article published on October 2005

List of works by Saburo Sone

5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor ⬇️

A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone2 in natural killer cell-depleted severe combined immunodeficient mice

A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer ⬇️

A novel Src kinase inhibitor, M475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration

A peptide mimetic of human interferon (IFN)-beta

A report of two bronchioloalveolar carcinoma cases which were rapidly improved by treatment with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 ("Iressa")

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice

Activity of a new vascular targeting agent, ZD6126, in pulmonary metastases by human lung adenocarcinoma in nude mice.

Antiangiogenic therapies for malignant pleural mesothelioma.

Cancer screening

Clinical trials for drug approval: a pilot study of the view of doctors at Tokushima University Hospital

Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors

Current status and perspective of angiogenesis and antivascular therapeutic strategy: non-small cell lung cancer

Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer.

E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor.

E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangiogenic cytokine production profiles.

Early growth response 4 is involved in cell proliferation of small cell lung cancer through transcriptional activation of its downstream genes

Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells

Effects of local administration of interferon-beta on proliferation of retinal pigment epithelium in rabbit after laser photocoagulation

Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats ⬇️

Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression.

Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property

Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice

Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice

Genetic modification of dendritic cells and its application for cancer immunotherapy

Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells.

Globalization of clinical trials

Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile analysis of non-small cell lung cancer in mice ⬇️

Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice.

Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.

MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer

Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironment ⬇️

Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancer.

Molecular mechanisms of angiogenesis in non-small cell lung cancer, and therapeutics targeting related molecules

Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone

Molecular targeting in the treatment of lung cancer--toward the development of individualized treatment

Multifunctional interleukin-1beta promotes metastasis of human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- and angiogenesis-related molecules

Phase II study of tailored S-1 monotherapy with a 1-week interval after a 2-week dosing period in elderly patients with advanced non-small cell lung cancer

Pleural Mesothelioma Instigates Tumor-Associated Fibroblasts To Promote Progression via a Malignant Cytokine Network ⬇️

Post launch studies

Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity

Role of Tyrosine Kinase Inhibitors in Tumor Immunology ⬇️

SU6668, a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model

Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor

Surfactant Protein-D Regulates Effector Cell Function and Fibrotic Lung Remodeling in Response to Bleomycin Injury ⬇️

Surfactant protein A suppresses lung cancer progression by regulating the polarization of tumor-associated macrophages.

The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association

The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice ⬇️

Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells ⬇️

Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.

[Bridging between molecular biology and clinical aspect of respiratory tract diseases: discussion]

[Cancer prevention].