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List of works by Karel van Erpecum

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

scientific article published in August 2016

A phylogenetic survey of biliary lipids in vertebrates

scientific article published in August 2005

Absence of apolipoprotein E4 genotype, good gallbladder motility and presence of solitary stones delay rather than prevent gallstone recurrence after extracorporeal shock wave lithotripsy

scientific article published in July 2001

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine.

scientific article published on 22 April 2011

Activation of extrinsic apoptosis pathway in HCV monoinfected and HIV-HCV coinfected patients, irrespective of liver disease severity

scientific article published on July 2014

Acute intraduodenal bile salt depletion leads to strong gallbladder contraction, altered antroduodenal motility and high plasma motilin levels in humans

scientific article published in October 2000

Adherence to ribavirin in chronic hepatitis C patients on antiviral treatment: Results from a randomized controlled trial using real-time medication monitoring.

scientific article published on 8 February 2016

Adherence to ursodeoxycholic acid therapy in patients with cholestatic and autoimmune liver disease

scientific article published on 13 September 2018

Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

scientific article published on 20 July 2012

Bacterial infections in cirrhosis: role of proton pump inhibitors and intestinal permeability ⬇️

scientific article published on January 31, 2012

Beneficial effect of successful HCV treatment in patients with inherited bleeding disorders, assessed by liver stiffness measurements

scientific article published on 21 November 2011

Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease

scientific article published on 23 April 2010

Biliary pronucleating proteins and apolipoprotein E in cholesterol and pigment stone patients

scientific article

Breath Tests to Assess Alcoholic Liver Disease.

scientific article published on 9 August 2016

CD4/CD8 ratio is a promising candidate for non-invasive measurement of liver fibrosis in chronic HCV-monoinfected patients

scientific article published on 22 January 2014

Cholesterol crystallization in model biles: effects of bile salt and phospholipid species composition

scientific article published in August 2001

Cholesterol crystals enhance and phospholipids protect against pancreatitis induced by hydrophobic bile salts: a rat model study

scientific article published on 01 May 2006

Cholesterol saturation rather than phospholipid/bile salt ratio or protein content affects crystallization sequences in human gallbladder bile

scientific article published in October 2004

Clinical and basal aspects of anemia during antiviral therapy for hepatitis C.

scientific article

Clinical impact of five large-scale screening projects for chronic hepatitis B in Chinese migrants in the Netherlands

scientific article

Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection

scientific article

Coordinate regulation of gallbladder motor function in the gut-liver axis.

scientific article published on June 2008

Current treatments of primary sclerosing cholangitis.

scientific article published on January 2007

Cytotoxic T lymphocyte antigen-4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis

scientific article

Diagnostics and treatment of hepatocellular carcinoma: trends in the Netherlands in the period 2003-2011

scientific article

Different interactions of egg-yolk phosphatidylcholine and sphingomyelin with detergent bile salts

scientific article published on July 2002

Drugs affecting biliary lipid secretion and gallbladder motility: their potential role in gallstone treatment and prevention

scientific article

ELF-test less accurately identifies liver cirrhosis diagnosed by liver stiffness measurement in non-Asian women with chronic hepatitis B.

scientific article published on 24 October 2014

Early endoscopic retrograde cholangiopancreatography in predicted severe acute biliary pancreatitis: a prospective multicenter study

scientific article

Early endoscopic retrograde cholangiopancreatography versus conservative management in acute biliary pancreatitis without cholangitis: a meta-analysis of randomized trials

scientific article published on February 2008

Effects of growth hormone deficiency and recombinant growth hormone therapy on postprandial gallbladder motility and cholecystokinin release

scientific article

Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles

scientific article

Effects of hydrophobic and hydrophilic bile salts on gallstone growth and dissolution in model biles

scientific article published in January 2005

Effects of preventive versus "on-demand" nutritional support on paid labour productivity, physical exercise and performance status during PEG-interferon-containing treatment for hepatitis C.

scientific article published on 15 July 2015

Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands.

scientific article published on 15 August 2014

Evaluation of gallbladder motility: comparison of two-dimensional and three-dimensional ultrasonography.

scientific article published in July 2007

Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease

scientific article

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

scientific journal article

Fibrates for itch (FITCH) in fibrosing cholangiopathies: a double blind, randomized, placebo-controlled trial

scientific article published on 05 October 2020

Gallbladder histopathology during murine gallstone formation: relation to motility and concentrating function.

scientific article published on 13 October 2005

Gallstones

scientific article published on 28 April 2016

Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

article

HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1.

scientific article published on 22 January 2015

Hepatitis B viral load and risk of HBV-related liver disease: from East to West? ⬇️

scientific article published on March 1, 2012

Hepatocellular carcinoma in cirrhotic versus noncirrhotic livers: results from a large cohort in the Netherlands

scientific article

Hepatocellular carcinoma in noncirrhotic livers is associated with steatosis rather than steatohepatitis: potential implications for pathogenesis

scientific article

Hepatocellular carcinoma: Dutch guideline for surveillance, diagnosis and therapy

scientific article

Historic and current hepatitis B viral DNA and quantitative HBsAg level are not associated with cirrhosis in non-Asian women with chronic hepatitis B.

scientific article published on 24 October 2014

How the concept of biochemical response influenced the management of primary biliary cholangitis over time

scientific article published in July 2016

Hydrophilic bile salts enhance differential distribution of sphingomyelin and phosphatidylcholine between micellar and vesicular phases: potential implications for their effects in vivo

scientific article published in April 2001

Impact of Fibroscan on management of chronic viral hepatitis in clinical practice

scientific article published on October 1, 2011

Impact of global Fxr deficiency on experimental acute pancreatitis and genetic variation in the FXR locus in human acute pancreatitis

scientific article

Impact of transient elastography on clinical decision-making in patients with chronic viral hepatitis.

scientific article published on 25 July 2013

Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid

scientific article published on 14 January 2009

Incorporation of cholesterol in sphingomyelin- phosphatidylcholine vesicles has profound effects on detergent-induced phase transitions.

scientific article published on July 2002

Increased Mortality Among Patients With vs Without Cirrhosis and Autoimmune Hepatitis

article

Indomethacin enhances bile salt detergent activity: relevance for NSAIDs-induced gastrointestinal mucosal injury

scientific article published on 01 April 2006

Interdigestive gallbladder emptying, antroduodenal motility, and motilin release patterns are altered in cholesterol gallstone patients

scientific article published in June 2001

Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis

article

Intestinal failure to produce FGF19: A culprit in intestinal failure-associated liver disease?

scientific article published on 18 March 2015

Intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs: role of bile salts.

scientific article published on 31 January 2007

Is complicated gallstone disease preceded by biliary colic?

scientific article published on 24 October 2008

Lack of consensus on the role of endoscopic retrograde cholangiography in acute biliary pancreatitis in published meta-analyses and guidelines: a systematic review

scientific article published on July 2013

Liver decompensation in HIV/Hepatitis B coinfection in the cART era does not seem increased compared to hepatitis B mono-infection

article

Liver disease associated with canalicular transport defects: current and future therapies

scientific article

Liver perfusion in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI): comparison of enhancement in Gd-BT-DO3A and Gd-EOB-DTPA in normal liver parenchyma

scientific article published on 5 July 2014

Liver stiffness measurements to assess progression of fibrosis in HCV-infected patients with inherited bleeding disorders

scientific article published on 27 April 2011

Long-term exclusive zinc monotherapy in symptomatic Wilson disease: experience in 17 patients

scientific article published in November 2009

Long-term follow-up of hepatitis C infection in a large cohort of patients with inherited bleeding disorders

scientific article

Low serum hyaluronic acid levels associated with spontaneous HBsAg clearance

scientific article

Lysophosphatidic acid is a potential mediator of cholestatic pruritus

scientific article

Measuring ribavirin concentrations during the earliest stages of antiviral therapy for hepatitis C: potential relevance for treatment outcome

scientific article published on August 2013

Micellar lipid composition profoundly affects LXR-dependent cholesterol transport across CaCo2 cells.

scientific article published on 20 March 2009

Microlithiasis: an important cause of "idiopathic" acute pancreatitis?

scientific article published on January 2003

Minimally invasive image-guided therapy for inoperable hepatocellular carcinoma: What is the evidence today? ⬇️

scientific article published on June 1, 2010

Modulation of cholesterol crystallization in bile. Implications for non-surgical treatment of cholesterol gallstone disease.

scientific article

Nasobiliary drainage induces long-lasting remission in benign recurrent intrahepatic cholestasis

scientific article

Natural history and treatment of HCV/HIV coinfection: Is it time to change paradigms?

scientific article published on 14 July 2015

No beneficial effects of amantadine in treatment of chronic hepatitis C patients

scientific article published on 16 December 2009

No increased risk of hepatocellular carcinoma in cirrhosis due to Wilson disease during long-term follow-up

scientific article published in March 2015

No reduction of radiation dose following the introduction of dose-area product measurement in endoscopic retrograde cholangiopancreatography

scientific article published on 01 December 2015

Overcoming Outpatient Loss to Follow-up as a Barrier to Efficiently Instituting Hepatitis B Liver-related Care

scientific article published on 10 November 2016

Pathogenesis of cholesterol and pigment gallstones: An update ⬇️

scientific article published on February 25, 2011

Pathogenesis of gallstones

scientific article published on 01 June 2010

Pathways of cholesterol crystallization in model bile and native bile.

scientific article

Patient adherence to antiviral treatment for chronic hepatitis B and C: a systematic review ⬇️

scientific article published on May 1, 2013

Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis.

scientific article

Pharmacological manipulation of biliary water and lipids: potential consequences for prevention of acute biliary pancreatitis

scientific article

Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: soluble pronucleating proteins in gallbladder and hepatic biles ⬇️

scientific article published on October 1, 2001

Plasma HCV-RNA decline in the first 48 h identifies hepatitis C virus mono-infected but not HCV/HIV-coinfected patients with an undetectable HCV viral load at week 4 of peginterferon-alfa-2a/ribavirin therapy

scientific article published on 11 May 2009

Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis ⬇️

scientific article published on October 17, 2013

Preventive versus "on-demand" nutritional support during antiviral treatment for hepatitis C: a randomized controlled trial

scientific article published in July 2012

Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease

scientific article published on March 8, 2012

Primary sclerosing cholangitis: updates in diagnosis and therapy

scientific article

Probiotics in primary sclerosing cholangitis: a randomized placebo-controlled crossover pilot study

scientific article

Progression to end-stage liver disease in patients with inherited bleeding disorders and hepatitis C: an international, multicenter cohort study

scientific article published on 9 January 2007

Protein energy malnutrition predicts complications in liver cirrhosis ⬇️

scientific article published on November 1, 2011

Quantitation of cholesterol crystallization from supersaturated model bile

scientific article published in April 2002

REtrieval And cure of Chronic Hepatitis C (REACH): results of micro-elimination in the Utrecht province

article

Radioembolization-induced liver disease: a systematic review

scientific article published on 6 December 2016

Randomized controlled trials of antibiotic prophylaxis in severe acute pancreatitis: relationship between methodological quality and outcome

scientific article published on 27 September 2007

Real life adherence of chronic hepatitis B patients to entecavir treatment

scientific article published on 8 April 2015

Regulation of biliary cholesterol secretion is independent of hepatocyte canalicular membrane lipid composition: a study in the diosgenin-fed rat model

scientific article

Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission ⬇️

scientific article published on September 16, 2012

Relevance of hereditary defects in lipid transport proteins for the pathogenesis of cholesterol gallstone disease

scientific article published on January 2004

Renal proximal tubular dysfunction due to tenofovir in a patient with chronic hepatitis B monoinfection

scientific article published on 03 March 2015

Reply to "Surveillance for hepatocellular carcinoma: A tale of two countries"

scientific article published on 23 December 2015

Resistance-associated polymorphisms in Dutch hepatitis C genotype 1a patients with and without HIV infection

Retrieval of chronic hepatitis C patients. A manifesto for action to eliminate hepatitis C in the Netherlands: the CELINE project

scientific article published on 01 May 2019

Review article: agents affecting gall-bladder motility--role in treatment and prevention of gallstones

scientific article

Ribavirin Concentration Is a More Important Predictor of Sustained Viral Response Than Anemia in Hepatitis C Patients ⬇️

scientific article published on March 25, 2011

Ribavirin rather than PEG-interferon pharmacodynamics predict nonresponse to antiviral therapy in naive chronic hepatitis C patients

scientific article published on 29 November 2010

Ribavirin steady-state plasma level is a predictor of sustained virological response in hepatitis C-infected patients treated with direct-acting antivirals.

scientific article published on 7 September 2017

Risk factors for primary sclerosing cholangitis

scientific article

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions.

scientific article published in October 2012

Serum immunoglobulin G4 and immunoglobulin G1 for distinguishing immunoglobulin G4-associated cholangitis from primary sclerosing cholangitis

scientific article published on April 2014

Small gallstones are associated with increased risk of acute pancreatitis: potential benefits of prophylactic cholecystectomy?

scientific article published in November 2005

Small gallstones, preserved gallbladder motility, and fast crystallization are associated with pancreatitis

scientific article published in April 2005

Sphingomyelin exhibits greatly enhanced protection compared with egg yolk phosphatidylcholine against detergent bile salts

scientific article published on 01 June 2000

Sphingomyelin protects against apoptosis and hyperproliferation induced by deoxycholate: potential implications for colon cancer.

scientific article

Strategies for achieving viral hepatitis C micro-elimination in the Netherlands

scientific article published on 29 September 2018

Suboptimal endogenous erythropoietin response in chronic hepatitis C patients during ribavirin and PEG interferon treatment

scientific article published on November 2010

Surveillance for hepatocellular carcinoma in chronic liver disease: evidence and controversies

scientific article published on October 2013

Surveillance for hepatocellular carcinoma is associated with increased survival: Results from a large cohort in the Netherlands

scientific article published on 19 June 2015

Survival in relation to hospital type after resection or sorafenib treatment for hepatocellular carcinoma in The Netherlands

scientific article published on 3 April 2015

T-cell responses at baseline and during therapy with peginterferon-alpha and ribavirin are not associated with outcome in chronic hepatitis C infected patients.

scientific article published on 12 June 2010

The 2012 revised Dutch national guidelines for the treatment of chronic hepatitis B virus infection

scientific article published on October 1, 2012

The H1069Q mutation in ATP7B is associated with late and neurologic presentation in Wilson disease: results of a meta-analysis

scientific article published on 01 November 2004

The Impact of Hepatitis C Virus Direct-Acting Antivirals on Patient-Reported Outcomes: A Dutch Prospective Cohort Study

scholarly article by Patricia A M Kracht et al published September 2018 in Infectious diseases and therapy

The hepatitis C virus nonstructural protein 3 Q80K polymorphism is frequently detected and transmitted among HIV-infected MSM in the Netherlands

scientific article published on January 2017

The natural history of childhood-acquired hepatitis C infection in patients with inherited bleeding disorders

scientific article published in August 2006

The physical presence of gallstone modulates ex vivo cholesterol crystallization pathways of human bile.

scientific article published on 5 December 2018

The potent bile acid sequestrant colesevelam is not effective in cholestatic pruritus: results of a double-blind, randomized, placebo-controlled trial

scientific article published on October 2010

The role of mycophenolate mofetil in the management of autoimmune hepatitis and overlap syndromes ⬇️

scientific article published on June 12, 2011

The “Von Meyenburg complex”: An unusual cause of cholangitis? ⬇️

scientific article published on August 17, 2011

Timing of cholecystectomy after endoscopic sphincterotomy for common bile duct stones.

scientific article published on 13 February 2008

Trans-arterial 90yttrium radioembolization for patients with unresectable tumors originating from the biliary tree ⬇️

scientific article published on 01 July 2011

Transarterial radioembolization versus chemoembolization for the treatment of hepatocellular carcinoma (TRACE): study protocol for a randomized controlled trial

scientific article

Treatment for Chronic Hepatitis E Virus Infection: A Systematic Review and Meta-analysis

scientific article published on 10 December 2020

Treatment of chronic hepatitis B virus infection - Dutch national guidelines

scientific article published on July 2008

Treatment of chronic hepatitis C virus infection - Dutch national guidelines.

scientific article

Trends in incidence, diagnosis, treatment and survival of hepatocellular carcinoma in a low-incidence country: Data from the Netherlands in the period 2009-2016

scientific article published on 13 August 2020

Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy

scientific article published in June 2006

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